Prestwick-983-6520 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the Prestwick-983-6520 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM20 ADAM metallopeptidase domain 20
ADGRG1 adhesion G protein-coupled receptor G1
ALOXE3 arachidonate lipoxygenase 3
ALS2CL ALS2 C-terminal like
AQP3 aquaporin 3 (Gill blood group)
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide
BMP2 bone morphogenetic protein 2
CADM3 cell adhesion molecule 3
CAPZB capping protein (actin filament) muscle Z-line, beta
CCDC40 coiled-coil domain containing 40
CCDC71 coiled-coil domain containing 71
CD6 CD6 molecule
CD7 CD7 molecule
CHI3L2 chitinase 3-like 2
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CYLD cylindromatosis (turban tumor syndrome)
DLC1 DLC1 Rho GTPase activating protein
DLG5 discs, large homolog 5 (Drosophila)
DLGAP4 discs, large (Drosophila) homolog-associated protein 4
DOK4 docking protein 4
DPT dermatopontin
DST dystonin
DTX2 deltex 2, E3 ubiquitin ligase
ERCC2 excision repair cross-complementation group 2
EXOSC1 exosome component 1
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2
FRMD4A FERM domain containing 4A
FRMD4B FERM domain containing 4B
GALC galactosylceramidase
GLUL glutamate-ammonia ligase
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GREB1 growth regulation by estrogen in breast cancer 1
GSTCD glutathione S-transferase, C-terminal domain containing
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2
HYAL4 hyaluronoglucosaminidase 4
ICOS inducible T-cell co-stimulator
IL33R interleukin 33 receptor
INCENP inner centromere protein antigens 135/155kDa
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIAA0232 KIAA0232
KRT17 keratin 17, type I
KRT6B keratin 6B, type II
MAGEB2 melanoma antigen family B2
MAOB monoamine oxidase B
MAX MYC associated factor X
MED25 mediator complex subunit 25
MEP1B meprin A, beta
MKL1 megakaryoblastic leukemia (translocation) 1
MST1 macrophage stimulating 1
MST1L macrophage stimulating 1-like
MST1R macrophage stimulating 1 receptor
MTMR8 myotubularin related protein 8
NF2 neurofibromin 2 (merlin)
NR2F1 nuclear receptor subfamily 2, group F, member 1
PCDHGA10 protocadherin gamma subfamily A, 10
PDIA2 protein disulfide isomerase family A, member 2
PHKG1 phosphorylase kinase, gamma 1 (muscle)
PHLDB1 pleckstrin homology-like domain, family B, member 1
PITX1 paired-like homeodomain 1
PLAUR plasminogen activator, urokinase receptor
PLK3 polo-like kinase 3
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D
PRKCA protein kinase C, alpha
PRR4 proline rich 4 (lacrimal)
PTGIS prostaglandin I2 (prostacyclin) synthase
PTPN11 protein tyrosine phosphatase, non-receptor type 11
QKI QKI, KH domain containing, RNA binding
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP4 retinol binding protein 4, plasma
REM1 RAS (RAD and GEM)-like GTP-binding 1
RGS3 regulator of G-protein signaling 3
RIN1 Ras and Rab interactor 1
SCN11A sodium channel, voltage gated, type XI alpha subunit
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4
STX5 syntaxin 5
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1
TAOK1 TAO kinase 1
TBXA2R thromboxane A2 receptor
TMEM40 transmembrane protein 40
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TTC38 tetratricopeptide repeat domain 38
TULP1 tubby like protein 1
UTRN utrophin
WDR91 WD repeat domain 91
ZNF639 zinc finger protein 639
ZNF711 zinc finger protein 711
ZNF75D zinc finger protein 75D
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
ADTRP androgen-dependent TFPI-regulating protein
ALOX15 arachidonate 15-lipoxygenase
ARHGAP24 Rho GTPase activating protein 24
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAHD1 bromo adjacent homology domain containing 1
BBC3 BCL2 binding component 3
BEX4 brain expressed, X-linked 4
BIRC7 baculoviral IAP repeat containing 7
C22ORF29 chromosome 22 open reading frame 29
C5ORF45 chromosome 5 open reading frame 45
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CCDC69 coiled-coil domain containing 69
CDKL3 cyclin-dependent kinase-like 3
CEP85 centrosomal protein 85kDa
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CRLF1 cytokine receptor-like factor 1
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DYSF dysferlin
DZANK1 double zinc ribbon and ankyrin repeat domains 1
EAF2 ELL associated factor 2
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EGFL7 EGF-like-domain, multiple 7
ELSPBP1 epididymal sperm binding protein 1
ENO3 enolase 3 (beta, muscle)
ERCC5 excision repair cross-complementation group 5
EVPL envoplakin
FAM110B family with sequence similarity 110, member B
FAM160B2 family with sequence similarity 160, member B2
FAM189A2 family with sequence similarity 189, member A2
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBRS fibrosin
FLJ22184
FURIN furin (paired basic amino acid cleaving enzyme)
GATA4 GATA binding protein 4
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNL1 guanine nucleotide binding protein-like 1
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXA4 homeobox A4
IMPG2 interphotoreceptor matrix proteoglycan 2
INPP5J inositol polyphosphate-5-phosphatase J
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM5C lysine (K)-specific demethylase 5C
LAMB3 laminin, beta 3
LIME1 Lck interacting transmembrane adaptor 1
LLPH LLP homolog, long-term synaptic facilitation (Aplysia)
LZTFL1 leucine zipper transcription factor-like 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MT1HL1 metallothionein 1H-like 1
MTA2 metastasis associated 1 family, member 2
MTSS1L metastasis suppressor 1-like
NKX3-2 NK3 homeobox 2
NNAT neuronatin
NPM3 nucleophosmin/nucleoplasmin 3
NR1H3 nuclear receptor subfamily 1, group H, member 3
NRGN neurogranin (protein kinase C substrate, RC3)
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
ONECUT2 one cut homeobox 2
PADI1 peptidyl arginine deiminase, type I
PARD6A par-6 family cell polarity regulator alpha
PDE12 phosphodiesterase 12
PDE8B phosphodiesterase 8B
PDGFD platelet derived growth factor D
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PLEKHO2 pleckstrin homology domain containing, family O member 2
PRAMEF10 PRAME family member 10
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein
RHBG Rh family, B glycoprotein (gene/pseudogene)
RIN2 Ras and Rab interactor 2
RLN1 relaxin 1
RNF31 ring finger protein 31
RPAP2 RNA polymerase II associated protein 2
SCN10A sodium channel, voltage gated, type X alpha subunit
SETMAR SET domain and mariner transposase fusion gene
SLC12A9 solute carrier family 12, member 9
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC39A1 solute carrier family 39 (zinc transporter), member 1
TCTN1 tectonic family member 1
VEGFC vascular endothelial growth factor C
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
WDR19 WD repeat domain 19
WNT10B wingless-type MMTV integration site family, member 10B
XYLT2 xylosyltransferase II
ZBTB22 zinc finger and BTB domain containing 22
ZDHHC14 zinc finger, DHHC-type containing 14
ZFHX2 zinc finger homeobox 2
ZMAT5 zinc finger, matrin-type 5
ZNF212 zinc finger protein 212
ZNF219 zinc finger protein 219
ZNF573 zinc finger protein 573
ZNF747 zinc finger protein 747
ZNF750 zinc finger protein 750