Proglumide_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Proglumide perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Proglumide_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.0951917
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0699444
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0619452
PABPC1 poly(A) binding protein, cytoplasmic 1 0.061225
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0566163
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0499128
RPS2 ribosomal protein S2 0.0486975
ERRFI1 ERBB receptor feedback inhibitor 1 0.0481154
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0464035
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0463248
VMP1 vacuole membrane protein 1 0.0425089
WDR43 WD repeat domain 43 0.0402269
WAC WW domain containing adaptor with coiled-coil 0.0366465
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.035899
SETD5 SET domain containing 5 0.0358335
PDIA6 protein disulfide isomerase family A, member 6 0.0350622
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0336662
PLS3 plastin 3 0.0335103
KTN1 kinectin 1 (kinesin receptor) 0.0327793
PUM1 pumilio RNA-binding family member 1 0.0325289
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0320328
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0300399
NUP58 nucleoporin 58 0.0296233
RNF145 ring finger protein 145 0.0296002
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0293167
ERBIN erbb2 interacting protein 0.0283549
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.027944
LOC102724023 ES1 protein homolog, mitochondrial 0.0279354
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0274704
RBM25 RNA binding motif protein 25 0.0273163
BRD2 bromodomain containing 2 0.0267505
SRRM1 serine/arginine repetitive matrix 1 0.0265362
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0263593
RHOA ras homolog family member A 0.0257298
GOLGA4 golgin A4 0.0254421
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0251107
RPS7 ribosomal protein S7 0.0248991
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0244812
FNBP1L formin binding protein 1-like 0.0243036
YTHDC1 YTH domain containing 1 0.0240999
CSNK1A1 casein kinase 1, alpha 1 0.0240602
TPM3 tropomyosin 3 0.0239428
YME1L1 YME1-like 1 ATPase 0.0238251
ARHGAP29 Rho GTPase activating protein 29 0.023395
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0233946
MSN moesin 0.0225901
SEC31A SEC31 homolog A (S. cerevisiae) 0.0223951
ZC3H15 zinc finger CCCH-type containing 15 0.0223624
TPD52 tumor protein D52 0.0218764
BCLAF1 BCL2-associated transcription factor 1 0.0215315
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0209794
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0209769
PCBP2 poly(rC) binding protein 2 0.0209326
GPBP1 GC-rich promoter binding protein 1 0.0207551
SRP54 signal recognition particle 54kDa 0.0206901
CLU clusterin 0.0206661
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.020646
PUM2 pumilio RNA-binding family member 2 0.0206052
CCNL1 cyclin L1 0.0205595
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0202096
NUP153 nucleoporin 153kDa 0.0201886
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0201137
UBA6 ubiquitin-like modifier activating enzyme 6 0.0198883
PAWR PRKC, apoptosis, WT1, regulator 0.0197345
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0195749
EIF4B eukaryotic translation initiation factor 4B 0.019408
KIF5B kinesin family member 5B 0.0190923
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0188475
PA2G4 proliferation-associated 2G4, 38kDa 0.0187141
PNN pinin, desmosome associated protein 0.0187109
ASXL1 additional sex combs like transcriptional regulator 1 0.0182052
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0181987
GTPBP4 GTP binding protein 4 0.0181471
TMF1 TATA element modulatory factor 1 0.017957
SRSF11 serine/arginine-rich splicing factor 11 0.0178073
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0176785
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0175909
USP15 ubiquitin specific peptidase 15 0.0175766
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0174937
PRPF4B pre-mRNA processing factor 4B 0.0173729
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 0.0172705
SET SET nuclear proto-oncogene 0.0172392
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0172169
RSL1D1 ribosomal L1 domain containing 1 0.0171128
TMEM41B transmembrane protein 41B 0.0170732
RAB1A RAB1A, member RAS oncogene family 0.0170203
PDIA3 protein disulfide isomerase family A, member 3 0.0169628
FERMT2 fermitin family member 2 0.0169522
INO80 INO80 complex subunit 0.0168802
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.016824
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.0167156
