Prestwick-857-3355 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the Prestwick-857-3355 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
AFF3 AF4/FMR2 family, member 3
AHCYL1 adenosylhomocysteinase-like 1
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARR3 arrestin 3, retinal (X-arrestin)
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATP10B ATPase, class V, type 10B
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BCAM basal cell adhesion molecule (Lutheran blood group)
BHMT2 betaine--homocysteine S-methyltransferase 2
BTF3P11 basic transcription factor 3 pseudogene 11
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CALD1 caldesmon 1
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CD70 CD70 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK17 cyclin-dependent kinase 17
CEP41 centrosomal protein 41kDa
CERS4 ceramide synthase 4
CES3 carboxylesterase 3
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLCA1 chloride channel accessory 1
COL3A1 collagen, type III, alpha 1
CPA4 carboxypeptidase A4
CSNK1G1 casein kinase 1, gamma 1
CTIF CBP80/20-dependent translation initiation factor
CYSLTR2 cysteinyl leukotriene receptor 2
DIO2 deiodinase, iodothyronine, type II
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12
DOK4 docking protein 4
EMC1 ER membrane protein complex subunit 1
EMID1 EMI domain containing 1
EXOC7 exocyst complex component 7
FHL1 four and a half LIM domains 1
GK3P glycerol kinase 3 pseudogene
GPR161 G protein-coupled receptor 161
GRM2 glutamate receptor, metabotropic 2
GZMK granzyme K (granzyme 3; tryptase II)
IL23A interleukin 23, alpha subunit p19
INHBA inhibin, beta A
IRS4 insulin receptor substrate 4
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KRT16 keratin 16, type I
LEPR leptin receptor
LIMD1 LIM domains containing 1
LOC157562 uncharacterized LOC157562
LTBP4 latent transforming growth factor beta binding protein 4
LYZL6 lysozyme-like 6
MMP11 matrix metallopeptidase 11
MPZ myelin protein zero
MST1R macrophage stimulating 1 receptor
MYO9B myosin IXB
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
MZF1 myeloid zinc finger 1
NCAPH2 non-SMC condensin II complex, subunit H2
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
OR2S2 olfactory receptor, family 2, subfamily S, member 2 (gene/pseudogene)
OVOL1 ovo-like zinc finger 1
PCSK6 proprotein convertase subtilisin/kexin type 6
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PHF20L1 PHD finger protein 20-like 1
PHOX2A paired-like homeobox 2a
PLEK pleckstrin
PLXNB3 plexin B3
PRKCI protein kinase C, iota
PVR poliovirus receptor
RAB6A RAB6A, member RAS oncogene family
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RIMS2 regulating synaptic membrane exocytosis 2
RND1 Rho family GTPase 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RORC RAR-related orphan receptor C
RPL35A ribosomal protein L35a
RPL5 ribosomal protein L5
RTCA RNA 3'-terminal phosphate cyclase
RUNX1 runt-related transcription factor 1
RXRB retinoid X receptor, beta
SHOX2 short stature homeobox 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SOCS7 suppressor of cytokine signaling 7
STARD8 StAR-related lipid transfer (START) domain containing 8
STRN striatin, calmodulin binding protein
TAGLN3 transgelin 3
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBCD tubulin folding cofactor D
TBX3 T-box 3
TFG TRK-fused gene
TIMELESS timeless circadian clock
TSC22D2 TSC22 domain family, member 2
TSPAN9 tetraspanin 9
UPK3A uroplakin 3A
VAMP5 vesicle-associated membrane protein 5
WIZ widely interspaced zinc finger motifs
WTAP Wilms tumor 1 associated protein
ZC3H13 zinc finger CCCH-type containing 13

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTL8 actin-like 8
APLP1 amyloid beta (A4) precursor-like protein 1
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
BCORL1 BCL6 corepressor-like 1
BET1L Bet1 golgi vesicular membrane trafficking protein-like
C14ORF79 chromosome 14 open reading frame 79
C22ORF46 chromosome 22 open reading frame 46
CAMK1D calcium/calmodulin-dependent protein kinase ID
CCP110 centriolar coiled coil protein 110kDa
CD82 CD82 molecule
CDK18 cyclin-dependent kinase 18
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa
CRELD1 cysteine-rich with EGF-like domains 1
CRY2 cryptochrome circadian clock 2
CUZD1 CUB and zona pellucida-like domains 1
CXADR coxsackie virus and adenovirus receptor
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DCAF4 DDB1 and CUL4 associated factor 4
DCBLD2 discoidin, CUB and LCCL domain containing 2
DOC2A double C2-like domains, alpha
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
ENO3 enolase 3 (beta, muscle)
FADS2 fatty acid desaturase 2
FAM186A family with sequence similarity 186, member A
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GFI1 growth factor independent 1 transcription repressor
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GPR143 G protein-coupled receptor 143
GRB7 growth factor receptor-bound protein 7
GREB1L growth regulation by estrogen in breast cancer-like
HIST1H2BO histone cluster 1, H2bo
HMOX1 heme oxygenase 1
HOXA4 homeobox A4
HOXC5 homeobox C5
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HSPA2 heat shock 70kDa protein 2
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IL22 interleukin 22
IQSEC2 IQ motif and Sec7 domain 2
KCTD7 potassium channel tetramerization domain containing 7
KDM5C lysine (K)-specific demethylase 5C
KLF3 Kruppel-like factor 3 (basic)
KLHL25 kelch-like family member 25
KLK5 kallikrein-related peptidase 5
KREMEN2 kringle containing transmembrane protein 2
LIN7B lin-7 homolog B (C. elegans)
LRP2 low density lipoprotein receptor-related protein 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA6 melanoma antigen family A6
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
NPFFR1 neuropeptide FF receptor 1
NPIPB15 nuclear pore complex interacting protein family, member B15
NPY5R neuropeptide Y receptor Y5
PCDHB13 protocadherin beta 13
PDE8B phosphodiesterase 8B
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLXNA3 plexin A3
PMEL premelanosome protein
PRR4 proline rich 4 (lacrimal)
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
RAB36 RAB36, member RAS oncogene family
SALL2 spalt-like transcription factor 2
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC26A6 solute carrier family 26 (anion exchanger), member 6
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SPTBN2 spectrin, beta, non-erythrocytic 2
SRD5A3 steroid 5 alpha-reductase 3
ST5 suppression of tumorigenicity 5
STAG3 stromal antigen 3
SYT17 synaptotagmin XVII
TESC tescalcin
THNSL2 threonine synthase-like 2 (S. cerevisiae)
THRAP3 thyroid hormone receptor associated protein 3
THRB thyroid hormone receptor, beta
TMEM120B transmembrane protein 120B
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TONSL tonsoku-like, DNA repair protein
TSGA10 testis specific, 10
TSPAN5 tetraspanin 5
TYRP1 tyrosinase-related protein 1
USP20 ubiquitin specific peptidase 20
VIPR1 vasoactive intestinal peptide receptor 1
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
XDH xanthine dehydrogenase
ZNF276 zinc finger protein 276
ZNF358 zinc finger protein 358
ZNF428 zinc finger protein 428
ZNF580 zinc finger protein 580