Procainamide (hydrochloride)_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Procainamide (hydrochloride) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Procainamide (hydrochloride)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.110742
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0943323
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0941011
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0697387
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0695634
POTEF POTE ankyrin domain family, member F 0.0637617
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0561361
ENO1 enolase 1, (alpha) 0.0521434
UBC ubiquitin C 0.0519525
PCBP2 poly(rC) binding protein 2 0.050471
SET SET nuclear proto-oncogene 0.0464691
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0439936
EEF2 eukaryotic translation elongation factor 2 0.043978
GARS1 glycyl-tRNA synthetase 1 0.042038
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0413766
RTN4 reticulon 4 0.0400238
ZNF292 zinc finger protein 292 0.0396839
MSN moesin 0.0395902
CENPF centromere protein F, 350/400kDa 0.0394647
KTN1 kinectin 1 (kinesin receptor) 0.0391723
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0388619
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0378614
WDR43 WD repeat domain 43 0.0374764
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0374369
GOLGA4 golgin A4 0.0362675
PRRC2C proline-rich coiled-coil 2C 0.0360632
NUP58 nucleoporin 58 0.0358077
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0357255
RPS12 ribosomal protein S12 0.0349513
PDIA6 protein disulfide isomerase family A, member 6 0.0339687
SPAG9 sperm associated antigen 9 0.0337652
SFPQ splicing factor proline/glutamine-rich 0.0331975
MATR3 matrin 3 0.0330146
RPL23 ribosomal protein L23 0.032847
ADAM17 ADAM metallopeptidase domain 17 0.0327258
RBM25 RNA binding motif protein 25 0.0325858
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0322589
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0309437
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0305093
RNF145 ring finger protein 145 0.0304235
ANKRD11 ankyrin repeat domain 11 0.0303517
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0302415
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0299995
XPO1 exportin 1 0.0299723
CAMTA1 calmodulin binding transcription activator 1 0.029772
PTBP2 polypyrimidine tract binding protein 2 0.0294576
TPM3 tropomyosin 3 0.0294508
EZR ezrin 0.0294321
ANXA1 annexin A1 0.0288326
PKM pyruvate kinase, muscle 0.0282255
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0280888
RSRC2 arginine/serine-rich coiled-coil 2 0.0280161
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0276761
TRA2B transformer 2 beta homolog (Drosophila) 0.027618
SMC4 structural maintenance of chromosomes 4 0.0274475
FXR1 fragile X mental retardation, autosomal homolog 1 0.0274341
FOSL1 FOS-like antigen 1 0.0273395
SEPTIN7 septin 7 0.027336
DSCAM Down syndrome cell adhesion molecule 0.0271432
RPS2 ribosomal protein S2 0.0270262
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0268938
ERRFI1 ERBB receptor feedback inhibitor 1 0.0263383
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0260207
RPS8 ribosomal protein S8 0.0257732
RHOA ras homolog family member A 0.0257026
CKAP5 cytoskeleton associated protein 5 0.0256944
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0255632
ATP13A3 ATPase type 13A3 0.0253321
PUM2 pumilio RNA-binding family member 2 0.0251296
PNISR PNN-interacting serine/arginine-rich protein 0.0251011
TXNIP thioredoxin interacting protein 0.0246763
SBF2 SET binding factor 2 0.0244588
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.024445
RBM39 RNA binding motif protein 39 0.0242035
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0239349
YBX1 Y box binding protein 1 0.0239266
WAC WW domain containing adaptor with coiled-coil 0.0238483
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0235936
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0235473
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0232234
KIF5B kinesin family member 5B 0.0231418
EREG epiregulin 0.0229978
ZFAND3 zinc finger, AN1-type domain 3 0.0229813
SRPK2 SRSF protein kinase 2 0.0227712
RPS27A ribosomal protein S27a 0.0225481
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0224951
EEF1G eukaryotic translation elongation factor 1 gamma 0.0220386
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.021923
RAI1 retinoic acid induced 1 0.0218383
MCL1 myeloid cell leukemia 1 0.0217626
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0216039
ACBD3 acyl-CoA binding domain containing 3 0.0215929
RPL5 ribosomal protein L5 0.0215721
PNN pinin, desmosome associated protein 0.0215509
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0215217
KMT2E lysine (K)-specific methyltransferase 2E 0.0214832
SRSF11 serine/arginine-rich splicing factor 11 0.0213247
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0212295
PUM1 pumilio RNA-binding family member 1 0.0209636
SPIRE1 spire-type actin nucleation factor 1 0.0209575

decreased expression

Symbol Name Standardized Value
TP63 tumor protein p63 -0.162487
