Procainamide (hydrochloride)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Procainamide (hydrochloride) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Procainamide (hydrochloride)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.190785
LAMB3 laminin, beta 3 0.144089
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.108555
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0960908
UBC ubiquitin C 0.0936096
KRT17 keratin 17, type I 0.093002
RPS27A ribosomal protein S27a 0.0928138
RPS3 ribosomal protein S3 0.0927002
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0820156
B2M beta-2-microglobulin 0.0790038
VMP1 vacuole membrane protein 1 0.075129
DSCAM Down syndrome cell adhesion molecule 0.0662288
AHNAK AHNAK nucleoprotein 0.0604179
KRT7 keratin 7, type II 0.0594744
PTMA prothymosin, alpha 0.0591602
MACF1 microtubule-actin crosslinking factor 1 0.0588387
RPS12 ribosomal protein S12 0.0578884
PCBP2 poly(rC) binding protein 2 0.0568678
EZR ezrin 0.0565069
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0533477
DSPP dentin sialophosphoprotein 0.0511227
RPS8 ribosomal protein S8 0.0499525
LAMC2 laminin, gamma 2 0.0489329
RPS6 ribosomal protein S6 0.0487948
TXNIP thioredoxin interacting protein 0.0485209
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0481454
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0471353
CTNND1 catenin (cadherin-associated protein), delta 1 0.0464217
RPL23 ribosomal protein L23 0.0463369
CALR calreticulin 0.045752
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0457223
TMF1 TATA element modulatory factor 1 0.0446372
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0442659
SET SET nuclear proto-oncogene 0.043872
EEF2 eukaryotic translation elongation factor 2 0.0426825
PRRC2C proline-rich coiled-coil 2C 0.0423994
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0422828
CANX calnexin 0.0420772
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0412629
RPS29 ribosomal protein S29 0.040845
RPL21 ribosomal protein L21 0.0400569
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0399495
TNIP1 TNFAIP3 interacting protein 1 0.0399197
AKAP12 A kinase (PRKA) anchor protein 12 0.0397151
EIF3A eukaryotic translation initiation factor 3, subunit A 0.038629
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0363686
GOLGA4 golgin A4 0.0362537
SMAD3 SMAD family member 3 0.0362469
RPL37A ribosomal protein L37a 0.0362157
ENO1 enolase 1, (alpha) 0.0361471
RBM25 RNA binding motif protein 25 0.0349014
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0349013
PCLO piccolo presynaptic cytomatrix protein 0.0342749
G0S2 G0/G1 switch 2 0.0330641
KTN1 kinectin 1 (kinesin receptor) 0.0330559
MYH9 myosin, heavy chain 9, non-muscle 0.0330482
RPS2 ribosomal protein S2 0.0330297
BRD2 bromodomain containing 2 0.0320447
TPM3 tropomyosin 3 0.0318934
SAMD4A sterile alpha motif domain containing 4A 0.0318155
H1-4 H1.4 linker histone, cluster member 0.0309072
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0308464
ATP13A3 ATPase type 13A3 0.0305369
RPL5 ribosomal protein L5 0.0305158
RPL37 ribosomal protein L37 0.0303355
ACTG1 actin gamma 1 0.0301651
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0299879
MATR3 matrin 3 0.0297498
DIAPH1 diaphanous-related formin 1 0.0296492
EIF1 eukaryotic translation initiation factor 1 0.0290707
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.028759
EEF1G eukaryotic translation elongation factor 1 gamma 0.0285575
RACK1 receptor for activated C kinase 1 0.0284522
RIOK3 RIO kinase 3 0.0281464
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.027771
DOCK5 dedicator of cytokinesis 5 0.0273142
KRT8 keratin 8, type II 0.0273025
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0261814
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.025921
YBX3 Y box binding protein 3 0.0256623
FLNB filamin B, beta 0.0255846
PLAUR plasminogen activator, urokinase receptor 0.0255729
POTEF POTE ankyrin domain family, member F 0.0254642
MT2A metallothionein 2A 0.0253767
MCL1 myeloid cell leukemia 1 0.0251008
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.025003
SRSF11 serine/arginine-rich splicing factor 11 0.0249541
ELL2 elongation factor, RNA polymerase II, 2 0.0249054
TGM2 transglutaminase 2 0.0247513
SENP5 SUMO1/sentrin specific peptidase 5 0.0242892
PUM1 pumilio RNA-binding family member 1 0.0241414
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0240888
KIF5B kinesin family member 5B 0.0240577
XPO1 exportin 1 0.0240355
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0238966
EIF4B eukaryotic translation initiation factor 4B 0.0238377
SRSF5 serine/arginine-rich splicing factor 5 0.0237841
MYOF myoferlin 0.0237479
FNIP1 folliculin interacting protein 1 0.0235354
BCAR3 breast cancer anti-estrogen resistance 3 0.0234712

decreased expression

Symbol Name Standardized Value
HMGA1 high mobility group AT-hook 1 -0.0850474
FTH1 ferritin, heavy polypeptide 1 -0.0769555
RPL35A ribosomal protein L35a -0.0667863
