Progeria Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description OMIM mapping confirmed by DO. [SN]. (Human Disease Ontology, DOID_3911)
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Genes

773 genes co-occuring with the disease Progeria in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
ZMPSTE24 zinc metallopeptidase STE24 3.775
LMNA lamin A/C 3.53
LMNB1 lamin B1 3.271
EMD emerin 3.215
WRN Werner syndrome, RecQ helicase-like 3.068
SUN1 Sad1 and UNC84 domain containing 1 3.066
LMNB2 lamin B2 2.997
SUN2 Sad1 and UNC84 domain containing 2 2.798
ICMT isoprenylcysteine carboxyl methyltransferase 2.75
LEMD3 LEM domain containing 3 2.7
RCE1 Ras converting CAAX endopeptidase 1 2.663
NAT10 N-acetyltransferase 10 (GCN5-related) 2.657
TP53BP1 tumor protein p53 binding protein 1 2.639
BANF2 barrier to autointegration factor 2 2.638
BANF1 barrier to autointegration factor 1 2.625
SYNE2 spectrin repeat containing, nuclear envelope 2 2.624
LBR lamin B receptor 2.622
ERCC1 excision repair cross-complementation group 1 2.569
SIRT6 sirtuin 6 2.486
LEMD2 LEM domain containing 2 2.47
SYNE1 spectrin repeat containing, nuclear envelope 1 2.445
GLB1 galactosidase, beta 1 2.403
ATM ATM serine/threonine kinase 2.401
XPA xeroderma pigmentosum, complementation group A 2.397
TP53 tumor protein p53 2.395
SIRT1 sirtuin 1 2.391
CBX5 chromobox homolog 5 2.38
NUP153 nucleoporin 153kDa 2.371
CDKN2A cyclin-dependent kinase inhibitor 2A 2.363
ERCC8 excision repair cross-complementation group 8 2.304
MTOR mechanistic target of rapamycin (serine/threonine kinase) 2.303
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 2.287
H3-3B H3.3 histone B 2.26
H3C12 H3 clustered histone 12 2.258
H3-5 H3.5 histone 2.242
H3-4 H3.4 histone, cluster member 2.241
H3C13 H3 clustered histone 13 2.24
IGF1 insulin-like growth factor 1 (somatomedin C) 2.196
ERCC6 excision repair cross-complementation group 6 2.183
SYNE4 spectrin repeat containing, nuclear envelope family member 4 2.167
SPRTN SprT-like N-terminal domain 2.161
ERCC2 excision repair cross-complementation group 2 2.133
KLF4 Kruppel-like factor 4 (gut) 2.118
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 2.116
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 2.113
TMPO thymopoietin 2.106
SOX2 SRY (sex determining region Y)-box 2 2.098
ERCC3 excision repair cross-complementation group 3 2.098
PRKDC protein kinase, DNA-activated, catalytic polypeptide 2.082
CGAS cyclic GMP-AMP synthase 2.071
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 2.066
TERT telomerase reverse transcriptase 2.045
POU5F1 POU class 5 homeobox 1 2.042
SIRT2 sirtuin 2 2.032
KL klotho 2.031
SIRT7 sirtuin 7 2.024
CKAP2 cytoskeleton associated protein 2 2.011
H2AX H2A.X variant histone 2.01
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 2.009
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 2.009
INS insulin 2.005
RECQL4 RecQ protein-like 4 2.003
ING1 inhibitor of growth family, member 1 2.001
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.975
CLMP CXADR-like membrane protein 1.967
RBBP4 retinoblastoma binding protein 4 1.962
RANBP17 RAN binding protein 17 1.962
IL6 interleukin 6 1.96
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.958
H2AC18 H2A clustered histone 18 1.955
H2AC20 H2A clustered histone 20 1.946
H2BC21 H2B clustered histone 21 1.935
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.934
SRSF1 serine/arginine-rich splicing factor 1 1.915
RAD50 RAD50 homolog (S. cerevisiae) 1.915
TGFB1 transforming growth factor, beta 1 1.905
DES desmin 1.894
PCNA proliferating cell nuclear antigen 1.892
RBBP7 retinoblastoma binding protein 7 1.889
NANOG Nanog homeobox 1.873
KAT2A K(lysine) acetyltransferase 2A 1.869
BLM Bloom syndrome, RecQ helicase-like 1.867
H4C7 H4 clustered histone 7 1.854
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 1.849
HDAC1 histone deacetylase 1 1.846
SUN3 Sad1 and UNC84 domain containing 3 1.846
MYH14 myosin, heavy chain 14, non-muscle 1.842
ACTB actin, beta 1.839
CTCF CCCTC-binding factor (zinc finger protein) 1.838
ELN elastin 1.837
AHCTF1 AT hook containing transcription factor 1 1.83
SYNE3 spectrin repeat containing, nuclear envelope family member 3 1.829
H4C6 H4 clustered histone 6 1.827
