Prestwick-920-3118 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the Prestwick-920-3118 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTA1 actin, alpha 1, skeletal muscle
ADORA1 adenosine A1 receptor
AGTR2 angiotensin II receptor, type 2
ALG12 ALG12, alpha-1,6-mannosyltransferase
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2
AQP4 aquaporin 4
ARHGAP35 Rho GTPase activating protein 35
ARMC4 armadillo repeat containing 4
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BMP6 bone morphogenetic protein 6
BNC2 basonuclin 2
BTF3P11 basic transcription factor 3 pseudogene 11
C4BPA complement component 4 binding protein, alpha
CA5B carbonic anhydrase VB, mitochondrial
CCDC181 coiled-coil domain containing 181
CD47 CD47 molecule
CD79A CD79a molecule, immunoglobulin-associated alpha
CENPT centromere protein T
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CNPY4 canopy FGF signaling regulator 4
CRHR2 corticotropin releasing hormone receptor 2
CXCL3 chemokine (C-X-C motif) ligand 3
DMTN dematin actin binding protein
DOCK9 dedicator of cytokinesis 9
DSTYK dual serine/threonine and tyrosine protein kinase
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EGR4 early growth response 4
ENDOD1 endonuclease domain containing 1
ENG endoglin
FAM49A family with sequence similarity 49, member A
FBXO22 F-box protein 22
FGB fibrinogen beta chain
FGFR1OP FGFR1 oncogene partner
FUBP1 far upstream element (FUSE) binding protein 1
GLTSCR1 glioma tumor suppressor candidate region gene 1
GRIK5 glutamate receptor, ionotropic, kainate 5
GUK1 guanylate kinase 1
HIST1H4E histone cluster 1, H4e
ICA1 islet cell autoantigen 1, 69kDa
ICAM1 intercellular adhesion molecule 1
IQCC IQ motif containing C
KIF1C kinesin family member 1C
LHX3 LIM homeobox 3
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAN1A2 mannosidase, alpha, class 1A, member 2
MAPK10 mitogen-activated protein kinase 10
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MLANA melan-A
MYOZ3 myozenin 3
MZF1 myeloid zinc finger 1
NQO1 NAD(P)H dehydrogenase, quinone 1
OLFML2A olfactomedin-like 2A
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCSK6 proprotein convertase subtilisin/kexin type 6
PML promyelocytic leukemia
PON3 paraoxonase 3
PRICKLE3 prickle homolog 3 (Drosophila)
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRO2964 uncharacterized protein PRO2964
PRPF18 pre-mRNA processing factor 18
PYGB phosphorylase, glycogen; brain
RAB2A RAB2A, member RAS oncogene family
RAP2B RAP2B, member of RAS oncogene family
RECQL5 RecQ protein-like 5
RETN resistin
SEC14L4 SEC14-like 4 (S. cerevisiae)
SERPINB13 serpin peptidase inhibitor, clade B (ovalbumin), member 13
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SIDT2 SID1 transmembrane family, member 2
SLC16A6 solute carrier family 16, member 6
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2
SLMO1 slowmo homolog 1 (Drosophila)
SORBS3 sorbin and SH3 domain containing 3
SOX12 SRY (sex determining region Y)-box 12
SRR serine racemase
SSH3 slingshot protein phosphatase 3
SYNJ2 synaptojanin 2
TACR1 tachykinin receptor 1
TBCD tubulin folding cofactor D
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TLN2 talin 2
TMEM63A transmembrane protein 63A
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TRAPPC9 trafficking protein particle complex 9
TRGV5 T cell receptor gamma variable 5
TRIM2 tripartite motif containing 2
TRIM3 tripartite motif containing 3
TSC22D2 TSC22 domain family, member 2
TUBG2 tubulin, gamma 2
TWF1 twinfilin actin binding protein 1
VNN3 vanin 3
ZC3H7B zinc finger CCCH-type containing 7B
ZER1 zyg-11 related, cell cycle regulator
ZFPL1 zinc finger protein-like 1
ZNF696 zinc finger protein 696
ZNF749 zinc finger protein 749

decreased expression

Symbol Name
ALS2CL ALS2 C-terminal like
ANAPC2 anaphase promoting complex subunit 2
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
B3GNT1
BEND5 BEN domain containing 5
BEST1 bestrophin 1
CBX4 chromobox homolog 4
CD37 CD37 molecule
CHML choroideremia-like (Rab escort protein 2)
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CLIP2 CAP-GLY domain containing linker protein 2
CNTN1 contactin 1
COG4 component of oligomeric golgi complex 4
COPG2IT1 COPG2 imprinted transcript 1 (non-protein coding)
CPTP ceramide-1-phosphate transfer protein
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTNNBIP1 catenin, beta interacting protein 1
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DCAF13 DDB1 and CUL4 associated factor 13
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1
DYSF dysferlin
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EPHA4 EPH receptor A4
ERCC2 excision repair cross-complementation group 2
FKBP9 FK506 binding protein 9, 63 kDa
FOXO4 forkhead box O4
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GLCE glucuronic acid epimerase
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR3 G protein-coupled receptor 3
GRIP2 glutamate receptor interacting protein 2
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3
HIST1H1B histone cluster 1, H1b
HIST1H1E histone cluster 1, H1e
HIST1H1T histone cluster 1, H1t
HYAL2 hyaluronoglucosaminidase 2
JMJD4 jumonji domain containing 4
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KIF24 kinesin family member 24
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LINC00260 long intergenic non-protein coding RNA 260
LLGL2 lethal giant larvae homolog 2 (Drosophila)
LOC390998 ribosomal protein L10 pseudogene
LRRC20 leucine rich repeat containing 20
LRRC6 leucine rich repeat containing 6
LRRK1 leucine-rich repeat kinase 1
LTBP3 latent transforming growth factor beta binding protein 3
MAST3 microtubule associated serine/threonine kinase 3
MAVS mitochondrial antiviral signaling protein
MICA MHC class I polypeptide-related sequence A
MKL2 MKL/myocardin-like 2
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MVP major vault protein
MXD3 MAX dimerization protein 3
NDE1 nudE neurodevelopment protein 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOL6 nucleolar protein 6 (RNA-associated)
NSD1 nuclear receptor binding SET domain protein 1
NUBP2 nucleotide binding protein 2
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
PADI1 peptidyl arginine deiminase, type I
PARP12 poly (ADP-ribose) polymerase family, member 12
PELP1 proline, glutamate and leucine rich protein 1
PIAS3 protein inhibitor of activated STAT, 3
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PNPLA6 patatin-like phospholipase domain containing 6
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PPIEL peptidylprolyl isomerase E-like pseudogene
PROS1 protein S (alpha)
PRR4 proline rich 4 (lacrimal)
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RAB33A RAB33A, member RAS oncogene family
RAB3D RAB3D, member RAS oncogene family
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RND1 Rho family GTPase 1
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
SCN10A sodium channel, voltage gated, type X alpha subunit
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STARD8 StAR-related lipid transfer (START) domain containing 8
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
THBS3 thrombospondin 3
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMEM134 transmembrane protein 134
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM3 tropomyosin 3
TRAF1 TNF receptor-associated factor 1
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WNT16 wingless-type MMTV integration site family, member 16
ZNF222 zinc finger protein 222
ZNF480 zinc finger protein 480
ZNF778 zinc finger protein 778
ZNF862 zinc finger protein 862
Funding