Prestwick-689-2514 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the Prestwick-689-2514 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSBG1 acyl-CoA synthetase bubblegum family member 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
APAF1 apoptotic peptidase activating factor 1
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATRNL1 attractin-like 1
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2
BRD7P3 bromodomain containing 7 pseudogene 3
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CCDC170 coiled-coil domain containing 170
CCR4 chemokine (C-C motif) receptor 4
CD59 CD59 molecule, complement regulatory protein
CD8B CD8b molecule
CDC14B cell division cycle 14B
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CLDN17 claudin 17
CLTA clathrin, light chain A
COL10A1 collagen, type X, alpha 1
COQ7 coenzyme Q7 homolog, ubiquinone (yeast)
CPED1 cadherin-like and PC-esterase domain containing 1
DNAI2 dynein, axonemal, intermediate chain 2
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
FADS3 fatty acid desaturase 3
FAM155A family with sequence similarity 155, member A
FAM198B family with sequence similarity 198, member B
FAM46C family with sequence similarity 46, member C
FGD6 FYVE, RhoGEF and PH domain containing 6
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOXJ1 forkhead box J1
FUS FUS RNA binding protein
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5
GAS6 growth arrest-specific 6
GAST gastrin
GDAP1 ganglioside induced differentiation associated protein 1
GLE1 GLE1 RNA export mediator
GNAS GNAS complex locus
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GPR137 G protein-coupled receptor 137
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
HOXC10 homeobox C10
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IGHA1 immunoglobulin heavy constant alpha 1
IL1R1 interleukin 1 receptor, type I
IL3RA interleukin 3 receptor, alpha (low affinity)
ING4 inhibitor of growth family, member 4
IRF4 interferon regulatory factor 4
ITGB5 integrin, beta 5
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KLHL1 kelch-like family member 1
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LTBP2 latent transforming growth factor beta binding protein 2
MIER2 mesoderm induction early response 1, family member 2
MLANA melan-A
NCAM1 neural cell adhesion molecule 1
NF1 neurofibromin 1
NIPAL2 NIPA-like domain containing 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRG2 neuregulin 2
OTOR otoraplin
PAX3 paired box 3
PCLO piccolo presynaptic cytomatrix protein
POU2F2 POU class 2 homeobox 2
POU3F4 POU class 3 homeobox 4
POU4F1 POU class 4 homeobox 1
PPP1R12B protein phosphatase 1, regulatory subunit 12B
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PTAFR platelet-activating factor receptor
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PVR poliovirus receptor
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RHOD ras homolog family member D
RNASE3 ribonuclease, RNase A family, 3
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
SIGLEC7 sialic acid binding Ig-like lectin 7
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter)
SLC17A4 solute carrier family 17, member 4
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SOCS6 suppressor of cytokine signaling 6
SRPK3 SRSF protein kinase 3
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STS steroid sulfatase (microsomal), isozyme S
TADA3 transcriptional adaptor 3
TAT tyrosine aminotransferase
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TEX41 testis expressed 41 (non-protein coding)
TMOD1 tropomodulin 1
TRPC6 transient receptor potential cation channel, subfamily C, member 6
UNC93A unc-93 homolog A (C. elegans)
VENTX VENT homeobox
ZER1 zyg-11 related, cell cycle regulator
ZNF286A zinc finger protein 286A
ZNF44 zinc finger protein 44

decreased expression

Symbol Name
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMT aminomethyltransferase
ANXA3 annexin A3
AP4M1 adaptor-related protein complex 4, mu 1 subunit
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARHGAP12 Rho GTPase activating protein 12
ASB13 ankyrin repeat and SOCS box containing 13
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BBS10 Bardet-Biedl syndrome 10
C8ORF60 chromosome 8 open reading frame 60
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CD70 CD70 molecule
CEP72 centrosomal protein 72kDa
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLDN15 claudin 15
CPNE7 copine VII
CRYZ crystallin, zeta (quinone reductase)
CTRL chymotrypsin-like
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEPDC1 DEP domain containing 1
DKK2 dickkopf WNT signaling pathway inhibitor 2
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
ERCC4 excision repair cross-complementation group 4
FAM63B family with sequence similarity 63, member B
FBXL15 F-box and leucine-rich repeat protein 15
FBXL6 F-box and leucine-rich repeat protein 6
FBXL7 F-box and leucine-rich repeat protein 7
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FKBPL FK506 binding protein like
GAA glucosidase, alpha; acid
GAB2 GRB2-associated binding protein 2
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2
GMPPA GDP-mannose pyrophosphorylase A
GPRC5C G protein-coupled receptor, class C, group 5, member C
GRWD1 glutamate-rich WD repeat containing 1
GSTCD glutathione S-transferase, C-terminal domain containing
HIRA histone cell cycle regulator
HPSE heparanase
HSPA1L heat shock 70kDa protein 1-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IMPACT impact RWD domain protein
INO80D INO80 complex subunit D
IRX5 iroquois homeobox 5
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
KIAA0319L KIAA0319-like
KIF1B kinesin family member 1B
KRT81 keratin 81, type II
LIN7A lin-7 homolog A (C. elegans)
LRRK1 leucine-rich repeat kinase 1
METRN meteorin, glial cell differentiation regulator
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MOGS mannosyl-oligosaccharide glucosidase
MRAS muscle RAS oncogene homolog
MTSS1L metastasis suppressor 1-like
MXD3 MAX dimerization protein 3
MYL5 myosin, light chain 5, regulatory
NDE1 nudE neurodevelopment protein 1
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFS1 NFS1 cysteine desulfurase
NPIPB3 nuclear pore complex interacting protein family, member B3
NT5M 5',3'-nucleotidase, mitochondrial
OASL 2'-5'-oligoadenylate synthetase-like
PLA2G12A phospholipase A2, group XIIA
POR P450 (cytochrome) oxidoreductase
PPDPF pancreatic progenitor cell differentiation and proliferation factor
RAB23 RAB23, member RAS oncogene family
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RNF144A ring finger protein 144A
SCUBE3 signal peptide, CUB domain, EGF-like 3
SFMBT1 Scm-like with four mbt domains 1
SHARPIN SHANK-associated RH domain interactor
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SMR3A submaxillary gland androgen regulated protein 3A
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SPATA2L spermatogenesis associated 2-like
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STX5 syntaxin 5
SV2A synaptic vesicle glycoprotein 2A
TCEA2 transcription elongation factor A (SII), 2
TEC tec protein tyrosine kinase
TESK1 testis-specific kinase 1
TMEM230 transmembrane protein 230
TPRA1 transmembrane protein, adipocyte asscociated 1
TRAIP TRAF interacting protein
TUBB2A tubulin, beta 2A class IIa
UNC119 unc-119 homolog (C. elegans)
UPB1 ureidopropionase, beta
VILL villin-like
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF215 zinc finger protein 215
ZNF350 zinc finger protein 350
ZNF671 zinc finger protein 671
ZNF675 zinc finger protein 675
ZNF862 zinc finger protein 862