Primary Myelofibrosis Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link https://www.disgenet.org/browser/0/1/0/C0001815
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Genes

265 genes associated with the disease Primary Myelofibrosis in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABI1 abl-interactor 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACE angiotensin I converting enzyme
ACTB actin, beta
AGGF1 angiogenic factor with G patch and FHA domains 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ALPI alkaline phosphatase, intestinal
ALPP alkaline phosphatase, placental
ASXL1 additional sex combs like transcriptional regulator 1
ATN1 atrophin 1
AURKA aurora kinase A
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L2 BCL2-like 2
BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough
BCR breakpoint cluster region
BID BH3 interacting domain death agonist
BMF Bcl2 modifying factor
BMP1 bone morphogenetic protein 1
BMP6 bone morphogenetic protein 6
BMP7 bone morphogenetic protein 7
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BORA bora, aurora kinase A activator
BRCA2 breast cancer 2, early onset
C6ORF25 chromosome 6 open reading frame 25
CA2 carbonic anhydrase II
CALB2 calbindin 2
CALR calreticulin
CAT catalase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCN1 cellular communication network factor 1
CCN2 cellular communication network factor 2
CD14 CD14 molecule
CD164 CD164 molecule, sialomucin
CD177 CD177 molecule
CD34 CD34 molecule
CD47 CD47 molecule
CD63 CD63 molecule
CD9 CD9 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEP43 centrosomal protein 43
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIT1 chitinase 1 (chitotriosidase)
CIP2A cellular inhibitor of PP2A
CNTNAP1 contactin associated protein 1
CRISP2 cysteine-rich secretory protein 2
CRP C-reactive protein, pentraxin-related
CSF1R colony stimulating factor 1 receptor
CSF3 colony stimulating factor 3 (granulocyte)
CSF3R colony stimulating factor 3 receptor (granulocyte)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUX1 cut-like homeobox 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
DERL1 derlin 1
DLK1 delta-like 1 homolog (Drosophila)
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EBI3 Epstein-Barr virus induced 3
EDA ectodysplasin A
ELN elastin
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENG endoglin
EPO erythropoietin
EPOR erythropoietin receptor
ETV6 ets variant 6
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FGF2 fibroblast growth factor 2 (basic)
FGF3 fibroblast growth factor 3
FGFR1 fibroblast growth factor receptor 1
FIP1L1 factor interacting with PAPOLA and CPSF1
FKBP4 FK506 binding protein 4, 59kDa
FKBP5 FK506 binding protein 5
FLT1 fms-related tyrosine kinase 1
FLT3 fms-related tyrosine kinase 3
FN1 fibronectin 1
FREM1 FRAS1 related extracellular matrix 1
FXYD5 FXYD domain containing ion transport regulator 5
FZD2 frizzled class receptor 2
G6PD glucose-6-phosphate dehydrogenase
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GADD45B growth arrest and DNA-damage-inducible, beta
GATA1 GATA binding protein 1 (globin transcription factor 1)
GDF11 growth differentiation factor 11
GFI1B growth factor independent 1B transcription repressor
GLI1 GLI family zinc finger 1
GLS glutaminase
HDAC11 histone deacetylase 11
HDAC6 histone deacetylase 6
HDAC9 histone deacetylase 9
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMGXB3 HMG box domain containing 3
HMGXB4 HMG box domain containing 4
HP haptoglobin
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB1 heat shock 27kDa protein 1
HSPB2 heat shock 27kDa protein 2
HSPB3 heat shock 27kDa protein 3
IAPP islet amyloid polypeptide
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IFI27 interferon, alpha-inducible protein 27
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IFNA2 interferon, alpha 2
IFNG interferon, gamma
IGF2 insulin-like growth factor 2
IL18R1 interleukin 18 receptor 1
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2RA interleukin 2 receptor, alpha
IL3 interleukin 3
IL6 interleukin 6
INTS1 integrator complex subunit 1
INTS2 integrator complex subunit 2
INTS3 integrator complex subunit 3
