Procainamide (hydrochloride)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Procainamide (hydrochloride) perturbation in AN3 CA cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Procainamide (hydrochloride)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.0422761
PCBP2 poly(rC) binding protein 2 0.0397609
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0370842
ZNF292 zinc finger protein 292 0.0364693
MED13L mediator complex subunit 13-like 0.0341115
RNF145 ring finger protein 145 0.0320117
HOXA3 homeobox A3 0.0304001
PELI1 pellino E3 ubiquitin protein ligase 1 0.0278892
NFIB nuclear factor I/B 0.0266518
PNISR PNN-interacting serine/arginine-rich protein 0.0260155
SSBP2 single-stranded DNA binding protein 2 0.0258303
RSRC1 arginine/serine-rich coiled-coil 1 0.0255606
USP9X ubiquitin specific peptidase 9, X-linked 0.0250438
ZEB1 zinc finger E-box binding homeobox 1 0.0247919
H1-2 H1.2 linker histone, cluster member 0.0236021
TAPBP TAP binding protein (tapasin) 0.0233462
CKAP5 cytoskeleton associated protein 5 0.0232716
PDE4B phosphodiesterase 4B, cAMP-specific 0.0232521
MEST mesoderm specific transcript 0.023034
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0229877
TBK1 TANK-binding kinase 1 0.0229661
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0220562
YEATS2 YEATS domain containing 2 0.0218185
NAMPT nicotinamide phosphoribosyltransferase 0.0215313
FKBP5 FK506 binding protein 5 0.0213376
DSCAM Down syndrome cell adhesion molecule 0.0209824
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0208732
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0204906
SRSF11 serine/arginine-rich splicing factor 11 0.0201243
SUCO SUN domain containing ossification factor 0.0199238
POM121 POM121 transmembrane nucleoporin 0.019492
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.019276
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0192296
ACBD3 acyl-CoA binding domain containing 3 0.0190594
CDK19 cyclin-dependent kinase 19 0.0190378
TOP2B topoisomerase (DNA) II beta 180kDa 0.0189572
ARRDC3 arrestin domain containing 3 0.0188128
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0187722
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0187128
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0187099
FGF10 fibroblast growth factor 10 0.0185713
RAB6A RAB6A, member RAS oncogene family 0.0185382
GPC6 glypican 6 0.0184739
HOXC6 homeobox C6 0.0180932
SRSF4 serine/arginine-rich splicing factor 4 0.0177702
CYLD cylindromatosis (turban tumor syndrome) 0.0174851
LINGO2 leucine rich repeat and Ig domain containing 2 0.0174695
TP53BP1 tumor protein p53 binding protein 1 0.017395
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0173612
MSMO1 methylsterol monooxygenase 1 0.0173161
KIF15 kinesin family member 15 0.017292
OPTN optineurin 0.0172667
FAR1 fatty acyl CoA reductase 1 0.0169504
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0167512
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0167421
H1-4 H1.4 linker histone, cluster member 0.0167383
PANK3 pantothenate kinase 3 0.0165146
SPAG9 sperm associated antigen 9 0.0163644
NUS1 nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 0.016175
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0161356
HELZ helicase with zinc finger 0.0160329
IGF2 insulin-like growth factor 2 0.0159737
ITPRID2 ITPR interacting domain containing 2 0.01597
SOX9 SRY (sex determining region Y)-box 9 0.0159451
ATL2 atlastin GTPase 2 0.0159433
HMGB2 high mobility group box 2 0.0157543
SRP54 signal recognition particle 54kDa 0.0157069
KDM7A lysine (K)-specific demethylase 7A 0.0155497
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.015445
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator 0.0153502
LONP2 lon peptidase 2, peroxisomal 0.0152519
SP3 Sp3 transcription factor 0.0152061
GAPVD1 GTPase activating protein and VPS9 domains 1 0.0151882
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0151392
NFE2L1 nuclear factor, erythroid 2-like 1 0.0151206
ATF7IP activating transcription factor 7 interacting protein 0.0150316
SMAP1 small ArfGAP 1 0.015023
TTK TTK protein kinase 0.0149376
GGNBP2 gametogenetin binding protein 2 0.0149125
HELLS helicase, lymphoid-specific 0.0148326
TBC1D15 TBC1 domain family, member 15 0.0147856
LEMD3 LEM domain containing 3 0.0146761
MSN moesin 0.0146605
CNOT8 CCR4-NOT transcription complex, subunit 8 0.0146438
SEC23A Sec23 homolog A (S. cerevisiae) 0.014626
PHC3 polyhomeotic homolog 3 (Drosophila) 0.014556
RNPS1 RNA binding protein S1, serine-rich domain 0.0145508
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.0144559
WDR41 WD repeat domain 41 0.0144387
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0144186
CCNL1 cyclin L1 0.0143036
ZFP36L1 ZFP36 ring finger protein-like 1 0.0141685
CIRSR corepressor of RBPJ and splicing regulator 0.0140672
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.0140098
BHLHE40 basic helix-loop-helix family, member e40 0.0139891
