| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species. (Chemical Entities of Biological Interest Ontology, CHEBI_17026) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5994 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Progesterone relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RGN | regucalcin | 2.65 |
| PCLO | piccolo presynaptic cytomatrix protein | 1.68 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 1.26 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.94 |
| SQLE | squalene epoxidase | 0.74 |
| INPP5J | inositol polyphosphate-5-phosphatase J | 0.69 |
| PTMA | prothymosin, alpha | 0.59 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.58 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.58 |
| COQ4 | coenzyme Q4 | 0.58 |
| ENO1 | enolase 1, (alpha) | 0.57 |
| DNAH8 | dynein, axonemal, heavy chain 8 | 0.57 |
| RWDD1 | RWD domain containing 1 | 0.53 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 0.51 |
| PRDM16 | PR domain containing 16 | 0.5 |
| SLC38A2 | solute carrier family 38, member 2 | 0.5 |
| MT-ATP6 | ATP synthase F0 subunit 6 | 0.49 |
| CD63 | CD63 molecule | 0.48 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 0.48 |
| ZNF696 | zinc finger protein 696 | 0.47 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 0.46 |
| NOTCH3 | notch 3 | 0.44 |
| PAIP2 | poly(A) binding protein interacting protein 2 | 0.44 |
| TPM4 | tropomyosin 4 | 0.43 |
| APOB | apolipoprotein B | 0.43 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.43 |
| MSMO1 | methylsterol monooxygenase 1 | 0.42 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.42 |
| NOVA1 | neuro-oncological ventral antigen 1 | 0.41 |
| RNF145 | ring finger protein 145 | 0.4 |
| DHCR24 | 24-dehydrocholesterol reductase | 0.4 |
| PTMS | parathymosin | 0.4 |
| CLNS1A | chloride channel, nucleotide-sensitive, 1A | 0.4 |
| E2F8 | E2F transcription factor 8 | 0.39 |
| DHCR7 | 7-dehydrocholesterol reductase | 0.37 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.37 |
| NDFIP1 | Nedd4 family interacting protein 1 | 0.37 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.36 |
| OSGIN2 | oxidative stress induced growth inhibitor family member 2 | 0.35 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.35 |
| RGP1 | RGP1 retrograde golgi transport homolog (S. cerevisiae) | 0.34 |
| COQ5 | coenzyme Q5 homolog, methyltransferase (S. cerevisiae) | 0.34 |
| LPIN1 | lipin 1 | 0.33 |
| CELSR2 | cadherin, EGF LAG seven-pass G-type receptor 2 | 0.33 |
| SATB1 | SATB homeobox 1 | 0.33 |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 0.33 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.33 |
| CCDC15 | coiled-coil domain containing 15 | 0.32 |
| LMBRD1 | LMBR1 domain containing 1 | 0.32 |
| HOXB4 | homeobox B4 | 0.32 |
| RCN2 | reticulocalbin 2, EF-hand calcium binding domain | 0.32 |
| SP110 | SP110 nuclear body protein | 0.32 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.31 |
| TCEA3 | transcription elongation factor A (SII), 3 | 0.31 |
| HIST2H3A | histone cluster 2, H3a | 0.31 |
| PAH | phenylalanine hydroxylase | 0.31 |
| HPCAL4 | hippocalcin like 4 | 0.31 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.31 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | 0.31 |
| MVK | mevalonate kinase | 0.3 |
| GAS8 | growth arrest-specific 8 | 0.3 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | 0.3 |
| LDLR | low density lipoprotein receptor | 0.3 |
| UQCRH | ubiquinol-cytochrome c reductase hinge protein | 0.3 |
| DNAH9 | dynein, axonemal, heavy chain 9 | 0.29 |
