Procainamide (hydrochloride)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Procainamide (hydrochloride) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Procainamide (hydrochloride)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.150521
NDRG1 N-myc downstream regulated 1 0.118649
VIM vimentin 0.113827
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.111111
RPS6 ribosomal protein S6 0.0990476
FTL ferritin, light polypeptide 0.0985008
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0879853
ELL2 elongation factor, RNA polymerase II, 2 0.0770229
KMT2E lysine (K)-specific methyltransferase 2E 0.0743176
EFNA5 ephrin-A5 0.0728901
RPS12 ribosomal protein S12 0.070955
PDE10A phosphodiesterase 10A 0.0665086
RPS8 ribosomal protein S8 0.0645867
ENO1 enolase 1, (alpha) 0.0642408
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0610052
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0607565
RPLP2 ribosomal protein, large, P2 0.0606844
TRIO trio Rho guanine nucleotide exchange factor 0.0606625
NAMPT nicotinamide phosphoribosyltransferase 0.0598132
LDHA lactate dehydrogenase A 0.0592811
FLNB filamin B, beta 0.058753
ERRFI1 ERBB receptor feedback inhibitor 1 0.0586811
GOLGA4 golgin A4 0.0573932
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0570448
RIGI RNA sensor RIG-I 0.0523996
ELP2 elongator acetyltransferase complex subunit 2 0.0523774
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0523024
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.051203
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0507573
UGCG UDP-glucose ceramide glucosyltransferase 0.0490283
HMGA2 high mobility group AT-hook 2 0.0482565
PTMA prothymosin, alpha 0.047524
CD44 CD44 molecule (Indian blood group) 0.0472372
OGA O-GlcNAcase 0.0469167
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.046823
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0457614
BHLHE40 basic helix-loop-helix family, member e40 0.0457113
PGK1 phosphoglycerate kinase 1 0.0454329
SRPK2 SRSF protein kinase 2 0.0440706
ZCCHC7 zinc finger, CCHC domain containing 7 0.0440356
TSC22D2 TSC22 domain family, member 2 0.0437777
BTG1 B-cell translocation gene 1, anti-proliferative 0.0436488
HILPDA hypoxia inducible lipid droplet-associated 0.0434288
DDIT4 DNA-damage-inducible transcript 4 0.0423959
RPLP1 ribosomal protein, large, P1 0.0423709
ATP13A3 ATPase type 13A3 0.0422416
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0416937
STC1 stanniocalcin 1 0.0401577
KMT2C lysine (K)-specific methyltransferase 2C 0.0401371
CALR calreticulin 0.0400835
GMDS GDP-mannose 4,6-dehydratase 0.0399921
AKAP12 A kinase (PRKA) anchor protein 12 0.0399874
GPHN gephyrin 0.0398691
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0396175
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0395483
DST dystonin 0.0392036
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0389105
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0389098
MTSS1 metastasis suppressor 1 0.0373855
RNF149 ring finger protein 149 0.0372551
TAS2R14 taste receptor, type 2, member 14 0.036946
ASPH aspartate beta-hydroxylase 0.0366091
MEF2A myocyte enhancer factor 2A 0.0361894
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0358107
PLAUR plasminogen activator, urokinase receptor 0.0355829
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0354366
MT2A metallothionein 2A 0.0349466
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0345432
RAB5A RAB5A, member RAS oncogene family 0.0344352
ETV3 ets variant 3 0.0343526
FAM13A family with sequence similarity 13, member A 0.0342932
YTHDC1 YTH domain containing 1 0.0339038
TMSB10 thymosin beta 10 0.0338302
MBNL1 muscleblind-like splicing regulator 1 0.0338194
PDLIM5 PDZ and LIM domain 5 0.0328464
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0320965
FRMD5 FERM domain containing 5 0.031949
DTNA dystrobrevin, alpha 0.0316162
RPS29 ribosomal protein S29 0.0314906
DOCK4 dedicator of cytokinesis 4 0.0314667
KDM5B lysine (K)-specific demethylase 5B 0.0313905
WSB1 WD repeat and SOCS box containing 1 0.0310577
EEF2 eukaryotic translation elongation factor 2 0.0309119
RPS19 ribosomal protein S19 0.0308812
EIF1 eukaryotic translation initiation factor 1 0.0307714
PUM1 pumilio RNA-binding family member 1 0.0304804
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0302395
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0301111
ANO6 anoctamin 6 0.0298194
GIGYF2 GRB10 interacting GYF protein 2 0.0296329
PTGES2 prostaglandin E synthase 2 0.0295358
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0294488
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0287782
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.028735
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0286424
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0284569
VDAC1 voltage-dependent anion channel 1 0.0281411
COL6A3 collagen, type VI, alpha 3 0.0279155
DLG1 discs, large homolog 1 (Drosophila) 0.0278196
ADM adrenomedullin 0.0274849

decreased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 -0.198301
