Prestwick-689-6076 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the Prestwick-689-6076 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
ADAM12 ADAM metallopeptidase domain 12
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ALK anaplastic lymphoma receptor tyrosine kinase
AQP4 aquaporin 4
ATN1 atrophin 1
BEX1 brain expressed, X-linked 1
C10ORF12 chromosome 10 open reading frame 12
C4BPB complement component 4 binding protein, beta
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CD96 CD96 molecule
CDRT1 CMT1A duplicated region transcript 1
CDX1 caudal type homeobox 1
CLDN18 claudin 18
CNOT4 CCR4-NOT transcription complex, subunit 4
COL13A1 collagen, type XIII, alpha 1
CRTAM cytotoxic and regulatory T cell molecule
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CXCL6 chemokine (C-X-C motif) ligand 6
DGCR5 DiGeorge syndrome critical region gene 5 (non-protein coding)
DLX2 distal-less homeobox 2
ECEL1 endothelin converting enzyme-like 1
FAM171A1 family with sequence similarity 171, member A1
FOS FBJ murine osteosarcoma viral oncogene homolog
FSTL1 follistatin-like 1
GABRA5 gamma-aminobutyric acid (GABA) A receptor, alpha 5
GBP2 guanylate binding protein 2, interferon-inducible
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPR132 G protein-coupled receptor 132
GRK5 G protein-coupled receptor kinase 5
GSTM5 glutathione S-transferase mu 5
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2
HIST1H4A histone cluster 1, H4a
HR hair growth associated
IGHM immunoglobulin heavy constant mu
IL1RN interleukin 1 receptor antagonist
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAG1 jagged 1
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KLF13 Kruppel-like factor 13
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LBX1 ladybird homeobox 1
LGALS14 lectin, galactoside-binding, soluble, 14
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LOC399491
MAP4 microtubule-associated protein 4
MCPH1 microcephalin 1
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MRPS18C mitochondrial ribosomal protein S18C
MUC3B mucin 3B, cell surface associated
MYOZ1 myozenin 1
NF2 neurofibromin 2 (merlin)
NOL12 nucleolar protein 12
NPY6R neuropeptide Y receptor Y6 (pseudogene)
OR52A1 olfactory receptor, family 52, subfamily A, member 1
PDE9A phosphodiesterase 9A
PKNOX2 PBX/knotted 1 homeobox 2
PLD1 phospholipase D1, phosphatidylcholine-specific
PPP5C protein phosphatase 5, catalytic subunit
PQBP1 polyglutamine binding protein 1
PRKCB protein kinase C, beta
PRUNE2 prune homolog 2 (Drosophila)
PSCA prostate stem cell antigen
PSD pleckstrin and Sec7 domain containing
PSD3 pleckstrin and Sec7 domain containing 3
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PURG purine-rich element binding protein G
RPH3A rabphilin 3A
RTN2 reticulon 2
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
SAMD4A sterile alpha motif domain containing 4A
SCEL sciellin
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SETBP1 SET binding protein 1
SFRP4 secreted frizzled-related protein 4
SFRP5 secreted frizzled-related protein 5
SIRT5 sirtuin 5
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SNPH syntaphilin
SNTA1 syntrophin, alpha 1
SRCAP Snf2-related CREBBP activator protein
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TAGLN3 transgelin 3
TBC1D19 TBC1 domain family, member 19
TGM2 transglutaminase 2
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TOR4A torsin family 4, member A
TREM2 triggering receptor expressed on myeloid cells 2
TRIL TLR4 interactor with leucine-rich repeats
UBE2D1 ubiquitin-conjugating enzyme E2D 1
XAF1 XIAP associated factor 1
ZNF385D zinc finger protein 385D
ZNF442 zinc finger protein 442

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ACAD10 acyl-CoA dehydrogenase family, member 10
ACADSB acyl-CoA dehydrogenase, short/branched chain
ALG12 ALG12, alpha-1,6-mannosyltransferase
ALPK1 alpha-kinase 1
ARMCX2 armadillo repeat containing, X-linked 2
AUTS2 autism susceptibility candidate 2
BAHCC1 BAH domain and coiled-coil containing 1
C1ORF159 chromosome 1 open reading frame 159
C8ORF60 chromosome 8 open reading frame 60
CA5BP1 carbonic anhydrase VB pseudogene 1
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CBX8 chromobox homolog 8
CCDC68 coiled-coil domain containing 68
CCNO cyclin O
CEMIP cell migration inducing protein, hyaluronan binding
CHKB choline kinase beta
CNR2 cannabinoid receptor 2 (macrophage)
CNTN1 contactin 1
CORO7 coronin 7
CORT cortistatin
CRIP1 cysteine-rich protein 1 (intestinal)
CRY2 cryptochrome circadian clock 2
CXORF56 chromosome X open reading frame 56
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DEAF1 DEAF1 transcription factor
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DSC2 desmocollin 2
ERN2 endoplasmic reticulum to nucleus signaling 2
F2R coagulation factor II (thrombin) receptor
FAM184A family with sequence similarity 184, member A
FCHO1 FCH domain only 1
FGD1 FYVE, RhoGEF and PH domain containing 1
FGL1 fibrinogen-like 1
GAMT guanidinoacetate N-methyltransferase
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GEMIN8 gem (nuclear organelle) associated protein 8
GPATCH3 G patch domain containing 3
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRB7 growth factor receptor-bound protein 7
HDAC11 histone deacetylase 11
HIST1H3B histone cluster 1, H3b
IDI2-AS1 IDI2 antisense RNA 1
IFT140 intraflagellar transport 140
IFT54 intraflagellar transport 54
IQCG IQ motif containing G
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KIAA0319L KIAA0319-like
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
LIN7A lin-7 homolog A (C. elegans)
LMO2 LIM domain only 2 (rhombotin-like 1)
LRRC37A3 leucine rich repeat containing 37, member A3
LYRM9 LYR motif containing 9
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAST3 microtubule associated serine/threonine kinase 3
NES nestin
NEUROD4 neuronal differentiation 4
NT5DC3 5'-nucleotidase domain containing 3
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OLFML2A olfactomedin-like 2A
PAIP2B poly(A) binding protein interacting protein 2B
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PGP phosphoglycolate phosphatase
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PLEKHO2 pleckstrin homology domain containing, family O member 2
PORCN porcupine homolog (Drosophila)
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRPH peripherin
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RAPSN receptor-associated protein of the synapse
RFXAP regulatory factor X-associated protein
RNF126P1 ring finger protein 126 pseudogene 1
SCAI suppressor of cancer cell invasion
SHARPIN SHANK-associated RH domain interactor
SLC17A2 solute carrier family 17, member 2
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNX16 sorting nexin 16
ST5 suppression of tumorigenicity 5
SYBU syntabulin (syntaxin-interacting)
TBX19 T-box 19
TCHH trichohyalin
THRAP3 thyroid hormone receptor associated protein 3
TM6SF1 transmembrane 6 superfamily member 1
TMEM242 transmembrane protein 242
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
UBQLN4 ubiquilin 4
UNC119 unc-119 homolog (C. elegans)
VGF VGF nerve growth factor inducible
XYLT2 xylosyltransferase II
ZBED1 zinc finger, BED-type containing 1
ZNF205 zinc finger protein 205