Proglumide_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Proglumide perturbation in COLO 205 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Proglumide_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0649545
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0501467
PDIA3 protein disulfide isomerase family A, member 3 0.0419767
MBNL2 muscleblind-like splicing regulator 2 0.0412434
GOLGA4 golgin A4 0.0355708
PTEN phosphatase and tensin homolog 0.0328289
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0327669
SREBF2 sterol regulatory element binding transcription factor 2 0.0321049
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0315541
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0291861
RNF149 ring finger protein 149 0.0283709
PTBP3 polypyrimidine tract binding protein 3 0.0279602
BCLAF1 BCL2-associated transcription factor 1 0.0274257
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0267107
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0248195
RHOBTB3 Rho-related BTB domain containing 3 0.0247594
AKAP9 A kinase (PRKA) anchor protein 9 0.0246319
TXNIP thioredoxin interacting protein 0.023058
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0229958
RNF43 ring finger protein 43 0.0214421
NRIP1 nuclear receptor interacting protein 1 0.0213923
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0212248
TMF1 TATA element modulatory factor 1 0.0205746
MKI67 marker of proliferation Ki-67 0.0204994
COG6 component of oligomeric golgi complex 6 0.0201771
TMEM39A transmembrane protein 39A 0.0199145
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.0199034
RAB1A RAB1A, member RAS oncogene family 0.0195696
ACBD3 acyl-CoA binding domain containing 3 0.01932
MCTP2 multiple C2 domains, transmembrane 2 0.0190134
DIAPH3 diaphanous-related formin 3 0.0185151
BHLHE40 basic helix-loop-helix family, member e40 0.0183309
VEGFA vascular endothelial growth factor A 0.0182742
FNDC3A fibronectin type III domain containing 3A 0.0177118
TSC22D2 TSC22 domain family, member 2 0.0176333
RPL21 ribosomal protein L21 0.0175252
CENPF centromere protein F, 350/400kDa 0.0173053
SRP54 signal recognition particle 54kDa 0.0172726
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0170788
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0167737
GRAMD2B GRAM domain containing 2B 0.0165622
RNF145 ring finger protein 145 0.0165264
ESYT2 extended synaptotagmin-like protein 2 0.0162632
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0162066
FNIP1 folliculin interacting protein 1 0.0161895
SEC24D SEC24 family member D 0.0161084
NUCB2 nucleobindin 2 0.016107
KMT2C lysine (K)-specific methyltransferase 2C 0.0160713
SBF2 SET binding factor 2 0.0158741
YEATS2 YEATS domain containing 2 0.015712
EPB41 erythrocyte membrane protein band 4.1 0.0156687
ARRDC3 arrestin domain containing 3 0.015575
SAMD4A sterile alpha motif domain containing 4A 0.0154555
KMT2E lysine (K)-specific methyltransferase 2E 0.0153405
RBM26 RNA binding motif protein 26 0.015265
TMEM263 transmembrane protein 263 0.0152166
GPBP1L1 GC-rich promoter binding protein 1-like 1 0.0150264
PHC3 polyhomeotic homolog 3 (Drosophila) 0.01497
USP3 ubiquitin specific peptidase 3 0.0149354
DYNC2I1 dynein 2 intermediate chain 1 0.0146789
RARS1 arginyl-tRNA synthetase 1 0.0145353
GOLGA2 golgin A2 0.0144227
USPL1 ubiquitin specific peptidase like 1 0.0143398
TMEM165 transmembrane protein 165 0.014282
SUCO SUN domain containing ossification factor 0.014275
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.014092
COPB1 coatomer protein complex, subunit beta 1 0.0139561
TENT2 terminal nucleotidyltransferase 2 0.0139039
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 0.0138655
RPS6 ribosomal protein S6 0.0137897
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0135116
ESRP1 epithelial splicing regulatory protein 1 0.013407
RAB6A RAB6A, member RAS oncogene family 0.0133802
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 0.0133417
KCTD3 potassium channel tetramerization domain containing 3 0.0132639
TNRC6A trinucleotide repeat containing 6A 0.0132143
USP47 ubiquitin specific peptidase 47 0.0132112
KLHL24 kelch-like family member 24 0.0131143
RAD54B RAD54 homolog B (S. cerevisiae) 0.0130924
CHD9 chromodomain helicase DNA binding protein 9 0.0130859
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0129502
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 0.0125811
SRRM1 serine/arginine repetitive matrix 1 0.0125688
SPICE1 spindle and centriole associated protein 1 0.0125499
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.012533
FAM114A1 family with sequence similarity 114, member A1 0.0124286
SPRED2 sprouty-related, EVH1 domain containing 2 0.0123349
ATP11B ATPase, class VI, type 11B 0.0121781
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0121692
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0120428
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0119753
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0119626
PDE8A phosphodiesterase 8A 0.0118961
TMEM87A transmembrane protein 87A 0.0118354
MON2 MON2 homolog (S. cerevisiae) 0.011771
