Proglumide_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Proglumide perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Proglumide_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.239748
FAM13A family with sequence similarity 13, member A 0.106363
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.091089
MAP1B microtubule-associated protein 1B 0.0723258
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0701972
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0635814
ZNF292 zinc finger protein 292 0.0599271
FNBP1 formin binding protein 1 0.058212
ITPRID2 ITPR interacting domain containing 2 0.05742
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0554877
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0516496
MEIS2 Meis homeobox 2 0.0516485
MEF2A myocyte enhancer factor 2A 0.049928
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0480628
DST dystonin 0.0453081
CENPF centromere protein F, 350/400kDa 0.0451079
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0443327
SOS1 son of sevenless homolog 1 (Drosophila) 0.0441483
PLAT plasminogen activator, tissue 0.0433562
HILPDA hypoxia inducible lipid droplet-associated 0.0399044
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.03989
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0392475
IGF2 insulin-like growth factor 2 0.0363485
DPH6 diphthamine biosynthesis 6 0.0363147
CSNK1A1 casein kinase 1, alpha 1 0.0355548
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0354271
ERRFI1 ERBB receptor feedback inhibitor 1 0.0345996
CEMIP2 cell migration inducing hyaluronidase 2 0.0345109
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0335477
KDM2A lysine (K)-specific demethylase 2A 0.0320141
NDRG1 N-myc downstream regulated 1 0.0314236
PHF3 PHD finger protein 3 0.0308361
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0307871
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0305079
UBA6 ubiquitin-like modifier activating enzyme 6 0.0303053
MYO6 myosin VI 0.0302412
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.029203
NAMPT nicotinamide phosphoribosyltransferase 0.0288879
SOX9 SRY (sex determining region Y)-box 9 0.0286568
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0283922
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0283383
YEATS2 YEATS domain containing 2 0.0279052
ESYT2 extended synaptotagmin-like protein 2 0.027783
FOXO3 forkhead box O3 0.0274074
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0266637
PCBP3 poly(rC) binding protein 3 0.0266459
WWTR1 WW domain containing transcription regulator 1 0.0261164
RNMT RNA (guanine-7-) methyltransferase 0.0258723
FNDC3B fibronectin type III domain containing 3B 0.0255428
TET2 tet methylcytosine dioxygenase 2 0.0252839
WDR26 WD repeat domain 26 0.0250698
KMT2E lysine (K)-specific methyltransferase 2E 0.0249564
KDM5B lysine (K)-specific demethylase 5B 0.0240913
MXI1 MAX interactor 1, dimerization protein 0.0236968
SETD5 SET domain containing 5 0.0236184
LIMS1 LIM and senescent cell antigen-like domains 1 0.0234488
SCAF11 SR-related CTD-associated factor 11 0.023448
SET SET nuclear proto-oncogene 0.0233886
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0233534
CEMIP cell migration inducing protein, hyaluronan binding 0.0230363
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0228758
XRN1 5'-3' exoribonuclease 1 0.0228426
STARD4 StAR-related lipid transfer (START) domain containing 4 0.022733
SCARB1 scavenger receptor class B, member 1 0.0227099
NGLY1 N-glycanase 1 0.0225712
TRIO trio Rho guanine nucleotide exchange factor 0.022513
BHLHE40 basic helix-loop-helix family, member e40 0.0224107
RSL1D1 ribosomal L1 domain containing 1 0.0223558
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0223488
IPMK inositol polyphosphate multikinase 0.022234
ITGA1 integrin, alpha 1 0.0221041
YTHDC1 YTH domain containing 1 0.021926
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0216088
VMP1 vacuole membrane protein 1 0.0213951
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0210282
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0207754
AKAP10 A kinase (PRKA) anchor protein 10 0.0207228
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0206315
ZFC3H1 zinc finger, C3H1-type containing 0.0205528
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0205334
RNF145 ring finger protein 145 0.0204467
PIAS2 protein inhibitor of activated STAT, 2 0.0204183
BCLAF1 BCL2-associated transcription factor 1 0.0202817
VGLL4 vestigial-like family member 4 0.0202061
FRYL FRY-like 0.0201863
RTN4 reticulon 4 0.0200661
CRH corticotropin releasing hormone 0.0199077
EPHA3 EPH receptor A3 0.0195305
CCNY cyclin Y 0.019178
CANX calnexin 0.0191117
ZMYM2 zinc finger, MYM-type 2 0.0190847
DSCAM Down syndrome cell adhesion molecule 0.019065
BTG1 B-cell translocation gene 1, anti-proliferative 0.0190062
IFI16 interferon, gamma-inducible protein 16 0.0189022
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0188142
