Procainamide (hydrochloride)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Procainamide (hydrochloride) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Procainamide (hydrochloride)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.213556
PSD3 pleckstrin and Sec7 domain containing 3 0.126565
BAIAP2L1 BAI1-associated protein 2-like 1 0.0977714
ITGA6 integrin, alpha 6 0.096499
EPS8 epidermal growth factor receptor pathway substrate 8 0.0947463
LMTK2 lemur tyrosine kinase 2 0.0939463
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0859805
ITPRID2 ITPR interacting domain containing 2 0.0793039
PTMA prothymosin, alpha 0.0756783
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0754435
SPTBN1 spectrin, beta, non-erythrocytic 1 0.072472
EZR ezrin 0.0687161
NEK7 NIMA-related kinase 7 0.0681505
ARHGAP42 Rho GTPase activating protein 42 0.066228
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0661404
ADAM9 ADAM metallopeptidase domain 9 0.0654676
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0650974
TSC22D2 TSC22 domain family, member 2 0.0644597
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0644023
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0633795
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0622425
VIM vimentin 0.0617476
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0602846
ERRFI1 ERBB receptor feedback inhibitor 1 0.0602727
RICTOR RPTOR independent companion of MTOR, complex 2 0.0598411
POTEF POTE ankyrin domain family, member F 0.0571835
FNDC3B fibronectin type III domain containing 3B 0.0560835
TOP1 topoisomerase (DNA) I 0.0553073
SQSTM1 sequestosome 1 0.0548257
ZEB1 zinc finger E-box binding homeobox 1 0.0544559
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0537865
JMJD1C jumonji domain containing 1C 0.0529881
NAMPT nicotinamide phosphoribosyltransferase 0.0527859
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0527298
PTPRR protein tyrosine phosphatase, receptor type, R 0.052282
PPARG peroxisome proliferator-activated receptor gamma 0.0510043
SMAD3 SMAD family member 3 0.0498312
RTN4 reticulon 4 0.0495395
SLMAP sarcolemma associated protein 0.0486552
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0478537
ACTG1 actin gamma 1 0.0478089
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0474294
MED13L mediator complex subunit 13-like 0.0467256
FOSL1 FOS-like antigen 1 0.0466019
ARHGAP26 Rho GTPase activating protein 26 0.0461021
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0459942
NCOA3 nuclear receptor coactivator 3 0.0450893
XPO1 exportin 1 0.0450399
TRA2A transformer 2 alpha homolog (Drosophila) 0.0449721
OGA O-GlcNAcase 0.0449389
EMP1 epithelial membrane protein 1 0.044231
ASPH aspartate beta-hydroxylase 0.0441327
BHLHE40 basic helix-loop-helix family, member e40 0.044059
KDM3A lysine (K)-specific demethylase 3A 0.0436573
VCL vinculin 0.0432624
S100A10 S100 calcium binding protein A10 0.0428293
CAB39 calcium binding protein 39 0.0426594
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0423419
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0419734
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0419553
EIF1 eukaryotic translation initiation factor 1 0.0415045
DSG2 desmoglein 2 0.0413543
VCAN versican 0.0409225
MYOF myoferlin 0.0408814
EPCAM epithelial cell adhesion molecule 0.0402931
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0400933
DSTN destrin (actin depolymerizing factor) 0.039637
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.039572
ANLN anillin, actin binding protein 0.0388209
BZW1 basic leucine zipper and W2 domains 1 0.038748
ZNF292 zinc finger protein 292 0.0384823
KCMF1 potassium channel modulatory factor 1 0.0384818
LDHA lactate dehydrogenase A 0.038252
CD2AP CD2-associated protein 0.0376319
CDC42SE2 CDC42 small effector 2 0.0371866
CAPN2 calpain 2, (m/II) large subunit 0.0371319
LMO7 LIM domain 7 0.0362982
RNF145 ring finger protein 145 0.0362963
LOC112694756 uncharaterized LOC112694756 0.035783
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0357065
SEPTIN7 septin 7 0.0355436
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0354574
PLAUR plasminogen activator, urokinase receptor 0.0351305
ARHGAP5 Rho GTPase activating protein 5 0.0348763
MATR3 matrin 3 0.03428
SLTM SAFB-like, transcription modulator 0.0339744
PCBP2 poly(rC) binding protein 2 0.0339129
SDC4 syndecan 4 0.0338411
PON2 paraoxonase 2 0.0335123
OSBPL3 oxysterol binding protein-like 3 0.0333967
SERTAD2 SERTA domain containing 2 0.0333533
FOXO3 forkhead box O3 0.0331593
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0331512
RAD21 RAD21 homolog (S. pombe) 0.0331149
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0329538
TES testin LIM domain protein 0.0327312
SPAG9 sperm associated antigen 9 0.0326631
AHNAK AHNAK nucleoprotein 0.0326183
MYO6 myosin VI 0.032118
GLS2 glutaminase 2 (liver, mitochondrial) 0.0318493

decreased expression

Symbol Name Standardized Value
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.18285
