| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/4911 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Probenecid relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VAV1 | vav 1 guanine nucleotide exchange factor | 1.61 |
| GGACT | gamma-glutamylamine cyclotransferase | 0.96 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.91 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.74 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | 0.68 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 0.66 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 0.63 |
| SYNE3 | spectrin repeat containing, nuclear envelope family member 3 | 0.52 |
| AURKAIP1 | aurora kinase A interacting protein 1 | 0.5 |
| TEN1 | TEN1 CST complex subunit | 0.49 |
| CCDC85B | coiled-coil domain containing 85B | 0.48 |
| ZNF180 | zinc finger protein 180 | 0.47 |
| SYTL3 | synaptotagmin-like 3 | 0.47 |
| SASH1 | SAM and SH3 domain containing 1 | 0.44 |
| INPP5E | inositol polyphosphate-5-phosphatase, 72 kDa | 0.43 |
| FAM8A1 | family with sequence similarity 8, member A1 | 0.42 |
| DERPC | DERPC proline and glycine rich nuclear protein | 0.42 |
| ASIC1 | acid sensing (proton gated) ion channel 1 | 0.4 |
| FBXL4 | F-box and leucine-rich repeat protein 4 | 0.4 |
| ABHD14A | abhydrolase domain containing 14A | 0.39 |
| ENDOV | endonuclease V | 0.38 |
| KLF2 | Kruppel-like factor 2 | 0.38 |
| UPF3A | UPF3 regulator of nonsense transcripts homolog A (yeast) | 0.35 |
| YRDC | yrdC N(6)-threonylcarbamoyltransferase domain containing | 0.35 |
| HOXB9 | homeobox B9 | 0.35 |
| ZNF777 | zinc finger protein 777 | 0.34 |
| MOCS2 | molybdenum cofactor synthesis 2 | 0.33 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.33 |
| ATXN1L | ataxin 1-like | 0.33 |
| ANKRD10 | ankyrin repeat domain 10 | 0.33 |
| SLC25A28 | solute carrier family 25 (mitochondrial iron transporter), member 28 | 0.33 |
| CCND3 | cyclin D3 | 0.33 |
| LSM11 | LSM11, U7 small nuclear RNA associated | 0.32 |
| ZMAT5 | zinc finger, matrin-type 5 | 0.32 |
| XBP1 | X-box binding protein 1 | 0.32 |
| MAP3K9 | mitogen-activated protein kinase kinase kinase 9 | 0.3 |
| RPL26 | ribosomal protein L26 | 0.3 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.3 |
| LMO4 | LIM domain only 4 | 0.3 |
| ADGRE2 | adhesion G protein-coupled receptor E2 | 0.3 |
| ZNF799 | zinc finger protein 799 | 0.29 |
| ACE | angiotensin I converting enzyme | 0.29 |
| TFAP4 | transcription factor AP-4 (activating enhancer binding protein 4) | 0.28 |
| B3GNTL1 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 | 0.28 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | 0.28 |
| PWWP2B | PWWP domain containing 2B | 0.27 |
| ZWINT | ZW10 interacting kinetochore protein | 0.27 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.27 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | 0.27 |
| AADAT | aminoadipate aminotransferase | 0.26 |
| TPST2 | tyrosylprotein sulfotransferase 2 | 0.26 |
| DNAAF2 | dynein, axonemal, assembly factor 2 | 0.26 |
| VWA1 | von Willebrand factor A domain containing 1 | 0.26 |
| FAM133B | family with sequence similarity 133, member B | 0.26 |
| PALB2 | partner and localizer of BRCA2 | 0.26 |
| RNF8 | ring finger protein 8, E3 ubiquitin protein ligase | 0.26 |
| TXNL4B | thioredoxin-like 4B | 0.26 |
| LINGO1 | leucine rich repeat and Ig domain containing 1 | 0.25 |
| KLF4 | Kruppel-like factor 4 (gut) | 0.25 |
| DEPDC1 | DEP domain containing 1 | 0.25 |
| GRK5 | G protein-coupled receptor kinase 5 | 0.25 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 0.24 |
| ZBTB40 | zinc finger and BTB domain containing 40 | 0.24 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.24 |
