Procainamide (hydrochloride)_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Procainamide (hydrochloride) perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Procainamide (hydrochloride)_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GOLGA4 golgin A4 0.107844
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.10198
RPS6 ribosomal protein S6 0.0823719
FTL ferritin, light polypeptide 0.0801503
EIF1 eukaryotic translation initiation factor 1 0.0793779
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0771078
B2M beta-2-microglobulin 0.0607914
AKAP9 A kinase (PRKA) anchor protein 9 0.0606532
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0559099
RPS8 ribosomal protein S8 0.0518239
RPL23 ribosomal protein L23 0.0495798
RPS12 ribosomal protein S12 0.0487285
RPS2 ribosomal protein S2 0.0484577
TMF1 TATA element modulatory factor 1 0.0427579
TOP2A topoisomerase (DNA) II alpha 170kDa 0.039756
RPL18 ribosomal protein L18 0.0388942
GARS1 glycyl-tRNA synthetase 1 0.0388225
S100P S100 calcium binding protein P 0.0384484
PNISR PNN-interacting serine/arginine-rich protein 0.038239
RPS3 ribosomal protein S3 0.0382383
DSTN destrin (actin depolymerizing factor) 0.0375807
RPL12 ribosomal protein L12 0.0365648
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0361932
RPL21 ribosomal protein L21 0.0357027
UBE2B ubiquitin-conjugating enzyme E2B 0.0350535
RPS19 ribosomal protein S19 0.0350534
ZNF292 zinc finger protein 292 0.0339187
FAM13A family with sequence similarity 13, member A 0.0337843
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0337276
TXNIP thioredoxin interacting protein 0.0327647
RPL26 ribosomal protein L26 0.0312209
NFE2L1 nuclear factor, erythroid 2-like 1 0.0299848
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0282803
RPL11 ribosomal protein L11 0.0275918
LIMA1 LIM domain and actin binding 1 0.0268855
SRP54 signal recognition particle 54kDa 0.026404
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0260929
RPL36A ribosomal protein L36a 0.0258744
RPL37A ribosomal protein L37a 0.025782
AGR3 anterior gradient 3 0.0257803
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0254048
SEC61G Sec61 gamma subunit 0.0252969
DSPP dentin sialophosphoprotein 0.0249273
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0246639
RPLP2 ribosomal protein, large, P2 0.0246397
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 0.0238963
PRRC2C proline-rich coiled-coil 2C 0.023861
RAB1A RAB1A, member RAS oncogene family 0.0237011
KIF5B kinesin family member 5B 0.023648
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0231449
WSB1 WD repeat and SOCS box containing 1 0.0231336
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0231154
RPLP1 ribosomal protein, large, P1 0.0231058
KTN1 kinectin 1 (kinesin receptor) 0.0228431
CLU clusterin 0.0226703
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0226526
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0223667
RPS29 ribosomal protein S29 0.0218752
RIOK3 RIO kinase 3 0.0217855
ANLN anillin, actin binding protein 0.0214334
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.021208
RPS7 ribosomal protein S7 0.021097
RPL35 ribosomal protein L35 0.0207392
DCAF7 DDB1 and CUL4 associated factor 7 0.0207157
PGM3 phosphoglucomutase 3 0.0205817
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0205733
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0205559
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0203736
RPL32 ribosomal protein L32 0.0203505
SEC62 SEC62 homolog (S. cerevisiae) 0.0203057
GSTP1 glutathione S-transferase pi 1 0.0202998
SLC31A1 solute carrier family 31 (copper transporter), member 1 0.0202296
NARS1 asparaginyl-tRNA synthetase 1 0.0201004
RPL36 ribosomal protein L36 0.0199976
SETD5 SET domain containing 5 0.0199116
RPS27 ribosomal protein S27 0.0197488
RPS16 ribosomal protein S16 0.0197111
TRA2A transformer 2 alpha homolog (Drosophila) 0.0196516
TES testin LIM domain protein 0.0196246
DDIT4 DNA-damage-inducible transcript 4 0.0194597
RPS14 ribosomal protein S14 0.0191609
AKAP10 A kinase (PRKA) anchor protein 10 0.0190826
VMP1 vacuole membrane protein 1 0.01887
RPL7A ribosomal protein L7a 0.0186939
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0186519
RAB2A RAB2A, member RAS oncogene family 0.0185286
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0184618
OGA O-GlcNAcase 0.0183629
KDM2A lysine (K)-specific demethylase 2A 0.0182554
RRBP1 ribosome binding protein 1 0.0182334
RB1CC1 RB1-inducible coiled-coil 1 0.0181159
PDIA3 protein disulfide isomerase family A, member 3 0.0180762
ESYT2 extended synaptotagmin-like protein 2 0.0179061
RPS25 ribosomal protein S25 0.0178007
KMT2E lysine (K)-specific methyltransferase 2E 0.0177629
SMC4 structural maintenance of chromosomes 4 0.0177551
LAMB3 laminin, beta 3 0.0176689
RBM39 RNA binding motif protein 39 0.0174646
GOLGA2 golgin A2 0.0174075
