Presynapse Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores 2025
Category structural or functional annotations
Type cellular component
External Link http://amigo.geneontology.org/amigo/term/GO:0098793
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Genes

259 proteins localized to the Presynapse cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

Symbol Name Standardized Value
SLC35G2 solute carrier family 35, member G2 5.0
CABP4 calcium binding protein 4 5.0
SLC5A7 solute carrier family 5 (sodium/choline cotransporter), member 7 5.0
TOR1A torsin family 1, member A (torsin A) 5.0
COPS5 COP9 signalosome subunit 5 5.0
DTNBP1 dystrobrevin binding protein 1 5.0
SLC35F1 solute carrier family 35, member F1 5.0
CLN3 ceroid-lipofuscinosis, neuronal 3 5.0
DMXL2 Dmx-like 2 5.0
SNAPIN SNAP-associated protein 5.0
TMEM230 transmembrane protein 230 5.0
SLC35D3 solute carrier family 35, member D3 5.0
SCN9A sodium channel, voltage gated, type IX alpha subunit 5.0
PPT1 palmitoyl-protein thioesterase 1 5.0
METTL5 methyltransferase like 5 5.0
SEPTIN5 septin 5 5.0
PCDH8 protocadherin 8 5.0
SLC30A3 solute carrier family 30 (zinc transporter), member 3 5.0
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 5.0
COPS4 COP9 signalosome subunit 4 5.0
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 5.0
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 4.0
DNMBP dynamin binding protein 4.0
DAO D-amino-acid oxidase 4.0
PTPRN protein tyrosine phosphatase, receptor type, N 4.0
SLC18B1 solute carrier family 18, subfamily B, member 1 4.0
PTPRS protein tyrosine phosphatase, receptor type, S 4.0
HIP1 huntingtin interacting protein 1 4.0
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 4.0
PI4K2A phosphatidylinositol 4-kinase type 2 alpha 4.0
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 4.0
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 4.0
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 4.0
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 4.0
PRRT2 proline-rich transmembrane protein 2 4.0
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 4.0
HCRT hypocretin (orexin) neuropeptide precursor 4.0
BRSK1 BR serine/threonine kinase 1 4.0
RNF112 ring finger protein 112 4.0
RAB43 RAB43, member RAS oncogene family 4.0
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 4.0
GRM7 glutamate receptor, metabotropic 7 4.0
CNTNAP4 contactin associated protein-like 4 4.0
RAD51 RAD51 recombinase 4.0
SPHK1 sphingosine kinase 1 4.0
CLCN3 chloride channel, voltage-sensitive 3 4.0
GRIA1 glutamate receptor, ionotropic, AMPA 1 4.0
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 4.0
SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 4.0
KIF1B kinesin family member 1B 4.0
KIRREL3 kin of IRRE like 3 (Drosophila) 4.0
DNM1 dynamin 1 4.0
RORA RAR-related orphan receptor A 4.0
MCTP1 multiple C2 domains, transmembrane 1 4.0
DISC1 disrupted in schizophrenia 1 4.0
GPER1 G protein-coupled estrogen receptor 1 4.0
SNAP25 synaptosomal-associated protein, 25kDa 4.0
POTEF POTE ankyrin domain family, member F 4.0
ICA1 islet cell autoantigen 1, 69kDa 4.0
TRIO trio Rho guanine nucleotide exchange factor 4.0
SLC4A10 solute carrier family 4, sodium bicarbonate transporter, member 10 4.0
RAB26 RAB26, member RAS oncogene family 4.0
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 4.0
TPRG1L tumor protein p63 regulated 1-like 4.0
FMR1 fragile X mental retardation 1 4.0
MT3 metallothionein 3 4.0
LRRK2 leucine-rich repeat kinase 2 4.0
IGSF21 immunoglobin superfamily, member 21 4.0
SYT4 synaptotagmin IV 4.0
CRHBP corticotropin releasing hormone binding protein 4.0
SYNGR2 synaptogyrin 2 4.0
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C 4.0
SYT7 synaptotagmin VII 4.0
TRAPPC4 trafficking protein particle complex 4 4.0
PDE2A phosphodiesterase 2A, cGMP-stimulated 4.0
