Procainamide (hydrochloride)_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Procainamide (hydrochloride) perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Procainamide (hydrochloride)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERBB2 erb-b2 receptor tyrosine kinase 2 0.0789293
VMP1 vacuole membrane protein 1 0.0699349
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0682931
CATSPERB catsper channel auxiliary subunit beta 0.0611047
PBX1 pre-B-cell leukemia homeobox 1 0.054095
KAZN kazrin, periplakin interacting protein 0.0521442
ALCAM activated leukocyte cell adhesion molecule 0.0417387
TRIO trio Rho guanine nucleotide exchange factor 0.0412072
LGALS12 lectin, galactoside-binding, soluble, 12 0.0404159
LMO7 LIM domain 7 0.0382687
TENM2 teneurin transmembrane protein 2 0.0365427
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0365009
TRPS1 trichorhinophalangeal syndrome I 0.0360743
ELOVL5 ELOVL fatty acid elongase 5 0.0360369
LRP1B low density lipoprotein receptor-related protein 1B 0.0359853
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0355395
TC2N tandem C2 domains, nuclear 0.0351571
DNAH14 dynein, axonemal, heavy chain 14 0.0349868
BCAS1 breast carcinoma amplified sequence 1 0.034023
GMDS GDP-mannose 4,6-dehydratase 0.0338071
SRCIN1 SRC kinase signaling inhibitor 1 0.0328737
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0327811
YPEL2 yippee-like 2 (Drosophila) 0.031073
TBC1D5 TBC1 domain family, member 5 0.0306491
MSI2 musashi RNA-binding protein 2 0.0300277
CEMIP cell migration inducing protein, hyaluronan binding 0.029269
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0287731
THSD4 thrombospondin, type I, domain containing 4 0.0276526
NAMPT nicotinamide phosphoribosyltransferase 0.0267523
GSE1 Gse1 coiled-coil protein 0.0262382
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.026123
CCSER1 coiled-coil serine-rich protein 1 0.025798
KIF16B kinesin family member 16B 0.025641
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0254602
CTNND1 catenin (cadherin-associated protein), delta 1 0.0252429
PTK2 protein tyrosine kinase 2 0.0251679
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0249117
WWOX WW domain containing oxidoreductase 0.0248005
BCAS3 breast carcinoma amplified sequence 3 0.0243659
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0240682
SRSF1 serine/arginine-rich splicing factor 1 0.0233739
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0233647
WAC WW domain containing adaptor with coiled-coil 0.0229648
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0228747
GPC5 glypican 5 0.0223803
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0218149
ITCH itchy E3 ubiquitin protein ligase 0.0217268
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0216941
AGFG1 ArfGAP with FG repeats 1 0.0215557
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0214426
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0213122
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0208726
EXT1 exostosin glycosyltransferase 1 0.0206942
LPP LIM domain containing preferred translocation partner in lipoma 0.0206099
SAMD12 sterile alpha motif domain containing 12 0.0205325
CNTNAP2 contactin associated protein-like 2 0.0202762
ANKRD36C ankyrin repeat domain 36C 0.0201418
ARHGAP32 Rho GTPase activating protein 32 0.0201103
MACROD2 MACRO domain containing 2 0.0199642
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0194715
ZFAND3 zinc finger, AN1-type domain 3 0.0194648
NRCAM neuronal cell adhesion molecule 0.0191059
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.0189121
MYO10 myosin X 0.0185627
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0185469
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0184689
TRAPPC9 trafficking protein particle complex 9 0.0184128
FOXP1 forkhead box P1 0.0182964
GPC6 glypican 6 0.0180303
CTNND2 catenin (cadherin-associated protein), delta 2 0.0179605
MYO5B myosin VB 0.0178997
FAR1 fatty acyl CoA reductase 1 0.017776
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0176623
NFIA nuclear factor I/A 0.0172546
PTPRK protein tyrosine phosphatase, receptor type, K 0.0169549
CENPP centromere protein P 0.0168601
NCAM2 neural cell adhesion molecule 2 0.0167395
VIPR2 vasoactive intestinal peptide receptor 2 0.0165966
DENND1B DENN/MADD domain containing 1B 0.0163762
PRKCH protein kinase C, eta 0.0163607
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.016317
USP3 ubiquitin specific peptidase 3 0.0162871
TMEM87A transmembrane protein 87A 0.0161728
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0159869
TBL1X transducin (beta)-like 1X-linked 0.0159699
NFIB nuclear factor I/B 0.0157563
ZFAND6 zinc finger, AN1-type domain 6 0.0156913
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0156845
AUTS2 autism susceptibility candidate 2 0.0156777
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0155841
PLCB4 phospholipase C, beta 4 0.0154408
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0154351
MAML3 mastermind-like 3 (Drosophila) 0.015435
KIF13A kinesin family member 13A 0.0152748
