Procainamide (hydrochloride)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Procainamide (hydrochloride) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Procainamide (hydrochloride)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLOT1 flotillin 1 0.0976176
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0880993
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0852887
ITPRID2 ITPR interacting domain containing 2 0.079357
AREG amphiregulin 0.0699035
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.068785
LAMC2 laminin, gamma 2 0.0655765
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0648803
PDE4B phosphodiesterase 4B, cAMP-specific 0.0624673
FERMT1 fermitin family member 1 0.0614119
PLAUR plasminogen activator, urokinase receptor 0.0570517
CPOX coproporphyrinogen oxidase 0.054475
EREG epiregulin 0.0529891
RPL21 ribosomal protein L21 0.0528011
GPHN gephyrin 0.0501933
LOC102724023 ES1 protein homolog, mitochondrial 0.0499196
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0494608
RCOR1 REST corepressor 1 0.048448
LAMA4 laminin, alpha 4 0.0475531
PRRC2C proline-rich coiled-coil 2C 0.0469911
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0463981
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0459408
AKAP12 A kinase (PRKA) anchor protein 12 0.0453206
COG5 component of oligomeric golgi complex 5 0.0437309
TJP1 tight junction protein 1 0.0430425
ITGA6 integrin, alpha 6 0.0411592
SEPTIN9 septin 9 0.041137
SRSF11 serine/arginine-rich splicing factor 11 0.0408938
GOLGA4 golgin A4 0.0408279
EGR1 early growth response 1 0.0402668
MACF1 microtubule-actin crosslinking factor 1 0.040257
CD36 CD36 molecule (thrombospondin receptor) 0.0401321
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0399923
FOSL1 FOS-like antigen 1 0.0395653
MED13L mediator complex subunit 13-like 0.0388646
PTBP2 polypyrimidine tract binding protein 2 0.0378461
SRRM2 serine/arginine repetitive matrix 2 0.0376552
SNX9 sorting nexin 9 0.0372644
EGFR epidermal growth factor receptor 0.0371372
VMP1 vacuole membrane protein 1 0.0370666
RPS2 ribosomal protein S2 0.0369114
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0366923
ATXN1 ataxin 1 0.0366708
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0365257
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.036489
ZFP36 ZFP36 ring finger protein 0.0363361
ARHGAP32 Rho GTPase activating protein 32 0.0352211
MKI67 marker of proliferation Ki-67 0.0349748
BIRC3 baculoviral IAP repeat containing 3 0.0349515
CENPF centromere protein F, 350/400kDa 0.0348093
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0347139
AKAP13 A kinase (PRKA) anchor protein 13 0.0346628
YAP1 Yes-associated protein 1 0.0345276
SMAD3 SMAD family member 3 0.0341001
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0337583
DSPP dentin sialophosphoprotein 0.0333364
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0325567
PCBP2 poly(rC) binding protein 2 0.0322756
RANBP9 RAN binding protein 9 0.0319933
PNN pinin, desmosome associated protein 0.0316359
UBA6 ubiquitin-like modifier activating enzyme 6 0.0310965
BCL2L1 BCL2-like 1 0.0310237
ZNRF3 zinc and ring finger 3 0.0309308
AXIN2 axin 2 0.0309073
FAT1 FAT atypical cadherin 1 0.0308722
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0297671
ARRDC3 arrestin domain containing 3 0.0294716
TES testin LIM domain protein 0.0294573
EFNB2 ephrin-B2 0.0294425
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0294255
KDM6A lysine (K)-specific demethylase 6A 0.0291627
GSK3B glycogen synthase kinase 3 beta 0.0288851
USP6NL USP6 N-terminal like 0.0286353
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0285555
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0285284
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0284005
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0281065
UTRN utrophin 0.0275059
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0273624
H1-2 H1.2 linker histone, cluster member 0.0272264
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0269888
ATP11B ATPase, class VI, type 11B 0.0269517
RPS12 ribosomal protein S12 0.026841
SFPQ splicing factor proline/glutamine-rich 0.0267233
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0265885
CCNL1 cyclin L1 0.0265222
SETD2 SET domain containing 2 0.0258618
DUSP4 dual specificity phosphatase 4 0.0258035
CDCP1 CUB domain containing protein 1 0.0254366
SRSF4 serine/arginine-rich splicing factor 4 0.0250985
TXNIP thioredoxin interacting protein 0.0249622
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0249553
DENR density-regulated protein 0.0249236
TMOD3 tropomodulin 3 (ubiquitous) 0.0249174
NUP58 nucleoporin 58 0.024752
KTN1 kinectin 1 (kinesin receptor) 0.0245091
SRRM1 serine/arginine repetitive matrix 1 0.0244674
H1-4 H1.4 linker histone, cluster member 0.0243472
