Procainamide (hydrochloride)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Procainamide (hydrochloride) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Procainamide (hydrochloride)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.0852211
CD44 CD44 molecule (Indian blood group) 0.077193
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0611281
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0544124
FOSL1 FOS-like antigen 1 0.0485429
NAMPT nicotinamide phosphoribosyltransferase 0.0452921
ZEB2 zinc finger E-box binding homeobox 2 0.0443616
VMP1 vacuole membrane protein 1 0.0442991
ATP13A3 ATPase type 13A3 0.0436595
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0403196
MSN moesin 0.0371757
RAI14 retinoic acid induced 14 0.0359839
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0359137
IL6ST interleukin 6 signal transducer 0.0332531
UBA6 ubiquitin-like modifier activating enzyme 6 0.0328903
AKAP12 A kinase (PRKA) anchor protein 12 0.0296424
RPL21 ribosomal protein L21 0.0288829
CCDC14 coiled-coil domain containing 14 0.028857
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0287179
SLC12A8 solute carrier family 12, member 8 0.0283196
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0280274
H1-4 H1.4 linker histone, cluster member 0.0277551
SULF1 sulfatase 1 0.0275458
ANXA5 annexin A5 0.0274874
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0274272
OSMR oncostatin M receptor 0.0270216
SBF2 SET binding factor 2 0.0269723
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0265648
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0259392
NALF1 NALCN channel auxiliary factor 1 0.0255788
ZBTB20 zinc finger and BTB domain containing 20 0.0250787
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0249517
SP3 Sp3 transcription factor 0.0235659
NAV2 neuron navigator 2 0.0231084
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0223119
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0220881
NEK7 NIMA-related kinase 7 0.0217388
VGLL3 vestigial-like family member 3 0.0215185
ERBIN erbb2 interacting protein 0.0209513
DRAM1 DNA-damage regulated autophagy modulator 1 0.0206799
BCAR3 breast cancer anti-estrogen resistance 3 0.0206239
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0203088
H1-2 H1.2 linker histone, cluster member 0.0199835
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0196225
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 0.0192364
PCLO piccolo presynaptic cytomatrix protein 0.0189822
LUZP1 leucine zipper protein 1 0.0189718
MAML2 mastermind-like 2 (Drosophila) 0.0187977
DST dystonin 0.0186587
ZNF652 zinc finger protein 652 0.0186388
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0185298
ZFC3H1 zinc finger, C3H1-type containing 0.018478
WDR26 WD repeat domain 26 0.0184061
ANKRD12 ankyrin repeat domain 12 0.0182565
MARCHF7 membrane associated ring-CH-type finger 7 0.0182202
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0179214
CADM1 cell adhesion molecule 1 0.0177065
PNN pinin, desmosome associated protein 0.0175441
HM13 histocompatibility (minor) 13 0.0173685
SCAF11 SR-related CTD-associated factor 11 0.0173674
TMF1 TATA element modulatory factor 1 0.0170754
TBC1D5 TBC1 domain family, member 5 0.0170506
BTBD10 BTB (POZ) domain containing 10 0.0170478
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0168882
NAV1 neuron navigator 1 0.0167732
EGFR epidermal growth factor receptor 0.0166928
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0164356
GRAMD2B GRAM domain containing 2B 0.0163947
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0163301
ZNF292 zinc finger protein 292 0.0161493
SETD5 SET domain containing 5 0.0160964
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0160956
DIAPH3 diaphanous-related formin 3 0.0160673
PLPP3 phospholipid phosphatase 3 0.0159705
CEP95 centrosomal protein 95kDa 0.0159624
PAIP1 poly(A) binding protein interacting protein 1 0.0159456
RTN4 reticulon 4 0.0159438
CENPF centromere protein F, 350/400kDa 0.0158523
BCL2L1 BCL2-like 1 0.0157382
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0156117
TCERG1 transcription elongation regulator 1 0.0155581
RASA2 RAS p21 protein activator 2 0.015441
TPM3 tropomyosin 3 0.0154082
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0154025
KLC1 kinesin light chain 1 0.0153028
RBM26 RNA binding motif protein 26 0.0152761
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0152264
SRSF4 serine/arginine-rich splicing factor 4 0.0152215
PTBP2 polypyrimidine tract binding protein 2 0.0152172
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0149856
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.0149749
FBXL5 F-box and leucine-rich repeat protein 5 0.014884
ITCH itchy E3 ubiquitin protein ligase 0.0148181
TM9SF4 transmembrane 9 superfamily protein member 4 0.0148179
GOLM2 golgi membrane protein 2 0.0147025
SRSF5 serine/arginine-rich splicing factor 5 0.014692
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0145508