| PNPO | pyridoxamine 5'-phosphate oxidase | 0.24 |
| ZNF587B | zinc finger protein 587B | 0.24 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | 0.24 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | 0.24 |
| FBXO9 | F-box protein 9 | 0.24 |
| NIN | ninein (GSK3B interacting protein) | 0.24 |
| TIPIN | TIMELESS interacting protein | 0.24 |
| MAPK14 | mitogen-activated protein kinase 14 | 0.24 |
| ZNF451 | zinc finger protein 451 | 0.24 |
| PPIE | peptidylprolyl isomerase E (cyclophilin E) | 0.23 |
| TSR2 | TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.23 |
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | 0.23 |
| TICRR | TOPBP1-interacting checkpoint and replication regulator | 0.23 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.23 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.23 |
| POLE4 | polymerase (DNA-directed), epsilon 4, accessory subunit | 0.23 |
| CKS2 | CDC28 protein kinase regulatory subunit 2 | 0.23 |
| AMPD1 | adenosine monophosphate deaminase 1 | 0.23 |
| CCNQ | cyclin Q | 0.23 |
| DCLK2 | doublecortin-like kinase 2 | 0.23 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | 0.23 |
| CC2D2A | coiled-coil and C2 domain containing 2A | 0.23 |
| ETV3 | ets variant 3 | 0.22 |
| CDPF1 | cysteine-rich, DPF motif domain containing 1 | 0.22 |
| CDK2AP1 | cyclin-dependent kinase 2 associated protein 1 | 0.22 |
| LARGE2 | LARGE xylosyl- and glucuronyltransferase 2 | 0.22 |
| POM121C | POM121 transmembrane nucleoporin C | 0.22 |
| DUSP6 | dual specificity phosphatase 6 | 0.22 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.22 |
| CEP83 | centrosomal protein 83kDa | 0.22 |
| CEP89 | centrosomal protein 89kDa | 0.22 |
| MSL2 | male-specific lethal 2 homolog (Drosophila) | 0.22 |
| PRMT7 | protein arginine methyltransferase 7 | 0.22 |
| FOXM1 | forkhead box M1 | 0.22 |
| CCDC97 | coiled-coil domain containing 97 | 0.22 |
| MTF1 | metal-regulatory transcription factor 1 | 0.22 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SEMG1 | semenogelin I | -2.67 |
| DNAH12 | dynein, axonemal, heavy chain 12 | -2.1 |
| SYN2 | synapsin II | -1.9 |
| FGG | fibrinogen gamma chain | -1.24 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -1.23 |
| HSP90AB3P | heat shock protein 90kDa alpha (cytosolic), class B member 3, pseudogene | -0.91 |
| SBSN | suprabasin | -0.91 |
| CLTB | clathrin, light chain B | -0.89 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.84 |
| USP48 | ubiquitin specific peptidase 48 | -0.79 |
| ZNF532 | zinc finger protein 532 | -0.74 |
| ADM | adrenomedullin | -0.72 |
| B2M | beta-2-microglobulin | -0.71 |
| TESK1 | testis-specific kinase 1 | -0.68 |
| C4BPA | complement component 4 binding protein, alpha | -0.6 |
| FN1 | fibronectin 1 | -0.55 |
| FGFBP1 | fibroblast growth factor binding protein 1 | -0.52 |
| FAT4 | FAT atypical cadherin 4 | -0.51 |
| SGSH | N-sulfoglucosamine sulfohydrolase | -0.5 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | -0.5 |
| HBA1 | hemoglobin, alpha 1 | -0.49 |
| TMOD2 | tropomodulin 2 (neuronal) | -0.48 |
| ABTB1 | ankyrin repeat and BTB (POZ) domain containing 1 | -0.47 |
| WASF3 | WAS protein family, member 3 | -0.47 |
| ZNF440 | zinc finger protein 440 | -0.46 |
| HAL | histidine ammonia-lyase | -0.46 |
| C18ORF32 | chromosome 18 open reading frame 32 | -0.46 |
| TMEM63A | transmembrane protein 63A | -0.46 |
| CLSTN3 | calsyntenin 3 | -0.45 |
| GDF15 | growth differentiation factor 15 | -0.45 |
| ALG3 | ALG3, alpha-1,3- mannosyltransferase | -0.44 |
| SAT2 | spermidine/spermine N1-acetyltransferase family member 2 | -0.44 |
| TNFSF9 | tumor necrosis factor (ligand) superfamily, member 9 | -0.44 |
