Prestwick-984-2903 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the Prestwick-984-2903 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AIF1 allograft inflammatory factor 1
ANGEL2 angel homolog 2 (Drosophila)
ATG10 autophagy related 10
BMPR1A bone morphogenetic protein receptor, type IA
C16ORF45 chromosome 16 open reading frame 45
C9ORF3 chromosome 9 open reading frame 3
CA8 carbonic anhydrase VIII
CD59 CD59 molecule, complement regulatory protein
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CEP41 centrosomal protein 41kDa
CLCN4 chloride channel, voltage-sensitive 4
CLIP2 CAP-GLY domain containing linker protein 2
COPZ2 coatomer protein complex, subunit zeta 2
CRYL1 crystallin, lambda 1
DCAKD dephospho-CoA kinase domain containing
DNM3 dynamin 3
DPYSL3 dihydropyrimidinase-like 3
DTNB dystrobrevin, beta
DVL2 dishevelled segment polarity protein 2
EDAR ectodysplasin A receptor
EFNA3 ephrin-A3
ENG endoglin
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative)
FAM3A family with sequence similarity 3, member A
FAS Fas cell surface death receptor
FBXO4 F-box protein 4
FCMR Fc fragment of IgM receptor
FER1L4 fer-1-like family member 4, pseudogene (functional)
FOXN2 forkhead box N2
GAL3ST4 galactose-3-O-sulfotransferase 4
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GPR15 G protein-coupled receptor 15
GULP1 GULP, engulfment adaptor PTB domain containing 1
HABP4 hyaluronan binding protein 4
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IDS iduronate 2-sulfatase
INO80B INO80 complex subunit B
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
LLGL1 lethal giant larvae homolog 1 (Drosophila)
MAST2 microtubule associated serine/threonine kinase 2
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MCC mutated in colorectal cancers
METRN meteorin, glial cell differentiation regulator
MMP3 matrix metallopeptidase 3
MTL5 metallothionein-like 5, testis-specific (tesmin)
MYL10 myosin, light chain 10, regulatory
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NEFH neurofilament, heavy polypeptide
NF2 neurofibromin 2 (merlin)
NLRP1 NLR family, pyrin domain containing 1
NOS1 nitric oxide synthase 1 (neuronal)
NPFFR1 neuropeptide FF receptor 1
NR2E3 nuclear receptor subfamily 2, group E, member 3
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
NUP160 nucleoporin 160kDa
NUP188 nucleoporin 188kDa
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
PDLIM7 PDZ and LIM domain 7 (enigma)
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PML promyelocytic leukemia
PORCN porcupine homolog (Drosophila)
PRSS22 protease, serine, 22
PTCRA pre T-cell antigen receptor alpha
PTPRH protein tyrosine phosphatase, receptor type, H
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAD51B RAD51 paralog B
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RFX2 regulatory factor X, 2 (influences HLA class II expression)
RGS5 regulator of G-protein signaling 5
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
S100A1 S100 calcium binding protein A1
SAMD4A sterile alpha motif domain containing 4A
SCARB2 scavenger receptor class B, member 2
SERINC5 serine incorporator 5
SETD1B SET domain containing 1B
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SGPP1 sphingosine-1-phosphate phosphatase 1
SLC16A5 solute carrier family 16 (monocarboxylate transporter), member 5
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SPHK1 sphingosine kinase 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRR serine racemase
THAP3 THAP domain containing, apoptosis associated protein 3
TIAM2 T-cell lymphoma invasion and metastasis 2
TLN2 talin 2
TMEM120B transmembrane protein 120B
TRAF4 TNF receptor-associated factor 4
TREML2 triggering receptor expressed on myeloid cells-like 2
TRPC4 transient receptor potential cation channel, subfamily C, member 4
VAV2 vav 2 guanine nucleotide exchange factor
ZNF174 zinc finger protein 174
ZNF177 zinc finger protein 177
ZNF574 zinc finger protein 574
ZNF696 zinc finger protein 696
ZNF771 zinc finger protein 771

decreased expression

Symbol Name
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADGRG2 adhesion G protein-coupled receptor G2
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
APOBEC2 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2
BAAT bile acid CoA:amino acid N-acyltransferase
BNC2 basonuclin 2
C17ORF53 chromosome 17 open reading frame 53
C17ORF80 chromosome 17 open reading frame 80
C3ORF18 chromosome 3 open reading frame 18
CARTPT CART prepropeptide
CASZ1 castor zinc finger 1
CD70 CD70 molecule
CDR2L cerebellar degeneration-related protein 2-like
CELP carboxyl ester lipase pseudogene
CLCN2 chloride channel, voltage-sensitive 2
CLEC2D C-type lectin domain family 2, member D
CPNE7 copine VII
DDN dendrin
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
EGR2 early growth response 2
EHMT1 euchromatic histone-lysine N-methyltransferase 1
EXOSC1 exosome component 1
FGL1 fibrinogen-like 1
FJX1 four jointed box 1 (Drosophila)
FMOD fibromodulin
FZD6 frizzled class receptor 6
GALE UDP-galactose-4-epimerase
GJA9 gap junction protein, alpha 9, 59kDa
GLTSCR1 glioma tumor suppressor candidate region gene 1
GPX2 glutathione peroxidase 2
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HIST1H3G histone cluster 1, H3g
HOXA4 homeobox A4
HOXC8 homeobox C8
HP haptoglobin
INO80D INO80 complex subunit D
ITGA10 integrin, alpha 10
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA1024 KIAA1024
KIF3A kinesin family member 3A
LIMD2 LIM domain containing 2
LOC729164 hCG1732469
LPPR3 lipid phosphate phosphatase-related protein type 3
MAGEF1 melanoma antigen family F1
MAPK3 mitogen-activated protein kinase 3
MOGS mannosyl-oligosaccharide glucosidase
MRAS muscle RAS oncogene homolog
MXD3 MAX dimerization protein 3
MYO5C myosin VC
MYOZ3 myozenin 3
NKX3-2 NK3 homeobox 2
NSUN6 NOP2/Sun domain family, member 6
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PADI2 peptidyl arginine deiminase, type II
PCDH12 protocadherin 12
PCDHGB5 protocadherin gamma subfamily B, 5
PDGFRL platelet-derived growth factor receptor-like
PDLIM1 PDZ and LIM domain 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPT2 palmitoyl-protein thioesterase 2
PRAF2 PRA1 domain family, member 2
PRICKLE3 prickle homolog 3 (Drosophila)
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B)
RANBP17 RAN binding protein 17
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RETN resistin
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RND1 Rho family GTPase 1
RNF126P1 ring finger protein 126 pseudogene 1
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SCG5 secretogranin V
SETD1A SET domain containing 1A
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22
SLC35F6 solute carrier family 35, member F6
SOX12 SRY (sex determining region Y)-box 12
ST7L suppression of tumorigenicity 7 like
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STX1A syntaxin 1A (brain)
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAGLN transgelin
TCTN2 tectonic family member 2
TESK1 testis-specific kinase 1
THEM6 thioesterase superfamily member 6
TMEM206 transmembrane protein 206
TMEM53 transmembrane protein 53
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TTC30A tetratricopeptide repeat domain 30A
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
VEGFB vascular endothelial growth factor B
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae)
WDR33 WD repeat domain 33
ZFHX2 zinc finger homeobox 2
ZNF549 zinc finger protein 549