Procainamide (hydrochloride)_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Procainamide (hydrochloride) perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Procainamide (hydrochloride)_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0777058
MYADM myeloid-associated differentiation marker 0.0420848
CLU clusterin 0.0412599
MSN moesin 0.0389326
SETD5 SET domain containing 5 0.0376651
ZFP36L1 ZFP36 ring finger protein-like 1 0.0352566
FOSL1 FOS-like antigen 1 0.0327203
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0286053
TRIO trio Rho guanine nucleotide exchange factor 0.0280827
PCBP2 poly(rC) binding protein 2 0.0258603
TIMP2 TIMP metallopeptidase inhibitor 2 0.0246233
NFE2L1 nuclear factor, erythroid 2-like 1 0.0225115
EGLN1 egl-9 family hypoxia-inducible factor 1 0.022471
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0224212
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0218587
RPS2 ribosomal protein S2 0.0218273
ZEB1 zinc finger E-box binding homeobox 1 0.0214823
HILPDA hypoxia inducible lipid droplet-associated 0.0200104
ZFP36 ZFP36 ring finger protein 0.0191687
MNT MAX network transcriptional repressor 0.018917
MT2A metallothionein 2A 0.0186537
VMP1 vacuole membrane protein 1 0.0186356
ZNF292 zinc finger protein 292 0.0183424
DDIT4 DNA-damage-inducible transcript 4 0.0182978
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0180041
WAC WW domain containing adaptor with coiled-coil 0.0177554
ABI3BP ABI family, member 3 (NESH) binding protein 0.0175864
DCLK2 doublecortin-like kinase 2 0.0173476
GOLGA4 golgin A4 0.0170147
RPL21 ribosomal protein L21 0.0169914
TMF1 TATA element modulatory factor 1 0.016982
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0168178
PNISR PNN-interacting serine/arginine-rich protein 0.0163165
KMT2E lysine (K)-specific methyltransferase 2E 0.0159216
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0158178
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0158077
NCOR2 nuclear receptor corepressor 2 0.0157774
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0156812
ESYT2 extended synaptotagmin-like protein 2 0.0156533
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 0.0154492
CD109 CD109 molecule 0.0153793
PABPN1 poly(A) binding protein, nuclear 1 0.0153237
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0150637
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 0.0149871
C1ORF21 chromosome 1 open reading frame 21 0.0148013
COL8A1 collagen, type VIII, alpha 1 0.0145015
PNN pinin, desmosome associated protein 0.0144271
CYLD cylindromatosis (turban tumor syndrome) 0.0143355
CCNL1 cyclin L1 0.0143335
ZMIZ1 zinc finger, MIZ-type containing 1 0.0141461
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0139197
SOX9 SRY (sex determining region Y)-box 9 0.0138065
POTEF POTE ankyrin domain family, member F 0.0137753
DSCAM Down syndrome cell adhesion molecule 0.0137653
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0133874
BHLHE40 basic helix-loop-helix family, member e40 0.0133774
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0133549
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0133013
CXXC5 CXXC finger protein 5 0.0132516
MIER1 mesoderm induction early response 1, transcriptional regulator 0.01314
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0130416
KDM6A lysine (K)-specific demethylase 6A 0.0129932
FAM193B family with sequence similarity 193, member B 0.0129434
RPS12 ribosomal protein S12 0.0128149
MMP12 matrix metallopeptidase 12 0.0127322
SRSF11 serine/arginine-rich splicing factor 11 0.0126065
ANKRD33B ankyrin repeat domain 33B 0.0125155
FAM13A family with sequence similarity 13, member A 0.0122645
SBF2 SET binding factor 2 0.0121797
UBA6 ubiquitin-like modifier activating enzyme 6 0.0121483
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0121035
RBM39 RNA binding motif protein 39 0.0119591
MBNL1 muscleblind-like splicing regulator 1 0.0119414
SSBP2 single-stranded DNA binding protein 2 0.0119175
ADM adrenomedullin 0.0117433
FXR1 fragile X mental retardation, autosomal homolog 1 0.0116286
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0115748
TPM3 tropomyosin 3 0.0115332
EIF4B eukaryotic translation initiation factor 4B 0.0115305
RNF24 ring finger protein 24 0.0115066
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0114656
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0113238
WDR43 WD repeat domain 43 0.0113012
FNIP2 folliculin interacting protein 2 0.0112737
RNMT RNA (guanine-7-) methyltransferase 0.0112668
PML promyelocytic leukemia 0.0112267
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.011156
MSI2 musashi RNA-binding protein 2 0.0111217
TSC22D2 TSC22 domain family, member 2 0.0110913
HELZ helicase with zinc finger 0.0110635
PIAS1 protein inhibitor of activated STAT, 1 0.0110278
ITSN1 intersectin 1 (SH3 domain protein) 0.0110155
ATL3 atlastin GTPase 3 0.0109735
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0109409
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0108211