CD44 CD44 molecule (Indian blood group) -0.134091
PSD3 pleckstrin and Sec7 domain containing 3 -0.113974
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.103979
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0858527
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0762037
RUNX1 runt-related transcription factor 1 -0.0708216
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0698441
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0641901
RIGI RNA sensor RIG-I -0.0634675
WARS1 tryptophanyl-tRNA synthetase 1 -0.0619361
SP100 SP100 nuclear antigen -0.0587079
HLA-B major histocompatibility complex, class I, B -0.0574163
ZDHHC14 zinc finger, DHHC-type containing 14 -0.057262
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0571403
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0476446
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0465703
RNF213 ring finger protein 213 -0.0463488
ZBTB38 zinc finger and BTB domain containing 38 -0.046311
EHBP1 EH domain binding protein 1 -0.0451734
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0439481
PLSCR1 phospholipid scramblase 1 -0.043585
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.042713
IFIH1 interferon induced with helicase C domain 1 -0.0407447
ARHGAP5 Rho GTPase activating protein 5 -0.0394249
CMIP c-Maf inducing protein -0.0384948
CFAP299 cilia and flagella associated protein 299 -0.0384169
CADM2 cell adhesion molecule 2 -0.0383881
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0383202
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0375219
VIM vimentin -0.0368973
GCLM glutamate-cysteine ligase, modifier subunit -0.0367031
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0366296
EPHA4 EPH receptor A4 -0.0359398
SLC38A2 solute carrier family 38, member 2 -0.0351477
VCL vinculin -0.0346589
NPAS2 neuronal PAS domain protein 2 -0.0345816
WWTR1 WW domain containing transcription regulator 1 -0.0342994
PDE10A phosphodiesterase 10A -0.0337838
BCAR3 breast cancer anti-estrogen resistance 3 -0.0335234
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0333544
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -0.0332192
DLG1 discs, large homolog 1 (Drosophila) -0.0317077
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0315319
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0311174
TMSB10 thymosin beta 10 -0.0307978
RAD51B RAD51 paralog B -0.0301005
RGS4 regulator of G-protein signaling 4 -0.0294043
PMP22 peripheral myelin protein 22 -0.0293508
SDCCAG8 serologically defined colon cancer antigen 8 -0.0291283
ACTG1 actin gamma 1 -0.0290677
NCEH1 neutral cholesterol ester hydrolase 1 -0.0289321
LOC102724023 ES1 protein homolog, mitochondrial -0.0288647
AHNAK2 AHNAK nucleoprotein 2 -0.0287703
RAB27B RAB27B, member RAS oncogene family -0.0283031
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0279818
TNS3 tensin 3 -0.027769
OSMR oncostatin M receptor -0.0274667
HDAC9 histone deacetylase 9 -0.0271346
DPYD dihydropyrimidine dehydrogenase -0.026594
TMSB4X thymosin beta 4, X-linked -0.0265168
TSC22D1 TSC22 domain family, member 1 -0.0261665
LPP LIM domain containing preferred translocation partner in lipoma -0.0256632
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0249771
EGR1 early growth response 1 -0.0248533
NT5E 5'-nucleotidase, ecto (CD73) -0.0243993
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0238376
BICD1 bicaudal D homolog 1 (Drosophila) -0.0230304
RPL35A ribosomal protein L35a -0.0228862
ZNFX1 zinc finger, NFX1-type containing 1 -0.0225641
ZMYND8 zinc finger, MYND-type containing 8 -0.0223096
HPCAL1 hippocalcin-like 1 -0.0219513
TRIM56 tripartite motif containing 56 -0.0218515
INTS6 integrator complex subunit 6 -0.0217309
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0217237
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0217138
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.021438
LOC112694756 uncharaterized LOC112694756 -0.0212133
TGM2 transglutaminase 2 -0.0205564
IFI6 interferon, alpha-inducible protein 6 -0.0205279
SGK1 serum/glucocorticoid regulated kinase 1 -0.0199051
DNER delta/notch-like EGF repeat containing -0.019885
TPT1 tumor protein, translationally-controlled 1 -0.0194572
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0194253
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0192065
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0189838
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0188102
BIRC2 baculoviral IAP repeat containing 2 -0.0186254
NEK10 NIMA-related kinase 10 -0.0182731
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.0180505
SMYD3 SET and MYND domain containing 3 -0.0180484
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0180283
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0178588
BMERB1 bMERB domain containing 1 -0.0174499
PHF14 PHD finger protein 14 -0.0174312
MACF1 microtubule-actin crosslinking factor 1 -0.0170115
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0169239
BIRC3 baculoviral IAP repeat containing 3 -0.0168503
MT2A metallothionein 2A -0.0167142
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.0165469