| PLAUR | plasminogen activator, urokinase receptor | 0.29 |
| GMCL2 | germ cell-less 2, spermatogenesis associated | 0.29 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.29 |
| ZNF449 | zinc finger protein 449 | 0.28 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | 0.28 |
| PMPCA | peptidase (mitochondrial processing) alpha | 0.28 |
| LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 0.27 |
| MVD | mevalonate (diphospho) decarboxylase | 0.27 |
| SIMC1 | SUMO-interacting motifs containing 1 | 0.27 |
| RNF26 | ring finger protein 26 | 0.26 |
| LAMA2 | laminin, alpha 2 | 0.26 |
| SLC25A29 | solute carrier family 25 (mitochondrial carnitine/acylcarnitine carrier), member 29 | 0.26 |
| EPDR1 | ependymin related 1 | 0.26 |
| HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7 | 0.26 |
| GXYLT1 | glucoside xylosyltransferase 1 | 0.26 |
| MIPOL1 | mirror-image polydactyly 1 | 0.26 |
| PLPP2 | phospholipid phosphatase 2 | 0.26 |
| GKAP1 | G kinase anchoring protein 1 | 0.26 |
| PTBP1 | polypyrimidine tract binding protein 1 | 0.25 |
| TMCC1 | transmembrane and coiled-coil domain family 1 | 0.25 |
| COQ6 | coenzyme Q6 monooxygenase | 0.25 |
| HDAC5 | histone deacetylase 5 | 0.25 |
| BID | BH3 interacting domain death agonist | 0.25 |
| ZNF584 | zinc finger protein 584 | 0.24 |
| VCAN | versican | 0.24 |
| ADCK5 | aarF domain containing kinase 5 | 0.24 |
| ZNF146 | zinc finger protein 146 | 0.24 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.24 |
| SC5D | sterol-C5-desaturase | 0.24 |
| KLHL15 | kelch-like family member 15 | 0.24 |
| TMEM135 | transmembrane protein 135 | 0.24 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.23 |
| C15ORF61 | chromosome 15 open reading frame 61 | 0.23 |
| CLCN3 | chloride channel, voltage-sensitive 3 | 0.23 |
| ARNTL | aryl hydrocarbon receptor nuclear translocator-like | 0.23 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DIPK1B | divergent protein kinase domain 1B | -2.33 |
| ZNF446 | zinc finger protein 446 | -0.97 |
| EID2 | EP300 interacting inhibitor of differentiation 2 | -0.79 |
| IER2 | immediate early response 2 | -0.79 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.74 |
| NUDT12 | nudix (nucleoside diphosphate linked moiety X)-type motif 12 | -0.72 |
| SLC41A3 | solute carrier family 41, member 3 | -0.68 |
| KLK6 | kallikrein-related peptidase 6 | -0.64 |
| CNNM1 | cyclin and CBS domain divalent metal cation transport mediator 1 | -0.61 |
| TBC1D16 | TBC1 domain family, member 16 | -0.61 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -0.57 |
| FXN | frataxin | -0.54 |
| ITGB2 | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | -0.52 |
| DNM1L | dynamin 1-like | -0.51 |
| CALD1 | caldesmon 1 | -0.51 |
| IL10RB | interleukin 10 receptor, beta | -0.5 |
| ODC1 | ornithine decarboxylase 1 | -0.5 |
| ZNF564 | zinc finger protein 564 | -0.48 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | -0.47 |
| RNASEH2C | ribonuclease H2, subunit C | -0.45 |
| SAYSD1 | SAYSVFN motif domain containing 1 | -0.45 |
| ANKRD18B | ankyrin repeat domain 18B | -0.45 |
| LZTR1 | leucine-zipper-like transcription regulator 1 | -0.44 |
| GRAMD2B | GRAM domain containing 2B | -0.44 |
| IFFO2 | intermediate filament family orphan 2 | -0.44 |
| MRAS | muscle RAS oncogene homolog | -0.43 |
| ARG2 | arginase 2 | -0.43 |
| ZNF227 | zinc finger protein 227 | -0.41 |
| S100A5 | S100 calcium binding protein A5 | -0.41 |
| POLE4 | polymerase (DNA-directed), epsilon 4, accessory subunit | -0.41 |
| ZRSR2 | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 | -0.4 |
| RCAN3 | RCAN family member 3 | -0.4 |
