Prestwick-860-4618 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the Prestwick-860-4618 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKR1C2 aldo-keto reductase family 1, member C2
ALOX5 arachidonate 5-lipoxygenase
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
APC2 adenomatosis polyposis coli 2
ARPP21 cAMP-regulated phosphoprotein, 21kDa
AURKC aurora kinase C
BTF3P11 basic transcription factor 3 pseudogene 11
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C1QL1 complement component 1, q subcomponent-like 1
C7ORF26 chromosome 7 open reading frame 26
CA2 carbonic anhydrase II
CA8 carbonic anhydrase VIII
CACNG4 calcium channel, voltage-dependent, gamma subunit 4
CAMK1G calcium/calmodulin-dependent protein kinase IG
CCDC87 coiled-coil domain containing 87
CD58 CD58 molecule
CD7 CD7 molecule
CHRNE cholinergic receptor, nicotinic, epsilon (muscle)
CLCN6 chloride channel, voltage-sensitive 6
CLEC4A C-type lectin domain family 4, member A
CLEC7A C-type lectin domain family 7, member A
COL2A1 collagen, type II, alpha 1
COL3A1 collagen, type III, alpha 1
CSF1 colony stimulating factor 1 (macrophage)
CTNND2 catenin (cadherin-associated protein), delta 2
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DDX25 DEAD (Asp-Glu-Ala-Asp) box helicase 25
DICER1 dicer 1, ribonuclease type III
DST dystonin
DUSP2 dual specificity phosphatase 2
EDNRA endothelin receptor type A
FBXO40 F-box protein 40
FCAR Fc fragment of IgA receptor
FZD10 frizzled class receptor 10
GNMT glycine N-methyltransferase
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPR135 G protein-coupled receptor 135
GTPBP1 GTP binding protein 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXC4 homeobox C4
HOXD1 homeobox D1
IAPP islet amyloid polypeptide
IFIH1 interferon induced with helicase C domain 1
IGKV1-5 immunoglobulin kappa variable 1-5
IHH indian hedgehog
IL20RA interleukin 20 receptor, alpha
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KLHL22 kelch-like family member 22
LOC390998 ribosomal protein L10 pseudogene
MAN2A2 mannosidase, alpha, class 2A, member 2
MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1
MATN3 matrilin 3
MSC musculin
MUC4 mucin 4, cell surface associated
NABP1 nucleic acid binding protein 1
NEFM neurofilament, medium polypeptide
NF1 neurofibromin 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRG2 neuregulin 2
NRP2 neuropilin 2
OSGIN2 oxidative stress induced growth inhibitor family member 2
OXCT2 3-oxoacid CoA transferase 2
PBX2 pre-B-cell leukemia homeobox 2
PCDHB3 protocadherin beta 3
PDE4D phosphodiesterase 4D, cAMP-specific
PDLIM3 PDZ and LIM domain 3
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PLA2G3 phospholipase A2, group III
PLK4 polo-like kinase 4
PMFBP1 polyamine modulated factor 1 binding protein 1
PPARA peroxisome proliferator-activated receptor alpha
RALYL RALY RNA binding protein-like
RAP2B RAP2B, member of RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RPH3AL rabphilin 3A-like (without C2 domains)
RPL23AP32 ribosomal protein L23a pseudogene 32
RRAGD Ras-related GTP binding D
SH3PXD2A SH3 and PX domains 2A
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SPRR3 small proline-rich protein 3
STOM stomatin
STS steroid sulfatase (microsomal), isozyme S
SYCP2 synaptonemal complex protein 2
SYK spleen tyrosine kinase
TAPBP TAP binding protein (tapasin)
TCF15 transcription factor 15 (basic helix-loop-helix)
TLE4 transducin-like enhancer of split 4
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
VIPR2 vasoactive intestinal peptide receptor 2
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae)
WNT8B wingless-type MMTV integration site family, member 8B
WT1 Wilms tumor 1
XAF1 XIAP associated factor 1