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0116586
PER2 period circadian clock 2 0.0116577
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0116557
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0116474
SFXN1 sideroflexin 1 0.0116067

decreased expression

Symbol Name Standardized Value
RNF213 ring finger protein 213 -0.173009
EPSTI1 epithelial stromal interaction 1 (breast) -0.165646
ANXA2 annexin A2 -0.145746
INTS6 integrator complex subunit 6 -0.137994
STAT1 signal transducer and activator of transcription 1, 91kDa -0.12098
LMO7 LIM domain 7 -0.117899
TPT1 tumor protein, translationally-controlled 1 -0.112731
VCL vinculin -0.111871
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.102102
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.100875
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.100553
SP100 SP100 nuclear antigen -0.0967507
RIGI RNA sensor RIG-I -0.094441
STS steroid sulfatase (microsomal), isozyme S -0.0896973
MX1 MX dynamin-like GTPase 1 -0.0864976
GMDS GDP-mannose 4,6-dehydratase -0.0857234
LCN2 lipocalin 2 -0.083404
HLA-B major histocompatibility complex, class I, B -0.0817037
MX2 MX dynamin-like GTPase 2 -0.080679
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.07996
EGR1 early growth response 1 -0.0796238
EXT1 exostosin glycosyltransferase 1 -0.0787106
C6ORF132 chromosome 6 open reading frame 132 -0.0746705
PKM pyruvate kinase, muscle -0.0745908
PLSCR2 phospholipid scramblase 2 -0.0728645
XAF1 XIAP associated factor 1 -0.0697842
PLSCR1 phospholipid scramblase 1 -0.0695285
LPP LIM domain containing preferred translocation partner in lipoma -0.0680793
AREG amphiregulin -0.0654478
GCLC glutamate-cysteine ligase, catalytic subunit -0.0649036
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0643338
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0635378
IFI6 interferon, alpha-inducible protein 6 -0.0631441
ANKRD10 ankyrin repeat domain 10 -0.062284
TJP1 tight junction protein 1 -0.0621933
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.06213
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0620202
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0617504
PERP PERP, TP53 apoptosis effector -0.0573844
EZR ezrin -0.0556735
MYO1E myosin IE -0.0545696
B2M beta-2-microglobulin -0.0544193
TSHZ2 teashirt zinc finger homeobox 2 -0.0538549
RAB7A RAB7A, member RAS oncogene family -0.0536452
AKAP13 A kinase (PRKA) anchor protein 13 -0.0529254
ARHGAP26 Rho GTPase activating protein 26 -0.052296
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0517995
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0508194
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0504721
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0500744
PRKCA protein kinase C, alpha -0.0499147
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0498978
TM4SF1 transmembrane 4 L six family member 1 -0.0495337
TSC22D1 TSC22 domain family, member 1 -0.0493477
LYZ lysozyme -0.0486659
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0485331
SQSTM1 sequestosome 1 -0.0476092
ASPH aspartate beta-hydroxylase -0.046751
SMAD3 SMAD family member 3 -0.0465444
MUC20 mucin 20, cell surface associated -0.0462093
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.045831
EFNB2 ephrin-B2 -0.0451111
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0450116
NCOA7 nuclear receptor coactivator 7 -0.0439992
PHF3 PHD finger protein 3 -0.0434266
NCKAP5 NCK-associated protein 5 -0.0432059
TRIO trio Rho guanine nucleotide exchange factor -0.0430651
ACTG1 actin gamma 1 -0.0424586
RABGAP1L RAB GTPase activating protein 1-like -0.0424494
KLF5 Kruppel-like factor 5 (intestinal) -0.0415228
CATSPERB catsper channel auxiliary subunit beta -0.0410044
EPS8 epidermal growth factor receptor pathway substrate 8 -0.040852
SAMD12 sterile alpha motif domain containing 12 -0.0399094
BTBD9 BTB (POZ) domain containing 9 -0.0398815
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0397366
RAD51B RAD51 paralog B -0.039359
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0392097
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0391666
ACTN4 actinin, alpha 4 -0.0391553
TM4SF19 transmembrane 4 L six family member 19 -0.0390347
MAP7 microtubule-associated protein 7 -0.0386063
MCL1 myeloid cell leukemia 1 -0.0381754
LAMA4 laminin, alpha 4 -0.0380433
PGK1 phosphoglycerate kinase 1 -0.0377045
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.037272
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0362623
JUN jun proto-oncogene -0.0361642
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.036117
TMSB10 thymosin beta 10 -0.0358516
TMC5 transmembrane channel-like 5 -0.0351492
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0349553
ERBIN erbb2 interacting protein -0.0349461
HLA-E major histocompatibility complex, class I, E -0.0349329
STK24 serine/threonine kinase 24 -0.0345753
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0345457
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -0.034076
ETV6 ets variant 6 -0.0338688
ITGA6 integrin, alpha 6 -0.0336529
SDC4 syndecan 4 -0.0336446
IGF1R insulin-like growth factor 1 receptor -0.033643