Primary Sjögren'S Syndrome Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link https://www.disgenet.org/browser/0/1/0/C0151449
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Genes

290 genes associated with the disease Primary Sjögren'S Syndrome in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACACA acetyl-CoA carboxylase alpha
ACR acrosin
ACSBG1 acyl-CoA synthetase bubblegum family member 1
ACTB actin, beta
ADAM17 ADAM metallopeptidase domain 17
AKNA AT-hook transcription factor
ANXA2 annexin A2
APOE apolipoprotein E
AQP1 aquaporin 1 (Colton blood group)
AQP4 aquaporin 4
ARHGAP45 Rho GTPase activating protein 45
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATM ATM serine/threonine kinase
ATN1 atrophin 1
B2M beta-2-microglobulin
BAK1 BCL2-antagonist/killer 1
BANK1 B-cell scaffold protein with ankyrin repeats 1
BCL6 B-cell CLL/lymphoma 6
BLK BLK proto-oncogene, Src family tyrosine kinase
BMS1 BMS1 ribosome biogenesis factor
BPIFB2 BPI fold containing family B, member 2
BST2 bone marrow stromal cell antigen 2
BTG3 BTG family, member 3
BTK Bruton agammaglobulinemia tyrosine kinase
C4A complement component 4A (Rodgers blood group)
CA6 carbonic anhydrase VI
CALML5 calmodulin-like 5
CALR calreticulin
CASP1 caspase 1, apoptosis-related cysteine peptidase
CBX5 chromobox homolog 5
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL25 chemokine (C-C motif) ligand 25
CCL27 chemokine (C-C motif) ligand 27
CCL3 chemokine (C-C motif) ligand 3
CCL3L1 chemokine (C-C motif) ligand 3-like 1
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CCN2 cellular communication network factor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR7 chemokine (C-C motif) receptor 7
CCR8 chemokine (C-C motif) receptor 8
CCR9 chemokine (C-C motif) receptor 9
CD14 CD14 molecule
CD19 CD19 molecule
CD27 CD27 molecule
CD274 CD274 molecule
CD276 CD276 molecule
CD28 CD28 molecule
CD40LG CD40 ligand
CD68 CD68 molecule
CD69 CD69 molecule
CD70 CD70 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDK1 cyclin-dependent kinase 1
CENPC centromere protein C
CFH complement factor H
CFL1 cofilin 1 (non-muscle)
CGA glycoprotein hormones, alpha polypeptide
CHRM3 cholinergic receptor, muscarinic 3
CHUK conserved helix-loop-helix ubiquitous kinase
CKAP4 cytoskeleton-associated protein 4
CLEC4A C-type lectin domain family 4, member A
CLU clusterin
CNTRL centriolin
COX1
COX2
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRP C-reactive protein, pentraxin-related
CST3 cystatin C
CST4 cystatin S
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTSS cathepsin S
CUBN cubilin (intrinsic factor-cobalamin receptor)
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR5 chemokine (C-X-C motif) receptor 5
CXORF21 chromosome X open reading frame 21
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEFB4A defensin, beta 4A
DEFB4B defensin, beta 4B
DIABLO diablo, IAP-binding mitochondrial protein
EBF1 early B-cell factor 1
EBI3 Epstein-Barr virus induced 3
EDA ectodysplasin A
EGFR epidermal growth factor receptor
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ENO1 enolase 1, (alpha)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FAM167A family with sequence similarity 167, member A
FAM188B family with sequence similarity 188, member B
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FCRL4 Fc receptor-like 4
FLT4 fms-related tyrosine kinase 4
FURIN furin (paired basic amino acid cleaving enzyme)
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
GRN granulin
GTF2I general transcription factor IIi
GTF2IRD1 GTF2I repeat domain containing 1
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HCRT hypocretin (orexin) neuropeptide precursor
HELLS helicase, lymphoid-specific
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HOXC6 homeobox C6
ICA1 islet cell autoantigen 1, 69kDa
ICAM1 intercellular adhesion molecule 1
ICOS inducible T-cell co-stimulator
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IFI44L interferon-induced protein 44-like
IFIH1 interferon induced with helicase C domain 1
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IGH immunoglobulin heavy locus
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL10 interleukin 10
IL11 interleukin 11
IL12A interleukin 12A
IL12RB2 interleukin 12 receptor, beta 2
IL13 interleukin 13
IL15 interleukin 15
IL17A interleukin 17A
IL17F interleukin 17F
IL18 interleukin 18
IL18BP interleukin 18 binding protein
IL1B interleukin 1, beta