SRSF11 serine/arginine-rich splicing factor 11 0.0145049
SUCO SUN domain containing ossification factor 0.0143308
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0142883

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.232951
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.197493
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.179674
HLA-B major histocompatibility complex, class I, B -0.166555
FTH1 ferritin, heavy polypeptide 1 -0.158827
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.115088
NDRG1 N-myc downstream regulated 1 -0.109861
LOC112694756 uncharaterized LOC112694756 -0.0859796
ANXA2 annexin A2 -0.0835787
PTMA prothymosin, alpha -0.0783728
TMSB10 thymosin beta 10 -0.0783587
EXT1 exostosin glycosyltransferase 1 -0.0782287
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0689226
DEK DEK proto-oncogene -0.0648609
CAVIN1 caveolae associated protein 1 -0.062508
MT1X metallothionein 1X -0.0609358
RPL35A ribosomal protein L35a -0.0595685
ADM adrenomedullin -0.0592097
GNAS GNAS complex locus -0.0591419
ACTG1 actin gamma 1 -0.0585966
PGK1 phosphoglycerate kinase 1 -0.0577063
LDHA lactate dehydrogenase A -0.056743
F3 coagulation factor III (thromboplastin, tissue factor) -0.0544842
UGCG UDP-glucose ceramide glucosyltransferase -0.0534895
HLA-C major histocompatibility complex, class I, C -0.0527289
LOX lysyl oxidase -0.0516484
WSB1 WD repeat and SOCS box containing 1 -0.0508724
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.050264
HLA-E major histocompatibility complex, class I, E -0.0498328
INTS6 integrator complex subunit 6 -0.0496695
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0493832
LMAN1 lectin, mannose-binding, 1 -0.049121
HLA-A major histocompatibility complex, class I, A -0.0478509
SLIT2 slit homolog 2 (Drosophila) -0.0464113
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0462845
LMNA lamin A/C -0.0453013
CALR calreticulin -0.0439997
TMSB4X thymosin beta 4, X-linked -0.0426353
AHNAK AHNAK nucleoprotein -0.0419728
IFITM3 interferon induced transmembrane protein 3 -0.0413337
CTSD cathepsin D -0.0411622
FLNA filamin A, alpha -0.0408616
SPAG9 sperm associated antigen 9 -0.0403612
TSC22D2 TSC22 domain family, member 2 -0.0393049
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0389749
ANKRD10 ankyrin repeat domain 10 -0.0389374
TPT1 tumor protein, translationally-controlled 1 -0.0381417
KDM3A lysine (K)-specific demethylase 3A -0.0381323
CANX calnexin -0.0380479
S100A10 S100 calcium binding protein A10 -0.0378984
HMGB2 high mobility group box 2 -0.0374536
NSD2 nuclear receptor binding SET domain protein 2 -0.0372759
TRA2A transformer 2 alpha homolog (Drosophila) -0.0369249
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0362576
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0362162
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0359095
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0358069
JUN jun proto-oncogene -0.0357386
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.035238
PKM pyruvate kinase, muscle -0.0351253
RTN3 reticulon 3 -0.0350804
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0345831
RAD21 RAD21 homolog (S. pombe) -0.0345416
RBM39 RNA binding motif protein 39 -0.0339516
ARF1 ADP-ribosylation factor 1 -0.0335065
RPLP1 ribosomal protein, large, P1 -0.0333324
RYBP RING1 and YY1 binding protein -0.0332719
NAP1L1 nucleosome assembly protein 1-like 1 -0.0330605
WDR45B WD repeat domain 45B -0.0321236
IER3 immediate early response 3 -0.0318932
ANXA1 annexin A1 -0.0317485
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0315952
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0306507
NPR2 natriuretic peptide receptor 2 -0.0305353
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0303775
IFITM1 interferon induced transmembrane protein 1 -0.0303331
RAB1A RAB1A, member RAS oncogene family -0.0300493
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0298884
NCOA3 nuclear receptor coactivator 3 -0.0294565
EIF4A1 eukaryotic translation initiation factor 4A1 -0.029248
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.029162
VDAC1 voltage-dependent anion channel 1 -0.0287897
ABI3BP ABI family, member 3 (NESH) binding protein -0.0287652
RPL37 ribosomal protein L37 -0.0282958
EIF1 eukaryotic translation initiation factor 1 -0.0280523
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0279786
FUS FUS RNA binding protein -0.0279031
LOC102724023 ES1 protein homolog, mitochondrial -0.0276566
WAC WW domain containing adaptor with coiled-coil -0.0274856
MLF1 myeloid leukemia factor 1 -0.0272531
RPL12 ribosomal protein L12 -0.0272502
MORF4L2 mortality factor 4 like 2 -0.0272273
RPS6 ribosomal protein S6 -0.027002
IGFBP3 insulin-like growth factor binding protein 3 -0.0269881
BASP1 brain abundant, membrane attached signal protein 1 -0.0266723
SFTPA2 surfactant protein A2 -0.026539
KPNB1 karyopherin (importin) beta 1 -0.0265156
TPD52 tumor protein D52 -0.0262947
SOD2 superoxide dismutase 2, mitochondrial -0.0262944
TKT transketolase -0.0261175