Proglumide_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Proglumide perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Proglumide_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDLIM5 PDZ and LIM domain 5 0.059236
VCL vinculin 0.049612
CLU clusterin 0.0459275
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0455571
LMO7 LIM domain 7 0.0440687
ALCAM activated leukocyte cell adhesion molecule 0.0395488
TIMP3 TIMP metallopeptidase inhibitor 3 0.0386139
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0358546
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0350907
NRIP1 nuclear receptor interacting protein 1 0.0329559
MTSS1 metastasis suppressor 1 0.0291182
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0264983
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0264307
SLC35F3 solute carrier family 35, member F3 0.0251654
AKAP9 A kinase (PRKA) anchor protein 9 0.0247455
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0236314
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0223422
FOXO1 forkhead box O1 0.0223083
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0202834
LAMC2 laminin, gamma 2 0.0199742
PLS3 plastin 3 0.0192126
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0184611
ZCCHC7 zinc finger, CCHC domain containing 7 0.0181834
TMF1 TATA element modulatory factor 1 0.017764
LUZP1 leucine zipper protein 1 0.0176472
RAI14 retinoic acid induced 14 0.0172847
RASAL2 RAS protein activator like 2 0.0166504
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0164332
ITSN1 intersectin 1 (SH3 domain protein) 0.0164312
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.015228
TXNIP thioredoxin interacting protein 0.0151196
BZW1 basic leucine zipper and W2 domains 1 0.0151104
EGR1 early growth response 1 0.0150619
ITPRID2 ITPR interacting domain containing 2 0.0147441
RCOR1 REST corepressor 1 0.0147206
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0144556
PHF3 PHD finger protein 3 0.014365
ABI3BP ABI family, member 3 (NESH) binding protein 0.014355
VMP1 vacuole membrane protein 1 0.0143331
GOLGB1 golgin B1 0.0140835
PICALM phosphatidylinositol binding clathrin assembly protein 0.0138945
PALLD palladin, cytoskeletal associated protein 0.0138223
RARS1 arginyl-tRNA synthetase 1 0.0138221
TMEM165 transmembrane protein 165 0.0137416
FN1 fibronectin 1 0.0135037
CDK13 cyclin-dependent kinase 13 0.0134774
DSPP dentin sialophosphoprotein 0.0134714
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0134236
KIF16B kinesin family member 16B 0.0129838
PTPRB protein tyrosine phosphatase, receptor type, B 0.0129454
AKAP13 A kinase (PRKA) anchor protein 13 0.0128541
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0128454
DUSP5 dual specificity phosphatase 5 0.012703
WASF2 WAS protein family, member 2 0.0126996
NLRP1 NLR family, pyrin domain containing 1 0.0126482
FNIP1 folliculin interacting protein 1 0.0125313
MEF2A myocyte enhancer factor 2A 0.0121649
LIMA1 LIM domain and actin binding 1 0.0121089
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0120955
BCL2L1 BCL2-like 1 0.0120935
COPB1 coatomer protein complex, subunit beta 1 0.0120934
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0120869
ZFC3H1 zinc finger, C3H1-type containing 0.0120579
SEC31A SEC31 homolog A (S. cerevisiae) 0.0119769
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 0.0117754
PDGFB platelet-derived growth factor beta polypeptide 0.0116986
DHFR dihydrofolate reductase 0.0115938
TMEM41B transmembrane protein 41B 0.0114674
RPL21 ribosomal protein L21 0.0114243
NCEH1 neutral cholesterol ester hydrolase 1 0.0113614
ARFGEF3 ARFGEF family member 3 0.0110565
DSG2 desmoglein 2 0.0109098
C4BPB complement component 4 binding protein, beta 0.010818
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 0.0107238
IQGAP1 IQ motif containing GTPase activating protein 1 0.0107105
LOXL2 lysyl oxidase-like 2 0.0106933
PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 0.0106325
FBXO11 F-box protein 11 0.0106194
BMAL2 basic helix-loop-helix ARNT like 2 0.0105276
YOD1 YOD1 deubiquitinase 0.0104758
GOLGA2 golgin A2 0.0104358
CAPRIN2 caprin family member 2 0.0103555
EGFR epidermal growth factor receptor 0.0102888
CEP95 centrosomal protein 95kDa 0.0102574
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0102361
DOCK5 dedicator of cytokinesis 5 0.0101958
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.010113
NBEAL1 neurobeachin-like 1 0.0100308
TSPAN5 tetraspanin 5 0.00989618
BLZF1 basic leucine zipper nuclear factor 1 0.00983735
NECTIN2 nectin cell adhesion molecule 2 0.0098368
WNT2B wingless-type MMTV integration site family, member 2B 0.0096983
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.00964205
MICU1 mitochondrial calcium uptake 1 0.0095574
