Primary Effusion Lymphoma Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Primary effusion lymphoma (PEL) is a large B-cell lymphoma located in the body cavities, characterized by pleural, peritoneal, and pericardial fluid lymphomatous effusions and that is always associated with human herpes virus-8 (HHV-8). (Orphanet Rare Disease Ontology, Orphanet_48686)
External Link https://www.disgenet.org/browser/0/1/0/C1292753
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Genes

162 genes associated with the disease Primary Effusion Lymphoma in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACKR3 atypical chemokine receptor 3
ADRA1A adrenoceptor alpha 1A
ADRA2B adrenoceptor alpha 2B
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ATN1 atrophin 1
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BCL6 B-cell CLL/lymphoma 6
BIRC5 baculoviral IAP repeat containing 5
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRD4 bromodomain containing 4
BRS3 bombesin-like receptor 3
BSG basigin (Ok blood group)
CALR calreticulin
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CAT catalase
CCK cholecystokinin
CCND2 cyclin D2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD274 CD274 molecule
CD47 CD47 molecule
CD86 CD86 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDK1 cyclin-dependent kinase 1
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN3 cyclin-dependent kinase inhibitor 3
CFLAR CASP8 and FADD-like apoptosis regulator
CIB1 calcium and integrin binding 1 (calmyrin)
CLIP1 CAP-GLY domain containing linker protein 1
CLIP2 CAP-GLY domain containing linker protein 2
CNTRL centriolin
CORO1C coronin, actin binding protein, 1C
COX2
CRBN cereblon
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTSD cathepsin D
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR6 chemokine (C-X-C motif) receptor 6
DHFR dihydrofolate reductase
DNASE1 deoxyribonuclease I
EBI3 Epstein-Barr virus induced 3
EDNRA endothelin receptor type A
EPHA2 EPH receptor A2
EPHA7 EPH receptor A7
EPHB2 EPH receptor B2
F10 coagulation factor X
FADD Fas (TNFRSF6)-associated via death domain
FAM107B family with sequence similarity 107, member B
FGF2 fibroblast growth factor 2 (basic)
FHIT fragile histidine triad
FKBP4 FK506 binding protein 4, 59kDa
FUS FUS RNA binding protein
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GPR42 G protein-coupled receptor 42 (gene/pseudogene)
GRAP2 GRB2-related adaptor protein 2
GSK3B glycogen synthase kinase 3 beta
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-C major histocompatibility complex, class I, C
ICAM1 intercellular adhesion molecule 1
IGF2R insulin-like growth factor 2 receptor
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IKZF3 IKAROS family zinc finger 3 (Aiolos)
IL10 interleukin 10
IL13 interleukin 13
IL18R1 interleukin 18 receptor 1
IL1B interleukin 1, beta
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
INAFM2 InaF-motif containing 2
IRAK1 interleukin-1 receptor-associated kinase 1
IRF4 interferon regulatory factor 4
IRF5 interferon regulatory factor 5
KAT5 K(lysine) acetyltransferase 5
KRT20 keratin 20, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LIF leukemia inhibitory factor
LPAR2 lysophosphatidic acid receptor 2
LRPPRC leucine-rich pentatricopeptide repeat containing
LTA4H leukotriene A4 hydrolase
MALT1 MALT1 paracaspase
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MNDA myeloid cell nuclear differentiation antigen
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MSC musculin
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUM1 melanoma associated antigen (mutated) 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAM1 neural cell adhesion molecule 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NLRP1 NLR family, pyrin domain containing 1
NOTCH1 notch 1
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
OPN1SW opsin 1 (cone pigments), short-wave-sensitive
OSGIN1 oxidative stress induced growth inhibitor 1
PABPC1 poly(A) binding protein, cytoplasmic 1
PAEP progestagen-associated endometrial protein
PAX5 paired box 5
PCNA proliferating cell nuclear antigen
PDLIM7 PDZ and LIM domain 7 (enigma)
PLXNB1 plexin B1
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POMC proopiomelanocortin
POU2AF1 POU class 2 associating factor 1
POU2F2 POU class 2 homeobox 2
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11
PRDM1 PR domain containing 1, with ZNF domain
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRKCZ protein kinase C, zeta
PSIP1 PC4 and SFRS1 interacting protein 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPRC protein tyrosine phosphatase, receptor type, C
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SDC1 syndecan 1
SELPLG selectin P ligand
SESN2 sestrin 2
SIRT1 sirtuin 1
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
SPHK1 sphingosine kinase 1
SPHK2 sphingosine kinase 2
SQSTM1 sequestosome 1
SSTR4 somatostatin receptor 4
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SUMO2 small ubiquitin-like modifier 2
TCL1A T-cell leukemia/lymphoma 1A
TCL1B T-cell leukemia/lymphoma 1B
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TNF tumor necrosis factor
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TP53 tumor protein p53
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM28 tripartite motif containing 28
TYRO3 TYRO3 protein tyrosine kinase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VKORC1 vitamin K epoxide reductase complex, subunit 1
WWOX WW domain containing oxidoreductase
XBP1 X-box binding protein 1
XK X-linked Kx blood group
XPO1 exportin 1
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)