| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Proglumide perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Proglumide_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | 0.331877 |
| VMP1 | vacuole membrane protein 1 | 0.0947058 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0570255 |
| MMP12 | matrix metallopeptidase 12 | 0.053909 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0468613 |
| TMEM41B | transmembrane protein 41B | 0.0462419 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0451288 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0436232 |
| KIF5B | kinesin family member 5B | 0.0408439 |
| RPS2 | ribosomal protein S2 | 0.0394659 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0350049 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0331667 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0316148 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0313769 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0312029 |
| NEK7 | NIMA-related kinase 7 | 0.0311754 |
| PNN | pinin, desmosome associated protein | 0.0305977 |
| EPHA6 | EPH receptor A6 | 0.0297017 |
| PRKCI | protein kinase C, iota | 0.029678 |
| SETD5 | SET domain containing 5 | 0.0288273 |
| BCAS3 | breast carcinoma amplified sequence 3 | 0.0264955 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0262093 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0259364 |
| RPS7 | ribosomal protein S7 | 0.0258131 |
| VCL | vinculin | 0.0248972 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0248779 |
| PCM1 | pericentriolar material 1 | 0.0239601 |
| HDAC9 | histone deacetylase 9 | 0.0238843 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0238517 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0236381 |
| PDGFC | platelet derived growth factor C | 0.0235218 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0230271 |
| CEP95 | centrosomal protein 95kDa | 0.0229414 |
| RPS12 | ribosomal protein S12 | 0.0228996 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0227551 |
| RASA2 | RAS p21 protein activator 2 | 0.022508 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0222577 |
| KIAA1328 | KIAA1328 | 0.0219903 |
| SET | SET nuclear proto-oncogene | 0.0219217 |
| NKTR | natural killer cell triggering receptor | 0.021714 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0215752 |
| RPL21 | ribosomal protein L21 | 0.021013 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0204301 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0200885 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0197239 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | 0.0195884 |
| NARS1 | asparaginyl-tRNA synthetase 1 | 0.019424 |
| TASOR2 | transcription activation suppressor family member 2 | 0.0193808 |
| PCBP2 | poly(rC) binding protein 2 | 0.019253 |
| YEATS2 | YEATS domain containing 2 | 0.018557 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0185234 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0183671 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0183298 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0182405 |
| TMF1 | TATA element modulatory factor 1 | 0.0182137 |
| NEBL | nebulette | 0.0181758 |
| SP3 | Sp3 transcription factor | 0.0179086 |
| MIB1 | mindbomb E3 ubiquitin protein ligase 1 | 0.0178382 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0177123 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0177 |
| WDR26 | WD repeat domain 26 | 0.0176569 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0176298 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0176083 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | 0.0175908 |
| SLMAP | sarcolemma associated protein | 0.0175643 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0172455 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.017083 |
| TRPC1 | transient receptor potential cation channel, subfamily C, member 1 | 0.0168616 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0168106 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0166832 |
| ARRDC3 | arrestin domain containing 3 | 0.016564 |
| THOC2 | THO complex 2 | 0.0163849 |
| KLC1 | kinesin light chain 1 | 0.0163355 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0163262 |
| CCNL1 | cyclin L1 | 0.0163004 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0162489 |
| EDN1 | endothelin 1 | 0.0160306 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0159878 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0159563 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0158499 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.0158368 |
| MED13L | mediator complex subunit 13-like | 0.015709 |
| DNAJC21 | DnaJ (Hsp40) homolog, subfamily C, member 21 | 0.0156661 |
| CLDND1 | claudin domain containing 1 | 0.0155079 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0154879 |
| FOXJ3 | forkhead box J3 | 0.0154415 |
| LEMD3 | LEM domain containing 3 | 0.015376 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0152588 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0152151 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0152024 |
| PRKAA1 | protein kinase, AMP-activated, alpha 1 catalytic subunit | 0.015188 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0151534 |
| KPNA1 | karyopherin alpha 1 (importin alpha 5) | 0.0151258 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0150961 |
| SSRP1 | structure specific recognition protein 1 | 0.0149592 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0149227 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0149152 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.014593 |
