Procainamide (hydrochloride)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Procainamide (hydrochloride) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

175 genes differentially expressed following the Procainamide (hydrochloride)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.145901
FN1 fibronectin 1 0.138951
FTL ferritin, light polypeptide 0.12917
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.127596
PDE4D phosphodiesterase 4D, cAMP-specific 0.124272
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.12007
PRELID2 PRELI domain containing 2 0.113265
PDE10A phosphodiesterase 10A 0.104269
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0951708
DGKD diacylglycerol kinase, delta 130kDa 0.0921086
LIMCH1 LIM and calponin homology domains 1 0.0901211
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0878565
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0871205
RPS3 ribosomal protein S3 0.0861737
SMAD3 SMAD family member 3 0.0828053
GDA guanine deaminase 0.0825492
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.0799168
PGK1 phosphoglycerate kinase 1 0.0785827
RPL11 ribosomal protein L11 0.0777456
TPI1 triosephosphate isomerase 1 0.0770961
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0767338
PHF21A PHD finger protein 21A 0.0757474
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0753221
GOLGA4 golgin A4 0.0711601
ZFAND3 zinc finger, AN1-type domain 3 0.0709786
TPT1 tumor protein, translationally-controlled 1 0.0704773
COL5A2 collagen, type V, alpha 2 0.0683633
RPS8 ribosomal protein S8 0.0665442
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0655264
MAML3 mastermind-like 3 (Drosophila) 0.0644851
RICTOR RPTOR independent companion of MTOR, complex 2 0.0638585
SLC38A1 solute carrier family 38, member 1 0.063041
EFNA5 ephrin-A5 0.0624487
SSBP2 single-stranded DNA binding protein 2 0.0622644
ARHGAP12 Rho GTPase activating protein 12 0.0614694
EGFR epidermal growth factor receptor 0.0614306
S100A6 S100 calcium binding protein A6 0.0611962
ADAM17 ADAM metallopeptidase domain 17 0.0598346
MT2A metallothionein 2A 0.0575858
SEPTIN9 septin 9 0.0573847
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0563417
RPL27A ribosomal protein L27a 0.0552734
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0551371
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.05254
FMNL2 formin-like 2 0.0503711
ACTG1 actin gamma 1 0.0497852
CDK13 cyclin-dependent kinase 13 0.0478581
RPL5 ribosomal protein L5 0.0466559
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0463922
TTC3 tetratricopeptide repeat domain 3 0.0460152
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0455409
SMYD3 SET and MYND domain containing 3 0.045063
FTH1 ferritin, heavy polypeptide 1 0.042581
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0423516
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0403947
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0398129
KMT2C lysine (K)-specific methyltransferase 2C 0.0371633
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0371491
ZNF292 zinc finger protein 292 0.0367868
FERMT2 fermitin family member 2 0.0353815
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0339818
MYOF myoferlin 0.0324391
APP amyloid beta (A4) precursor protein 0.0310808
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0296722
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0293495
CDC73 cell division cycle 73 0.0292714
PDLIM5 PDZ and LIM domain 5 0.0291803
TMSB10 thymosin beta 10 0.0273865
ENO1 enolase 1, (alpha) 0.0259889
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0258329
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0251784
RPL23 ribosomal protein L23 0.0244975
WDFY3 WD repeat and FYVE domain containing 3 0.0244516
YME1L1 YME1-like 1 ATPase 0.0227995
ATXN2 ataxin 2 0.0227173
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.021766
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0209245
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0209191
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0187454
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0173995
RBM39 RNA binding motif protein 39 0.0173911
MARCHF6 membrane associated ring-CH-type finger 6 0.0153337
CD44 CD44 molecule (Indian blood group) 0.0148964
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0144865
