Procainamide (hydrochloride)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Procainamide (hydrochloride) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Procainamide (hydrochloride)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS12 ribosomal protein S12 0.103669
RPS2 ribosomal protein S2 0.100075
GOLGA4 golgin A4 0.079469
RPS6 ribosomal protein S6 0.0785393
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.076176
RPL21 ribosomal protein L21 0.0734523
RPS8 ribosomal protein S8 0.0398941
VMP1 vacuole membrane protein 1 0.0384433
RNF145 ring finger protein 145 0.0354504
PCBP2 poly(rC) binding protein 2 0.0323462
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0322651
PNISR PNN-interacting serine/arginine-rich protein 0.0321942
ZNF292 zinc finger protein 292 0.0284221
UBA6 ubiquitin-like modifier activating enzyme 6 0.0283653
TMF1 TATA element modulatory factor 1 0.0267767
EREG epiregulin 0.0267024
BRD2 bromodomain containing 2 0.0260923
RPS7 ribosomal protein S7 0.0259435
AKAP9 A kinase (PRKA) anchor protein 9 0.025602
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0244583
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.024053
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0236914
AREG amphiregulin 0.0236697
ACBD3 acyl-CoA binding domain containing 3 0.0235819
P4HB prolyl 4-hydroxylase, beta polypeptide 0.02337
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0232161
PTBP3 polypyrimidine tract binding protein 3 0.0230046
SETD5 SET domain containing 5 0.0228879
RPS17 ribosomal protein S17 0.0227477
PNN pinin, desmosome associated protein 0.0226214
TMEM165 transmembrane protein 165 0.0215332
FXR1 fragile X mental retardation, autosomal homolog 1 0.0208072
CCNL1 cyclin L1 0.0206385
SRP54 signal recognition particle 54kDa 0.0202942
KMT2E lysine (K)-specific methyltransferase 2E 0.0200592
WAC WW domain containing adaptor with coiled-coil 0.0200433
MXI1 MAX interactor 1, dimerization protein 0.0200408
TRA2A transformer 2 alpha homolog (Drosophila) 0.019926
NUP58 nucleoporin 58 0.0196835
RARS1 arginyl-tRNA synthetase 1 0.0196155
CDK19 cyclin-dependent kinase 19 0.0195485
RBM39 RNA binding motif protein 39 0.0191302
DDIT4 DNA-damage-inducible transcript 4 0.0190569
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0189408
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.018481
RPL23 ribosomal protein L23 0.0184385
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.018085
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0176212
SRRM2 serine/arginine repetitive matrix 2 0.0174588
NRDC nardilysin convertase 0.017399
AKAP12 A kinase (PRKA) anchor protein 12 0.017317
SUCO SUN domain containing ossification factor 0.0172412
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0165482
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0162229
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0160299
PGM3 phosphoglucomutase 3 0.0157938
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0156029
RACK1 receptor for activated C kinase 1 0.0149155
RPL37A ribosomal protein L37a 0.0148787
EIF4B eukaryotic translation initiation factor 4B 0.014861
RNMT RNA (guanine-7-) methyltransferase 0.0147833
RTN4 reticulon 4 0.0147255
KDM2A lysine (K)-specific demethylase 2A 0.014583
RSRC2 arginine/serine-rich coiled-coil 2 0.0144513
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0144227
ARRDC3 arrestin domain containing 3 0.0144037
SRSF11 serine/arginine-rich splicing factor 11 0.0142368
HELZ helicase with zinc finger 0.0140601
VEGFA vascular endothelial growth factor A 0.0139382
GOLGA2 golgin A2 0.0138977
SET SET nuclear proto-oncogene 0.0138269
BBX bobby sox homolog (Drosophila) 0.0136355
MIS18BP1 MIS18 binding protein 1 0.0135532
RPS3 ribosomal protein S3 0.0134559
DENR density-regulated protein 0.0134314
TPM3 tropomyosin 3 0.0134164
PRRC2C proline-rich coiled-coil 2C 0.0133707
NACA nascent polypeptide-associated complex alpha subunit 0.0132937
SON SON DNA binding protein 0.0132855
SRRM1 serine/arginine repetitive matrix 1 0.0132039
YOD1 YOD1 deubiquitinase 0.0130574
NKTR natural killer cell triggering receptor 0.0129875
SMC4 structural maintenance of chromosomes 4 0.0129322
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0128821
RIOK3 RIO kinase 3 0.0128802
HILPDA hypoxia inducible lipid droplet-associated 0.0127787
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0125389
SSRP1 structure specific recognition protein 1 0.0125072
H1-2 H1.2 linker histone, cluster member 0.0125063
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0124988
USP47 ubiquitin specific peptidase 47 0.0123703
NCKAP1 NCK-associated protein 1 0.0123537
PTBP2 polypyrimidine tract binding protein 2 0.0123344
CSNK1A1 casein kinase 1, alpha 1 0.0123047
MLEC malectin 0.0122489
RBM17 RNA binding motif protein 17 0.0122422
FAM13A family with sequence similarity 13, member A 0.012172
VIM vimentin 0.0120673
DSCAM Down syndrome cell adhesion molecule 0.0120484