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZNF423 zinc finger protein 423
ZNF814 zinc finger protein 814

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AGO4 argonaute RISC catalytic component 4
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
ALOX12P2 arachidonate 12-lipoxygenase pseudogene 2
ANXA2P1 annexin A2 pseudogene 1
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BAG4 BCL2-associated athanogene 4
BCAS3 breast carcinoma amplified sequence 3
BLMH bleomycin hydrolase
C11ORF30 chromosome 11 open reading frame 30
C14ORF105 chromosome 14 open reading frame 105
C16ORF62 chromosome 16 open reading frame 62
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C7ORF69 chromosome 7 open reading frame 69
CASP5 caspase 5, apoptosis-related cysteine peptidase
CCDC88C coiled-coil domain containing 88C
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CDKL3 cyclin-dependent kinase-like 3
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
CEP131 centrosomal protein 131kDa
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CIR1 corepressor interacting with RBPJ, 1
CLIC3 chloride intracellular channel 3
CPNE7 copine VII
CXORF56 chromosome X open reading frame 56
DCAF13 DDB1 and CUL4 associated factor 13
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DLK2 delta-like 2 homolog (Drosophila)
DTX2 deltex 2, E3 ubiquitin ligase
EGF epidermal growth factor
ERAP2 endoplasmic reticulum aminopeptidase 2
FAM110B family with sequence similarity 110, member B
FAT4 FAT atypical cadherin 4
FPGS folylpolyglutamate synthase
GALK1 galactokinase 1
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GJC1 gap junction protein, gamma 1, 45kDa
GLS2 glutaminase 2 (liver, mitochondrial)
GMIP GEM interacting protein
GMPR guanosine monophosphate reductase
GNA13 guanine nucleotide binding protein (G protein), alpha 13
HIST1H2AL histone cluster 1, H2al
HIST1H2AM histone cluster 1, H2am
HOOK1 hook microtubule-tethering protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IQCG IQ motif containing G
KIAA0895 KIAA0895
KLF7 Kruppel-like factor 7 (ubiquitous)
LIG4 ligase IV, DNA, ATP-dependent
LOC100127972 uncharacterized LOC100127972
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRRC61 leucine rich repeat containing 61
MAGEF1 melanoma antigen family F1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MX1 MX dynamin-like GTPase 1
NAG18 NAG18 mRNA
NDE1 nudE neurodevelopment protein 1
NDRG4 NDRG family member 4
NTF3 neurotrophin 3
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OSMR oncostatin M receptor
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PALMD palmdelphin
PARM1 prostate androgen-regulated mucin-like protein 1
PDE8B phosphodiesterase 8B
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLEKHO1 pleckstrin homology domain containing, family O member 1
POMT2 protein-O-mannosyltransferase 2
PWAR5 Prader Willi/Angelman region RNA 5
RAB23 RAB23, member RAS oncogene family
RANBP17 RAN binding protein 17
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RRAGB Ras-related GTP binding B
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SARS2 seryl-tRNA synthetase 2, mitochondrial
SEC14L2 SEC14-like 2 (S. cerevisiae)
SYNPO synaptopodin
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
THBS3 thrombospondin 3
TMEM242 transmembrane protein 242
TPCN1 two pore segment channel 1
TRAPPC2 trafficking protein particle complex 2
TRDMT1 tRNA aspartic acid methyltransferase 1
TRIM66 tripartite motif containing 66
TUBG2 tubulin, gamma 2
ULBP2 UL16 binding protein 2
ZNF205 zinc finger protein 205
ZNF222 zinc finger protein 222
ZNF408 zinc finger protein 408
ZNF446 zinc finger protein 446
ZNF671 zinc finger protein 671
ZNF747 zinc finger protein 747
ZSCAN2 zinc finger and SCAN domain containing 2