NCAPG2 non-SMC condensin II complex, subunit G2 0.0139508
DENND5A DENN/MADD domain containing 5A 0.0138952
INTU inturned planar cell polarity protein 0.0138769
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0137874
CEP170 centrosomal protein 170kDa 0.0137808

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.299546
CADM2 cell adhesion molecule 2 -0.139418
PRKG1 protein kinase, cGMP-dependent, type I -0.131387
MGP matrix Gla protein -0.120599
HMGA2 high mobility group AT-hook 2 -0.115101
SOX4 SRY (sex determining region Y)-box 4 -0.104761
PEG10 paternally expressed 10 -0.093076
PTMA prothymosin, alpha -0.092999
FGFR1 fibroblast growth factor receptor 1 -0.0874368
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.080894
ACTG1 actin gamma 1 -0.0764906
RPS24 ribosomal protein S24 -0.0760613
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0657149
TPT1 tumor protein, translationally-controlled 1 -0.0619147
CANX calnexin -0.0606434
AFF4 AF4/FMR2 family, member 4 -0.0600916
RPLP1 ribosomal protein, large, P1 -0.0591095
RPS8 ribosomal protein S8 -0.0569441
RPLP0 ribosomal protein, large, P0 -0.0556535
VCL vinculin -0.0551359
RPS6 ribosomal protein S6 -0.0545353
TPK1 thiamin pyrophosphokinase 1 -0.0531766
TMSB10 thymosin beta 10 -0.0522316
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0508413
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0506743
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0490954
RPL19 ribosomal protein L19 -0.0479435
RAB7A RAB7A, member RAS oncogene family -0.047655
RPL35A ribosomal protein L35a -0.0468095
RACK1 receptor for activated C kinase 1 -0.0453391
ZFAND3 zinc finger, AN1-type domain 3 -0.0432513
TMSB4X thymosin beta 4, X-linked -0.0420475
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0406415
RPL37 ribosomal protein L37 -0.0405585
RPL31 ribosomal protein L31 -0.0399072
IER3 immediate early response 3 -0.0397208
MSRB3 methionine sulfoxide reductase B3 -0.0394895
FBXL7 F-box and leucine-rich repeat protein 7 -0.0392719
TRIO trio Rho guanine nucleotide exchange factor -0.0386839
TPM4 tropomyosin 4 -0.0386723
ERBIN erbb2 interacting protein -0.0382479
TBCA tubulin folding cofactor A -0.0382274
PKM pyruvate kinase, muscle -0.0376134
MT2A metallothionein 2A -0.0371789
JMJD1C jumonji domain containing 1C -0.036784
LDHA lactate dehydrogenase A -0.0365532
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0363496
RPL34 ribosomal protein L34 -0.0346276
COL1A2 collagen, type I, alpha 2 -0.0345806
TCF12 transcription factor 12 -0.0342847
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0341823
SEPTIN11 septin 11 -0.0340456
HDAC8 histone deacetylase 8 -0.0340212
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0336708
SLC38A2 solute carrier family 38, member 2 -0.0336661
KDM5B lysine (K)-specific demethylase 5B -0.0335969
RPS11 ribosomal protein S11 -0.0333056
RPS25 ribosomal protein S25 -0.0322124
RPL13A ribosomal protein L13a -0.0321709
GTF2IRD1 GTF2I repeat domain containing 1 -0.0319964
RPL23 ribosomal protein L23 -0.0316445
SENP6 SUMO1/sentrin specific peptidase 6 -0.0314349
ATP11A ATPase, class VI, type 11A -0.0314135
THSD4 thrombospondin, type I, domain containing 4 -0.0312109
NIPBL Nipped-B homolog (Drosophila) -0.0307588
LOC112694756 uncharaterized LOC112694756 -0.0305178
LPP LIM domain containing preferred translocation partner in lipoma -0.0304792
RANBP17 RAN binding protein 17 -0.0302606
MEOX2 mesenchyme homeobox 2 -0.0300869
RPS3 ribosomal protein S3 -0.0300005
RPL26 ribosomal protein L26 -0.0297975
RSU1 Ras suppressor protein 1 -0.0297711
RPL12 ribosomal protein L12 -0.0295693
KPNB1 karyopherin (importin) beta 1 -0.0295182
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0291625
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0289792
VDAC1 voltage-dependent anion channel 1 -0.0287005
ACACA acetyl-CoA carboxylase alpha -0.0285375
IGF2R insulin-like growth factor 2 receptor -0.0284683
SMC4 structural maintenance of chromosomes 4 -0.0284649
RPLP2 ribosomal protein, large, P2 -0.0280234
MARCHF6 membrane associated ring-CH-type finger 6 -0.0275209
MTDH metadherin -0.0270533
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0269857
DOCK3 dedicator of cytokinesis 3 -0.0269855
TRIM9 tripartite motif containing 9 -0.0268213
FTL ferritin, light polypeptide -0.0266559
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0264967
MAP1B microtubule-associated protein 1B -0.0264927
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0263021
TUBB tubulin, beta class I -0.0262601
FBXO11 F-box protein 11 -0.0262577
DEK DEK proto-oncogene -0.0261092
TSHZ2 teashirt zinc finger homeobox 2 -0.0260804
TULP4 tubby like protein 4 -0.0260634
GMDS GDP-mannose 4,6-dehydratase -0.0260352
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0260162
ARB2A ARB2 cotranscriptional regulator A -0.0257297
RPS13 ribosomal protein S13 -0.0256085
RPL11 ribosomal protein L11 -0.0255946