SLMAP sarcolemma associated protein 0.0120295

decreased expression

Symbol Name Standardized Value
THSD4 thrombospondin, type I, domain containing 4 -0.177029
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.159547
EPS8 epidermal growth factor receptor pathway substrate 8 -0.145557
RPLP1 ribosomal protein, large, P1 -0.132974
FLNB filamin B, beta -0.101578
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0979814
LMO7 LIM domain 7 -0.0907218
MSI2 musashi RNA-binding protein 2 -0.0873111
TPT1 tumor protein, translationally-controlled 1 -0.0872932
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0866313
RNF213 ring finger protein 213 -0.0829788
MYO1E myosin IE -0.0801899
FAT1 FAT atypical cadherin 1 -0.0796179
TMSB10 thymosin beta 10 -0.0795518
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0749786
PTPRK protein tyrosine phosphatase, receptor type, K -0.0742928
P3H2 prolyl 3-hydroxylase 2 -0.0736053
PDE4D phosphodiesterase 4D, cAMP-specific -0.0718005
MX1 MX dynamin-like GTPase 1 -0.0710493
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0687816
RPL4 ribosomal protein L4 -0.0675946
KRT18 keratin 18, type I -0.067517
GMDS GDP-mannose 4,6-dehydratase -0.0666327
ACTN4 actinin, alpha 4 -0.0657171
PTPRG protein tyrosine phosphatase, receptor type, G -0.0654904
SP100 SP100 nuclear antigen -0.0634047
PTPRR protein tyrosine phosphatase, receptor type, R -0.0624895
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0621968
RIGI RNA sensor RIG-I -0.0611582
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0605023
STAT1 signal transducer and activator of transcription 1, 91kDa -0.060408
RPL35A ribosomal protein L35a -0.0603206
PTPRB protein tyrosine phosphatase, receptor type, B -0.0585992
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0572717
MYOF myoferlin -0.0560841
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0559885
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0554489
EZR ezrin -0.0553075
ANXA2 annexin A2 -0.0537483
ACTG1 actin gamma 1 -0.0534666
PKM pyruvate kinase, muscle -0.0528325
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0520602
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0517955
CUX1 cut-like homeobox 1 -0.0513749
BACE2 beta-site APP-cleaving enzyme 2 -0.0503747
PALLD palladin, cytoskeletal associated protein -0.0503032
AOPEP aminopeptidase O (putative) -0.0501453
MYO1D myosin ID -0.0490749
AHNAK AHNAK nucleoprotein -0.0488393
SPON1 spondin 1, extracellular matrix protein -0.0483981
HDLBP high density lipoprotein binding protein -0.0474514
PLSCR1 phospholipid scramblase 1 -0.047041
VCL vinculin -0.0470068
LOC112694756 uncharaterized LOC112694756 -0.0468113
KLF5 Kruppel-like factor 5 (intestinal) -0.0466894
KRT8 keratin 8, type II -0.0458892
F3 coagulation factor III (thromboplastin, tissue factor) -0.0458012
CANX calnexin -0.0457811
ITGA6 integrin, alpha 6 -0.0456352
SLC38A2 solute carrier family 38, member 2 -0.0452811
LPP LIM domain containing preferred translocation partner in lipoma -0.0450138
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0433043
RPS24 ribosomal protein S24 -0.0419652
TCF12 transcription factor 12 -0.0416133
COBL cordon-bleu WH2 repeat protein -0.0412263
SERINC5 serine incorporator 5 -0.041209
SHROOM3 shroom family member 3 -0.0408963
MX2 MX dynamin-like GTPase 2 -0.0405824
CEMIP cell migration inducing protein, hyaluronan binding -0.0400377
RIMKLB ribosomal modification protein rimK-like family member B -0.0400258
PATJ PATJ crumbs cell polarity complex component -0.0396505
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0394862
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.038912
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) -0.038445
FOXP1 forkhead box P1 -0.0382152
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0381624
PGK1 phosphoglycerate kinase 1 -0.0376782
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0375208
AKAP13 A kinase (PRKA) anchor protein 13 -0.0373185
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0371793
RAD51B RAD51 paralog B -0.0370538
IFIH1 interferon induced with helicase C domain 1 -0.0370131
IARS1 isoleucyl-tRNA synthetase 1 -0.0366836
PLAC8 placenta-specific 8 -0.0358963
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0356962
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 -0.0353986
IQGAP2 IQ motif containing GTPase activating protein 2 -0.0349749
TSPAN8 tetraspanin 8 -0.0345557
EXT1 exostosin glycosyltransferase 1 -0.034248
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0339907
PCDHB16 protocadherin beta 16 -0.0338983
RPL34 ribosomal protein L34 -0.0337829
LAMB3 laminin, beta 3 -0.0337389
CCSER1 coiled-coil serine-rich protein 1 -0.0334535
AHCYL2 adenosylhomocysteinase-like 2 -0.0332401
WARS1 tryptophanyl-tRNA synthetase 1 -0.032266
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0322065
TC2N tandem C2 domains, nuclear -0.0321075
MPRIP myosin phosphatase Rho interacting protein -0.0316713
EXOC4 exocyst complex component 4 -0.031464