Prestwick-920-6497 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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198 genes differentially expressed following the Prestwick-920-6497 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
AIM1L absent in melanoma 1-like
AKAP8L A kinase (PRKA) anchor protein 8-like
ANG angiogenin, ribonuclease, RNase A family, 5
AQP1 aquaporin 1 (Colton blood group)
ARHGEF17 Rho guanine nucleotide exchange factor (GEF) 17
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATRNL1 attractin-like 1
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BCL2 B-cell CLL/lymphoma 2
BICC1 BicC family RNA binding protein 1
C19ORF73 chromosome 19 open reading frame 73
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C9ORF16 chromosome 9 open reading frame 16
CACTIN cactin, spliceosome C complex subunit
CADM4 cell adhesion molecule 4
CALB2 calbindin 2
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD58 CD58 molecule
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CDRT1 CMT1A duplicated region transcript 1
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CTRL chymotrypsin-like
CUZD1 CUB and zona pellucida-like domains 1
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
DCAF11 DDB1 and CUL4 associated factor 11
DGCR8 DGCR8 microprocessor complex subunit
DICER1 dicer 1, ribonuclease type III
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DOCK9 dedicator of cytokinesis 9
DRD2 dopamine receptor D2
DTX2 deltex 2, E3 ubiquitin ligase
ELOVL5 ELOVL fatty acid elongase 5
EPHB2 EPH receptor B2
FOXF1 forkhead box F1
FPR1 formyl peptide receptor 1
GPR21 G protein-coupled receptor 21
GREB1 growth regulation by estrogen in breast cancer 1
GRM2 glutamate receptor, metabotropic 2
HIST1H2BC histone cluster 1, H2bc
HMG20B high mobility group 20B
HSPA1L heat shock 70kDa protein 1-like
IRF4 interferon regulatory factor 4
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2
JPH3 junctophilin 3
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KLRG1 killer cell lectin-like receptor subfamily G, member 1
KRIT1 KRIT1, ankyrin repeat containing
KSR1 kinase suppressor of ras 1
LINC00341 long intergenic non-protein coding RNA 341
LY9 lymphocyte antigen 9
MATK megakaryocyte-associated tyrosine kinase
MAX MYC associated factor X
MIER2 mesoderm induction early response 1, family member 2
MMP13 matrix metallopeptidase 13
MPPE1 metallophosphoesterase 1
MST1 macrophage stimulating 1
MTA1 metastasis associated 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUSK muscle, skeletal, receptor tyrosine kinase
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NCOR2 nuclear receptor corepressor 2
NSUN6 NOP2/Sun domain family, member 6
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
POM121 POM121 transmembrane nucleoporin
PRKD1 protein kinase D1
PRUNE2 prune homolog 2 (Drosophila)
PSD3 pleckstrin and Sec7 domain containing 3
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PTCH1 patched 1
QSER1 glutamine and serine rich 1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RCAN1 regulator of calcineurin 1
REM1 RAS (RAD and GEM)-like GTP-binding 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
SAYSD1 SAYSVFN motif domain containing 1
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SP1 Sp1 transcription factor
SP100 SP100 nuclear antigen
SRSF1 serine/arginine-rich splicing factor 1
TAPBP TAP binding protein (tapasin)
THNSL2 threonine synthase-like 2 (S. cerevisiae)
TLR2 toll-like receptor 2
TRIM2 tripartite motif containing 2
TSHR thyroid stimulating hormone receptor
WDR62 WD repeat domain 62
WDR91 WD repeat domain 91
WNT2B wingless-type MMTV integration site family, member 2B
ZNF287 zinc finger protein 287
ZNF318 zinc finger protein 318
ZNF37BP zinc finger protein 37B, pseudogene
ZNF75D zinc finger protein 75D

decreased expression

Symbol Name
ABLIM3 actin binding LIM protein family, member 3
ACSS3 acyl-CoA synthetase short-chain family member 3
ADGRG2 adhesion G protein-coupled receptor G2
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ARR3 arrestin 3, retinal (X-arrestin)
AUTS2 autism susceptibility candidate 2
BFSP1 beaded filament structural protein 1, filensin
C9ORF9 chromosome 9 open reading frame 9
CALCOCO1 calcium binding and coiled-coil domain 1
CDH10 cadherin 10, type 2 (T2-cadherin)
CDKL3 cyclin-dependent kinase-like 3
CDON cell adhesion associated, oncogene regulated
CEMIP cell migration inducing protein, hyaluronan binding
CFD complement factor D (adipsin)
CGA glycoprotein hormones, alpha polypeptide
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CTAGE9 CTAGE family, member 9
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DET1 de-etiolated homolog 1 (Arabidopsis)
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DOC2A double C2-like domains, alpha
DOCK4 dedicator of cytokinesis 4
DSCAM Down syndrome cell adhesion molecule
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EAF2 ELL associated factor 2
EGLN3 egl-9 family hypoxia-inducible factor 3
EMID1 EMI domain containing 1
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
EXD3 exonuclease 3'-5' domain containing 3
FAM120C family with sequence similarity 120C
FXN frataxin
GATB glutamyl-tRNA(Gln) amidotransferase, subunit B
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HIRA histone cell cycle regulator
HIST1H4A histone cluster 1, H4a
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMOX1 heme oxygenase 1
HOXA4 homeobox A4
HYI hydroxypyruvate isomerase (putative)
IDI2-AS1 IDI2 antisense RNA 1
IL17RA interleukin 17 receptor A
INF2 inverted formin, FH2 and WH2 domain containing
ITGA10 integrin, alpha 10
ITPKB inositol-trisphosphate 3-kinase B
KDM8 lysine (K)-specific demethylase 8
KIAA0125 KIAA0125
KIAA0355 KIAA0355
KLHL21 kelch-like family member 21
KLHL25 kelch-like family member 25
LMO2 LIM domain only 2 (rhombotin-like 1)
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LTBP2 latent transforming growth factor beta binding protein 2
LZTR1 leucine-zipper-like transcription regulator 1
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MBTPS2 membrane-bound transcription factor peptidase, site 2
MTERF4 mitochondrial transcription termination factor 4
N4BP3 NEDD4 binding protein 3
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NPFFR1 neuropeptide FF receptor 1
ONECUT2 one cut homeobox 2
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PARP16 poly (ADP-ribose) polymerase family, member 16
PCDHB3 protocadherin beta 3
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PER3 period circadian clock 3
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLD3 phospholipase D family, member 3
PRMT7 protein arginine methyltransferase 7
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
RBL1 retinoblastoma-like 1
RBM23 RNA binding motif protein 23
RHBG Rh family, B glycoprotein (gene/pseudogene)
RIBC2 RIB43A domain with coiled-coils 2
RNF2 ring finger protein 2
RPL10L ribosomal protein L10-like
SDC3 syndecan 3
SH2B2 SH2B adaptor protein 2
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STK25 serine/threonine kinase 25
TCHH trichohyalin
TINF2 TERF1 (TRF1)-interacting nuclear factor 2
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator
TRAIP TRAF interacting protein
TRPM4 transient receptor potential cation channel, subfamily M, member 4
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UPP1 uridine phosphorylase 1
VGF VGF nerve growth factor inducible
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZNF16 zinc finger protein 16
ZNF573 zinc finger protein 573
ZNF768 zinc finger protein 768
ZNF816 zinc finger protein 816
ZNF862 zinc finger protein 862
ZSWIM1 zinc finger, SWIM-type containing 1