SCG2 secretogranin II 0.0188003
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0187551
RBM5 RNA binding motif protein 5 0.0185433
MYH10 myosin, heavy chain 10, non-muscle 0.0184616
COL4A5 collagen, type IV, alpha 5 0.0184088

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.128913
LSAMP limbic system-associated membrane protein -0.109747
VCL vinculin -0.102907
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0876901
NALF1 NALCN channel auxiliary factor 1 -0.0834829
RPL23 ribosomal protein L23 -0.0816139
ACTG1 actin gamma 1 -0.0775339
TPT1 tumor protein, translationally-controlled 1 -0.0635013
RPLP1 ribosomal protein, large, P1 -0.0625143
EXT1 exostosin glycosyltransferase 1 -0.0623559
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0611999
PTMA prothymosin, alpha -0.0607249
NRG1 neuregulin 1 -0.058544
RPL34 ribosomal protein L34 -0.0566825
VIM vimentin -0.0560612
CADM2 cell adhesion molecule 2 -0.0558588
RPL38 ribosomal protein L38 -0.0555833
COL1A1 collagen, type I, alpha 1 -0.053691
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0504765
TMSB10 thymosin beta 10 -0.049692
RPL37A ribosomal protein L37a -0.0492209
RPS6 ribosomal protein S6 -0.0490986
THSD4 thrombospondin, type I, domain containing 4 -0.0469628
RPL35A ribosomal protein L35a -0.0468853
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.04535
RPL27 ribosomal protein L27 -0.0443026
TPM1 tropomyosin 1 (alpha) -0.0416
SLIT2 slit homolog 2 (Drosophila) -0.0409216
TPST1 tyrosylprotein sulfotransferase 1 -0.0405867
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0401748
RPL9 ribosomal protein L9 -0.0401202
RPS24 ribosomal protein S24 -0.0400115
PRKCA protein kinase C, alpha -0.0399777
MSI2 musashi RNA-binding protein 2 -0.0396141
RPS20 ribosomal protein S20 -0.0392961
EIF1 eukaryotic translation initiation factor 1 -0.0390797
NAP1L1 nucleosome assembly protein 1-like 1 -0.0378709
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0376444
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0369844
RPS23 ribosomal protein S23 -0.0368103
RPL31 ribosomal protein L31 -0.0361265
LMNA lamin A/C -0.035879
PDZRN3 PDZ domain containing ring finger 3 -0.0351443
GREM2 gremlin 2, DAN family BMP antagonist -0.0350587
EGR1 early growth response 1 -0.0343235
RPL19 ribosomal protein L19 -0.034018
PKM pyruvate kinase, muscle -0.0338977
LPIN1 lipin 1 -0.0338583
RPS19 ribosomal protein S19 -0.0335467
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.033473
PTPRK protein tyrosine phosphatase, receptor type, K -0.0333814
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0320647
RPS8 ribosomal protein S8 -0.0318213
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0309137
MED13 mediator complex subunit 13 -0.0307668
DNM3 dynamin 3 -0.0307309
ZNF804A zinc finger protein 804A -0.0306797
ZFAND3 zinc finger, AN1-type domain 3 -0.0304759
ANTXR1 anthrax toxin receptor 1 -0.029946
KCNIP4 Kv channel interacting protein 4 -0.0299051
RPLP0 ribosomal protein, large, P0 -0.0294852
RPS12 ribosomal protein S12 -0.0294754
POTEF POTE ankyrin domain family, member F -0.0291167
PDLIM5 PDZ and LIM domain 5 -0.0290416
H3-3B H3.3 histone B -0.0283911
RABGAP1L RAB GTPase activating protein 1-like -0.0278234
RPTOR regulatory associated protein of MTOR, complex 1 -0.0275511
RPL12 ribosomal protein L12 -0.027539
LOC112694756 uncharaterized LOC112694756 -0.0272901
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0270335
LPP LIM domain containing preferred translocation partner in lipoma -0.0265646
TLE4 transducin-like enhancer of split 4 -0.0265507
GMDS GDP-mannose 4,6-dehydratase -0.0263744
UNC5C unc-5 homolog C (C. elegans) -0.0262294
S100A6 S100 calcium binding protein A6 -0.0257506
RPLP2 ribosomal protein, large, P2 -0.0253449
UBAP2 ubiquitin associated protein 2 -0.0251925
JPT1 Jupiter microtubule associated homolog 1 -0.0249282
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.024899
DACH2 dachshund family transcription factor 2 -0.0242633
GLCCI1 glucocorticoid induced 1 -0.0237477
CDH13 cadherin 13 -0.0237197
SLC38A2 solute carrier family 38, member 2 -0.0236788
MAP2K4 mitogen-activated protein kinase kinase 4 -0.0233989
RPL30 ribosomal protein L30 -0.0233632
RPS27 ribosomal protein S27 -0.0233377
INTS6 integrator complex subunit 6 -0.0232593
S100A9 S100 calcium binding protein A9 -0.0231985
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog -0.0229929
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0229721
TENM4 teneurin transmembrane protein 4 -0.0226754
RPL7A ribosomal protein L7a -0.0226219
MED13L mediator complex subunit 13-like -0.0226073
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0223918
BCAS3 breast carcinoma amplified sequence 3 -0.02232
RPS11 ribosomal protein S11 -0.0222821
EXOC4 exocyst complex component 4 -0.0222644
RPL13A ribosomal protein L13a -0.0221012
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0219649
CNTN4 contactin 4 -0.0218721