RPL37A ribosomal protein L37a 0.014435
TBC1D22A TBC1 domain family, member 22A 0.00849765
POTEF POTE ankyrin domain family, member F 0.00741268
DSCAM Down syndrome cell adhesion molecule 0.00680276
VMP1 vacuole membrane protein 1 0.00663185
PARD3 par-3 family cell polarity regulator 0.00651201
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.00609976
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.00570283
EZR ezrin 0.00542434
NAV2 neuron navigator 2 0.00526395
FAF1 Fas (TNFRSF6) associated factor 1 0.00319655
GPC6 glypican 6 0.00272249
RPS6 ribosomal protein S6 0.00214981
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 7.67885E-4

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.212345
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.184419
RAP1B RAP1B, member of RAS oncogene family -0.164642
ANKRD11 ankyrin repeat domain 11 -0.141985
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.141162
NALF1 NALCN channel auxiliary factor 1 -0.139977
SYAP1 synapse associated protein 1 -0.124796
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.111588
FNDC3B fibronectin type III domain containing 3B -0.11026
KTN1 kinectin 1 (kinesin receptor) -0.104746
FNIP1 folliculin interacting protein 1 -0.103897
CLTC clathrin, heavy chain (Hc) -0.102358
EEF2 eukaryotic translation elongation factor 2 -0.101191
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.101152
PUM2 pumilio RNA-binding family member 2 -0.0977794
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0958334
ZBTB20 zinc finger and BTB domain containing 20 -0.0876553
LAMB3 laminin, beta 3 -0.0870568
HMGA2 high mobility group AT-hook 2 -0.0856743
MACF1 microtubule-actin crosslinking factor 1 -0.0846272
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0821638
PTK2 protein tyrosine kinase 2 -0.0807237
NCOR1 nuclear receptor corepressor 1 -0.0801817
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0799017
NF1 neurofibromin 1 -0.0752466
FLNB filamin B, beta -0.0751618
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0731391
VIM vimentin -0.0724701
AFDN afadin, adherens junction formation factor -0.0663904
FBXO11 F-box protein 11 -0.0653713
NAMPT nicotinamide phosphoribosyltransferase -0.0645332
ELL2 elongation factor, RNA polymerase II, 2 -0.0632121
RPS19 ribosomal protein S19 -0.0601334
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0581462
ANKRD12 ankyrin repeat domain 12 -0.055005
TXNRD1 thioredoxin reductase 1 -0.0544296
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0542356
TRIO trio Rho guanine nucleotide exchange factor -0.0514941
CSNK1A1 casein kinase 1, alpha 1 -0.0506054
PRRC2C proline-rich coiled-coil 2C -0.0491827
NDRG1 N-myc downstream regulated 1 -0.0488413
GPHN gephyrin -0.0470026
RORA RAR-related orphan receptor A -0.0433663
HELZ helicase with zinc finger -0.0409375
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0407524
EXT1 exostosin glycosyltransferase 1 -0.0406318
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0390207
BBX bobby sox homolog (Drosophila) -0.0380562
PTMA prothymosin, alpha -0.0379674
WSB1 WD repeat and SOCS box containing 1 -0.0355796
MMP1 matrix metallopeptidase 1 -0.0348548
JMJD1C jumonji domain containing 1C -0.0331393
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0329418
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0321356
IGF2 insulin-like growth factor 2 -0.031995
MYO1E myosin IE -0.0316448
MCL1 myeloid cell leukemia 1 -0.0313686
ALCAM activated leukocyte cell adhesion molecule -0.0282536
RNF213 ring finger protein 213 -0.0262129
VCL vinculin -0.0252634
BPTF bromodomain PHD finger transcription factor -0.0212737
JAM3 junctional adhesion molecule 3 -0.0195328
CLINT1 clathrin interactor 1 -0.017296
CANX calnexin -0.0172382
ASPH aspartate beta-hydroxylase -0.014237
ANXA2 annexin A2 -0.0125923
MED13L mediator complex subunit 13-like -0.0120522
DST dystonin -0.011027
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0102627
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.00786751
UBA6 ubiquitin-like modifier activating enzyme 6 -0.00643691
CADM1 cell adhesion molecule 1 -0.00617329
KMT2E lysine (K)-specific methyltransferase 2E -0.00445982
LDHA lactate dehydrogenase A -0.00305422
KDM2A lysine (K)-specific demethylase 2A -0.00222116
PSD3 pleckstrin and Sec7 domain containing 3 -0.00186944
INHBA inhibin, beta A -0.0011634