Prestwick-860-3378 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the Prestwick-860-3378 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ADGRA2 adhesion G protein-coupled receptor A2
ADORA1 adenosine A1 receptor
AKAP5 A kinase (PRKA) anchor protein 5
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARNT aryl hydrocarbon receptor nuclear translocator
ART1 ADP-ribosyltransferase 1
ATP10B ATPase, class V, type 10B
BDKRB2 bradykinin receptor B2
CA4 carbonic anhydrase IV
CCDC64 coiled-coil domain containing 64
CD101 CD101 molecule
CD52 CD52 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEP162 centrosomal protein 162kDa
CERS4 ceramide synthase 4
CES1 carboxylesterase 1
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
DNAH17 dynein, axonemal, heavy chain 17
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
ECE1 endothelin converting enzyme 1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
ERP44 endoplasmic reticulum protein 44
F13A1 coagulation factor XIII, A1 polypeptide
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FOXO4 forkhead box O4
FRZB frizzled-related protein
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
GFER growth factor, augmenter of liver regeneration
GJD2 gap junction protein, delta 2, 36kDa
GK glycerol kinase
GM2A GM2 ganglioside activator
GRIK5 glutamate receptor, ionotropic, kainate 5
GSTP1 glutathione S-transferase pi 1
HIST1H3E histone cluster 1, H3e
HNMT histamine N-methyltransferase
HOXA10 homeobox A10
HSF1 heat shock transcription factor 1
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IL2RB interleukin 2 receptor, beta
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KEL Kell blood group, metallo-endopeptidase
KERA keratocan
KLHL3 kelch-like family member 3
LAMB4 laminin, beta 4
LENEP lens epithelial protein
LOXL2 lysyl oxidase-like 2
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MARK2 MAP/microtubule affinity-regulating kinase 2
MATN1 matrilin 1, cartilage matrix protein
MEF2C myocyte enhancer factor 2C
MID1 midline 1
MNMIP1 manchette microtubule inner protein 1
MRPL41 mitochondrial ribosomal protein L41
MUC3B mucin 3B, cell surface associated
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MYOC myocilin, trabecular meshwork inducible glucocorticoid response
MYOF myoferlin
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
NIPSNAP3B nipsnap homolog 3B (C. elegans)
NOVA2 neuro-oncological ventral antigen 2
NPTXR neuronal pentraxin receptor
OGFR opioid growth factor receptor
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPP5C protein phosphatase 5, catalytic subunit
PRKCB protein kinase C, beta
RBM17 RNA binding motif protein 17
RPL23AP53 ribosomal protein L23a pseudogene 53
RUFY3 RUN and FYVE domain containing 3
SAMD9 sterile alpha motif domain containing 9
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SERHL2 serine hydrolase-like 2
SFRP4 secreted frizzled-related protein 4
SFTPB surfactant protein B
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMG7-AS1 SMG7 antisense RNA 1
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SNX13 sorting nexin 13
SPON2 spondin 2, extracellular matrix protein
STK16 serine/threonine kinase 16
TBX6 T-box 6
TBXA2R thromboxane A2 receptor
TEF thyrotrophic embryonic factor
TJAP1 tight junction associated protein 1 (peripheral)
TM4SF1 transmembrane 4 L six family member 1
TP53I11 tumor protein p53 inducible protein 11
TPM2 tropomyosin 2 (beta)
TUBB7P tubulin, beta 7, pseudogene
VAC14 Vac14 homolog (S. cerevisiae)
WIZ widely interspaced zinc finger motifs
WNT10B wingless-type MMTV integration site family, member 10B
ZDHHC14 zinc finger, DHHC-type containing 14

decreased expression

Symbol Name
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
AFF4 AF4/FMR2 family, member 4
ALOX15 arachidonate 15-lipoxygenase
ALPK1 alpha-kinase 1
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARID3B AT rich interactive domain 3B (BRIGHT-like)
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCORL1 BCL6 corepressor-like 1
BMP15 bone morphogenetic protein 15
C11ORF63 chromosome 11 open reading frame 63
C1ORF105 chromosome 1 open reading frame 105
C2ORF27A chromosome 2 open reading frame 27A
CCDC132 coiled-coil domain containing 132
CCDC9 coiled-coil domain containing 9
CCNK cyclin K
CDADC1 cytidine and dCMP deaminase domain containing 1
CGA glycoprotein hormones, alpha polypeptide
CIC capicua transcriptional repressor
CLIP4 CAP-GLY domain containing linker protein family, member 4
CXORF56 chromosome X open reading frame 56
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DPY19L1P1 DPY19L1 pseudogene 1
DYSF dysferlin
EGLN2 egl-9 family hypoxia-inducible factor 2
EPHX2 epoxide hydrolase 2, cytoplasmic
ERCC6 excision repair cross-complementation group 6
FAM131A family with sequence similarity 131, member A
FAM184A family with sequence similarity 184, member A
FLJ11710 uncharacterized protein FLJ11710
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GAREM GRB2 associated, regulator of MAPK1
GCHFR GTP cyclohydrolase I feedback regulator
GLCE glucuronic acid epimerase
GMPR guanosine monophosphate reductase
GPR143 G protein-coupled receptor 143
GPR21 G protein-coupled receptor 21
GPR27 G protein-coupled receptor 27
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HIST1H4F histone cluster 1, H4f
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HYAL1 hyaluronoglucosaminidase 1
IDI2-AS1 IDI2 antisense RNA 1
IFT54 intraflagellar transport 54
IMPACT impact RWD domain protein
IQSEC2 IQ motif and Sec7 domain 2
IRF6 interferon regulatory factor 6
KCNK12 potassium channel, two pore domain subfamily K, member 12
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KREMEN2 kringle containing transmembrane protein 2
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LHX6 LIM homeobox 6
LZTS3 leucine zipper, putative tumor suppressor family member 3
MBNL3 muscleblind-like splicing regulator 3
MITF microphthalmia-associated transcription factor
MTCL1 microtubule crosslinking factor 1
NACA2 nascent polypeptide-associated complex alpha subunit 2
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NIPAL2 NIPA-like domain containing 2
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein
NT5DC3 5'-nucleotidase domain containing 3
NXPE3 neurexophilin and PC-esterase domain family, member 3
ODF2 outer dense fiber of sperm tails 2
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
PHEX phosphate regulating endopeptidase homolog, X-linked
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PODNL1 podocan-like 1
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RASAL1 RAS protein activator like 1 (GAP1 like)
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RPL23AP32 ribosomal protein L23a pseudogene 32
SCGB2A2 secretoglobin, family 2A, member 2
SCN1B sodium channel, voltage gated, type I beta subunit
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SMIM14 small integral membrane protein 14
STIM1 stromal interaction molecule 1
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBC1D19 TBC1 domain family, member 19
TBC1D2 TBC1 domain family, member 2
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TEX40 testis expressed 40
TH tyrosine hydroxylase
TMPRSS4 transmembrane protease, serine 4
TMSB15A thymosin beta 15a
TRIM36 tripartite motif containing 36
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TUBA3D tubulin, alpha 3d
WDR33 WD repeat domain 33
XDH xanthine dehydrogenase
ZBTB22 zinc finger and BTB domain containing 22
ZBTB6 zinc finger and BTB domain containing 6
ZFHX4 zinc finger homeobox 4
ZMAT5 zinc finger, matrin-type 5
ZNF230 zinc finger protein 230
ZNF446 zinc finger protein 446
ZSCAN26 zinc finger and SCAN domain containing 26