KAT2B K(lysine) acetyltransferase 2B 1.823
CBX3 chromobox homolog 3 1.821
DMD dystrophin 1.812
GPS2 G protein pathway suppressor 2 1.809
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.806
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.802
H1-0 H1.0 linker histone 1.801
NUP107 nucleoporin 107kDa 1.794
CHEK1 checkpoint kinase 1 1.792
APOE apolipoprotein E 1.784
CBX1 chromobox homolog 1 1.78
NUP133 nucleoporin 133kDa 1.779
PRR14 proline rich 14 1.777
ALPL alkaline phosphatase, liver/bone/kidney 1.776
PHGDH phosphoglycerate dehydrogenase 1.773
NUP62 nucleoporin 62kDa 1.765
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.765
TMEM201 transmembrane protein 201 1.764
ERCC4 excision repair cross-complementation group 4 1.763
ZNF239 zinc finger protein 239 1.762
FOXO3 forkhead box O3 1.761
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 1.761
BRCA1 breast cancer 1, early onset 1.759
TMEM43 transmembrane protein 43 1.759
TERF2 telomeric repeat binding factor 2 1.75
POLD1 polymerase (DNA directed), delta 1, catalytic subunit 1.746
GTF2H5 general transcription factor IIH, polypeptide 5 1.743
ANKLE2 ankyrin repeat and LEM domain containing 2 1.738
PLPP7 phospholipid phosphatase 7 (inactive) 1.732
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 1.732
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa 1.729
CHEK2 checkpoint kinase 2 1.724
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 1.724
PLEC plectin 1.724
GPS1 G protein pathway suppressor 1 1.717
SIRT3 sirtuin 3 1.71
IL1B interleukin 1, beta 1.709
RAD52 RAD52 homolog (S. cerevisiae) 1.704
UBE2I ubiquitin-conjugating enzyme E2I 1.694
FDPS farnesyl diphosphate synthase 1.693
HDAC3 histone deacetylase 3 1.692
NFE2L2 nuclear factor, erythroid 2-like 2 1.69
PPARG peroxisome proliferator-activated receptor gamma 1.687
NUP50 nucleoporin 50kDa 1.678
TNF tumor necrosis factor 1.678
RECQL RecQ helicase-like 1.677
RUNX2 runt-related transcription factor 2 1.669
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.659
DNAH8 dynein, axonemal, heavy chain 8 1.657
NUP93 nucleoporin 93kDa 1.654
RAD51 RAD51 recombinase 1.653
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 1.652
ATG7 autophagy related 7 1.65
ATR ATR serine/threonine kinase 1.647
TOR1AIP1 torsin A interacting protein 1 1.642
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.642
PGGT1B protein geranylgeranyltransferase type I, beta subunit 1.641
MTX2 metaxin 2 1.634
SREBF1 sterol regulatory element binding transcription factor 1 1.633
GFAP glial fibrillary acidic protein 1.631
HDAC9 histone deacetylase 9 1.626
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2 1.623
DKC1 dyskeratosis congenita 1, dyskerin 1.623
FNTB farnesyltransferase, CAAX box, beta 1.62
ALB albumin 1.614
PINK1 PTEN induced putative kinase 1 1.611
CHMP7 charged multivesicular body protein 7 1.608
AKTIP AKT interacting protein 1.607
FOXO4 forkhead box O4 1.606
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 1.599
IL1A interleukin 1, alpha 1.597
PARP1 poly (ADP-ribose) polymerase 1 1.597
DNMT1 DNA (cytosine-5-)-methyltransferase 1 1.594
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 1.591
FGF2 fibroblast growth factor 2 (basic) 1.591
NUP88 nucleoporin 88kDa 1.59
XPO1 exportin 1 1.588
EHMT2 euchromatic histone-lysine N-methyltransferase 2 1.587
LIN28A lin-28 homolog A (C. elegans) 1.585
RBBP8 retinoblastoma binding protein 8 1.585
FBL fibrillarin 1.582
POLG polymerase (DNA directed), gamma 1.582
TAGLN transgelin 1.581
FOXO1 forkhead box O1 1.578
NUP35 nucleoporin 35kDa 1.575
VRK1 vaccinia related kinase 1 1.575
VCL vinculin 1.574
APP amyloid beta (A4) precursor protein 1.574
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.572
H2AZ1 H2A.Z variant histone 1 1.57
BMP4 bone morphogenetic protein 4 1.569
KAT8 K(lysine) acetyltransferase 8 1.567
SCGB1D4 secretoglobin, family 1D, member 4 1.567
TTN titin 1.564
SQSTM1 sequestosome 1 1.564
NUTF2 nuclear transport factor 2 1.564
GLYATL1 glycine-N-acyltransferase-like 1 1.557
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 1.556
BMP2 bone morphogenetic protein 2 1.553
CAVIN1 caveolae associated protein 1 1.553
BGLAP bone gamma-carboxyglutamate (gla) protein 1.543
OGG1 8-oxoguanine DNA glycosylase 1.541