| SLC43A2 | solute carrier family 43 (amino acid system L transporter), member 2 | -0.4 |
| ADIPOR1 | adiponectin receptor 1 | -0.4 |
| GBA | glucosidase, beta, acid | -0.39 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | -0.38 |
| CREG1 | cellular repressor of E1A-stimulated genes 1 | -0.37 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.36 |
| KCTD18 | potassium channel tetramerization domain containing 18 | -0.36 |
| PPP1R14C | protein phosphatase 1, regulatory (inhibitor) subunit 14C | -0.36 |
| LGALSL | lectin, galactoside-binding-like | -0.36 |
| JPT1 | Jupiter microtubule associated homolog 1 | -0.36 |
| CERK | ceramide kinase | -0.36 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.36 |
| ATL1 | atlastin GTPase 1 | -0.36 |
| ZNF700 | zinc finger protein 700 | -0.35 |
| UPP1 | uridine phosphorylase 1 | -0.35 |
| NAGS | N-acetylglutamate synthase | -0.35 |
| MRFAP1 | Morf4 family associated protein 1 | -0.35 |
| TMEM179B | transmembrane protein 179B | -0.35 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.35 |
| TRIB3 | tribbles pseudokinase 3 | -0.35 |
| KLC1 | kinesin light chain 1 | -0.34 |
| HTATIP2 | HIV-1 Tat interactive protein 2, 30kDa | -0.33 |
| ACTN4 | actinin, alpha 4 | -0.33 |
| RABEP2 | rabaptin, RAB GTPase binding effector protein 2 | -0.33 |
| DOLK | dolichol kinase | -0.33 |
| ABHD2 | abhydrolase domain containing 2 | -0.33 |
| AFG1L | AFG1 like ATPase | -0.32 |
| TBRG1 | transforming growth factor beta regulator 1 | -0.32 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | -0.32 |
| BRK1 | BRICK1, SCAR/WAVE actin-nucleating complex subunit | -0.32 |
| SELENOF | selenoprotein F | -0.32 |
| AADAT | aminoadipate aminotransferase | -0.32 |
| SOX12 | SRY (sex determining region Y)-box 12 | -0.31 |
| MAGEA2 | melanoma antigen family A2 | -0.31 |
| CETN1 | centrin, EF-hand protein, 1 | -0.3 |
| CCNQ | cyclin Q | -0.3 |
| ZNF580 | zinc finger protein 580 | -0.3 |
| MFAP3 | microfibrillar-associated protein 3 | -0.3 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.3 |
| FLYWCH1 | FLYWCH-type zinc finger 1 | -0.3 |
| DOHH | deoxyhypusine hydroxylase/monooxygenase | -0.3 |
| PRKD3 | protein kinase D3 | -0.3 |
| MCEE | methylmalonyl CoA epimerase | -0.3 |
| TCTN1 | tectonic family member 1 | -0.29 |
| HECW1 | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 | -0.29 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.29 |
| TIPIN | TIMELESS interacting protein | -0.29 |
| TOLLIP | toll interacting protein | -0.29 |
| BTBD11 | BTB (POZ) domain containing 11 | -0.29 |
| CCDC57 | coiled-coil domain containing 57 | -0.29 |
| CLCN2 | chloride channel, voltage-sensitive 2 | -0.29 |
| LDHD | lactate dehydrogenase D | -0.29 |
| DBNL | drebrin-like | -0.28 |
| ATP8B2 | ATPase, aminophospholipid transporter, class I, type 8B, member 2 | -0.28 |
| SMAD1 | SMAD family member 1 | -0.28 |
| MDP1 | magnesium-dependent phosphatase 1 | -0.28 |
| BNIP2 | BCL2/adenovirus E1B 19kDa interacting protein 2 | -0.28 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.28 |
| ZNF503 | zinc finger protein 503 | -0.27 |
| CALB2 | calbindin 2 | -0.27 |
| ABHD17C | abhydrolase domain containing 17C | -0.27 |
| FBXL8 | F-box and leucine-rich repeat protein 8 | -0.27 |
| NUS1 | nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) | -0.27 |
| ERCC6 | excision repair cross-complementation group 6 | -0.27 |
| SLC16A6 | solute carrier family 16, member 6 | -0.27 |
| ZNF7 | zinc finger protein 7 | -0.27 |
| TRHDE | thyrotropin-releasing hormone degrading enzyme | -0.27 |
| FBXW9 | F-box and WD repeat domain containing 9 | -0.26 |