SYAP1 synapse associated protein 1 4.0
SNCAIP synuclein, alpha interacting protein 4.0
TMEM163 transmembrane protein 163 4.0
FLRT3 fibronectin leucine rich transmembrane protein 3 4.0
SEPTIN8 septin 8 4.0
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 4.0
ADGRL1 adhesion G protein-coupled receptor L1 4.0
OTOF otoferlin 4.0
GRAP GRB2-related adaptor protein 4.0
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 4.0
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 4.0
ADCY8 adenylate cyclase 8 (brain) 4.0
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 3.0
EFNB1 ephrin-B1 3.0
RAB12 RAB12, member RAS oncogene family 3.0
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 3.0
GIPC1 GIPC PDZ domain containing family, member 1 3.0
PDYN prodynorphin 3.0
SCGN secretagogin, EF-hand calcium binding protein 3.0
RAB13 RAB13, member RAS oncogene family 3.0
ACOD1 aconitate decarboxylase 1 3.0
BSN bassoon presynaptic cytomatrix protein 3.0
SEPTIN2 septin 2 3.0
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 3.0
SEPTIN3 septin 3 3.0
SEPTIN4 septin 4 3.0
SEPTIN1 septin 1 3.0
RAB3A RAB3A, member RAS oncogene family 3.0
PNISR PNN-interacting serine/arginine-rich protein 3.0
AP3D1 adaptor-related protein complex 3, delta 1 subunit 3.0
UNC13B unc-13 homolog B (C. elegans) 3.0
UNC13C unc-13 homolog C (C. elegans) 3.0
SNCA synuclein, alpha (non A4 component of amyloid precursor) 3.0
UNC13A unc-13 homolog A (C. elegans) 3.0
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 3.0
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 3.0
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 3.0
BORCS5 BLOC-1 related complex subunit 5 3.0
EFNB3 ephrin-B3 3.0
NTS neurotensin 3.0
SYT12 synaptotagmin XII 3.0
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 3.0
AMPH amphiphysin 3.0
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) 3.0
MTMR2 myotubularin related protein 2 3.0
SYNPR synaptoporin 3.0
RAB3B RAB3B, member RAS oncogene family 3.0
RAB3C RAB3C, member RAS oncogene family 3.0
RAB3D RAB3D, member RAS oncogene family 3.0
MYOF myoferlin 3.0
NPFF neuropeptide FF-amide peptide precursor 3.0
DYSF dysferlin 3.0
PICALM phosphatidylinositol binding clathrin assembly protein 3.0
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 3.0
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 3.0
STON1 stonin 1 3.0
STX1A syntaxin 1A (brain) 3.0
KCNC4 potassium channel, voltage gated Shaw related subfamily C, member 4 3.0
STX11 syntaxin 11 3.0
FER1L5 fer-1-like family member 5 3.0
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.0
PCLO piccolo presynaptic cytomatrix protein 3.0
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 3.0
CLTA clathrin, light chain A 3.0
CLTB clathrin, light chain B 3.0
AAK1 AP2 associated kinase 1 3.0
TBC1D24 TBC1 domain family, member 24 3.0
CADM3 cell adhesion molecule 3 3.0
SYNJ1 synaptojanin 1 3.0
SYNJ2 synaptojanin 2 3.0
STX19 syntaxin 19 3.0
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 3.0
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 3.0
STX12 syntaxin 12 3.0
STX10 syntaxin 10 3.0
ATP6V1G3 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 3.0
BIN1 bridging integrator 1 3.0
RIMS3 regulating synaptic membrane exocytosis 3 3.0
RIMS2 regulating synaptic membrane exocytosis 2 3.0
RIMS1 regulating synaptic membrane exocytosis 1 3.0
RIMS4 regulating synaptic membrane exocytosis 4 3.0
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 3.0
NPTN neuroplastin 3.0
CALB2 calbindin 2 3.0
ITSN2 intersectin 2 3.0
ITSN1 intersectin 1 (SH3 domain protein) 3.0
DRD2 dopamine receptor D2 3.0
CRHR2 corticotropin releasing hormone receptor 2 3.0
CDHR3 cadherin-related family member 3 3.0
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 3.0
SV2A synaptic vesicle glycoprotein 2A 3.0
SYPL2 synaptophysin-like 2 3.0