CDK1 cyclin-dependent kinase 1 1.538
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 1.537
SOD1 superoxide dismutase 1, soluble 1.537
RANGAP1 Ran GTPase activating protein 1 1.537
GATA4 GATA binding protein 4 1.536
TPR translocated promoter region, nuclear basket protein 1.535
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 1.535
SRF serum response factor (c-fos serum response element-binding transcription factor) 1.535
POLI polymerase (DNA directed) iota 1.533
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 1.532
NUP98 nucleoporin 98kDa 1.532
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 1.531
PXDN peroxidasin 1.53
GDF11 growth differentiation factor 11 1.528
PXDNL peroxidasin-like 1.526
RCC1 regulator of chromosome condensation 1 1.526
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 1.524
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 1.522
FN1 fibronectin 1 1.52
SP7 Sp7 transcription factor 1.517
FEN1 flap structure-specific endonuclease 1 1.517
FOS FBJ murine osteosarcoma viral oncogene homolog 1.516
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.515
ULK1 unc-51 like autophagy activating kinase 1 1.514
COL1A1 collagen, type I, alpha 1 1.513
RHOA ras homolog family member A 1.512
TFAM transcription factor A, mitochondrial 1.509
EXO1 exonuclease 1 1.508
SOD2 superoxide dismutase 2, mitochondrial 1.507
HTT huntingtin 1.507
CCL2 chemokine (C-C motif) ligand 2 1.506
MAPK3 mitogen-activated protein kinase 3 1.505
TARDBP TAR DNA binding protein 1.496
DDB2 damage-specific DNA binding protein 2, 48kDa 1.495
EGF epidermal growth factor 1.494
LIG4 ligase IV, DNA, ATP-dependent 1.49
ACAN aggrecan 1.489
SETD2 SET domain containing 2 1.488
MYOD1 myogenic differentiation 1 1.485
CNN1 calponin 1, basic, smooth muscle 1.483
RANBP2 RAN binding protein 2 1.483
NDC1 NDC1 transmembrane nucleoporin 1.482
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.48
HSPA4 heat shock 70kDa protein 4 1.479
KAT5 K(lysine) acetyltransferase 5 1.478
EP300 E1A binding protein p300 1.477
SRSF5 serine/arginine-rich splicing factor 5 1.477
RHEB Ras homolog enriched in brain 1.476
LMO7 LIM domain 7 1.473
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 1.472
PECAM1 platelet/endothelial cell adhesion molecule 1 1.47
RTEL1 regulator of telomere elongation helicase 1 1.47
LEP leptin 1.469
RGPD2 RANBP2-like and GRIP domain containing 2 1.469
NAT8 N-acetyltransferase 8 (GCN5-related, putative) 1.466
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 1.466
MYOCD myocardin 1.465
HDAC2 histone deacetylase 2 1.465
PAX7 paired box 7 1.464
MAPT microtubule-associated protein tau 1.463
CXCL8 chemokine (C-X-C motif) ligand 8 1.462
KEAP1 kelch-like ECH-associated protein 1 1.46
ATG5 autophagy related 5 1.458
JUN jun proto-oncogene 1.455
DNA2 DNA replication helicase/nuclease 2 1.453
NUP160 nucleoporin 160kDa 1.451
MECP2 methyl CpG binding protein 2 1.45
SCN5A sodium channel, voltage gated, type V alpha subunit 1.45
BRD4 bromodomain containing 4 1.449
DOT1L DOT1-like histone H3K79 methyltransferase 1.445
GABARAPL1 GABA(A) receptor-associated protein like 1 1.445
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.445
FBN1 fibrillin 1 1.444
MYH11 myosin, heavy chain 11, smooth muscle 1.442
SRSF2 serine/arginine-rich splicing factor 2 1.441
RBM20 RNA binding motif protein 20 1.441
RPTOR regulatory associated protein of MTOR, complex 1 1.441
RECQL5 RecQ protein-like 5 1.44
XAB2 XPA binding protein 2 1.44
TOR1AIP2 torsin A interacting protein 2 1.439
SF1 splicing factor 1 1.439
MDC1 mediator of DNA-damage checkpoint 1 1.438
SPAG4 sperm associated antigen 4 1.437
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.437
HMGN5 high mobility group nucleosome binding domain 5 1.436
THUMPD1 THUMP domain containing 1 1.435
KDM6B lysine (K)-specific demethylase 6B 1.435
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 1.434
GADD45A growth arrest and DNA-damage-inducible, alpha 1.43
TNPO1 transportin 1 1.43
MRTFA myocardin related transcription factor A 1.429
WDR5 WD repeat domain 5 1.428
PRKN parkin RBR E3 ubiquitin protein ligase 1.427
NT5E 5'-nucleotidase, ecto (CD73) 1.427
GSK3B glycogen synthase kinase 3 beta 1.427
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.426
