Procainamide (hydrochloride)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Procainamide (hydrochloride) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Procainamide (hydrochloride)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.114127
RPS8 ribosomal protein S8 0.0997145
RPS12 ribosomal protein S12 0.0869885
TPT1 tumor protein, translationally-controlled 1 0.0701963
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.06828
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0665697
RPL23 ribosomal protein L23 0.0651142
ALCAM activated leukocyte cell adhesion molecule 0.0632496
GOLGA4 golgin A4 0.0617123
RPS2 ribosomal protein S2 0.0586982
RPL12 ribosomal protein L12 0.058087
RPS6 ribosomal protein S6 0.0570435
RPS3 ribosomal protein S3 0.0569235
RPL26 ribosomal protein L26 0.0568499
RACK1 receptor for activated C kinase 1 0.0553077
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0547891
SET SET nuclear proto-oncogene 0.0531309
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0521212
RHEX regulator of hemoglobinization and erythroid cell expansion 0.0515728
NAP1L1 nucleosome assembly protein 1-like 1 0.0515264
SBF2 SET binding factor 2 0.0506229
BCAR3 breast cancer anti-estrogen resistance 3 0.0503015
RPL21 ribosomal protein L21 0.0501058
AFDN afadin, adherens junction formation factor 0.0494969
WAC WW domain containing adaptor with coiled-coil 0.0489874
BRWD1 bromodomain and WD repeat domain containing 1 0.0485573
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.04774
UBE2D2 ubiquitin-conjugating enzyme E2D 2 0.0461883
SQSTM1 sequestosome 1 0.0447394
RPS25 ribosomal protein S25 0.0446202
RPL7A ribosomal protein L7a 0.0445077
VMP1 vacuole membrane protein 1 0.042924
ANKRD10 ankyrin repeat domain 10 0.0424385
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.041513
PTMA prothymosin, alpha 0.0412842
B2M beta-2-microglobulin 0.0393345
SLMAP sarcolemma associated protein 0.0392489
NCOR1 nuclear receptor corepressor 1 0.0390078
KLF6 Kruppel-like factor 6 0.0389849
RPL37A ribosomal protein L37a 0.0387564
RPS7 ribosomal protein S7 0.0387072
PTBP2 polypyrimidine tract binding protein 2 0.0385075
H1-4 H1.4 linker histone, cluster member 0.0379888
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0376074
KTN1 kinectin 1 (kinesin receptor) 0.0368389
PRRC2C proline-rich coiled-coil 2C 0.0367512
RNF145 ring finger protein 145 0.0362819
KIF5B kinesin family member 5B 0.0362125
NCKAP1 NCK-associated protein 1 0.0355822
RPL11 ribosomal protein L11 0.035497
SETD2 SET domain containing 2 0.0354647
RPL35 ribosomal protein L35 0.0350945
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.034308
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0339846
RPL18 ribosomal protein L18 0.0338437
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0337539
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0334319
ZNF292 zinc finger protein 292 0.0332113
RLF rearranged L-myc fusion 0.0331013
PNN pinin, desmosome associated protein 0.0330776
ARHGAP29 Rho GTPase activating protein 29 0.0330019
RPL32 ribosomal protein L32 0.0329844
S100A9 S100 calcium binding protein A9 0.0329315
MED13L mediator complex subunit 13-like 0.0329043
RPS29 ribosomal protein S29 0.032856
NR1D2 nuclear receptor subfamily 1, group D, member 2 0.0327296
MATR3 matrin 3 0.0321772
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0319954
RPLP2 ribosomal protein, large, P2 0.0319568
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0317297
RPS27A ribosomal protein S27a 0.0315197
RPS23 ribosomal protein S23 0.0314357
NEK7 NIMA-related kinase 7 0.031401
WDR43 WD repeat domain 43 0.0312601
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.0309607
RPS16 ribosomal protein S16 0.0307739
PUM2 pumilio RNA-binding family member 2 0.0302886
SRSF11 serine/arginine-rich splicing factor 11 0.0301219
SETD5 SET domain containing 5 0.029628
RSL1D1 ribosomal L1 domain containing 1 0.0292499
RPS27 ribosomal protein S27 0.0292335
PHF3 PHD finger protein 3 0.0290185
NPEPPS aminopeptidase puromycin sensitive 0.028715
RPL19 ribosomal protein L19 0.0286511
BHLHE40 basic helix-loop-helix family, member e40 0.0285271
RPL23A ribosomal protein L23a 0.0284239
RPS17 ribosomal protein S17 0.0278115
DDIT4 DNA-damage-inducible transcript 4 0.027696
LDHB lactate dehydrogenase B 0.0276519
SON SON DNA binding protein 0.0275176
NIPBL Nipped-B homolog (Drosophila) 0.02743
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0270598
ANKRD12 ankyrin repeat domain 12 0.0269933
XPO1 exportin 1 0.0268572
BICD1 bicaudal D homolog 1 (Drosophila) 0.026555
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 0.0262428
CELF1 CUGBP, Elav-like family member 1 0.0261899
TRIM2 tripartite motif containing 2 0.0261522
FAM162A family with sequence similarity 162, member A 0.0259977