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.17922
MUC16 mucin 16, cell surface associated -0.118979
ATOSA atos homolog A -0.111721
LAMC2 laminin, gamma 2 -0.10928
MYO1E myosin IE -0.0994803
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0940616
PARD3 par-3 family cell polarity regulator -0.0873424
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0845281
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0796614
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0773675
CEMIP cell migration inducing protein, hyaluronan binding -0.0758578
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0705758
GRB10 growth factor receptor-bound protein 10 -0.0699349
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0683578
BACE2 beta-site APP-cleaving enzyme 2 -0.0664697
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0630366
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0628099
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0611696
KIF13B kinesin family member 13B -0.0611242
PTPRM protein tyrosine phosphatase, receptor type, M -0.0578898
LIMCH1 LIM and calponin homology domains 1 -0.0567485
FNDC3B fibronectin type III domain containing 3B -0.0559654
LAMB3 laminin, beta 3 -0.0549108
TJP1 tight junction protein 1 -0.054245
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0539224
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0535849
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.053351
SAMD4A sterile alpha motif domain containing 4A -0.0531906
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0518666
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0505714
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0502641
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0502448
MACC1 metastasis associated in colon cancer 1 -0.0491178
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0490015
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0482149
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0469075
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.046877
ANXA2 annexin A2 -0.0468661
SPNS2 spinster homolog 2 (Drosophila) -0.0463503
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0452731
TJP2 tight junction protein 2 -0.0446894
OSMR oncostatin M receptor -0.0445699
USP34 ubiquitin specific peptidase 34 -0.0440475
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0439857
NEBL nebulette -0.0437811
ABHD17C abhydrolase domain containing 17C -0.0435072
SMOC1 SPARC related modular calcium binding 1 -0.0427878
TGFA transforming growth factor, alpha -0.0425835
MYO6 myosin VI -0.0424927
RNF213 ring finger protein 213 -0.042476
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0421589
PLSCR1 phospholipid scramblase 1 -0.0421552
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -0.041893
CD46 CD46 molecule, complement regulatory protein -0.041786
STEAP4 STEAP family member 4 -0.0416333
CMIP c-Maf inducing protein -0.0412572
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0410765
SSH2 slingshot protein phosphatase 2 -0.0407642
PATJ PATJ crumbs cell polarity complex component -0.0404623
ERBIN erbb2 interacting protein -0.040166
INTS6 integrator complex subunit 6 -0.0400749
SLMAP sarcolemma associated protein -0.0400269
MCU mitochondrial calcium uniporter -0.0400045
RBM47 RNA binding motif protein 47 -0.0399755
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0398743
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0396915
ANTXR2 anthrax toxin receptor 2 -0.0394652
PARD6B par-6 family cell polarity regulator beta -0.0394234
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0387552
BMAL2 basic helix-loop-helix ARNT like 2 -0.0386082
SMAD3 SMAD family member 3 -0.0380752
AHNAK AHNAK nucleoprotein -0.0379946
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0379858
CD2AP CD2-associated protein -0.0379414
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0378799
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.0377546
TMEM165 transmembrane protein 165 -0.0373135
S100A9 S100 calcium binding protein A9 -0.036675
KATNBL1 katanin p80 subunit B-like 1 -0.0365572
CATSPERB catsper channel auxiliary subunit beta -0.0363083
ANKRD36C ankyrin repeat domain 36C -0.0360442
ZNF185 zinc finger protein 185 (LIM domain) -0.0360276
HLA-A major histocompatibility complex, class I, A -0.0358817
PRDM1 PR domain containing 1, with ZNF domain -0.034865
FOSL2 FOS-like antigen 2 -0.0338228
RICTOR RPTOR independent companion of MTOR, complex 2 -0.03359
CNKSR3 CNKSR family member 3 -0.0335764
FN1 fibronectin 1 -0.0335384
SCEL sciellin -0.0334268
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0331913
AKAP13 A kinase (PRKA) anchor protein 13 -0.0331403
SOX4 SRY (sex determining region Y)-box 4 -0.0327884
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0324338
ZFAND6 zinc finger, AN1-type domain 6 -0.0321319
GSK3B glycogen synthase kinase 3 beta -0.0319528
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0314026
FTH1 ferritin, heavy polypeptide 1 -0.0313826
HMBOX1 homeobox containing 1 -0.0313741
SPDYA speedy/RINGO cell cycle regulator family member A -0.0309683