Prestwick-984-6603 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the Prestwick-984-6603 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ACACB acetyl-CoA carboxylase beta
ADGRF5 adhesion G protein-coupled receptor F5
ALK anaplastic lymphoma receptor tyrosine kinase
ARHGAP44 Rho GTPase activating protein 44
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
BBC3 BCL2 binding component 3
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BEAN1 brain expressed, associated with NEDD4, 1
BMP3 bone morphogenetic protein 3
C1ORF116 chromosome 1 open reading frame 116
C1ORF54 chromosome 1 open reading frame 54
CCDC87 coiled-coil domain containing 87
CD2 CD2 molecule
CNTD2 cyclin N-terminal domain containing 2
CROCCP3 ciliary rootlet coiled-coil, rootletin pseudogene 3
CRYAB crystallin, alpha B
DGKQ diacylglycerol kinase, theta 110kDa
DKFZP434C153 DKFZP434C153 protein
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
EPAS1 endothelial PAS domain protein 1
EXOSC1 exosome component 1
FAM63A family with sequence similarity 63, member A
FOXO4 forkhead box O4
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GADD45GIP1 growth arrest and DNA-damage-inducible, gamma interacting protein 1
GBP2 guanylate binding protein 2, interferon-inducible
GGT1 gamma-glutamyltransferase 1
GIMAP5 GTPase, IMAP family member 5
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
ING2 inhibitor of growth family, member 2
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa
IRGC immunity-related GTPase family, cinema
KCNIP1 Kv channel interacting protein 1
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM5B lysine (K)-specific demethylase 5B
KIAA0485 uncharacterized LOC57235
KIAA1024 KIAA1024
KITLG KIT ligand
KLF3 Kruppel-like factor 3 (basic)
KLHL11 kelch-like family member 11
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LAIR2 leukocyte-associated immunoglobulin-like receptor 2
LEFTY1 left-right determination factor 1
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LMTK2 lemur tyrosine kinase 2
LOX lysyl oxidase
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MATK megakaryocyte-associated tyrosine kinase
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEGF6 multiple EGF-like-domains 6
MUC4 mucin 4, cell surface associated
MUC7 mucin 7, secreted
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NACAD NAC alpha domain containing
NEBL nebulette
NNMT nicotinamide N-methyltransferase
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NTNG1 netrin G1
PAPPA2 pappalysin 2
PARP6 poly (ADP-ribose) polymerase family, member 6
PBX2 pre-B-cell leukemia homeobox 2
PCDH1 protocadherin 1
PCDHB3 protocadherin beta 3
PLK4 polo-like kinase 4
POU2F2 POU class 2 homeobox 2
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
RAB40AL RAB40A, member RAS oncogene family-like
RASL11B RAS-like, family 11, member B
RPL35A ribosomal protein L35a
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
RUFY3 RUN and FYVE domain containing 3
SCN3B sodium channel, voltage gated, type III beta subunit
SFTPD surfactant protein D
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SOS2 son of sevenless homolog 2 (Drosophila)
SSX3 synovial sarcoma, X breakpoint 3
TAOK2 TAO kinase 2
TBC1D30 TBC1 domain family, member 30
THRA thyroid hormone receptor, alpha
TJP3 tight junction protein 3
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TRIM3 tripartite motif containing 3
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VCAN versican
WDR1 WD repeat domain 1
WRNIP1 Werner helicase interacting protein 1
ZC3H7B zinc finger CCCH-type containing 7B
ZCCHC11 zinc finger, CCHC domain containing 11
ZNF3 zinc finger protein 3

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
AFF4 AF4/FMR2 family, member 4
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
BATF3 basic leucine zipper transcription factor, ATF-like 3
C4ORF19 chromosome 4 open reading frame 19
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CBX4 chromobox homolog 4
CCDC85C coiled-coil domain containing 85C
CDON cell adhesion associated, oncogene regulated
CENPJ centromere protein J
CENPO centromere protein O
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DDN dendrin
DEAF1 DEAF1 transcription factor
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DMTN dematin actin binding protein
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DSPP dentin sialophosphoprotein
EEF2KMT eukaryotic elongation factor 2 lysine methyltransferase
EFNA3 ephrin-A3
EN2 engrailed homeobox 2
ERN2 endoplasmic reticulum to nucleus signaling 2
EYA4 EYA transcriptional coactivator and phosphatase 4
FBXL15 F-box and leucine-rich repeat protein 15
FUZ fuzzy planar cell polarity protein
GEMIN8 gem (nuclear organelle) associated protein 8
GLS2 glutaminase 2 (liver, mitochondrial)
GPR1 G protein-coupled receptor 1
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRAMD1C GRAM domain containing 1C
H2AFJ H2A histone family, member J
HAMP hepcidin antimicrobial peptide
HOXA4 homeobox A4
IGSF3 immunoglobulin superfamily, member 3
IL12B interleukin 12B
IL7R interleukin 7 receptor
INF2 inverted formin, FH2 and WH2 domain containing
IPO13 importin 13
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KIF13B kinesin family member 13B
KPNA5 karyopherin alpha 5 (importin alpha 6)
LAMC3 laminin, gamma 3
LRP3 low density lipoprotein receptor-related protein 3
LYPD3 LY6/PLAUR domain containing 3
LYRM9 LYR motif containing 9
MCC mutated in colorectal cancers
MDM4 MDM4, p53 regulator
MUC3B mucin 3B, cell surface associated
MXD3 MAX dimerization protein 3
NCS1 neuronal calcium sensor 1
NDRG4 NDRG family member 4
NT5M 5',3'-nucleotidase, mitochondrial
NUBP2 nucleotide binding protein 2
OASL 2'-5'-oligoadenylate synthetase-like
OLFML2B olfactomedin-like 2B
OSR2 odd-skipped related transciption factor 2
OVGP1 oviductal glycoprotein 1, 120kDa
PC pyruvate carboxylase
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLD2 phospholipase D2
PLEKHO1 pleckstrin homology domain containing, family O member 1
PPT2 palmitoyl-protein thioesterase 2
PRF1 perforin 1 (pore forming protein)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PYCR1 pyrroline-5-carboxylate reductase 1
RBM38 RNA binding motif protein 38
RPAP2 RNA polymerase II associated protein 2
RPGRIP1L RPGRIP1-like
SAYSD1 SAYSVFN motif domain containing 1
SKA1 spindle and kinetochore associated complex subunit 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC35C2 solute carrier family 35 (GDP-fucose transporter), member C2
SLC4A3 solute carrier family 4 (anion exchanger), member 3
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2
SPTBN2 spectrin, beta, non-erythrocytic 2
SSBP3 single stranded DNA binding protein 3
STARD3 StAR-related lipid transfer (START) domain containing 3
STARD5 StAR-related lipid transfer (START) domain containing 5
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
THRAP3 thyroid hormone receptor associated protein 3
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TOM1 target of myb1 (chicken)
TTLL7 tubulin tyrosine ligase-like family member 7
TXLNG taxilin gamma
VARS valyl-tRNA synthetase
VASH1 vasohibin 1
VASH2 vasohibin 2
WDR4 WD repeat domain 4
ZNF227 zinc finger protein 227
ZNF286A zinc finger protein 286A
ZNF385D zinc finger protein 385D
ZNF549 zinc finger protein 549
ZNF747 zinc finger protein 747
ZNF816 zinc finger protein 816
ZXDB zinc finger, X-linked, duplicated B