SRSF6 serine/arginine-rich splicing factor 6 1.424
CENPA centromere protein A 1.424
GCNA germ cell nuclear acidic peptidase 1.423
IGF1R insulin-like growth factor 1 receptor 1.422
BCL2 B-cell CLL/lymphoma 2 1.42
LDLR low density lipoprotein receptor 1.419
GLE1 GLE1 RNA export mediator 1.413
PSEN1 presenilin 1 1.41
GABARAPL2 GABA(A) receptor-associated protein-like 2 1.41
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.409
DDB1 damage-specific DNA binding protein 1, 127kDa 1.409
UVSSA UV-stimulated scaffold protein A 1.409
CD34 CD34 molecule 1.408
CTRL chymotrypsin-like 1.408
INSR insulin receptor 1.408
NUP155 nucleoporin 155kDa 1.407
FHOD1 formin homology 2 domain containing 1 1.406
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.403
TET1 tet methylcytosine dioxygenase 1 1.402
SMN1 survival of motor neuron 1, telomeric 1.401
CTC1 CTS telomere maintenance complex component 1 1.401
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 1.399
BDNF brain-derived neurotrophic factor 1.398
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.398
ASF1A anti-silencing function 1A histone chaperone 1.397
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 1.397
MMP3 matrix metallopeptidase 3 1.396
RAD23B RAD23 homolog B (S. cerevisiae) 1.395
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.395
MYH7 myosin, heavy chain 7, cardiac muscle, beta 1.392
KMT5C lysine methyltransferase 5C 1.391
MUS81 MUS81 structure-specific endonuclease subunit 1.388
NES nestin 1.383
THY1 Thy-1 cell surface antigen 1.383
KRAS Kirsten rat sarcoma viral oncogene homolog 1.383
PCSK9 proprotein convertase subtilisin/kexin type 9 1.382
MACROH2A1 macroH2A.1 histone 1.381
CDKN3 cyclin-dependent kinase inhibitor 3 1.38
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 1.378
NEUROG2 neurogenin 2 1.378
CENPF centromere protein F, 350/400kDa 1.374
BECN1 beclin 1, autophagy related 1.371
LGALS4 lectin, galactoside-binding, soluble, 4 1.37
APTX aprataxin 1.369
PCNT pericentrin 1.369
KDM1A lysine (K)-specific demethylase 1A 1.368
PTPRC protein tyrosine phosphatase, receptor type, C 1.368
MEOX2 mesenchyme homeobox 2 1.367
PTEN phosphatase and tensin homolog 1.364
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.363
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 1.362
CYCS cytochrome c, somatic 1.36
CHD3 chromodomain helicase DNA binding protein 3 1.36
TFEB transcription factor EB 1.358
VCAM1 vascular cell adhesion molecule 1 1.358
SMN2 survival of motor neuron 2, centromeric 1.358
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 1.357
MSTN myostatin 1.356
CDH5 cadherin 5, type 2 (vascular endothelium) 1.356
CDK4 cyclin-dependent kinase 4 1.35
FNTA farnesyltransferase, CAAX box, alpha 1.348
HRAS Harvey rat sarcoma viral oncogene homolog 1.345
CTCFL CCCTC-binding factor (zinc finger protein)-like 1.345
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 1.344
DICER1 dicer 1, ribonuclease type III 1.343
SPP1 secreted phosphoprotein 1 1.343
LEF1 lymphoid enhancer-binding factor 1 1.34
GADD45B growth arrest and DNA-damage-inducible, beta 1.339
NEIL1 nei endonuclease VIII-like 1 (E. coli) 1.339
SIRT4 sirtuin 4 1.338
NAMPT nicotinamide phosphoribosyltransferase 1.338
NUP205 nucleoporin 205kDa 1.337
HES5 hes family bHLH transcription factor 5 1.335
E2F1 E2F transcription factor 1 1.334
NUCLEOLIN nucleolin multifunctional protein 1.333
HMOX1 heme oxygenase 1 1.333
ENG endoglin 1.332
CDK2 cyclin-dependent kinase 2 1.331
BCL2L1 BCL2-like 1 1.329
CD8A CD8a molecule 1.329
ADIPOQ adiponectin, C1Q and collagen domain containing 1.326
CDC42 cell division cycle 42 1.324
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.323
HBB hemoglobin, beta 1.322
CENPE centromere protein E, 312kDa 1.32
NHEJ1 nonhomologous end-joining factor 1 1.318
ACTA2 actin, alpha 2, smooth muscle, aorta 1.318
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) 1.318
KDM6A lysine (K)-specific demethylase 6A 1.317
STAT1 signal transducer and activator of transcription 1, 91kDa 1.317
HSPG2 heparan sulfate proteoglycan 2 1.316
DNASE2 deoxyribonuclease II, lysosomal 1.316
TOP1 topoisomerase (DNA) I 1.313
PRELP proline/arginine-rich end leucine-rich repeat protein 1.313