| FHIT | fragile histidine triad | -0.42 |
| FGB | fibrinogen beta chain | -0.42 |
| L1CAM | L1 cell adhesion molecule | -0.41 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.41 |
| CYP27B1 | cytochrome P450, family 27, subfamily B, polypeptide 1 | -0.41 |
| PGPEP1 | pyroglutamyl-peptidase I | -0.39 |
| SERPING1 | serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | -0.39 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.39 |
| CEP152 | centrosomal protein 152kDa | -0.39 |
| SSNA1 | Sjogren syndrome nuclear autoantigen 1 | -0.38 |
| TNFAIP1 | tumor necrosis factor, alpha-induced protein 1 (endothelial) | -0.37 |
| ABCA7 | ATP-binding cassette, sub-family A (ABC1), member 7 | -0.36 |
| RAB40C | RAB40C, member RAS oncogene family | -0.36 |
| GLRX | glutaredoxin (thioltransferase) | -0.36 |
| ERG28 | ergosterol biosynthesis 28 homolog | -0.36 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | -0.35 |
| YIPF6 | Yip1 domain family, member 6 | -0.35 |
| EVI5L | ecotropic viral integration site 5-like | -0.35 |
| HS6ST1 | heparan sulfate 6-O-sulfotransferase 1 | -0.35 |
| POLR2M | polymerase (RNA) II (DNA directed) polypeptide M | -0.34 |
| HRH1 | histamine receptor H1 | -0.34 |
| LIPH | lipase, member H | -0.34 |
| ZNF444 | zinc finger protein 444 | -0.34 |
| ARAP2 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 | -0.33 |
| PEMT | phosphatidylethanolamine N-methyltransferase | -0.33 |
| MYO3A | myosin IIIA | -0.32 |
| MSRB2 | methionine sulfoxide reductase B2 | -0.32 |
| NEIL1 | nei endonuclease VIII-like 1 (E. coli) | -0.32 |
| TMEM59 | transmembrane protein 59 | -0.32 |
| MAP2 | microtubule-associated protein 2 | -0.32 |
| FTL | ferritin, light polypeptide | -0.32 |
| MACC1 | metastasis associated in colon cancer 1 | -0.32 |
| RAB27B | RAB27B, member RAS oncogene family | -0.32 |
| IGFBP6 | insulin-like growth factor binding protein 6 | -0.32 |
| PLPP3 | phospholipid phosphatase 3 | -0.31 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.31 |
| CCDC102A | coiled-coil domain containing 102A | -0.3 |
| CBARP | CACN subunit beta associated regulatory protein | -0.3 |
| ABAT | 4-aminobutyrate aminotransferase | -0.3 |
| SLC39A4 | solute carrier family 39 (zinc transporter), member 4 | -0.3 |
| LRP10 | low density lipoprotein receptor-related protein 10 | -0.3 |
| AZI2 | 5-azacytidine induced 2 | -0.3 |
| YIPF1 | Yip1 domain family, member 1 | -0.3 |
| LRP5 | low density lipoprotein receptor-related protein 5 | -0.29 |
| FCHO1 | FCH domain only 1 | -0.29 |
| SLC37A1 | solute carrier family 37 (glucose-6-phosphate transporter), member 1 | -0.29 |
| METTL7A | methyltransferase like 7A | -0.29 |
| CDK10 | cyclin-dependent kinase 10 | -0.29 |
| ATP11A | ATPase, class VI, type 11A | -0.29 |
| LIPT1 | lipoyltransferase 1 | -0.29 |
| TRIB3 | tribbles pseudokinase 3 | -0.29 |
| PTGES | prostaglandin E synthase | -0.28 |
| DSTYK | dual serine/threonine and tyrosine protein kinase | -0.28 |
| FGFR4 | fibroblast growth factor receptor 4 | -0.28 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.28 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | -0.28 |
| SMOX | spermine oxidase | -0.28 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | -0.28 |
| FSTL3 | follistatin-like 3 (secreted glycoprotein) | -0.27 |
| RNF170 | ring finger protein 170 | -0.27 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.27 |
| PLEKHA3 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 | -0.27 |
| GALT | galactose-1-phosphate uridylyltransferase | -0.27 |
| GPANK1 | G patch domain and ankyrin repeats 1 | -0.27 |
| LAMA3 | laminin, alpha 3 | -0.27 |
| CERCAM | cerebral endothelial cell adhesion molecule | -0.27 |