RBM25 RNA binding motif protein 25 0.0107236
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0106276
ADARB1 adenosine deaminase, RNA-specific, B1 0.0105604
GADD45B growth arrest and DNA-damage-inducible, beta 0.0104969
LUC7L LUC7-like (S. cerevisiae) 0.0102963

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.333719
VIM vimentin -0.249258
LOX lysyl oxidase -0.148143
TMSB10 thymosin beta 10 -0.138687
AHNAK AHNAK nucleoprotein -0.137559
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.116851
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.111315
THBS2 thrombospondin 2 -0.103806
PODXL podocalyxin-like -0.101238
COL3A1 collagen, type III, alpha 1 -0.0928471
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.090784
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0881598
FBN1 fibrillin 1 -0.0817434
HLA-B major histocompatibility complex, class I, B -0.0760906
S100A10 S100 calcium binding protein A10 -0.0745736
MAP1B microtubule-associated protein 1B -0.0716425
CANX calnexin -0.0690194
ANXA2 annexin A2 -0.068407
CD44 CD44 molecule (Indian blood group) -0.0608385
TMSB4X thymosin beta 4, X-linked -0.0598409
PTMA prothymosin, alpha -0.0593664
LOC112694756 uncharaterized LOC112694756 -0.0581333
COL5A2 collagen, type V, alpha 2 -0.0565935
LOXL2 lysyl oxidase-like 2 -0.0561389
COL1A2 collagen, type I, alpha 2 -0.054799
CALR calreticulin -0.0537906
CCND1 cyclin D1 -0.0536133
S100A6 S100 calcium binding protein A6 -0.0535639
NAV1 neuron navigator 1 -0.0526137
TPM4 tropomyosin 4 -0.0511666
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0509994
APP amyloid beta (A4) precursor protein -0.0477997
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0473099
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0470168
NDRG1 N-myc downstream regulated 1 -0.0459207
CAVIN1 caveolae associated protein 1 -0.0454762
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0450454
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0447954
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0432059
HLA-C major histocompatibility complex, class I, C -0.0428124
LMNA lamin A/C -0.0426763
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0426196
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0414006
PLAT plasminogen activator, tissue -0.0401753
FSTL1 follistatin-like 1 -0.0390677
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0389165
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0388042
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0387958
IGFBP3 insulin-like growth factor binding protein 3 -0.0377753
AHNAK2 AHNAK nucleoprotein 2 -0.0358598
CTSB cathepsin B -0.0358553
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0353809
UBC ubiquitin C -0.0347793
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0342222
LDHA lactate dehydrogenase A -0.0339706
HLA-E major histocompatibility complex, class I, E -0.0336161
RNF213 ring finger protein 213 -0.0334225
HDLBP high density lipoprotein binding protein -0.0329595
SUCNR1 succinate receptor 1 -0.03291
NPR2 natriuretic peptide receptor 2 -0.0327632
PKM pyruvate kinase, muscle -0.0327215
SOD2 superoxide dismutase 2, mitochondrial -0.0326415
ZBTB20 zinc finger and BTB domain containing 20 -0.0324499
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0314956
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0312622
TPT1 tumor protein, translationally-controlled 1 -0.0309548
CD99 CD99 molecule -0.0308268
SH3KBP1 SH3-domain kinase binding protein 1 -0.0307916
IFI16 interferon, gamma-inducible protein 16 -0.0297434
RPS24 ribosomal protein S24 -0.0293172
ARF1 ADP-ribosylation factor 1 -0.0290958
ACTG1 actin gamma 1 -0.0289381
PGK1 phosphoglycerate kinase 1 -0.028838
FBXL7 F-box and leucine-rich repeat protein 7 -0.028605
SLC38A1 solute carrier family 38, member 1 -0.027317
NAV2 neuron navigator 2 -0.0273098
RPL35A ribosomal protein L35a -0.0270945
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0270271
FTH1 ferritin, heavy polypeptide 1 -0.0269991
COL5A1 collagen, type V, alpha 1 -0.0268672
OSMR oncostatin M receptor -0.0264549
SFTPA2 surfactant protein A2 -0.0263137
FLNA filamin A, alpha -0.0257685
ZNFX1 zinc finger, NFX1-type containing 1 -0.025611
BSG basigin (Ok blood group) -0.0253014
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0252502
HSPA13 heat shock protein 70kDa family, member 13 -0.0247124
SAMD9 sterile alpha motif domain containing 9 -0.0245442
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 -0.0241883
LMAN1 lectin, mannose-binding, 1 -0.0240998
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0239997
TUBB4B tubulin, beta 4B class IVb -0.0239924
GLG1 golgi glycoprotein 1 -0.0237065
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0236835
ZNF217 zinc finger protein 217 -0.0231649
SQSTM1 sequestosome 1 -0.0230347
SLFN5 schlafen family member 5 -0.0230331
NF1 neurofibromin 1 -0.0229444
NT5E 5'-nucleotidase, ecto (CD73) -0.0228831
AKAP12 A kinase (PRKA) anchor protein 12 -0.0228012