SYPL1 synaptophysin-like 1 3.0
RAB40A RAB40A, member RAS oncogene family 3.0
RAB40B RAB40B, member RAS oncogene family 3.0
RAB40C RAB40C, member RAS oncogene family 3.0
STON2 stonin 2 3.0
SYN1 synapsin I 3.0
SYN3 synapsin III 3.0
SYN2 synapsin II 3.0
SV2B synaptic vesicle glycoprotein 2B 3.0
SV2C synaptic vesicle glycoprotein 2C 3.0
RAB5A RAB5A, member RAS oncogene family 3.0
VTI1B vesicle transport through interaction with t-SNAREs 1B 3.0
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 3.0
CPLX2 complexin 2 3.0
ARHGAP44 Rho GTPase activating protein 44 3.0
SYP synaptophysin 3.0
SYT5 synaptotagmin V 3.0
SYT2 synaptotagmin II 3.0
SYT1 synaptotagmin I 3.0
SYT8 synaptotagmin VIII 3.0
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 3.0
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 3.0
SLC18A3 solute carrier family 18 (vesicular acetylcholine transporter), member 3 3.0
KCTD12 potassium channel tetramerization domain containing 12 3.0
KCTD16 potassium channel tetramerization domain containing 16 3.0
PENK proenkephalin 3.0
VTI1A vesicle transport through interaction with t-SNAREs 1A 3.0
CALB1 calbindin 1, 28kDa 3.0
RAB40AL RAB40A, member RAS oncogene family-like 3.0
SNCB synuclein, beta 3.0
SNCG synuclein, gamma (breast cancer-specific protein 1) 3.0
NTF4 neurotrophin 4 3.0
NTF3 neurotrophin 3 3.0
SVOP SV2 related protein homolog (rat) 3.0
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8 3.0
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 3.0
SYNGR4 synaptogyrin 4 3.0
SNAP91 synaptosomal-associated protein, 91kDa 3.0
SYNGR3 synaptogyrin 3 3.0
CPLX3 complexin 3 3.0
SYNDIG1 synapse differentiation inducing 1 3.0
NRXN1 neurexin 1 3.0
NRXN3 neurexin 3 3.0
SYNGR1 synaptogyrin 1 3.0
BDNF brain-derived neurotrophic factor 3.0
RPH3A rabphilin 3A 3.0
EFNB2 ephrin-B2 3.0
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 3.0
SH3GL2 SH3-domain GRB2-like 2 3.0
SH3GL3 SH3-domain GRB2-like 3 3.0
CPLX1 complexin 1 3.0
CPLX4 complexin 4 3.0
CLCN5 chloride channel, voltage-sensitive 5 3.0
LGI3 leucine-rich repeat LGI family, member 3 3.0
STX6 syntaxin 6 3.0
STX7 syntaxin 7 3.0
STX2 syntaxin 2 3.0
STX3 syntaxin 3 3.0
PNOC prepronociceptin 3.0
GPRIN1 G protein regulated inducer of neurite outgrowth 1 3.0
ERC2 ELKS/RAB6-interacting/CAST family member 2 3.0
ERC1 ELKS/RAB6-interacting/CAST family member 1 3.0
NMU neuromedin U 3.0
CLCN4 chloride channel, voltage-sensitive 4 3.0
SH3GL1 SH3-domain GRB2-like 1 3.0
OPHN1 oligophrenin 1 3.0
RAB8B RAB8B, member RAS oncogene family 3.0
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 3.0
CDH8 cadherin 8, type 2 3.0
PICK1 protein interacting with PRKCA 1 3.0
MCTP2 multiple C2 domains, transmembrane 2 3.0
KCNC3 potassium channel, voltage gated Shaw related subfamily C, member 3 3.0
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 3.0
KCNC1 potassium channel, voltage gated Shaw related subfamily C, member 1 3.0
DOC2A double C2-like domains, alpha 3.0
NGF nerve growth factor (beta polypeptide) 3.0
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 3.0
RAB8A RAB8A, member RAS oncogene family 3.0
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 3.0
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2) 3.0
GHRH growth hormone releasing hormone 3.0
MMP12 matrix metallopeptidase 12 3.0
ADAM23 ADAM metallopeptidase domain 23 3.0
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 3.0
GRIK5 glutamate receptor, ionotropic, kainate 5 3.0
GRIK4 glutamate receptor, ionotropic, kainate 4 3.0
GRIK3 glutamate receptor, ionotropic, kainate 3 3.0
GRIK1 glutamate receptor, ionotropic, kainate 1 3.0
SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2 3.0
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 3.0
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 3.0
LLGL1 lethal giant larvae homolog 1 (Drosophila) 3.0