SLMAP sarcolemma associated protein 0.0242769
SCFD1 sec1 family domain containing 1 0.0239918

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.291393
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.146208
TMSB10 thymosin beta 10 -0.145372
PTMA prothymosin, alpha -0.127673
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.112385
TPT1 tumor protein, translationally-controlled 1 -0.110917
EEF2 eukaryotic translation elongation factor 2 -0.0773605
ANXA2 annexin A2 -0.0768869
RPLP1 ribosomal protein, large, P1 -0.0761902
IER3 immediate early response 3 -0.0744399
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0731381
RPL35A ribosomal protein L35a -0.0677956
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0614992
LOC112694756 uncharaterized LOC112694756 -0.057669
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0567525
ARF1 ADP-ribosylation factor 1 -0.0560629
RPL4 ribosomal protein L4 -0.0551556
SQSTM1 sequestosome 1 -0.0530817
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0501545
CUX1 cut-like homeobox 1 -0.0479936
ACTG1 actin gamma 1 -0.0478638
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0474096
RPS24 ribosomal protein S24 -0.0470885
HDAC2 histone deacetylase 2 -0.0469492
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.045221
NPR2 natriuretic peptide receptor 2 -0.0444926
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0429493
EMP1 epithelial membrane protein 1 -0.0392223
PKM pyruvate kinase, muscle -0.037827
RPLP0 ribosomal protein, large, P0 -0.037161
RPL34 ribosomal protein L34 -0.0363548
HSPA8 heat shock 70kDa protein 8 -0.0354495
AHNAK AHNAK nucleoprotein -0.0349151
PRRC2B proline-rich coiled-coil 2B -0.0329586
UBC ubiquitin C -0.0317308
MYO5B myosin VB -0.0313852
RPS4X ribosomal protein S4, X-linked -0.0311774
RPL36 ribosomal protein L36 -0.0307628
RPS28 ribosomal protein S28 -0.0301396
HLA-B major histocompatibility complex, class I, B -0.0287994
KLF5 Kruppel-like factor 5 (intestinal) -0.0287472
FTH1 ferritin, heavy polypeptide 1 -0.0285644
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0269901
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0268838
RPS27A ribosomal protein S27a -0.0260367
PDLIM5 PDZ and LIM domain 5 -0.025781
RPS16 ribosomal protein S16 -0.0257601
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0252006
RPL31 ribosomal protein L31 -0.0250438
GDF15 growth differentiation factor 15 -0.0248025
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0246886
UBE3C ubiquitin protein ligase E3C -0.0245028
MDN1 MDN1, midasin homolog (yeast) -0.0241119
RPL32 ribosomal protein L32 -0.0239711
RPL6 ribosomal protein L6 -0.0239385
RPS25 ribosomal protein S25 -0.0237611
OXSR1 oxidative stress responsive 1 -0.0235938
EIF1 eukaryotic translation initiation factor 1 -0.0235356
HDLBP high density lipoprotein binding protein -0.0234128
LMAN1 lectin, mannose-binding, 1 -0.0234021
TKT transketolase -0.0232531
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0228886
RPL13A ribosomal protein L13a -0.0228885
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0226917
RPL28 ribosomal protein L28 -0.0226886
GPC5 glypican 5 -0.0225255
ESYT2 extended synaptotagmin-like protein 2 -0.0224915
HMGA2 high mobility group AT-hook 2 -0.0223981
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0223876
ANXA1 annexin A1 -0.0223581
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0220302
AOPEP aminopeptidase O (putative) -0.0219736
IARS1 isoleucyl-tRNA synthetase 1 -0.0217724
PDIA4 protein disulfide isomerase family A, member 4 -0.0214981
PPP4R3A protein phosphatase 4 regulatory subunit 3A -0.0212174
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0211888
OSBPL3 oxysterol binding protein-like 3 -0.0211847
S100A6 S100 calcium binding protein A6 -0.0211136
FTL ferritin, light polypeptide -0.0208271
ZC3H14 zinc finger CCCH-type containing 14 -0.0207919
ACTN4 actinin, alpha 4 -0.0207325
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0206883
RPL26 ribosomal protein L26 -0.0206629
RACK1 receptor for activated C kinase 1 -0.0205974
KPNB1 karyopherin (importin) beta 1 -0.0205152
RPL35 ribosomal protein L35 -0.0204498
RTN3 reticulon 3 -0.0203281
PERP PERP, TP53 apoptosis effector -0.0200085
APP amyloid beta (A4) precursor protein -0.0198836
RPL12 ribosomal protein L12 -0.0196158
HLA-E major histocompatibility complex, class I, E -0.0196143
EIF3E eukaryotic translation initiation factor 3, subunit E -0.0194844
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.0193964
GNAS GNAS complex locus -0.019345
HLA-C major histocompatibility complex, class I, C -0.0192867
PRPF8 pre-mRNA processing factor 8 -0.0191851
UGDH UDP-glucose 6-dehydrogenase -0.0191729
RPS29 ribosomal protein S29 -0.0191617
RPS8 ribosomal protein S8 -0.0191218
OGA O-GlcNAcase -0.0191012