Prestwick-864-3994 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the Prestwick-864-3994 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSM3 acyl-CoA synthetase medium-chain family member 3
ACVR1B activin A receptor, type IB
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
ANTXR1 anthrax toxin receptor 1
APOE apolipoprotein E
ARSD arylsulfatase D
ATG10 autophagy related 10
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C10ORF12 chromosome 10 open reading frame 12
C14ORF79 chromosome 14 open reading frame 79
CCDC186 coiled-coil domain containing 186
CD58 CD58 molecule
CDK12 cyclin-dependent kinase 12
CEP295 centrosomal protein 295kDa
CES3 carboxylesterase 3
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CLTCL1 clathrin, heavy chain-like 1
COBL cordon-bleu WH2 repeat protein
CRTC1 CREB regulated transcription coactivator 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DGKE diacylglycerol kinase, epsilon 64kDa
DLGAP2 discs, large (Drosophila) homolog-associated protein 2
EDRF1 erythroid differentiation regulatory factor 1
EML2 echinoderm microtubule associated protein like 2
ERAP1 endoplasmic reticulum aminopeptidase 1
EXD3 exonuclease 3'-5' domain containing 3
FBXO21 F-box protein 21
FBXO22 F-box protein 22
GAL3ST4 galactose-3-O-sulfotransferase 4
GLP1R glucagon-like peptide 1 receptor
GPR157 G protein-coupled receptor 157
GSPT1 G1 to S phase transition 1
HIST1H4D histone cluster 1, H4d
HSF1 heat shock transcription factor 1
IL12A interleukin 12A
IL18R1 interleukin 18 receptor 1
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IQCA1 IQ motif containing with AAA domain 1
IQCK IQ motif containing K
IZUMO4 IZUMO family member 4
KCNIP1 Kv channel interacting protein 1
KIF17 kinesin family member 17
KIFC3 kinesin family member C3
KMT2A lysine (K)-specific methyltransferase 2A
MBTD1 mbt domain containing 1
MEGF6 multiple EGF-like-domains 6
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMP13 matrix metallopeptidase 13
MST1 macrophage stimulating 1
MYBPC3 myosin binding protein C, cardiac
MYEF2 myelin expression factor 2
NAV3 neuron navigator 3
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NGLY1 N-glycanase 1
NOL12 nucleolar protein 12
PAFAH2 platelet-activating factor acetylhydrolase 2, 40kDa
PDE2A phosphodiesterase 2A, cGMP-stimulated
PGP phosphoglycolate phosphatase
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
POU6F1 POU class 6 homeobox 1
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PTBP3 polypyrimidine tract binding protein 3
PTPRF protein tyrosine phosphatase, receptor type, F
REC8 REC8 meiotic recombination protein
RHOBTB3 Rho-related BTB domain containing 3
RPA4 replication protein A4, 30kDa
SCAPER S-phase cyclin A-associated protein in the ER
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SGSM3 small G protein signaling modulator 3
SH3BP2 SH3-domain binding protein 2
SLC16A4 solute carrier family 16, member 4
SLMO1 slowmo homolog 1 (Drosophila)
SMAD4 SMAD family member 4
SOX15 SRY (sex determining region Y)-box 15
SPATA6 spermatogenesis associated 6
SRCAP Snf2-related CREBBP activator protein
STRN striatin, calmodulin binding protein
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila)
THEMIS2 thymocyte selection associated family member 2
TLK1 tousled-like kinase 1
TP73-AS1 TP73 antisense RNA 1
TRA2A transformer 2 alpha homolog (Drosophila)
TSPAN8 tetraspanin 8
TTC39A tetratricopeptide repeat domain 39A
TTC9 tetratricopeptide repeat domain 9
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
VAMP5 vesicle-associated membrane protein 5
VPRBP Vpr (HIV-1) binding protein
WT1-AS WT1 antisense RNA
XYLT1 xylosyltransferase I
ZNF24 zinc finger protein 24
ZNF391 zinc finger protein 391
ZNF440 zinc finger protein 440
ZNF500 zinc finger protein 500
