| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Procainamide (hydrochloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Procainamide (hydrochloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.158114 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.105817 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0891267 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0824108 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0803075 |
| MT2A | metallothionein 2A | 0.0675245 |
| FNDC3B | fibronectin type III domain containing 3B | 0.067124 |
| RPS6 | ribosomal protein S6 | 0.0665653 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0569555 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0553781 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0535278 |
| VMP1 | vacuole membrane protein 1 | 0.0522373 |
| VEGFA | vascular endothelial growth factor A | 0.0519852 |
| RTN4 | reticulon 4 | 0.0509677 |
| MRTFA | myocardin related transcription factor A | 0.0507005 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.049593 |
| C3 | complement component 3 | 0.0435246 |
| PCBP2 | poly(rC) binding protein 2 | 0.0435231 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0434282 |
| SNX9 | sorting nexin 9 | 0.0407142 |
| JMJD1C | jumonji domain containing 1C | 0.0382113 |
| ANKRD12 | ankyrin repeat domain 12 | 0.038028 |
| GOLGA4 | golgin A4 | 0.0380091 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0369962 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0358727 |
| FCHSD2 | FCH and double SH3 domains 2 | 0.0343337 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0339286 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0338335 |
| PCM1 | pericentriolar material 1 | 0.0337646 |
| AFDN | afadin, adherens junction formation factor | 0.033685 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0329795 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0329088 |
| SRPK1 | SRSF protein kinase 1 | 0.0324326 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0314048 |
| ITGAV | integrin, alpha V | 0.0313236 |
| ZFP36 | ZFP36 ring finger protein | 0.0311798 |
| LRRC1 | leucine rich repeat containing 1 | 0.0308764 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 0.0305728 |
| SLMAP | sarcolemma associated protein | 0.0301207 |
| DSPP | dentin sialophosphoprotein | 0.0299454 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.029819 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0293682 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0292144 |
| RPL21 | ribosomal protein L21 | 0.0291192 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0290962 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0288705 |
| CCNL1 | cyclin L1 | 0.0285852 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0285648 |
| RBM25 | RNA binding motif protein 25 | 0.0285602 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0284751 |
| ARHGEF18 | Rho/Rac guanine nucleotide exchange factor (GEF) 18 | 0.0283271 |
| AHR | aryl hydrocarbon receptor | 0.027652 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.027465 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0273851 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0272763 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0269415 |
| CRLS1 | cardiolipin synthase 1 | 0.0268882 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0267866 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0266662 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0266349 |
| DIDO1 | death inducer-obliterator 1 | 0.0264849 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0263989 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0262129 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0259796 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.02589 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0258588 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.025822 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0258036 |
| ZNF292 | zinc finger protein 292 | 0.0256402 |
| PNN | pinin, desmosome associated protein | 0.0255977 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0255335 |
| YME1L1 | YME1-like 1 ATPase | 0.0255071 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0252428 |
| RNF145 | ring finger protein 145 | 0.0250832 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0248932 |
| DTNA | dystrobrevin, alpha | 0.0246314 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0241653 |
| RAB18 | RAB18, member RAS oncogene family | 0.0241325 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0238161 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0237724 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0237723 |
| TBK1 | TANK-binding kinase 1 | 0.0237603 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0236505 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0235755 |
| PDS5B | PDS5 cohesin associated factor B | 0.0232863 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0232605 |
| OPTN | optineurin | 0.0230348 |
| PDS5A | PDS5 cohesin associated factor A | 0.0227017 |
| TPM3 | tropomyosin 3 | 0.0226854 |
| CDK8 | cyclin-dependent kinase 8 | 0.0225265 |
| QKI | QKI, KH domain containing, RNA binding | 0.0224369 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0221935 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0221508 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0220109 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0220031 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0219164 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0218829 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0215995 |