IRAK1 interleukin-1 receptor-associated kinase 1
ITGA9 integrin, alpha 9
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JARID2 jumonji, AT rich interactive domain 2
JUN jun proto-oncogene
KIDINS220 kinase D-interacting substrate, 220kDa
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRT7 keratin 7, type II
LDHA lactate dehydrogenase A
LDHB lactate dehydrogenase B
LEF1 lymphoid enhancer-binding factor 1
LEP leptin
LEPR leptin receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LIG3 ligase III, DNA, ATP-dependent
LIG4 ligase IV, DNA, ATP-dependent
LOX lysyl oxidase
MAGT1 magnesium transporter 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MCAM melanoma cell adhesion molecule
MMP13 matrix metallopeptidase 13
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP8 matrix metallopeptidase 8
MMRN1 multimerin 1
MPL MPL proto-oncogene, thrombopoietin receptor
MRPL28 mitochondrial ribosomal protein L28
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MVD mevalonate (diphospho) decarboxylase
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOM2 myomesin 2
NBEAL2 neurobeachin-like 2
NCOR2 nuclear receptor corepressor 2
NFE2 nuclear factor, erythroid 2
NFE2L2 nuclear factor, erythroid 2-like 2
NOG noggin
NOS2 nitric oxide synthase 2, inducible
NOS3 nitric oxide synthase 3 (endothelial cell)
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRM nurim (nuclear envelope membrane protein)
NXT1 nuclear transport factor 2-like export factor 1
PAEP progestagen-associated endometrial protein
PAOX polyamine oxidase (exo-N4-amino)
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PLK1 polo-like kinase 1
PPARG peroxisome proliferator-activated receptor gamma
PRB1 proline-rich protein BstNI subfamily 1
PRDX2 peroxiredoxin 2
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PROM1 prominin 1
PRSS27 protease, serine 27
PRSS55 protease, serine, 55
PTH parathyroid hormone
PTHLH parathyroid hormone-like hormone
PTK2 protein tyrosine kinase 2
PYCARD PYD and CARD domain containing
RARB retinoic acid receptor, beta
RARS1 arginyl-tRNA synthetase 1
RET ret proto-oncogene
RPS14 ribosomal protein S14
RUNX1 runt-related transcription factor 1
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCT secretin
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SETBP1 SET binding protein 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SGSM3 small G protein signaling modulator 3
SH2B3 SH2B adaptor protein 3
SHOC2 soc-2 suppressor of clear homolog (C. elegans)
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SNRPF small nuclear ribonucleoprotein polypeptide F
SOAT1 sterol O-acyltransferase 1
SOCS3 suppressor of cytokine signaling 3
SOCS6 suppressor of cytokine signaling 6
SOD2 superoxide dismutase 2, mitochondrial
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPP1 secreted phosphoprotein 1
SPZ1 spermatogenic leucine zipper 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF2 serine/arginine-rich splicing factor 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STIM2 stromal interaction molecule 2
STS steroid sulfatase (microsomal), isozyme S
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SUB1 SUB1 homolog (S. cerevisiae)
TAC1 tachykinin, precursor 1
TBK1 TANK-binding kinase 1
TBXAS1 thromboxane A synthase 1 (platelet)
TET2 tet methylcytosine dioxygenase 2
TGFB1 transforming growth factor, beta 1
TGFBR1 transforming growth factor, beta receptor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBD thrombomodulin
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THPO thrombopoietin
THRB thyroid hormone receptor, beta
THY1 Thy-1 cell surface antigen
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TP53 tumor protein p53
TPO thyroid peroxidase
TRPC4 transient receptor potential cation channel, subfamily C, member 4
TSLIG1 tRNA splicing ligase complex subunit 1
TYK2 tyrosine kinase 2
TYROBP TYRO protein tyrosine kinase binding protein
U2AF1 U2 small nuclear RNA auxiliary factor 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae)
WNT1 wingless-type MMTV integration site family, member 1
WT1 Wilms tumor 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZFPM1 zinc finger protein, FOG family member 1
ZMYM2 zinc finger, MYM-type 2