ZNF639 zinc finger protein 639
ZNF695 zinc finger protein 695

decreased expression

Symbol Name
ADGRE2 adhesion G protein-coupled receptor E2
AGO4 argonaute RISC catalytic component 4
ALOX15B arachidonate 15-lipoxygenase, type B
ANXA2P1 annexin A2 pseudogene 1
APOC4 apolipoprotein C-IV
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ATF7IP2 activating transcription factor 7 interacting protein 2
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
C14ORF105 chromosome 14 open reading frame 105
C1R complement component 1, r subcomponent
C5ORF45 chromosome 5 open reading frame 45
C7ORF69 chromosome 7 open reading frame 69
CA9 carbonic anhydrase IX
CASP5 caspase 5, apoptosis-related cysteine peptidase
CDH7 cadherin 7, type 2
CDK3 cyclin-dependent kinase 3
CENPJ centromere protein J
CHI3L2 chitinase 3-like 2
CISH cytokine inducible SH2-containing protein
CLEC2B C-type lectin domain family 2, member B
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CNGB3 cyclic nucleotide gated channel beta 3
CPED1 cadherin-like and PC-esterase domain containing 1
CRYBA2 crystallin, beta A2
CYB5R2 cytochrome b5 reductase 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DAGLA diacylglycerol lipase, alpha
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DENND4A DENN/MADD domain containing 4A
DGCR9 DiGeorge syndrome critical region gene 9 (non-protein coding)
EPN1 epsin 1
EYA3 EYA transcriptional coactivator and phosphatase 3
FKBP5 FK506 binding protein 5
FLJ21369 uncharacterized protein FLJ21369
FLT4 fms-related tyrosine kinase 4
FMO4 flavin containing monooxygenase 4
FRMPD1 FERM and PDZ domain containing 1
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GFPT2 glutamine-fructose-6-phosphate transaminase 2
GJA9 gap junction protein, alpha 9, 59kDa
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPC3 glypican 3
GPR39 G protein-coupled receptor 39
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
HIST1H1D histone cluster 1, H1d
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HSPB6 heat shock protein, alpha-crystallin-related, B6
HYAL3 hyaluronoglucosaminidase 3
IGLL1 immunoglobulin lambda-like polypeptide 1
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL2 interleukin 2
IPO8 importin 8
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
LMTK1 lemur tail kinase 1
LRRK1 leucine-rich repeat kinase 1
LYPD3 LY6/PLAUR domain containing 3
MAP3K7CL MAP3K7 C-terminal like
MTA2 metastasis associated 1 family, member 2
MYL5 myosin, light chain 5, regulatory
NAT6 N-acetyltransferase 6 (GCN5-related)
NFIX nuclear factor I/X (CCAAT-binding transcription factor)
OSMR oncostatin M receptor
PADI1 peptidyl arginine deiminase, type I
PARP3 poly (ADP-ribose) polymerase family, member 3
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PRSS53 protease, serine, 53
PSORS1C1 psoriasis susceptibility 1 candidate 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RGCC regulator of cell cycle
RPRM reprimo, TP53 dependent G2 arrest mediator candidate
SCGB2A2 secretoglobin, family 2A, member 2
SLAMF7 SLAM family member 7
SLC16A6 solute carrier family 16, member 6
SLC46A3 solute carrier family 46, member 3
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SPIDR scaffolding protein involved in DNA repair
SSTR4 somatostatin receptor 4
STEAP4 STEAP family member 4
SUGCT succinyl-CoA:glutarate-CoA transferase
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TCTN1 tectonic family member 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRDMT1 tRNA aspartic acid methyltransferase 1
TXK TXK tyrosine kinase
UNC119 unc-119 homolog (C. elegans)
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WNT1 wingless-type MMTV integration site family, member 1
ZNF358 zinc finger protein 358
ZNF528 zinc finger protein 528