Prestwick-691-4172 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the Prestwick-691-4172 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACPP acid phosphatase, prostate
ADAM12 ADAM metallopeptidase domain 12
ADAM29 ADAM metallopeptidase domain 29
AKAP1 A kinase (PRKA) anchor protein 1
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ANG angiogenin, ribonuclease, RNase A family, 5
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
AVPR1B arginine vasopressin receptor 1B
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C11ORF16 chromosome 11 open reading frame 16
C14ORF1 chromosome 14 open reading frame 1
C22ORF24 chromosome 22 open reading frame 24
C3ORF18 chromosome 3 open reading frame 18
C4BPA complement component 4 binding protein, alpha
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CALCR calcitonin receptor
CALD1 caldesmon 1
CASP4 caspase 4, apoptosis-related cysteine peptidase
CCL5 chemokine (C-C motif) ligand 5
CD209 CD209 molecule
CD300C CD300c molecule
CD52 CD52 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CNOT2 CCR4-NOT transcription complex, subunit 2
COL14A1 collagen, type XIV, alpha 1
COL7A1 collagen, type VII, alpha 1
COL8A1 collagen, type VIII, alpha 1
CORO2B coronin, actin binding protein, 2B
CXCL8 chemokine (C-X-C motif) ligand 8
EDN1 endothelin 1
ELP6 elongator acetyltransferase complex subunit 6
ERC2-IT1 ERC2 intronic transcript 1
FLJ11292
FRMPD1 FERM and PDZ domain containing 1
FYB FYN binding protein
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GBP1 guanylate binding protein 1, interferon-inducible
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GRIA3 glutamate receptor, ionotropic, AMPA 3
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRK5 G protein-coupled receptor kinase 5
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
GYPB glycophorin B (MNS blood group)
HAS2 hyaluronan synthase 2
HERC2P3 hect domain and RLD 2 pseudogene 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGHA1 immunoglobulin heavy constant alpha 1
ITGB7 integrin, beta 7
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
KLF1 Kruppel-like factor 1 (erythroid)
LAMB4 laminin, beta 4
LILRB2 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
MAOA monoamine oxidase A
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
N4BP1 NEDD4 binding protein 1
NAG18 NAG18 mRNA
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NRF1 nuclear respiratory factor 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PDAP1 PDGFA associated protein 1
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PILRA paired immunoglobin-like type 2 receptor alpha
PLXNA2 plexin A2
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PSG6 pregnancy specific beta-1-glycoprotein 6
RUSC2 RUN and SH3 domain containing 2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCARF1 scavenger receptor class F, member 1
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SOGA1 suppressor of glucose, autophagy associated 1
SP100 SP100 nuclear antigen
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SSX1 synovial sarcoma, X breakpoint 1
STATH statherin
STS steroid sulfatase (microsomal), isozyme S
TBX5 T-box 5
TEK TEK tyrosine kinase, endothelial
TMEM212 transmembrane protein 212
TRA T cell receptor alpha locus
TRANK1 tetratricopeptide repeat and ankyrin repeat containing 1
WIPF1 WAS/WASL interacting protein family, member 1
ZNF384 zinc finger protein 384
ZNF440 zinc finger protein 440
ZNF711 zinc finger protein 711
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1

decreased expression

Symbol Name
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADCK4 aarF domain containing kinase 4
ADGRE1 adhesion G protein-coupled receptor E1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
ASIC3 acid sensing (proton gated) ion channel 3
BARX2 BARX homeobox 2
BIRC7 baculoviral IAP repeat containing 7
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2
CALML5 calmodulin-like 5
CD8A CD8a molecule
CDK3 cyclin-dependent kinase 3
CFAP70 cilia and flagella associated protein 70
CFD complement factor D (adipsin)
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CTSO cathepsin O
DGKE diacylglycerol kinase, epsilon 64kDa
DLK2 delta-like 2 homolog (Drosophila)
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DVL1 dishevelled segment polarity protein 1
EN1 engrailed homeobox 1
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
ERCC4 excision repair cross-complementation group 4
FAM76A family with sequence similarity 76, member A
FBXO2 F-box protein 2
FBXO22 F-box protein 22
FBXO31 F-box protein 31
G6PC2 glucose-6-phosphatase, catalytic, 2
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GLDC glycine dehydrogenase (decarboxylating)
GMEB1 glucocorticoid modulatory element binding protein 1
GPR182 G protein-coupled receptor 182
GRM6 glutamate receptor, metabotropic 6
GSTP1 glutathione S-transferase pi 1
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HCN4 hyperpolarization activated cyclic nucleotide gated potassium channel 4
HSPB6 heat shock protein, alpha-crystallin-related, B6
IFNA17 interferon, alpha 17
IGSF6 immunoglobulin superfamily, member 6
INO80D INO80 complex subunit D
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KEL Kell blood group, metallo-endopeptidase
LENEP lens epithelial protein
LHX3 LIM homeobox 3
LIF leukemia inhibitory factor
LONRF3 LON peptidase N-terminal domain and ring finger 3
LRRC17 leucine rich repeat containing 17
LRRC75B leucine rich repeat containing 75B
MAGEA5 melanoma antigen family A5
MAPK10 mitogen-activated protein kinase 10
MMP2 matrix metallopeptidase 2
MRPL52 mitochondrial ribosomal protein L52
NDOR1 NADPH dependent diflavin oxidoreductase 1
NOD1 nucleotide-binding oligomerization domain containing 1
NPR3 natriuretic peptide receptor 3
NUPR1 nuclear protein, transcriptional regulator, 1
ONECUT2 one cut homeobox 2
OR1D2 olfactory receptor, family 1, subfamily D, member 2
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLA2G1B phospholipase A2, group IB (pancreas)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAC4 placenta-specific 4
PLXNB3 plexin B3
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
POM121L2 POM121 transmembrane nucleoporin-like 2
PRKCE protein kinase C, epsilon
RAB30 RAB30, member RAS oncogene family
RAB40C RAB40C, member RAS oncogene family
REC8 REC8 meiotic recombination protein
RGS2 regulator of G-protein signaling 2
RND1 Rho family GTPase 1
RPH3A rabphilin 3A
RPL10L ribosomal protein L10-like
RPS4Y1 ribosomal protein S4, Y-linked 1
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SNCAIP synuclein, alpha interacting protein
STARD3 StAR-related lipid transfer (START) domain containing 3
STIM1 stromal interaction molecule 1
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
TAS2R4 taste receptor, type 2, member 4
TCTN2 tectonic family member 2
TMEM8B transmembrane protein 8B
TRIM25 tripartite motif containing 25
TSC22D4 TSC22 domain family, member 4
TYRP1 tyrosinase-related protein 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAX2 ventral anterior homeobox 2
VN1R1 vomeronasal 1 receptor 1
VPREB3 pre-B lymphocyte 3
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
WDR33 WD repeat domain 33
WNT16 wingless-type MMTV integration site family, member 16
ZIM2 zinc finger, imprinted 2
ZNF16 zinc finger protein 16
ZSWIM1 zinc finger, SWIM-type containing 1