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0151224
CADM2 cell adhesion molecule 2 0.0149616
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0148956
MUC19 mucin 19, oligomeric 0.0148701
MSMO1 methylsterol monooxygenase 1 0.0148419
MED13L mediator complex subunit 13-like 0.0148405

decreased expression

Symbol Name Standardized Value
RPL23 ribosomal protein L23 -0.204788
RPL19 ribosomal protein L19 -0.198169
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.129224
ZMYND8 zinc finger, MYND-type containing 8 -0.125209
NDRG1 N-myc downstream regulated 1 -0.093385
FTH1 ferritin, heavy polypeptide 1 -0.0853797
FBXL20 F-box and leucine-rich repeat protein 20 -0.081303
ACTG1 actin gamma 1 -0.0666598
MT2A metallothionein 2A -0.0656497
TMSB10 thymosin beta 10 -0.0592499
RPS3 ribosomal protein S3 -0.0563494
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.053853
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0534808
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.052612
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.046525
RAB7A RAB7A, member RAS oncogene family -0.0456118
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0439064
RPL35A ribosomal protein L35a -0.0423562
ASPH aspartate beta-hydroxylase -0.0417355
SBF2 SET binding factor 2 -0.0413613
GRB7 growth factor receptor-bound protein 7 -0.0403797
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.040347
LOC112694756 uncharaterized LOC112694756 -0.0395466
PTMA prothymosin, alpha -0.0392643
TMEM165 transmembrane protein 165 -0.0381064
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.037701
LDHA lactate dehydrogenase A -0.0373127
CANX calnexin -0.0367065
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0364452
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0351887
SLC38A1 solute carrier family 38, member 1 -0.035128
RAB22A RAB22A, member RAS oncogene family -0.0348709
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0337574
CCNI cyclin I -0.0331168
SRRM2 serine/arginine repetitive matrix 2 -0.0329735
LOC102724023 ES1 protein homolog, mitochondrial -0.0327022
FAM13A family with sequence similarity 13, member A -0.0320853
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0318678
RPS19 ribosomal protein S19 -0.031738
JMJD1C jumonji domain containing 1C -0.0315797
PGK1 phosphoglycerate kinase 1 -0.0310055
PRRC2C proline-rich coiled-coil 2C -0.0309887
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0308883
KRT19 keratin 19, type I -0.0304957
NCOA6 nuclear receptor coactivator 6 -0.0296756
SMC4 structural maintenance of chromosomes 4 -0.0293138
RESF1 retroelement silencing factor 1 -0.0291952
ANKRD12 ankyrin repeat domain 12 -0.0290532
PKM pyruvate kinase, muscle -0.0286443
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0285837
VEGFA vascular endothelial growth factor A -0.0281489
S100A14 S100 calcium binding protein A14 -0.0280714
RPS6 ribosomal protein S6 -0.0276769
UBE2H ubiquitin-conjugating enzyme E2H -0.0274029
FTL ferritin, light polypeptide -0.0272162
RPLP1 ribosomal protein, large, P1 -0.0272102
KDM5B lysine (K)-specific demethylase 5B -0.0269427
IFI6 interferon, alpha-inducible protein 6 -0.0269235
RPL12 ribosomal protein L12 -0.0268807
UBC ubiquitin C -0.0268455
KIAA1217 KIAA1217 -0.026672
B2M beta-2-microglobulin -0.0265588
EGFR epidermal growth factor receptor -0.0265393
NCOA3 nuclear receptor coactivator 3 -0.0259918
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0258604
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0257691
POTEF POTE ankyrin domain family, member F -0.0257152
SMYD3 SET and MYND domain containing 3 -0.0256231
CLTC clathrin, heavy chain (Hc) -0.0255627
RPL31 ribosomal protein L31 -0.0254824
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -0.0251396
EEF2 eukaryotic translation elongation factor 2 -0.0248957
ENO1 enolase 1, (alpha) -0.024458
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -0.0243947
DYNLRB1 dynein, light chain, roadblock-type 1 -0.0241286
RPL27A ribosomal protein L27a -0.0240928
TPT1 tumor protein, translationally-controlled 1 -0.0240844
MYOF myoferlin -0.0240463
GGNBP2 gametogenetin binding protein 2 -0.0240179
RPS24 ribosomal protein S24 -0.0234977
LMNA lamin A/C -0.0233785
UBAP1 ubiquitin associated protein 1 -0.0233354
MTDH metadherin -0.0232654
RPS29 ribosomal protein S29 -0.0229323
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C -0.0227927
EGR1 early growth response 1 -0.0227713
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0227634
HLA-C major histocompatibility complex, class I, C -0.0226769
WSB1 WD repeat and SOCS box containing 1 -0.0223577
FOXO3 forkhead box O3 -0.0221787
KDM2A lysine (K)-specific demethylase 2A -0.0221392
ACTN4 actinin, alpha 4 -0.0220902
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0219711
RPLP0 ribosomal protein, large, P0 -0.0219313
MYL12B myosin, light chain 12B, regulatory -0.0216698
GOLGA4 golgin A4 -0.021621
S100A9 S100 calcium binding protein A9 -0.0215328
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0215188
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -0.0207851
AZIN1 antizyme inhibitor 1 -0.0207559