SLX4 SLX4 structure-specific endonuclease subunit 1.312
COMMD3-BMI1 COMMD3-BMI1 readthrough 1.312
ZBTB7B zinc finger and BTB domain containing 7B 1.311
ISL1 ISL LIM homeobox 1 1.31
RBL2 retinoblastoma-like 2 1.308
BMI1 BMI1 proto-oncogene, polycomb ring finger 1.307
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.307
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 1.304
MDFIC MyoD family inhibitor domain containing 1.304
CD4 CD4 molecule 1.303
TET2 tet methylcytosine dioxygenase 2 1.301
RB1 retinoblastoma 1 1.301
UNG uracil-DNA glycosylase 1.299
MGP matrix Gla protein 1.299
SNW1 SNW domain containing 1 1.297
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.297
BRIP1 BRCA1 interacting protein C-terminal helicase 1 1.296
ATRX alpha thalassemia/mental retardation syndrome X-linked 1.296
ICAM1 intercellular adhesion molecule 1 1.295
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 1.292
LAMP2 lysosomal-associated membrane protein 2 1.29
RNF8 ring finger protein 8, E3 ubiquitin protein ligase 1.29
C9ORF72 chromosome 9 open reading frame 72 1.289
SRSF3 serine/arginine-rich splicing factor 3 1.288
FGF21 fibroblast growth factor 21 1.287
LPAR3 lysophosphatidic acid receptor 3 1.286
IRF3 interferon regulatory factor 3 1.286
TNNT2 troponin T type 2 (cardiac) 1.284
NUP210 nucleoporin 210kDa 1.283
TBK1 TANK-binding kinase 1 1.281
TOR1A torsin family 1, member A (torsin A) 1.281
ETV2 ets variant 2 1.279
SUMO1 small ubiquitin-like modifier 1 1.277
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 1.276
GJA1 gap junction protein, alpha 1, 43kDa 1.275
CHD4 chromodomain helicase DNA binding protein 4 1.274
FOXM1 forkhead box M1 1.273
GGPS1 geranylgeranyl diphosphate synthase 1 1.272
MMP13 matrix metallopeptidase 13 1.27
LOX lysyl oxidase 1.268
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 1.266
IGFBP3 insulin-like growth factor binding protein 3 1.265
ERCC5 excision repair cross-complementation group 5 1.265
NOS3 nitric oxide synthase 3 (endothelial cell) 1.264
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) 1.263
SIRT5 sirtuin 5 1.262
FUS FUS RNA binding protein 1.262
TLN2 talin 2 1.262
CRYBG1 crystallin beta-gamma domain containing 1 1.261
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 1.261
NRM nurim (nuclear envelope membrane protein) 1.26
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.26
CAV1 caveolin 1, caveolae protein, 22kDa 1.26
TOPBP1 topoisomerase (DNA) II binding protein 1 1.259
TXN thioredoxin 1.255
CD44 CD44 molecule (Indian blood group) 1.254
RPS6 ribosomal protein S6 1.251
FLNC filamin C, gamma 1.251
RETREG1 reticulophagy regulator 1 1.251
WIPI1 WD repeat domain, phosphoinositide interacting 1 1.245
ANKLE1 ankyrin repeat and LEM domain containing 1 1.245
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 1.242
BIVM-ERCC5 BIVM-ERCC5 readthrough 1.242
COL3A1 collagen, type III, alpha 1 1.241
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 1.239
TCHP trichoplein, keratin filament binding 1.238
BRAF B-Raf proto-oncogene, serine/threonine kinase 1.238
PLIN1 perilipin 1 1.236
AHSG alpha-2-HS-glycoprotein 1.236
BRCA2 breast cancer 2, early onset 1.235
MYBPC3 myosin binding protein C, cardiac 1.234
SHH sonic hedgehog 1.233
SMC5 structural maintenance of chromosomes 5 1.232
SMAD3 SMAD family member 3 1.228
HPRT1 hypoxanthine phosphoribosyltransferase 1 1.228
NOP10 NOP10 ribonucleoprotein 1.228
TLN1 talin 1 1.228
EGR1 early growth response 1 1.225
TDP1 tyrosyl-DNA phosphodiesterase 1 1.224
FOXA2 forkhead box A2 1.222
CTSL cathepsin L 1.222
CDA cytidine deaminase 1.222
TH tyrosine hydroxylase 1.221
VCP valosin containing protein 1.221
PIWIL1 piwi-like RNA-mediated gene silencing 1 1.221
IGFBP7 insulin-like growth factor binding protein 7 1.22
IRS1 insulin receptor substrate 1 1.219
ASCL1 achaete-scute family bHLH transcription factor 1 1.218
CIDEC cell death-inducing DFFA-like effector c 1.215
STN1 STN1 subunit of CST complex 1.212
IFNB1 interferon, beta 1, fibroblast 1.211
MYT1L myelin transcription factor 1-like 1.209
KAT7 K(lysine) acetyltransferase 7 1.209
FGF23 fibroblast growth factor 23 1.209
IGFBP5 insulin-like growth factor binding protein 5 1.209
RICTOR RPTOR independent companion of MTOR, complex 2 1.208