ZFP36 ZFP36 ring finger protein 0.00953011
CREB1 cAMP responsive element binding protein 1 0.0094047
FRMD6 FERM domain containing 6 0.00938599
TUT7 terminal uridylyl transferase 7 0.00928073
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 0.00923309
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.00915094

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.0793003
POTEF POTE ankyrin domain family, member F -0.0734597
ENO1 enolase 1, (alpha) -0.0702704
FLNB filamin B, beta -0.0683108
LOC112694756 uncharaterized LOC112694756 -0.0639433
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0622159
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0591183
PLEC plectin -0.0558242
KRT17 keratin 17, type I -0.0534043
UBC ubiquitin C -0.0531671
PKM pyruvate kinase, muscle -0.0508461
AHNAK AHNAK nucleoprotein -0.0481913
LMNA lamin A/C -0.0470892
ACTN4 actinin, alpha 4 -0.0464669
FLNA filamin A, alpha -0.0447811
RPS21 ribosomal protein S21 -0.0444313
MYH9 myosin, heavy chain 9, non-muscle -0.0405203
NAMPT nicotinamide phosphoribosyltransferase -0.0404288
PTMA prothymosin, alpha -0.0395631
MYOF myoferlin -0.0389788
LDHA lactate dehydrogenase A -0.0387811
FOXP1 forkhead box P1 -0.0385994
EEF2 eukaryotic translation elongation factor 2 -0.0385139
TMSB4X thymosin beta 4, X-linked -0.0379824
NDRG1 N-myc downstream regulated 1 -0.0364412
PTK2 protein tyrosine kinase 2 -0.0363752
ASPH aspartate beta-hydroxylase -0.0362335
RPLP1 ribosomal protein, large, P1 -0.0354656
TXNRD1 thioredoxin reductase 1 -0.0350922
CD44 CD44 molecule (Indian blood group) -0.0346497
RPS8 ribosomal protein S8 -0.0339339
TGM2 transglutaminase 2 -0.0333652
TOP1 topoisomerase (DNA) I -0.0322104
GRB10 growth factor receptor-bound protein 10 -0.0320893
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0318688
RPS27A ribosomal protein S27a -0.0318099
YBX1 Y box binding protein 1 -0.0312291
RPL23 ribosomal protein L23 -0.0309907
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0309856
B2M beta-2-microglobulin -0.0305007
TPT1 tumor protein, translationally-controlled 1 -0.0303123
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0299616
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0296195
PGK1 phosphoglycerate kinase 1 -0.0289977
ITGA6 integrin, alpha 6 -0.0283795
CEMIP cell migration inducing protein, hyaluronan binding -0.0276515
RPS3 ribosomal protein S3 -0.0273509
RPLP2 ribosomal protein, large, P2 -0.026904
ANXA1 annexin A1 -0.0264741
S100A10 S100 calcium binding protein A10 -0.0264656
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0264567
SULF2 sulfatase 2 -0.0264521
SLC38A2 solute carrier family 38, member 2 -0.0257087
DPYD dihydropyrimidine dehydrogenase -0.025523
RBM39 RNA binding motif protein 39 -0.0253321
ANXA2 annexin A2 -0.0253013
KRT6A keratin 6A, type II -0.0252851
SMAD3 SMAD family member 3 -0.0251353
MT2A metallothionein 2A -0.0249896
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0247864
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0247683
MYO10 myosin X -0.0245821
MATR3 matrin 3 -0.0243374
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0242217
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0240851
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0240737
LAMA5 laminin, alpha 5 -0.0239147
RPL11 ribosomal protein L11 -0.0235755
CANX calnexin -0.0234883
PCBP2 poly(rC) binding protein 2 -0.0233479
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.023306
RPL8 ribosomal protein L8 -0.0231656
JAG1 jagged 1 -0.0227877
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0224018
IFITM3 interferon induced transmembrane protein 3 -0.022337
RPL37 ribosomal protein L37 -0.0222816
EPHA2 EPH receptor A2 -0.022076
HLA-B major histocompatibility complex, class I, B -0.022032
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0220022
DSTN destrin (actin depolymerizing factor) -0.0214294
RPS19 ribosomal protein S19 -0.0212485
PFN1 profilin 1 -0.0210825
MBNL2 muscleblind-like splicing regulator 2 -0.0210135
RPS13 ribosomal protein S13 -0.0208454
RPL37A ribosomal protein L37a -0.0207737
NAP1L1 nucleosome assembly protein 1-like 1 -0.0204329
PODXL podocalyxin-like -0.0202748
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0200094
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0199404
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0199019
ITGB4 integrin, beta 4 -0.0197838
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0196722
RPL5 ribosomal protein L5 -0.0196384
EMP1 epithelial membrane protein 1 -0.0195934
GATA6 GATA binding protein 6 -0.0195749
KDM3A lysine (K)-specific demethylase 3A -0.0194853
KIAA1217 KIAA1217 -0.0194749
RPL9 ribosomal protein L9 -0.019333
ZNFX1 zinc finger, NFX1-type containing 1 -0.0192528
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0191206