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0172882

decreased expression

Symbol Name Standardized Value
GMDS GDP-mannose 4,6-dehydratase -0.238456
FGFR2 fibroblast growth factor receptor 2 -0.188949
NPSR1 neuropeptide S receptor 1 -0.143048
MAML2 mastermind-like 2 (Drosophila) -0.128491
CEMIP cell migration inducing protein, hyaluronan binding -0.117376
PTMA prothymosin, alpha -0.0900722
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0864162
LMO7 LIM domain 7 -0.0721684
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0691417
TNIK TRAF2 and NCK interacting kinase -0.0663221
RNF213 ring finger protein 213 -0.0653915
CDK6 cyclin-dependent kinase 6 -0.0652664
FAT1 FAT atypical cadherin 1 -0.0624066
EHBP1 EH domain binding protein 1 -0.0622501
TMEM123 transmembrane protein 123 -0.0605549
RUNX1 runt-related transcription factor 1 -0.0566264
KRT8 keratin 8, type II -0.0563552
FLNB filamin B, beta -0.0513853
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0485675
CMIP c-Maf inducing protein -0.0476737
POTEF POTE ankyrin domain family, member F -0.0471457
PTPRK protein tyrosine phosphatase, receptor type, K -0.0456659
KRT18 keratin 18, type I -0.0453214
TRPS1 trichorhinophalangeal syndrome I -0.0430148
SLC38A2 solute carrier family 38, member 2 -0.0422889
LPP LIM domain containing preferred translocation partner in lipoma -0.0418832
CUX1 cut-like homeobox 1 -0.0418532
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0414176
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0412314
ITGA6 integrin, alpha 6 -0.0409425
PRKCA protein kinase C, alpha -0.0408444
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0402354
FNDC3B fibronectin type III domain containing 3B -0.0392469
MCU mitochondrial calcium uniporter -0.0385277
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0384991
EXOC4 exocyst complex component 4 -0.038151
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0378937
ACTN4 actinin, alpha 4 -0.0377246
ATXN1 ataxin 1 -0.0369776
COBL cordon-bleu WH2 repeat protein -0.0368798
ETV6 ets variant 6 -0.0365872
MSI2 musashi RNA-binding protein 2 -0.03654
CCND1 cyclin D1 -0.0363674
SIK3 SIK family kinase 3 -0.0362212
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0362
BCL2L1 BCL2-like 1 -0.035625
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0354047
ASPH aspartate beta-hydroxylase -0.0351005
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0349581
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0337215
ARHGAP32 Rho GTPase activating protein 32 -0.0336892
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0336722
KLHL29 kelch-like family member 29 -0.0329
SEPTIN9 septin 9 -0.032834
ANO1 anoctamin 1, calcium activated chloride channel -0.0327508
YAP1 Yes-associated protein 1 -0.0323062
PKM pyruvate kinase, muscle -0.0322585
ANXA2 annexin A2 -0.0321778
MTUS1 microtubule associated tumor suppressor 1 -0.0319973
H1-0 H1.0 linker histone -0.0314946
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0314741
TMSB10 thymosin beta 10 -0.0314194
CTBP2 C-terminal binding protein 2 -0.0311936
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0307595
SAMD12 sterile alpha motif domain containing 12 -0.030653
KRT7 keratin 7, type II -0.0303055
SP100 SP100 nuclear antigen -0.0302007
INTS6 integrator complex subunit 6 -0.0301465
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0298897
AOPEP aminopeptidase O (putative) -0.0297372
UBASH3B ubiquitin associated and SH3 domain containing B -0.0297236
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0297217
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.02936
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.029232
PHF14 PHD finger protein 14 -0.0286537
DENND1A DENN/MADD domain containing 1A -0.028272
RAD51B RAD51 paralog B -0.0282526
TBC1D22A TBC1 domain family, member 22A -0.0279713
DIAPH2 diaphanous-related formin 2 -0.0274073
WARS1 tryptophanyl-tRNA synthetase 1 -0.0270958
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0270868
MYO1E myosin IE -0.0269438
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0269246
PATJ PATJ crumbs cell polarity complex component -0.0267424
PTPRG protein tyrosine phosphatase, receptor type, G -0.0266127
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0265507
TFRC transferrin receptor -0.0265149
ACACA acetyl-CoA carboxylase alpha -0.0263336
XKR6 XK, Kell blood group complex subunit-related family, member 6 -0.0257152
CATSPERB catsper channel auxiliary subunit beta -0.0256221
AHR aryl hydrocarbon receptor -0.0254074
PKP4 plakophilin 4 -0.0251009
SETX senataxin -0.0248954
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0248505
PCDH7 protocadherin 7 -0.0247883
TCF12 transcription factor 12 -0.0246993
PGK1 phosphoglycerate kinase 1 -0.0244883
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0242632
EFNA5 ephrin-A5 -0.024183
MBNL2 muscleblind-like splicing regulator 2 -0.0241352