NDRG1 N-myc downstream regulated 1 -0.0651046
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.062603
MUC4 mucin 4, cell surface associated -0.0600086
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0583008
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0562961
TMEM123 transmembrane protein 123 -0.0558267
RNF213 ring finger protein 213 -0.0515071
FAM3C family with sequence similarity 3, member C -0.0498298
KRT19 keratin 19, type I -0.0486829
RUNX1 runt-related transcription factor 1 -0.0466989
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0461195
F3 coagulation factor III (thromboplastin, tissue factor) -0.0441093
MUC16 mucin 16, cell surface associated -0.0424482
TMSB4X thymosin beta 4, X-linked -0.0417087
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0402804
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0394167
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0367594
MAML2 mastermind-like 2 (Drosophila) -0.0362063
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0345856
EGR1 early growth response 1 -0.0343748
FTL ferritin, light polypeptide -0.0335718
LMO7 LIM domain 7 -0.0335272
EFNA5 ephrin-A5 -0.0330562
HLA-C major histocompatibility complex, class I, C -0.0311
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0300248
TAPBP TAP binding protein (tapasin) -0.0296308
ARF1 ADP-ribosylation factor 1 -0.0295242
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0285809
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0282986
WDR45B WD repeat domain 45B -0.0277049
PRELID2 PRELI domain containing 2 -0.0276482
LOC102724023 ES1 protein homolog, mitochondrial -0.0257881
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0253532
SRSF3 serine/arginine-rich splicing factor 3 -0.0248822
NT5C2 5'-nucleotidase, cytosolic II -0.0248308
VCL vinculin -0.0242771
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0242019
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0237328
LDHA lactate dehydrogenase A -0.023328
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.0233194
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0230232
H1-0 H1.0 linker histone -0.0229539
BSG basigin (Ok blood group) -0.0226889
NCOA7 nuclear receptor coactivator 7 -0.0219922
CLMN calmin (calponin-like, transmembrane) -0.0217875
ATN1 atrophin 1 -0.0210209
ANKRD10 ankyrin repeat domain 10 -0.0209458
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0203602
MX1 MX dynamin-like GTPase 1 -0.0202211
NRP1 neuropilin 1 -0.0202089
DLG1 discs, large homolog 1 (Drosophila) -0.0199899
FOXO3 forkhead box O3 -0.0199395
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0193582
GNAS GNAS complex locus -0.0190879
HLA-B major histocompatibility complex, class I, B -0.0190625
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0189543
ITGB4 integrin, beta 4 -0.0188517
MX2 MX dynamin-like GTPase 2 -0.0188284
PDE8A phosphodiesterase 8A -0.0185729
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0183555
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0183298
ITGAV integrin, alpha V -0.0181339
PTPRK protein tyrosine phosphatase, receptor type, K -0.0181247
EPSTI1 epithelial stromal interaction 1 (breast) -0.0181103
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -0.0180859
FOSL1 FOS-like antigen 1 -0.017864
SULF2 sulfatase 2 -0.0178321
TGFA transforming growth factor, alpha -0.0174395
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.017415
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0174132
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0171715
LPP LIM domain containing preferred translocation partner in lipoma -0.0170061
TSC22D2 TSC22 domain family, member 2 -0.0167644
IFI16 interferon, gamma-inducible protein 16 -0.0167073
ANXA1 annexin A1 -0.0166968
KPNB1 karyopherin (importin) beta 1 -0.0165996
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0163244
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 -0.0162747
CABIN1 calcineurin binding protein 1 -0.0162286
FNDC3B fibronectin type III domain containing 3B -0.0160136
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0159315
CMTM7 CKLF-like MARVEL transmembrane domain containing 7 -0.0159301
BLTP1 bridge-like lipid transfer protein family member 1 -0.0157673
SP100 SP100 nuclear antigen -0.0157225
HLA-A major histocompatibility complex, class I, A -0.0156961
CBX3 chromobox homolog 3 -0.0156758
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0155043
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0154211
SLC38A2 solute carrier family 38, member 2 -0.0153907
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0153273
PARD3 par-3 family cell polarity regulator -0.0152624
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0152518
RAB14 RAB14, member RAS oncogene family -0.0152454
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -0.0152405
UFM1 ubiquitin-fold modifier 1 -0.0152252
PLEKHA7 pleckstrin homology domain containing, family A member 7 -0.0151622
C6ORF132 chromosome 6 open reading frame 132 -0.0151242