| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Proglumide perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Proglumide_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0833588 |
| TF | transferrin | 0.0777629 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0714701 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.0690855 |
| DTNA | dystrobrevin, alpha | 0.0679348 |
| VEGFA | vascular endothelial growth factor A | 0.0575844 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0553068 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0552513 |
| RPL11 | ribosomal protein L11 | 0.0547461 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0540881 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0539619 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0520281 |
| RPS12 | ribosomal protein S12 | 0.0513343 |
| RPL26 | ribosomal protein L26 | 0.0513236 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0508553 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0487744 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0486481 |
| QKI | QKI, KH domain containing, RNA binding | 0.0478781 |
| ZNF292 | zinc finger protein 292 | 0.0470854 |
| CRY1 | cryptochrome circadian clock 1 | 0.0460174 |
| CPE | carboxypeptidase E | 0.0446195 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0443247 |
| RPS8 | ribosomal protein S8 | 0.0437447 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0436213 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0431902 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.04177 |
| SPAG9 | sperm associated antigen 9 | 0.0417255 |
| RBM39 | RNA binding motif protein 39 | 0.0416922 |
| RPS14 | ribosomal protein S14 | 0.0416742 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0403323 |
| GRK3 | G protein-coupled receptor kinase 3 | 0.0402896 |
| RPL21 | ribosomal protein L21 | 0.0398968 |
| RRBP1 | ribosome binding protein 1 | 0.0383262 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.038103 |
| RACK1 | receptor for activated C kinase 1 | 0.0380683 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0365211 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0356085 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.03552 |
| RNF149 | ring finger protein 149 | 0.0353813 |
| GOLGA4 | golgin A4 | 0.0350847 |
| PTMA | prothymosin, alpha | 0.0349792 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0325072 |
| SLC11A2 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 | 0.0324415 |
| PER2 | period circadian clock 2 | 0.0319222 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0318301 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0312275 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0302286 |
| FAM162A | family with sequence similarity 162, member A | 0.0301625 |
| VMP1 | vacuole membrane protein 1 | 0.030102 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0299679 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0299128 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0298453 |
| NUP58 | nucleoporin 58 | 0.0295993 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0295454 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0291188 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0289667 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0287882 |
| PDE10A | phosphodiesterase 10A | 0.0287536 |
| RPS2 | ribosomal protein S2 | 0.0286928 |
| MYO1B | myosin IB | 0.0281453 |
| GK | glycerol kinase | 0.0279323 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.027887 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0276786 |
| HDGF | hepatoma-derived growth factor | 0.0274968 |
| NOTUM | notum pectinacetylesterase homolog (Drosophila) | 0.0274588 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0274449 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0272631 |
| FMNL2 | formin-like 2 | 0.0270441 |
| TRIM26 | tripartite motif containing 26 | 0.0267562 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0267227 |
| RPL37A | ribosomal protein L37a | 0.0266389 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0266177 |
| PPP2CB | protein phosphatase 2, catalytic subunit, beta isozyme | 0.0263798 |
| WDR45B | WD repeat domain 45B | 0.0262925 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0262339 |
| RLF | rearranged L-myc fusion | 0.0262229 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0261873 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0261801 |
| CLU | clusterin | 0.0258977 |
| APOH | apolipoprotein H (beta-2-glycoprotein I) | 0.0257158 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0256294 |
| ZNF207 | zinc finger protein 207 | 0.0252301 |
| TCIM | transcriptional and immune response regulator | 0.0252158 |
| AFDN | afadin, adherens junction formation factor | 0.0252046 |
| RPS11 | ribosomal protein S11 | 0.0247585 |
| SIK3 | SIK family kinase 3 | 0.0244206 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0242969 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0242886 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0242592 |
| RAB10 | RAB10, member RAS oncogene family | 0.024025 |
| CASC3 | cancer susceptibility candidate 3 | 0.023983 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0239074 |
| PDE8A | phosphodiesterase 8A | 0.0236962 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0234965 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0233903 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0231032 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0229804 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0227588 |
