Progesterone-mediated oocyte maturation Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP. (Kyoto Encyclopedia of Genes and Genomes, hsa04914)
External Link https://www.kegg.jp/entry/hsa04914
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Genes

108 proteins participating in the Progesterone-mediated oocyte maturation pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
ADCY2 adenylate cyclase 2 (brain)
ADCY4 adenylate cyclase 4
ADCY5 adenylate cyclase 5
ADCY6 adenylate cyclase 6
ADCY7 adenylate cyclase 7
ADCY8 adenylate cyclase 8 (brain)
ADCY9 adenylate cyclase 9
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ANAPC1 anaphase promoting complex subunit 1
ANAPC10 anaphase promoting complex subunit 10
ANAPC11 anaphase promoting complex subunit 11
ANAPC13 anaphase promoting complex subunit 13
ANAPC15 anaphase promoting complex subunit 15
ANAPC16 anaphase promoting complex subunit 16
ANAPC2 anaphase promoting complex subunit 2
ANAPC4 anaphase promoting complex subunit 4
ANAPC5 anaphase promoting complex subunit 5
ANAPC7 anaphase promoting complex subunit 7
ARAF A-Raf proto-oncogene, serine/threonine kinase
AURKA aurora kinase A
BRAF B-Raf proto-oncogene, serine/threonine kinase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA1 cyclin A1
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCNB3 cyclin B3
CDC16 cell division cycle 16
CDC23 cell division cycle 23
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC25C cell division cycle 25C
CDC26 cell division cycle 26
CDC27 cell division cycle 27
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CLSTN1 calsyntenin 1
CPEB1 cytoplasmic polyadenylation element binding protein 1
CPEB2 cytoplasmic polyadenylation element binding protein 2
CPEB3 cytoplasmic polyadenylation element binding protein 3
CPEB4 cytoplasmic polyadenylation element binding protein 4
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
INS insulin
KIF22 kinesin family member 22
LNCEGFL7OS lncRNA EGFL7 opposite strand
LNCOG lncRNA osteogenesis associated
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast)
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK11 mitogen-activated protein kinase 11
MAPK12 mitogen-activated protein kinase 12
MAPK13 mitogen-activated protein kinase 13
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MOCOS molybdenum cofactor sulfurase
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PDE3B phosphodiesterase 3B, cGMP-inhibited
PGR progesterone receptor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PLK1 polo-like kinase 1
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKACG protein kinase, cAMP-dependent, catalytic, gamma
PRKCA protein kinase C, alpha
RNASE3 ribonuclease, RNase A family, 3
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SPDYA speedy/RINGO cell cycle regulator family member A
SPDYC speedy/RINGO cell cycle regulator family member C
SPDYE1 speedy/RINGO cell cycle regulator family member E1
SPDYE10 speedy/RINGO cell cycle regulator family member E10
SPDYE11 speedy/RINGO cell cycle regulator family member E11
SPDYE12 speedy/RINGO cell cycle regulator family member E12
SPDYE13 speedy/RINGO cell cycle regulator family member E13
SPDYE14 speedy/RINGO cell cycle regulator family member E14
SPDYE16 speedy/RINGO cell cycle regulator family member E16
SPDYE17 speedy/RINGO cell cycle regulator family member E17
SPDYE18 speedy/RINGO cell cycle regulator family member E18
SPDYE2 speedy/RINGO cell cycle regulator family member E2
SPDYE21 speedy/RINGO cell cycle regulator family member E21
SPDYE2B speedy/RINGO cell cycle regulator family member E2B
SPDYE3 speedy/RINGO cell cycle regulator family member E3
SPDYE4 speedy/RINGO cell cycle regulator family member E4
SPDYE5 speedy/RINGO cell cycle regulator family member E5
SPDYE6 speedy/RINGO cell cycle regulator family member E6
SPDYE8 speedy/RINGO cell cycle regulator family member E8
STK10 serine/threonine kinase 10