IL1F10 interleukin 1 family, member 10 (theta)
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL21 interleukin 21
IL21R interleukin 21 receptor
IL22 interleukin 22
IL22RA2 interleukin 22 receptor, alpha 2
IL23A interleukin 23, alpha subunit p19
IL2RA interleukin 2 receptor, alpha
IL34 interleukin 34
IL36A interleukin 36, alpha
IL36R interleukin 36 receptor
IL37 interleukin 37
IL4 interleukin 4
IL6 interleukin 6
IL7 interleukin 7
IRAK1 interleukin-1 receptor-associated kinase 1
IRF5 interferon regulatory factor 5
ISG20 interferon stimulated exonuclease gene 20kDa
JAK1 Janus kinase 1
KLK3 kallikrein-related peptidase 3
KLRB1 killer cell lectin-like receptor subfamily B, member 1
KLRC4-KLRK1 KLRC4-KLRK1 readthrough
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KRT19 keratin 19, type I
KRT20 keratin 20, type I
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LIFR leukemia inhibitory factor receptor alpha
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
LOC102723407 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8
LOC102724971 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8
LRP2 low density lipoprotein receptor-related protein 2
LTA lymphotoxin alpha
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
MBL2 mannose-binding lectin (protein C) 2, soluble
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MECP2 methyl CpG binding protein 2
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIP major intrinsic protein of lens fiber
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MUC1 mucin 1, cell surface associated
MYD88 myeloid differentiation primary response 88
NCR2 natural cytotoxicity triggering receptor 2
NCR3 natural cytotoxicity triggering receptor 3
NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NGF nerve growth factor (beta polypeptide)
NLRP3 NLR family, pyrin domain containing 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NT5C1A 5'-nucleotidase, cytosolic IA
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
ORM2 orosomucoid 2
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PDCD1 programmed cell death 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PKN1 protein kinase N1
PLA2G1B phospholipase A2, group IB (pancreas)
PLCL1 phospholipase C-like 1
PNPLA6 patatin-like phospholipase domain containing 6
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
PON1 paraoxonase 1
POT1 protection of telomeres 1
POU2AF1 POU class 2 associating factor 1
POU2F1 POU class 2 homeobox 1
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RAB3D RAB3D, member RAS oncogene family
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
RBM45 RNA binding motif protein 45
REG1A regenerating islet-derived 1 alpha
RGS13 regulator of G-protein signaling 13
RO60 Ro60, Y RNA binding protein
RORA RAR-related orphan receptor A
RPE65 retinal pigment epithelium-specific protein 65kDa
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RUNX1 runt-related transcription factor 1
S100A8 S100 calcium binding protein A8
SDC1 syndecan 1
SEC14L3 SEC14-like 3 (S. cerevisiae)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPD surfactant protein D
SH2B2 SH2B adaptor protein 2
SIGLEC5 sialic acid binding Ig-like lectin 5
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC25A40 solute carrier family 25, member 40
SOAT1 sterol O-acyltransferase 1
SOCS1 suppressor of cytokine signaling 1
SOCS3 suppressor of cytokine signaling 3
SPTAN1 spectrin, alpha, non-erythrocytic 1
SSB Sjogren syndrome antigen B (autoantigen La)
SST somatostatin
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
SUMO4 small ubiquitin-like modifier 4
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TBK1 TANK-binding kinase 1
TGFB1 transforming growth factor, beta 1
TLR1 toll-like receptor 1
TLR2 toll-like receptor 2
TLR3 toll-like receptor 3
TLR5 toll-like receptor 5
TLR7 toll-like receptor 7
TLR8 toll-like receptor 8
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNIP1 TNFAIP3 interacting protein 1
TP53 tumor protein p53
TP63 tumor protein p63
TPP1 tripeptidyl peptidase I
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TREX1 three prime repair exonuclease 1
TRIM21 tripartite motif containing 21
TSLP thymic stromal lymphopoietin
TUBA1C tubulin, alpha 1c
TYRO3 TYRO3 protein tyrosine kinase
UTS2B urotensin 2B
UVRAG UV radiation resistance associated
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFC vascular endothelial growth factor C
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1