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0258864

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.16333
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.144543
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.128712
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.118736
CCND1 cyclin D1 -0.0912172
RNF213 ring finger protein 213 -0.0760888
PKM pyruvate kinase, muscle -0.0747607
FNDC3B fibronectin type III domain containing 3B -0.0735326
POTEF POTE ankyrin domain family, member F -0.0719122
EGR1 early growth response 1 -0.0627107
FLNA filamin A, alpha -0.0620774
EEF2 eukaryotic translation elongation factor 2 -0.0614176
IARS1 isoleucyl-tRNA synthetase 1 -0.0602743
ACTG1 actin gamma 1 -0.058811
LOC112694756 uncharaterized LOC112694756 -0.0567968
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0548954
PRELID2 PRELI domain containing 2 -0.0510174
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0502587
FTH1 ferritin, heavy polypeptide 1 -0.0490937
RAD51B RAD51 paralog B -0.0480522
RPL35A ribosomal protein L35a -0.0478006
TPM4 tropomyosin 4 -0.0466476
RUNX1 runt-related transcription factor 1 -0.0449731
TXNRD1 thioredoxin reductase 1 -0.0438732
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0419586
CD44 CD44 molecule (Indian blood group) -0.0412097
SEPTIN9 septin 9 -0.0407347
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0404379
TMSB10 thymosin beta 10 -0.0401891
LMAN1 lectin, mannose-binding, 1 -0.0398107
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0388859
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0386403
ITGB8 integrin, beta 8 -0.0384843
EZR ezrin -0.0376834
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0374921
ZBTB20 zinc finger and BTB domain containing 20 -0.0372845
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 -0.0366663
ANXA2 annexin A2 -0.0366386
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0364246
CREB5 cAMP responsive element binding protein 5 -0.0363939
COPA coatomer protein complex, subunit alpha -0.0363742
LAMA4 laminin, alpha 4 -0.036022
RPLP1 ribosomal protein, large, P1 -0.0356604
YBX1 Y box binding protein 1 -0.0351753
INTS6 integrator complex subunit 6 -0.0350143
ARF4 ADP-ribosylation factor 4 -0.0347828
ATP5F1B ATP synthase F1 subunit beta -0.034187
FNIP1 folliculin interacting protein 1 -0.0341683
MBNL2 muscleblind-like splicing regulator 2 -0.0329707
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0325531
TNIK TRAF2 and NCK interacting kinase -0.0324949
MACC1 metastasis associated in colon cancer 1 -0.0323941
BBS9 Bardet-Biedl syndrome 9 -0.032211
TTC3 tetratricopeptide repeat domain 3 -0.0316259
ITGA6 integrin, alpha 6 -0.0316181
CANX calnexin -0.0314646
TBC1D22A TBC1 domain family, member 22A -0.031187
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0309707
ADAM9 ADAM metallopeptidase domain 9 -0.0307594
PLEC plectin -0.0307196
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0305199
CDCP1 CUB domain containing protein 1 -0.0298753
F3 coagulation factor III (thromboplastin, tissue factor) -0.0297792
GOLGB1 golgin B1 -0.0296942
ATXN1 ataxin 1 -0.0296152
CBX3 chromobox homolog 3 -0.0292136
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0290952
SETX senataxin -0.0290777
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0289431
TIMP2 TIMP metallopeptidase inhibitor 2 -0.028925
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0287439
MAP4 microtubule-associated protein 4 -0.0284956
MYOF myoferlin -0.0283794
GARS1 glycyl-tRNA synthetase 1 -0.027984
KLHL29 kelch-like family member 29 -0.0277463
ECT2 epithelial cell transforming 2 -0.0275535
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) -0.0272585
ENO2 enolase 2 (gamma, neuronal) -0.027255
ACTN4 actinin, alpha 4 -0.0272363
MYEOV myeloma overexpressed -0.0269135
CLTC clathrin, heavy chain (Hc) -0.0269013
FRYL FRY-like -0.0263737
KRT19 keratin 19, type I -0.0261831
MORF4L2 mortality factor 4 like 2 -0.026077
PTEN phosphatase and tensin homolog -0.0260151
HKDC1 hexokinase domain containing 1 -0.0259412
COG6 component of oligomeric golgi complex 6 -0.0254846
SGMS1 sphingomyelin synthase 1 -0.0254708
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0254248
CYSTM1 cysteine-rich transmembrane module containing 1 -0.0253917
ANXA1 annexin A1 -0.0249392
SPDYA speedy/RINGO cell cycle regulator family member A -0.0247696
CMIP c-Maf inducing protein -0.024262
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0239435
OFD1 oral-facial-digital syndrome 1 -0.0238186
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0236116
LIMCH1 LIM and calponin homology domains 1 -0.0234364
PCBP2 poly(rC) binding protein 2 -0.0233717
LDHA lactate dehydrogenase A -0.0233211
ATN1 atrophin 1 -0.023298