Procainamide (hydrochloride)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Procainamide (hydrochloride) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Procainamide (hydrochloride)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.110115
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.064487
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0592761
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0501953
HILPDA hypoxia inducible lipid droplet-associated 0.0486474
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.0477595
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0472219
RPS2 ribosomal protein S2 0.047154
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.046965
KTN1 kinectin 1 (kinesin receptor) 0.0459908
DST dystonin 0.0457076
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.045058
NEBL nebulette 0.0442618
FMNL2 formin-like 2 0.0430494
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0419566
SOX5 SRY (sex determining region Y)-box 5 0.0403605
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0401837
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0396799
RPL21 ribosomal protein L21 0.0373711
SETD5 SET domain containing 5 0.0367658
KMT2C lysine (K)-specific methyltransferase 2C 0.0364786
ZNF292 zinc finger protein 292 0.0353245
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0353227
NGLY1 N-glycanase 1 0.0351605
FXR1 fragile X mental retardation, autosomal homolog 1 0.0337899
SRRM1 serine/arginine repetitive matrix 1 0.0337732
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0336391
SET SET nuclear proto-oncogene 0.0324595
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0318592
TRIO trio Rho guanine nucleotide exchange factor 0.0318114
PIAS2 protein inhibitor of activated STAT, 2 0.031615
ZFP36L1 ZFP36 ring finger protein-like 1 0.0310147
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0309813
MXI1 MAX interactor 1, dimerization protein 0.0308107
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0290547
DENR density-regulated protein 0.0289049
MBNL1 muscleblind-like splicing regulator 1 0.0285296
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.028347
YEATS2 YEATS domain containing 2 0.0282951
NUP58 nucleoporin 58 0.027788
MEF2A myocyte enhancer factor 2A 0.0271585
KIF1B kinesin family member 1B 0.0270954
TBK1 TANK-binding kinase 1 0.0269643
ATRN attractin 0.026826
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0264074
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.026264
SCAF11 SR-related CTD-associated factor 11 0.0261458
GOLGA4 golgin A4 0.0261201
SERBP1 SERPINE1 mRNA binding protein 1 0.0259303
CASC3 cancer susceptibility candidate 3 0.0251851
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0250928
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0247013
PTBP2 polypyrimidine tract binding protein 2 0.0245492
FNDC3B fibronectin type III domain containing 3B 0.0244747
SRSF4 serine/arginine-rich splicing factor 4 0.0243198
PNN pinin, desmosome associated protein 0.0241915
EIF4B eukaryotic translation initiation factor 4B 0.0238952
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0237054
SLF1 SMC5-SMC6 complex localization factor 1 0.0236091
PUS7 pseudouridylate synthase 7 (putative) 0.0234298
AKAP9 A kinase (PRKA) anchor protein 9 0.0233974
ATXN2 ataxin 2 0.0233438
BRWD1 bromodomain and WD repeat domain containing 1 0.0233331
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0231043
GYS1 glycogen synthase 1 (muscle) 0.0226483
KMT2E lysine (K)-specific methyltransferase 2E 0.0225218
CCNL1 cyclin L1 0.0221585
CDC27 cell division cycle 27 0.0220954
NCKAP1 NCK-associated protein 1 0.0219624
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0216531
LPIN2 lipin 2 0.0214087
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.02133
ZNF326 zinc finger protein 326 0.0211565
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0210426
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0208954
CHD1 chromodomain helicase DNA binding protein 1 0.0208831
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0207875
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0207803
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0207403
LDHA lactate dehydrogenase A 0.0205763
THOC2 THO complex 2 0.0205302
SEC63 SEC63 homolog (S. cerevisiae) 0.0205037
RPS7 ribosomal protein S7 0.0203923
AHCTF1 AT hook containing transcription factor 1 0.020307
MDN1 MDN1, midasin homolog (yeast) 0.0201815
PCBP2 poly(rC) binding protein 2 0.0200239
ZEB1 zinc finger E-box binding homeobox 1 0.0199656
TCERG1 transcription elongation regulator 1 0.0198797
NFE2L1 nuclear factor, erythroid 2-like 1 0.0198705
PA2G4 proliferation-associated 2G4, 38kDa 0.0198432
WAC WW domain containing adaptor with coiled-coil 0.0196928
LARS1 leucyl-tRNA synthetase 1 0.0196325
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0194263
SREBF2 sterol regulatory element binding transcription factor 2 0.0192705
SLK STE20-like kinase 0.0192058