SH2D1B SH2 domain containing 1B 1.208
H2BC1 H2B clustered histone 1 1.207
RNF4 ring finger protein 4 1.206
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.206
CUL4A cullin 4A 1.205
YY1 YY1 transcription factor 1.202
RHOB ras homolog family member B 1.202
CANX calnexin 1.202
FANCD2 Fanconi anemia, complementation group D2 1.201
CFL1 cofilin 1 (non-muscle) 1.201
AKT2 v-akt murine thymoma viral oncogene homolog 2 1.2
IL10 interleukin 10 1.198
NUP214 nucleoporin 214kDa 1.197
H2BC3 H2B clustered histone 3 1.195
CCND1 cyclin D1 1.194
PLK1 polo-like kinase 1 1.194
TEK TEK tyrosine kinase, endothelial 1.193
ING3 inhibitor of growth family, member 3 1.192
H2BW1 H2B.W histone 1 1.188
PSEN2 presenilin 2 1.187
FGF13 fibroblast growth factor 13 1.187
H2BW2 H2B.W histone 2 1.187
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 1.186
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 1.186
ERF Ets2 repressor factor 1.184
MEF2C myocyte enhancer factor 2C 1.181
H2BC13 H2B clustered histone 13 1.179
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.178
PRPS1 phosphoribosyl pyrophosphate synthetase 1 1.178
DSP desmoplakin 1.178
H2BC18 H2B clustered histone 18 1.178
SOX9 SRY (sex determining region Y)-box 9 1.177
H2BC14 H2B clustered histone 14 1.177
IFNG interferon, gamma 1.177
H2BC17 H2B clustered histone 17 1.176
JAK1 Janus kinase 1 1.176
H2BC12 H2B clustered histone 12 1.175
HNF4A hepatocyte nuclear factor 4, alpha 1.175
SUN5 Sad1 and UNC84 domain containing 5 1.174
LIG1 ligase I, DNA, ATP-dependent 1.174
MCAT malonyl CoA:ACP acyltransferase (mitochondrial) 1.173
TGFB2 transforming growth factor, beta 2 1.171
KDM4A lysine (K)-specific demethylase 4A 1.171
BACE1 beta-site APP-cleaving enzyme 1 1.17
FGF8 fibroblast growth factor 8 (androgen-induced) 1.169
BAG3 BCL2-associated athanogene 3 1.169
CREB1 cAMP responsive element binding protein 1 1.168
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 1.167
PIWIL4 piwi-like RNA-mediated gene silencing 4 1.166
H2BC9 H2B clustered histone 9 1.166
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 1.165
PCYT1A phosphate cytidylyltransferase 1, choline, alpha 1.164
MMP9 matrix metallopeptidase 9 1.164
RASA1 RAS p21 protein activator (GTPase activating protein) 1 1.164
H2BC11 H2B clustered histone 11 1.164
GABARAP GABA(A) receptor-associated protein 1.163
RPA2 replication protein A2, 32kDa 1.162
MFN2 mitofusin 2 1.162
H2BC15 H2B clustered histone 15 1.161
TM7SF2 transmembrane 7 superfamily member 2 1.16
TXNRD1 thioredoxin reductase 1 1.159
CKM creatine kinase, muscle 1.158
FGF10 fibroblast growth factor 10 1.156
TBP TATA box binding protein 1.154
FGF4 fibroblast growth factor 4 1.152
PPARGC1B peroxisome proliferator-activated receptor gamma, coactivator 1 beta 1.151
MAPK14 mitogen-activated protein kinase 14 1.151
RAD18 RAD18 E3 ubiquitin protein ligase 1.151
TRIM28 tripartite motif containing 28 1.148
FGF17 fibroblast growth factor 17 1.148
PKP2 plakophilin 2 1.147
MYH1 myosin, heavy chain 1, skeletal muscle, adult 1.146
SAMHD1 SAM domain and HD domain 1 1.146
CCN2 cellular communication network factor 2 1.144
SPO11 SPO11 meiotic protein covalently bound to DSB 1.144
SEH1L SEH1-like (S. cerevisiae) 1.144
KLF2 Kruppel-like factor 2 1.144
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.144
HSPA8 heat shock 70kDa protein 8 1.144
SEC62 SEC62 homolog (S. cerevisiae) 1.143
FGF7 fibroblast growth factor 7 1.139
HSPA9 heat shock 70kDa protein 9 (mortalin) 1.138
H2BC4 H2B clustered histone 4 1.136
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.136
RAD9A RAD9 homolog A (S. pombe) 1.135
SMTN smoothelin 1.135
LMX1A LIM homeobox transcription factor 1, alpha 1.134
CELF1 CUGBP, Elav-like family member 1 1.133
DIAPH3 diaphanous-related formin 3 1.133
FANCI Fanconi anemia, complementation group I 1.133
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.132
XBP1 X-box binding protein 1 1.132
AURKB aurora kinase B 1.132
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 1.131
SETDB1 SET domain, bifurcated 1 1.13
FGF22 fibroblast growth factor 22 1.129
NOLC1 nucleolar and coiled-body phosphoprotein 1 1.129
TMEM120A transmembrane protein 120A 1.128
BCL2L2 BCL2-like 2 1.126
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 1.126