LAMB3 laminin, beta 3 -0.112325
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0986472
SACK1A scaffolding CK1 anchoring protein A -0.077162
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.073425
PMM2 phosphomannomutase 2 -0.0700978
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.06726
KLK10 kallikrein-related peptidase 10 -0.0661953
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0659554
PPARD peroxisome proliferator-activated receptor delta -0.0644097
F3 coagulation factor III (thromboplastin, tissue factor) -0.0635607
EXT1 exostosin glycosyltransferase 1 -0.0590112
MCL1 myeloid cell leukemia 1 -0.0584252
THSD4 thrombospondin, type I, domain containing 4 -0.0577143
CLMP CXADR-like membrane protein -0.0554147
HDAC9 histone deacetylase 9 -0.0538267
SLC35F3 solute carrier family 35, member F3 -0.0512971
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0509762
RASAL2 RAS protein activator like 2 -0.050112
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0495683
TRRAP transformation/transcription domain-associated protein -0.0493603
EGR1 early growth response 1 -0.0470298
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0457843
NDRG1 N-myc downstream regulated 1 -0.0450282
MXD1 MAX dimerization protein 1 -0.0445486
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0445395
BLZF1 basic leucine zipper nuclear factor 1 -0.0432799
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0427183
BMP6 bone morphogenetic protein 6 -0.0417626
MSN moesin -0.0410448
PARD3 par-3 family cell polarity regulator -0.0410328
TXNRD1 thioredoxin reductase 1 -0.0408467
INTS6 integrator complex subunit 6 -0.0400746
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha -0.0396991
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0396214
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0380996
HMGA2 high mobility group AT-hook 2 -0.0378396
SEC31A SEC31 homolog A (S. cerevisiae) -0.0372624
PDLIM5 PDZ and LIM domain 5 -0.037066
ZHX2 zinc fingers and homeoboxes 2 -0.0364687
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0362387
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0361715
UBAP2 ubiquitin associated protein 2 -0.0356797
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0352706
TXNIP thioredoxin interacting protein -0.0348626
AK1 adenylate kinase 1 -0.0347686
DIAPH2 diaphanous-related formin 2 -0.034175
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0339593
TGFA transforming growth factor, alpha -0.0338615
ABTB3 ankyrin repeat and BTB domain containing 3 -0.033803
TTC3 tetratricopeptide repeat domain 3 -0.0337578
GREB1L growth regulation by estrogen in breast cancer-like -0.0337123
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0330041
USP34 ubiquitin specific peptidase 34 -0.0329193
FBXO11 F-box protein 11 -0.0326741
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0326357
RAB7A RAB7A, member RAS oncogene family -0.0326008
SETX senataxin -0.0323159
DIAPH1 diaphanous-related formin 1 -0.0323013
FMNL2 formin-like 2 -0.0317209
CALU calumenin -0.0315725
UBE2H ubiquitin-conjugating enzyme E2H -0.0313371
SMC3 structural maintenance of chromosomes 3 -0.0313064
HM13 histocompatibility (minor) 13 -0.0311915
SEC24A SEC24 family member A -0.0309474
SP100 SP100 nuclear antigen -0.0305076
RAB2A RAB2A, member RAS oncogene family -0.0302281
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0300911
SPDYA speedy/RINGO cell cycle regulator family member A -0.0300594
TRIP12 thyroid hormone receptor interactor 12 -0.0300036
NABP1 nucleic acid binding protein 1 -0.0299055
CDK13 cyclin-dependent kinase 13 -0.0297499
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0296115
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0295689
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0287744
RNF213 ring finger protein 213 -0.0287186
SVIL supervillin -0.0286176
LARP4B La ribonucleoprotein domain family, member 4B -0.0284887
SEC23IP SEC23 interacting protein -0.0284233
MAML2 mastermind-like 2 (Drosophila) -0.0283229
COPA coatomer protein complex, subunit alpha -0.0273256
ARF4 ADP-ribosylation factor 4 -0.0271253
AHRR aryl-hydrocarbon receptor repressor -0.0268958
DENND2C DENN/MADD domain containing 2C -0.0260739
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0259969
BMAL2 basic helix-loop-helix ARNT like 2 -0.0256984
SEC16A SEC16 homolog A (S. cerevisiae) -0.0255115
SRRM2 serine/arginine repetitive matrix 2 -0.0250396
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0250146
RAD51B RAD51 paralog B -0.02495
EFNB2 ephrin-B2 -0.0248299
LPP LIM domain containing preferred translocation partner in lipoma -0.0247155
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0245955
LAMC2 laminin, gamma 2 -0.0245306
PICALM phosphatidylinositol binding clathrin assembly protein -0.0241266
ANTXR2 anthrax toxin receptor 2 -0.024092
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0237511
MYO5B myosin VB -0.0237439
ZNF83 zinc finger protein 83 -0.0235642
AKAP9 A kinase (PRKA) anchor protein 9 -0.0235068