| STK17A | serine/threonine kinase 17a | 0.0227178 |
| SETD5 | SET domain containing 5 | 0.0225855 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.194428 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.167783 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.133934 |
| IGF2 | insulin-like growth factor 2 | -0.124823 |
| MT2A | metallothionein 2A | -0.109918 |
| SLC38A2 | solute carrier family 38, member 2 | -0.107607 |
| GPC6 | glypican 6 | -0.0907492 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0853223 |
| EHBP1 | EH domain binding protein 1 | -0.0687239 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0674269 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0610917 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0573388 |
| FOXP1 | forkhead box P1 | -0.056847 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0540228 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0513998 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0502583 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.049135 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0481051 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.047 |
| VCL | vinculin | -0.0466699 |
| HMGA1 | high mobility group AT-hook 1 | -0.045291 |
| PEG3 | paternally expressed 3 | -0.0445205 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0428245 |
| FRMD5 | FERM domain containing 5 | -0.0420523 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0415192 |
| ITGB5 | integrin, beta 5 | -0.0413792 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0412527 |
| RUNX1 | runt-related transcription factor 1 | -0.0403242 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0391969 |
| TMSB10 | thymosin beta 10 | -0.0389871 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0383415 |
| CNKSR3 | CNKSR family member 3 | -0.0375671 |
| SMYD3 | SET and MYND domain containing 3 | -0.0373281 |
| JAG1 | jagged 1 | -0.0370027 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.036668 |
| ZSWIM5 | zinc finger, SWIM-type containing 5 | -0.0364471 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0359819 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.035393 |
| TRAM1 | translocation associated membrane protein 1 | -0.0353662 |
| FAT1 | FAT atypical cadherin 1 | -0.0339627 |
| ATXN1 | ataxin 1 | -0.0333907 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0332703 |
| AOPEP | aminopeptidase O (putative) | -0.032861 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0325001 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0320536 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0320126 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0318934 |
| ATP10A | ATPase, class V, type 10A | -0.0318771 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0316542 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0313993 |
| LAP3 | leucine aminopeptidase 3 | -0.0313126 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.031082 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0307835 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0307699 |
| PRKCA | protein kinase C, alpha | -0.0302521 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.0301522 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0299726 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0299367 |
| PGK1 | phosphoglycerate kinase 1 | -0.0298367 |
| RPS5 | ribosomal protein S5 | -0.029826 |
| SMAD3 | SMAD family member 3 | -0.0298152 |
| ARFGEF3 | ARFGEF family member 3 | -0.0297501 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0293482 |
| ANKRD11 | ankyrin repeat domain 11 | -0.029227 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0291555 |
| JMJD1C | jumonji domain containing 1C | -0.0289936 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0285093 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.028432 |
| KRT8 | keratin 8, type II | -0.028356 |
| TMEM50A | transmembrane protein 50A | -0.0280214 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0279848 |
| RPS19 | ribosomal protein S19 | -0.0279737 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.027972 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | -0.0279619 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0279303 |
| FOXN3 | forkhead box N3 | -0.0279068 |
| PARD3 | par-3 family cell polarity regulator | -0.0278827 |
| ACTN4 | actinin, alpha 4 | -0.0278575 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0274483 |
| CFB | complement factor B | -0.0273231 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0272714 |
| C3 | complement component 3 | -0.0272116 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0271654 |
| MT1X | metallothionein 1X | -0.0262962 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.0261449 |
| LPIN2 | lipin 2 | -0.0260671 |
| LCOR | ligand dependent nuclear receptor corepressor | -0.0257048 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0254158 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0251058 |
| RELL1 | RELT-like 1 | -0.0250037 |
| SORBS1 | sorbin and SH3 domain containing 1 | -0.0249879 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0248705 |
| GLRX | glutaredoxin (thioltransferase) | -0.024835 |
| WASF2 | WAS protein family, member 2 | -0.0246662 |
| ASPH | aspartate beta-hydroxylase | -0.0244465 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | -0.0244023 |
| FERMT1 | fermitin family member 1 | -0.02424 |
| PHF14 | PHD finger protein 14 | -0.0240833 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0240442 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0239147 |