KRT5 keratin 5, type II 1.126
PLA2R1 phospholipase A2 receptor 1, 180kDa 1.125
RYR2 ryanodine receptor 2 (cardiac) 1.125
SETD1A SET domain containing 1A 1.125
RBX1 ring-box 1, E3 ubiquitin protein ligase 1.121
TMEM38A transmembrane protein 38A 1.121
IGF2 insulin-like growth factor 2 1.12
SMAD2 SMAD family member 2 1.12
CCNA2 cyclin A2 1.119
CUL3 cullin 3 1.118
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 1.118
FGF5 fibroblast growth factor 5 1.117
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 1.117
MPLKIP M-phase specific PLK1 interacting protein 1.116
KPNA6 karyopherin alpha 6 (importin alpha 7) 1.116
TRA2B transformer 2 beta homolog (Drosophila) 1.115
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.115
H2BC5 H2B clustered histone 5 1.115
MYOG myogenin (myogenic factor 4) 1.114
FGF20 fibroblast growth factor 20 1.114
STK11 serine/threonine kinase 11 1.113
NQO1 NAD(P)H dehydrogenase, quinone 1 1.113
WRAP53 WD repeat containing, antisense to TP53 1.113
GCLC glutamate-cysteine ligase, catalytic subunit 1.11
CDK6 cyclin-dependent kinase 6 1.11
FGF18 fibroblast growth factor 18 1.109
CNBP CCHC-type zinc finger, nucleic acid binding protein 1.109
RABIF RAB interacting factor 1.109
ING2 inhibitor of growth family, member 2 1.109
PAX6 paired box 6 1.108
ATF3 activating transcription factor 3 1.108
NUP85 nucleoporin 85kDa 1.108
MORC2 MORC family CW-type zinc finger 2 1.107
TSC2 tuberous sclerosis 2 1.106
TCEA3 transcription elongation factor A (SII), 3 1.105
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.105
SATB1 SATB homeobox 1 1.104
RABGGTB Rab geranylgeranyltransferase, beta subunit 1.104
SLCO6A1 solute carrier organic anion transporter family, member 6A1 1.101
PGD phosphogluconate dehydrogenase 1.099
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.099
ATRIP ATR interacting protein 1.099
FGF6 fibroblast growth factor 6 1.098
FANCA Fanconi anemia, complementation group A 1.098
TLE7 TLE family member 7 1.097
NEUROD1 neuronal differentiation 1 1.097
CDC6 cell division cycle 6 1.096
EGFR epidermal growth factor receptor 1.095
WNT3A wingless-type MMTV integration site family, member 3A 1.095
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 1.095
FGF3 fibroblast growth factor 3 1.094
TWIST2 twist family bHLH transcription factor 2 1.094
POTEF POTE ankyrin domain family, member F 1.093
CKB creatine kinase, brain 1.092
GTF2H2 general transcription factor IIH, polypeptide 2, 44kDa 1.092
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 1.091
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.09
GPX7 glutathione peroxidase 7 1.09
FGF16 fibroblast growth factor 16 1.09
DAXX death-domain associated protein 1.088
GDNF glial cell derived neurotrophic factor 1.087
NIPBL Nipped-B homolog (Drosophila) 1.086
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.085
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 1.084
FLNA filamin A, alpha 1.083
MLIP muscular LMNA-interacting protein 1.082
NOTCH1 notch 1 1.082
FGF9 fibroblast growth factor 9 1.081
FKBP1A FK506 binding protein 1A, 12kDa 1.078
SUZ12 SUZ12 polycomb repressive complex 2 subunit 1.078
SMAD4 SMAD family member 4 1.078
PXN paxillin 1.077
RPA1 replication protein A1, 70kDa 1.075
LRRK2 leucine-rich repeat kinase 2 1.075
FABP4 fatty acid binding protein 4, adipocyte 1.074
FMR1 fragile X mental retardation 1 1.073
GPX2 glutathione peroxidase 2 1.072
MBNL1 muscleblind-like splicing regulator 1 1.072
COL1A2 collagen, type I, alpha 2 1.071
TAPT1 transmembrane anterior posterior transformation 1 1.071
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.07
CDT1 chromatin licensing and DNA replication factor 1 1.07
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.069
CKMT1B creatine kinase, mitochondrial 1B 1.069
PAX3 paired box 3 1.069
LHX3 LIM homeobox 3 1.069
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) 1.069
MAPK8 mitogen-activated protein kinase 8 1.068
MYF5 myogenic factor 5 1.067
KRTAP10-7 keratin associated protein 10-7 1.067
NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 1.067
IPO9 importin 9 1.064
POU3F2 POU class 3 homeobox 2 1.064
NUP188 nucleoporin 188kDa 1.063
NHP2 NHP2 ribonucleoprotein 1.06
FANCM Fanconi anemia, complementation group M 1.06
