Prestwick-981-7464 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the Prestwick-981-7464 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAP1 ArfGAP with dual PH domains 1
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AHNAK2 AHNAK nucleoprotein 2
AMPD3 adenosine monophosphate deaminase 3
APC adenomatous polyposis coli
AQP3 aquaporin 3 (Gill blood group)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BAIAP2 BAI1-associated protein 2
BTG2 BTG family, member 2
C5ORF45 chromosome 5 open reading frame 45
CA5BP1 carbonic anhydrase VB pseudogene 1
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CASP1 caspase 1, apoptosis-related cysteine peptidase
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD84 CD84 molecule
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3
COL3A1 collagen, type III, alpha 1
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CST6 cystatin E/M
DAGLA diacylglycerol lipase, alpha
DAPK3 death-associated protein kinase 3
DGKQ diacylglycerol kinase, theta 110kDa
EDN1 endothelin 1
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
ELOVL5 ELOVL fatty acid elongase 5
ELP6 elongator acetyltransferase complex subunit 6
ERAP1 endoplasmic reticulum aminopeptidase 1
FADS3 fatty acid desaturase 3
FLCN folliculin
FOLR1 folate receptor 1 (adult)
GATA4 GATA binding protein 4
GHRHR growth hormone releasing hormone receptor
GJA4 gap junction protein, alpha 4, 37kDa
GM2A GM2 ganglioside activator
GPATCH2L G patch domain containing 2-like
GPR137 G protein-coupled receptor 137
GSK3A glycogen synthase kinase 3 alpha
GYG2 glycogenin 2
HLA-C major histocompatibility complex, class I, C
HOXA6 homeobox A6
HS6ST1 heparan sulfate 6-O-sulfotransferase 1
IL17RB interleukin 17 receptor B
IRS2 insulin receptor substrate 2
JAKMIP2 janus kinase and microtubule interacting protein 2
KCNB1 potassium channel, voltage gated Shab related subfamily B, member 1
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
LENEP lens epithelial protein
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MAP4 microtubule-associated protein 4
MAST3 microtubule associated serine/threonine kinase 3
MED16 mediator complex subunit 16
MET MET proto-oncogene, receptor tyrosine kinase
MTMR3 myotubularin related protein 3
MVK mevalonate kinase
MXD4 MAX dimerization protein 4
NPTX1 neuronal pentraxin I
NUP62CL nucleoporin 62kDa C-terminal like
PAQR6 progestin and adipoQ receptor family member VI
PARD6B par-6 family cell polarity regulator beta
PIAS4 protein inhibitor of activated STAT, 4
PLEKHO2 pleckstrin homology domain containing, family O member 2
PRB1 proline-rich protein BstNI subfamily 1
PTN pleiotrophin
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RAB30 RAB30, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RANBP3 RAN binding protein 3
RAP1GAP RAP1 GTPase activating protein
RAPSN receptor-associated protein of the synapse
RIN2 Ras and Rab interactor 2
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RNFT2 ring finger protein, transmembrane 2
RYR2 ryanodine receptor 2 (cardiac)
S100A4 S100 calcium binding protein A4
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SFTPB surfactant protein B
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SOCS7 suppressor of cytokine signaling 7
SPAG4 sperm associated antigen 4
SYNGR1 synaptogyrin 1
TADA3 transcriptional adaptor 3
TBC1D17 TBC1 domain family, member 17
TBC1D5 TBC1 domain family, member 5
TMCC2 transmembrane and coiled-coil domain family 2
TMEM161A transmembrane protein 161A
TOP3A topoisomerase (DNA) III alpha
TP53I11 tumor protein p53 inducible protein 11
TREX1 three prime repair exonuclease 1
ULK2 unc-51 like autophagy activating kinase 2
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
WDR25 WD repeat domain 25
YY2 YY2 transcription factor
ZBTB17 zinc finger and BTB domain containing 17
ZC3H7B zinc finger CCCH-type containing 7B
ZNF211 zinc finger protein 211

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ADRA2C adrenoceptor alpha 2C
ALS2CL ALS2 C-terminal like
ANKRD28 ankyrin repeat domain 28
APH1B APH1B gamma secretase subunit
ASB6 ankyrin repeat and SOCS box containing 6
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BAHD1 bromo adjacent homology domain containing 1
C11ORF30 chromosome 11 open reading frame 30
C7ORF43 chromosome 7 open reading frame 43
C9ORF40 chromosome 9 open reading frame 40
CCNO cyclin O
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CEP85 centrosomal protein 85kDa
CEP97 centrosomal protein 97kDa
CHST10 carbohydrate sulfotransferase 10
CLASP1 cytoplasmic linker associated protein 1
COL4A5 collagen, type IV, alpha 5
CORO2A coronin, actin binding protein, 2A
CTC1 CTS telomere maintenance complex component 1
DDIT3 DNA-damage-inducible transcript 3
DGKE diacylglycerol kinase, epsilon 64kDa
DIXDC1 DIX domain containing 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNM1 dynamin 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1
ERCC4 excision repair cross-complementation group 4
FAM184A family with sequence similarity 184, member A
FKBP10 FK506 binding protein 10, 65 kDa
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GPATCH3 G patch domain containing 3
GPR87 G protein-coupled receptor 87
GPX2 glutathione peroxidase 2
HAUS6 HAUS augmin-like complex, subunit 6
HDAC11 histone deacetylase 11
HIST1H2AG histone cluster 1, H2ag
HPSE heparanase
IL4R interleukin 4 receptor
IMPACT impact RWD domain protein
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KRT13 keratin 13, type I
MBNL3 muscleblind-like splicing regulator 3
MRPL44 mitochondrial ribosomal protein L44
MUL1 mitochondrial E3 ubiquitin protein ligase 1
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
NEO1 neogenin 1
NT5DC3 5'-nucleotidase domain containing 3
PAIP2B poly(A) binding protein interacting protein 2B
PARP12 poly (ADP-ribose) polymerase family, member 12
PC pyruvate carboxylase
PIBF1 progesterone immunomodulatory binding factor 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLEKHO1 pleckstrin homology domain containing, family O member 1
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2
PYCRL pyrroline-5-carboxylate reductase-like
RAB11FIP5 RAB11 family interacting protein 5 (class I)
RAB33B RAB33B, member RAS oncogene family
RFTN1 raftlin, lipid raft linker 1
RNF19B ring finger protein 19B
RNF25 ring finger protein 25
RPAP2 RNA polymerase II associated protein 2
SERTAD3 SERTA domain containing 3
SHPK sedoheptulokinase
SIGMAR1 sigma non-opioid intracellular receptor 1
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STK16 serine/threonine kinase 16
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SYBU syntabulin (syntaxin-interacting)
TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa
TCTN1 tectonic family member 1
THRAP3 thyroid hormone receptor associated protein 3
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMEM209 transmembrane protein 209
TMPRSS3 transmembrane protease, serine 3
TMPRSS4 transmembrane protease, serine 4
TTC23 tetratricopeptide repeat domain 23
TUBG2 tubulin, gamma 2
UBXN6 UBX domain protein 6
WDR19 WD repeat domain 19
WDR62 WD repeat domain 62
XAB2 XPA binding protein 2
XPA xeroderma pigmentosum, complementation group A
ZBTB39 zinc finger and BTB domain containing 39
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF16 zinc finger protein 16
ZNF226 zinc finger protein 226
ZNF273 zinc finger protein 273
ZNF324 zinc finger protein 324
ZW10 zw10 kinetochore protein
ZXDC ZXD family zinc finger C