Prestwick-864-3333 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the Prestwick-864-3333 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ACRV1 acrosomal vesicle protein 1
AKAP6 A kinase (PRKA) anchor protein 6
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
C21ORF2 chromosome 21 open reading frame 2
C6 complement component 6
CES3 carboxylesterase 3
CLEC3B C-type lectin domain family 3, member B
CLSTN2 calsyntenin 2
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CNTNAP2 contactin associated protein-like 2
COL11A2 collagen, type XI, alpha 2
COL1A1 collagen, type I, alpha 1
COL21A1 collagen, type XXI, alpha 1
CTSE cathepsin E
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1
DCTN1 dynactin 1
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DENND5B DENN/MADD domain containing 5B
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNAI2 dynein, axonemal, intermediate chain 2
DNAJC16 DnaJ (Hsp40) homolog, subfamily C, member 16
DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1
DOCK6 dedicator of cytokinesis 6
DUSP10 dual specificity phosphatase 10
EMC3 ER membrane protein complex subunit 3
EXT1 exostosin glycosyltransferase 1
FBXO21 F-box protein 21
FN1 fibronectin 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GK glycerol kinase
GPC3 glypican 3
GRIA4 glutamate receptor, ionotropic, AMPA 4
GRIK5 glutamate receptor, ionotropic, kainate 5
GSN gelsolin
HDLBP high density lipoprotein binding protein
HIF3A hypoxia inducible factor 3, alpha subunit
HR hair growth associated
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDS iduronate 2-sulfatase
IFNA10 interferon, alpha 10
IGHM immunoglobulin heavy constant mu
IL1B interleukin 1, beta
IL23A interleukin 23, alpha subunit p19
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KCNK2 potassium channel, two pore domain subfamily K, member 2
KDM4B lysine (K)-specific demethylase 4B
KIF1C kinesin family member 1C
KSR1 kinase suppressor of ras 1
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LDHB lactate dehydrogenase B
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
LYZL6 lysozyme-like 6
MAP1A microtubule-associated protein 1A
MBD2 methyl-CpG binding domain protein 2
MBNL2 muscleblind-like splicing regulator 2
MFAP5 microfibrillar associated protein 5
MORC1 MORC family CW-type zinc finger 1
MST1L macrophage stimulating 1-like
NCAM1 neural cell adhesion molecule 1
NME5 NME/NM23 family member 5
NR4A1 nuclear receptor subfamily 4, group A, member 1
OR3A3 olfactory receptor, family 3, subfamily A, member 3
OXCT2 3-oxoacid CoA transferase 2
PARD6B par-6 family cell polarity regulator beta
PDE3B phosphodiesterase 3B, cGMP-inhibited
PER1 period circadian clock 1
PICK1 protein interacting with PRKCA 1
PLAC4 placenta-specific 4
PLCL2 phospholipase C-like 2
PRDM16 PR domain containing 16
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RRBP1 ribosome binding protein 1
RUNX1 runt-related transcription factor 1
SCARF1 scavenger receptor class F, member 1
SLC17A2 solute carrier family 17, member 2
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPDEF SAM pointed domain containing ETS transcription factor
SYT2 synaptotagmin II
T T, brachyury homolog (mouse)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFG TRK-fused gene
TM4SF1 transmembrane 4 L six family member 1
TRA T cell receptor alpha locus
TRIM48 tripartite motif containing 48
TRPM2 transient receptor potential cation channel, subfamily M, member 2
UCP1 uncoupling protein 1 (mitochondrial, proton carrier)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
WDFY3 WD repeat and FYVE domain containing 3
WDR55 WD repeat domain 55
ZC3H13 zinc finger CCCH-type containing 13
ZCCHC14 zinc finger, CCHC domain containing 14

decreased expression

Symbol Name
ACTL8 actin-like 8
ALG12 ALG12, alpha-1,6-mannosyltransferase
ANP32A-IT1 ANP32A intronic transcript 1
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
AXIN1 axin 1
BAHCC1 BAH domain and coiled-coil containing 1
BCAS1 breast carcinoma amplified sequence 1
BRD9 bromodomain containing 9
C11ORF30 chromosome 11 open reading frame 30
C19ORF40 chromosome 19 open reading frame 40
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CCNK cyclin K
CDK18 cyclin-dependent kinase 18
CENPO centromere protein O
CEP85 centrosomal protein 85kDa
CLSPN claspin
CRELD1 cysteine-rich with EGF-like domains 1
CUZD1 CUB and zona pellucida-like domains 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DCAF4 DDB1 and CUL4 associated factor 4
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DOCK1 dedicator of cytokinesis 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
DYSF dysferlin
ERN2 endoplasmic reticulum to nucleus signaling 2
ETAA1 Ewing tumor-associated antigen 1
EXO5 exonuclease 5
F2R coagulation factor II (thrombin) receptor
FAM169A family with sequence similarity 169, member A
FLJ22184
GINS4 GINS complex subunit 4 (Sld5 homolog)
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUSBP3 glucuronidase, beta pseudogene 3
HDAC11 histone deacetylase 11
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-J major histocompatibility complex, class I, J (pseudogene)
HMGB3P1 high mobility group box 3 pseudogene 1
HOXA4 homeobox A4
IQCG IQ motif containing G
JMJD4 jumonji domain containing 4
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
LRRC37A3 leucine rich repeat containing 37, member A3
LYRM9 LYR motif containing 9
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MAST3 microtubule associated serine/threonine kinase 3
MBTD1 mbt domain containing 1
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MTCP1 mature T-cell proliferation 1
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYO1D myosin ID
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NOD1 nucleotide-binding oligomerization domain containing 1
NT5DC3 5'-nucleotidase domain containing 3
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OR7E156P olfactory receptor, family 7, subfamily E, member 156 pseudogene
OSMR oncostatin M receptor
PAIP2B poly(A) binding protein interacting protein 2B
PGPEP1 pyroglutamyl-peptidase I
PHEX phosphate regulating endopeptidase homolog, X-linked
PLD3 phospholipase D family, member 3
PLEKHA6 pleckstrin homology domain containing, family A member 6
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PXN paxillin
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
RCOR3 REST corepressor 3
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae)
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RNF208 ring finger protein 208
SIRT6 sirtuin 6
SNAI2 snail family zinc finger 2
STAG3 stromal antigen 3
STARD3 StAR-related lipid transfer (START) domain containing 3
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYBU syntabulin (syntaxin-interacting)
TH tyrosine hydroxylase
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TLR5 toll-like receptor 5
TMEM120B transmembrane protein 120B
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TUBGCP5 tubulin, gamma complex associated protein 5
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UNC93B1 unc-93 homolog B1 (C. elegans)
USB1 U6 snRNA biogenesis 1
VGF VGF nerve growth factor inducible
WDR33 WD repeat domain 33
WDR91 WD repeat domain 91
ZNF16 zinc finger protein 16
ZNF652 zinc finger protein 652
ZNF669 zinc finger protein 669
ZNF701 zinc finger protein 701
ZNF721 zinc finger protein 721
ZNHIT2 zinc finger, HIT-type containing 2