ATF6 activating transcription factor 6 1.057
MMP1 matrix metallopeptidase 1 1.057
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) 1.056
PRDM16 PR domain containing 16 1.056
CTSK cathepsin K 1.055
UBTF upstream binding transcription factor, RNA polymerase I 1.055
OPA1 optic atrophy 1 (autosomal dominant) 1.054
MYB v-myb avian myeloblastosis viral oncogene homolog 1.054
FHL1 four and a half LIM domains 1 1.053
RPL32 ribosomal protein L32 1.053
EME1 essential meiotic structure-specific endonuclease 1 1.052
GSR glutathione reductase 1.052
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 1.051
CNEP1R1 CTD nuclear envelope phosphatase 1 regulatory subunit 1 1.051
RNF123 ring finger protein 123 1.048
TCEA2 transcription elongation factor A (SII), 2 1.048
KPNA7 karyopherin alpha 7 (importin alpha 8) 1.047
GDF15 growth differentiation factor 15 1.047
CDH17 cadherin 17, LI cadherin (liver-intestine) 1.047
EDARADD EDAR-associated death domain 1.046
ESR1 estrogen receptor 1 1.045
CLOCK clock circadian regulator 1.045
ATG3 autophagy related 3 1.044
KMT5B lysine methyltransferase 5B 1.044
SUMO2 small ubiquitin-like modifier 2 1.044
GCLM glutamate-cysteine ligase, modifier subunit 1.043
NFE2 nuclear factor, erythroid 2 1.043
CFL2 cofilin 2 (muscle) 1.041
TCEA1 transcription elongation factor A (SII), 1 1.04
ATF4 activating transcription factor 4 1.038
IER3 immediate early response 3 1.038
NEIL2 nei endonuclease VIII-like 2 (E. coli) 1.037
LPIN1 lipin 1 1.037
GPX3 glutathione peroxidase 3 1.036
CLCN1 chloride channel, voltage-sensitive 1 1.036
KDM5A lysine (K)-specific demethylase 5A 1.035
BAX BCL2-associated X protein 1.034
DSG2 desmoglein 2 1.033
MAP2K1 mitogen-activated protein kinase kinase 1 1.031
EIF4E eukaryotic translation initiation factor 4E 1.031
FAM111B family with sequence similarity 111, member B 1.031
CAND1 cullin-associated and neddylation-dissociated 1 1.03
RFC2 replication factor C (activator 1) 2, 40kDa 1.03
HMGB2 high mobility group box 2 1.03
GPX5 glutathione peroxidase 5 1.029
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 1.028
NCOR1 nuclear receptor corepressor 1 1.028
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.027
MYL2 myosin, light chain 2, regulatory, cardiac, slow 1.026
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 1.026
PYCR1 pyrroline-5-carboxylate reductase 1 1.025
RING1 ring finger protein 1 1.025
BGN biglycan 1.025
XPO6 exportin 6 1.025
RHO rhodopsin 1.025
PPARA peroxisome proliferator-activated receptor alpha 1.025
RNF2 ring finger protein 2 1.024
NRF1 nuclear respiratory factor 1 1.023
OLIG2 oligodendrocyte lineage transcription factor 2 1.022
KMT5A lysine methyltransferase 5A 1.022
CHML choroideremia-like (Rab escort protein 2) 1.022
GPX6 glutathione peroxidase 6 1.021
ATG13 autophagy related 13 1.021
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 1.02
HDAC6 histone deacetylase 6 1.02
COIL coilin 1.019
GPX8 glutathione peroxidase 8 (putative) 1.019
CCNA1 cyclin A1 1.018
PARK7 parkinson protein 7 1.017
CCNB1 cyclin B1 1.016
LIG3 ligase III, DNA, ATP-dependent 1.015
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 1.015
BUB3 BUB3 mitotic checkpoint protein 1.015
PRDX1 peroxiredoxin 1 1.014
PCGF2 polycomb group ring finger 2 1.013
CDON cell adhesion associated, oncogene regulated 1.013
WDFY3 WD repeat and FYVE domain containing 3 1.013
LOXL4 lysyl oxidase-like 4 1.013
HUS1 HUS1 checkpoint homolog (S. pombe) 1.011
CALR calreticulin 1.01
EDN3 endothelin 3 1.01
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 1.01
CAMK2D calcium/calmodulin-dependent protein kinase II delta 1.009
POLR1C polymerase (RNA) I polypeptide C, 30kDa 1.009
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 1.008
EIF2AK4 eukaryotic translation initiation factor 2 alpha kinase 4 1.008
ATG12 autophagy related 12 1.008
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 1.005
POLL polymerase (DNA directed), lambda 1.005
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 1.004
MSX2 msh homeobox 2 1.003
COL2A1 collagen, type II, alpha 1 1.003
DDIT4 DNA-damage-inducible transcript 4 1.002
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 1.001
SP6 Sp6 transcription factor 1.001
ATG9A autophagy related 9A 1.001