| UIMC1 | ubiquitin interaction motif containing 1 | 0.0215101 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0214649 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.235359 |
| FN1 | fibronectin 1 | -0.187288 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.146176 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.117042 |
| GPC3 | glypican 3 | -0.107467 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0918576 |
| PEG3 | paternally expressed 3 | -0.0841281 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0799634 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.079042 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0788986 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0751824 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.074955 |
| ASPH | aspartate beta-hydroxylase | -0.0728064 |
| GPC6 | glypican 6 | -0.0714572 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.0705676 |
| SDC4 | syndecan 4 | -0.0697515 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0687387 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0660866 |
| CP | ceruloplasmin (ferroxidase) | -0.064884 |
| RPS24 | ribosomal protein S24 | -0.0609808 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0597433 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0596438 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0586063 |
| APOB | apolipoprotein B | -0.0585369 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0584388 |
| INTS6 | integrator complex subunit 6 | -0.0574944 |
| TMEM123 | transmembrane protein 123 | -0.0573155 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.056968 |
| ATXN1 | ataxin 1 | -0.0566838 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0565231 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0555876 |
| FAM107B | family with sequence similarity 107, member B | -0.0540044 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0536342 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | -0.0514801 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.051037 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0504658 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0504195 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0481378 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0478258 |
| NPR2 | natriuretic peptide receptor 2 | -0.0478216 |
| IGF1R | insulin-like growth factor 1 receptor | -0.04702 |
| A2M | alpha-2-macroglobulin | -0.0462546 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0460574 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0458365 |
| TNS3 | tensin 3 | -0.0456369 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0442294 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0437127 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0430128 |
| SMAD3 | SMAD family member 3 | -0.0427567 |
| EHBP1 | EH domain binding protein 1 | -0.0422007 |
| CANX | calnexin | -0.0415651 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0400819 |
| LDHA | lactate dehydrogenase A | -0.0398727 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0398358 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0388893 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0385599 |
| H1-0 | H1.0 linker histone | -0.0383944 |
| ARF1 | ADP-ribosylation factor 1 | -0.0383943 |
| AHNAK | AHNAK nucleoprotein | -0.0383218 |
| HDLBP | high density lipoprotein binding protein | -0.0382368 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0378187 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0369098 |
| ACTN4 | actinin, alpha 4 | -0.0360459 |
| RPL11 | ribosomal protein L11 | -0.0359579 |
| RPS27A | ribosomal protein S27a | -0.0347352 |
| PEG10 | paternally expressed 10 | -0.0344568 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0341321 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0335889 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0333984 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0333234 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0332129 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0330328 |
| FTL | ferritin, light polypeptide | -0.0328606 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0321624 |
| HDAC4 | histone deacetylase 4 | -0.0320923 |
| RPL4 | ribosomal protein L4 | -0.0318805 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0318526 |
| CADM1 | cell adhesion molecule 1 | -0.0318271 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0318144 |
| ACTG1 | actin gamma 1 | -0.0316132 |
| SELENOP | selenoprotein P | -0.0315317 |
| RPLP1 | ribosomal protein, large, P1 | -0.0312272 |
| STK17A | serine/threonine kinase 17a | -0.0310964 |
| KIF21A | kinesin family member 21A | -0.0306267 |
| GNAS | GNAS complex locus | -0.0306139 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0303973 |
| AHSG | alpha-2-HS-glycoprotein | -0.0303583 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0300172 |
| GK | glycerol kinase | -0.0298733 |
| FAM135A | family with sequence similarity 135, member A | -0.0293928 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0293853 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | -0.0292212 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0289955 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0288568 |
| RPL28 | ribosomal protein L28 | -0.0288048 |
| SEPTIN9 | septin 9 | -0.0281686 |
| PHF3 | PHD finger protein 3 | -0.0280848 |
| RPS5 | ribosomal protein S5 | -0.0278157 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0277117 |
| RPL34 | ribosomal protein L34 | -0.0276834 |