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0191816
UBE3A ubiquitin protein ligase E3A 0.0191747
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0190676
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.019029
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0189923

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.130227
STAT1 signal transducer and activator of transcription 1, 91kDa -0.107715
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.107228
IFI6 interferon, alpha-inducible protein 6 -0.103534
RPLP1 ribosomal protein, large, P1 -0.103216
RAD51B RAD51 paralog B -0.101755
TMSB10 thymosin beta 10 -0.098909
ACTG1 actin gamma 1 -0.0823994
ADGRG6 adhesion G protein-coupled receptor G6 -0.0823873
RPL28 ribosomal protein L28 -0.0784473
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0749418
RPS4X ribosomal protein S4, X-linked -0.0702626
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.067645
RPL9 ribosomal protein L9 -0.0659434
NR4A3 nuclear receptor subfamily 4, group A, member 3 -0.0651245
VCL vinculin -0.0646935
SOX4 SRY (sex determining region Y)-box 4 -0.064218
RPS19 ribosomal protein S19 -0.0606383
RPLP2 ribosomal protein, large, P2 -0.0603087
RPS24 ribosomal protein S24 -0.0600119
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0591406
RPL34 ribosomal protein L34 -0.0583821
PTMA prothymosin, alpha -0.0579734
TENM3 teneurin transmembrane protein 3 -0.0571097
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0563979
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0563438
EGR1 early growth response 1 -0.0561326
RPL19 ribosomal protein L19 -0.0560542
MYL12B myosin, light chain 12B, regulatory -0.0558269
RPL11 ribosomal protein L11 -0.0547619
EXT1 exostosin glycosyltransferase 1 -0.0541205
RPL32 ribosomal protein L32 -0.0534614
GNAS GNAS complex locus -0.0531943
TPT1 tumor protein, translationally-controlled 1 -0.0525936
LOC112694756 uncharaterized LOC112694756 -0.051888
MT2A metallothionein 2A -0.0517808
RPL35A ribosomal protein L35a -0.0500107
RPL31 ribosomal protein L31 -0.0496678
RPL13A ribosomal protein L13a -0.0486016
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0485811
RPS21 ribosomal protein S21 -0.048125
RPLP0 ribosomal protein, large, P0 -0.0467437
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0466407
SMYD3 SET and MYND domain containing 3 -0.0454687
RPS6 ribosomal protein S6 -0.0451294
RPL37 ribosomal protein L37 -0.0449986
HMGB1 high mobility group box 1 -0.0439701
RIGI RNA sensor RIG-I -0.0426188
RPL5 ribosomal protein L5 -0.0425941
RPS11 ribosomal protein S11 -0.0424293
RPS8 ribosomal protein S8 -0.0424216
RPS29 ribosomal protein S29 -0.0422978
ISG15 ISG15 ubiquitin-like modifier -0.0422844
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0420955
MLIP muscular LMNA-interacting protein -0.0418275
FBXL7 F-box and leucine-rich repeat protein 7 -0.0416484
ARL15 ADP-ribosylation factor-like 15 -0.0409056
RPS15 ribosomal protein S15 -0.040751
RPL36 ribosomal protein L36 -0.0405445
FTL ferritin, light polypeptide -0.0396666
KDM3A lysine (K)-specific demethylase 3A -0.0385737
PDE4D phosphodiesterase 4D, cAMP-specific -0.0384344
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0382886
UBC ubiquitin C -0.0379598
CENPF centromere protein F, 350/400kDa -0.0374329
ATG10 autophagy related 10 -0.0373734
RPL12 ribosomal protein L12 -0.0367298
TUBB4B tubulin, beta 4B class IVb -0.036696
SEPTIN7 septin 7 -0.0365232
RPS23 ribosomal protein S23 -0.0365214
NALF1 NALCN channel auxiliary factor 1 -0.0363443
HLA-B major histocompatibility complex, class I, B -0.0363424
HLA-C major histocompatibility complex, class I, C -0.0362293
BNC2 basonuclin 2 -0.0352219
RPS5 ribosomal protein S5 -0.0342738
RPS16 ribosomal protein S16 -0.0342628
RPS20 ribosomal protein S20 -0.0340572
RPS27A ribosomal protein S27a -0.0338424
FUS FUS RNA binding protein -0.0334489
PGK1 phosphoglycerate kinase 1 -0.0333623
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0324458
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0323185
EEF2 eukaryotic translation elongation factor 2 -0.0321539
CCSER1 coiled-coil serine-rich protein 1 -0.0321249
CBX3 chromobox homolog 3 -0.0318998
RPL4 ribosomal protein L4 -0.031819
RPL37A ribosomal protein L37a -0.031757
HDAC8 histone deacetylase 8 -0.0314978
SLC38A2 solute carrier family 38, member 2 -0.0312119
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.0304728
ZBTB20 zinc finger and BTB domain containing 20 -0.0302232
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0300955
CARD18 caspase recruitment domain family, member 18 -0.0300587
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0300012
RPL26 ribosomal protein L26 -0.0297075
TMEM41B transmembrane protein 41B -0.0295853
KNL1 kinetochore scaffold 1 -0.0292914
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0292133
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -0.0289598
ENAH enabled homolog (Drosophila) -0.028906