| SRSF4 | serine/arginine-rich splicing factor 4 | 0.0145678 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | 0.0143026 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.235387 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.210776 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.182005 |
| NLGN1 | neuroligin 1 | -0.155104 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.114512 |
| TMSB10 | thymosin beta 10 | -0.0963518 |
| ACTG1 | actin gamma 1 | -0.0811929 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0785417 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0772957 |
| PCDH7 | protocadherin 7 | -0.0764254 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.068404 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0678362 |
| RPL35A | ribosomal protein L35a | -0.0593946 |
| CCND1 | cyclin D1 | -0.0587779 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0576325 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0552115 |
| FTL | ferritin, light polypeptide | -0.0516559 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0514729 |
| HMGA2 | high mobility group AT-hook 2 | -0.0494457 |
| ANXA1 | annexin A1 | -0.0488195 |
| NHSL1 | NHS-like 1 | -0.0486461 |
| CALR | calreticulin | -0.048213 |
| AHNAK | AHNAK nucleoprotein | -0.0481516 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0479817 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0457059 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0445163 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0440561 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0430058 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0427662 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0409667 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0403256 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0388296 |
| PTMA | prothymosin, alpha | -0.0385959 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0383757 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.036689 |
| RASAL2 | RAS protein activator like 2 | -0.0365625 |
| CAVIN1 | caveolae associated protein 1 | -0.0365098 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0362947 |
| PCDH9 | protocadherin 9 | -0.0362057 |
| RNF213 | ring finger protein 213 | -0.0357857 |
| CANX | calnexin | -0.0357082 |
| S100A6 | S100 calcium binding protein A6 | -0.0349253 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0347609 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0345756 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0342284 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0342102 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0336364 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0331916 |
| GNAS | GNAS complex locus | -0.0329902 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0327793 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0327159 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0325422 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0324057 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0316069 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.030549 |
| RPLP1 | ribosomal protein, large, P1 | -0.0304128 |
| CLDN1 | claudin 1 | -0.030093 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0297431 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.029718 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0293835 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0292525 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.028997 |
| TXNRD1 | thioredoxin reductase 1 | -0.02864 |
| YAP1 | Yes-associated protein 1 | -0.028075 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0277747 |
| MGAT4C | MGAT4 family, member C | -0.0275915 |
| PKM | pyruvate kinase, muscle | -0.027581 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0275104 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0274831 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0273261 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0269478 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0267815 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0264321 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0263959 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | -0.0263072 |
| PRDX1 | peroxiredoxin 1 | -0.0263064 |
| S100A10 | S100 calcium binding protein A10 | -0.0260833 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0260588 |
| TMEM123 | transmembrane protein 123 | -0.0260431 |
| PSMD2 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 | -0.0259235 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0257793 |
| ASPH | aspartate beta-hydroxylase | -0.0253184 |
| RPL4 | ribosomal protein L4 | -0.0252077 |
| HMGB1 | high mobility group box 1 | -0.0251427 |
| RPL19 | ribosomal protein L19 | -0.0250334 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0249704 |
| YBX1 | Y box binding protein 1 | -0.0248733 |
| FUS | FUS RNA binding protein | -0.0245205 |
| CUX1 | cut-like homeobox 1 | -0.0244143 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0239902 |
| RPL34 | ribosomal protein L34 | -0.0239728 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0239423 |
| RPL13A | ribosomal protein L13a | -0.0238592 |
| TUBB | tubulin, beta class I | -0.0237295 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0235654 |
| USP34 | ubiquitin specific peptidase 34 | -0.0234007 |
| DIAPH2 | diaphanous-related formin 2 | -0.0231583 |
| LDHA | lactate dehydrogenase A | -0.0230959 |
| MAP4 | microtubule-associated protein 4 | -0.0230079 |
| PEG10 | paternally expressed 10 | -0.0227806 |