SSRP1 structure specific recognition protein 1 0.0166804
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0166254
NCEH1 neutral cholesterol ester hydrolase 1 0.0164103
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0163832
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0161667
FOXJ3 forkhead box J3 0.0160817
TMEM87A transmembrane protein 87A 0.0157753
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0157356
UTP6 UTP6, small subunit (SSU) processome component, homolog (yeast) 0.015722

decreased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B -0.290778
MT2A metallothionein 2A -0.230115
PDE4D phosphodiesterase 4D, cAMP-specific -0.230112
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.194559
TMSB10 thymosin beta 10 -0.165132
THSD4 thrombospondin, type I, domain containing 4 -0.133746
VIM vimentin -0.109071
FTH1 ferritin, heavy polypeptide 1 -0.104315
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0988218
TXNRD1 thioredoxin reductase 1 -0.0938923
PM20D1 peptidase M20 domain containing 1 -0.0883016
DOCK4 dedicator of cytokinesis 4 -0.0825846
WWOX WW domain containing oxidoreductase -0.0757805
BICC1 BicC family RNA binding protein 1 -0.0733763
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0728832
OSMR oncostatin M receptor -0.0692581
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0691355
FNDC3B fibronectin type III domain containing 3B -0.0628635
RPLP1 ribosomal protein, large, P1 -0.0609494
FTL ferritin, light polypeptide -0.0589994
TM4SF1 transmembrane 4 L six family member 1 -0.0570272
CMIP c-Maf inducing protein -0.0563664
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0551388
ASPH aspartate beta-hydroxylase -0.0547331
RPL19 ribosomal protein L19 -0.0538401
RAD51B RAD51 paralog B -0.0521919
BIRC3 baculoviral IAP repeat containing 3 -0.0515803
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0510551
RPL35A ribosomal protein L35a -0.049719
DST dystonin -0.0464518
NNMT nicotinamide N-methyltransferase -0.0462007
MAML3 mastermind-like 3 (Drosophila) -0.0447927
IGF2 insulin-like growth factor 2 -0.0447481
TFPI2 tissue factor pathway inhibitor 2 -0.0440081
C15ORF48 chromosome 15 open reading frame 48 -0.0433748
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0433592
NRG1 neuregulin 1 -0.0433558
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0431022
RPS21 ribosomal protein S21 -0.0425113
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.042471
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0406923
RPL23 ribosomal protein L23 -0.0404494
GLIS3 GLIS family zinc finger 3 -0.0387635
SVIL supervillin -0.0381081
RPS24 ribosomal protein S24 -0.0373576
RPL4 ribosomal protein L4 -0.0368996
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0363338
TTC28 tetratricopeptide repeat domain 28 -0.0357266
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0353123
APP amyloid beta (A4) precursor protein -0.0352786
LOC112694756 uncharaterized LOC112694756 -0.0352555
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.035044
TPT1 tumor protein, translationally-controlled 1 -0.0348822
FAM107B family with sequence similarity 107, member B -0.0347535
RNF213 ring finger protein 213 -0.0345884
SOD2 superoxide dismutase 2, mitochondrial -0.034567
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0344203
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0339664
NCOA7 nuclear receptor coactivator 7 -0.0338845
ATXN1 ataxin 1 -0.0337302
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0326548
AHNAK AHNAK nucleoprotein -0.0326097
CFLAR CASP8 and FADD-like apoptosis regulator -0.0322331
ARHGAP26 Rho GTPase activating protein 26 -0.0319098
FHIT fragile histidine triad -0.0318836
NHSL1 NHS-like 1 -0.0311638
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.0305672
RPS5 ribosomal protein S5 -0.0303776
NAV3 neuron navigator 3 -0.030186
CENPF centromere protein F, 350/400kDa -0.0299451
BABAM2 BRISC and BRCA1 A complex member 2 -0.029576
EHBP1 EH domain binding protein 1 -0.0291826
PFKP phosphofructokinase, platelet -0.0291404
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0288042
PKM pyruvate kinase, muscle -0.028796
EFNA5 ephrin-A5 -0.0287164
RPS27A ribosomal protein S27a -0.02865
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0284928
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0283899
ACTG1 actin gamma 1 -0.0283379
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0280164
RPL30 ribosomal protein L30 -0.02782
SLC38A2 solute carrier family 38, member 2 -0.027679
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0275505
AGO2 argonaute RISC catalytic component 2 -0.0267933
RPL9 ribosomal protein L9 -0.0267535
BIRC2 baculoviral IAP repeat containing 2 -0.0266453
SMYD3 SET and MYND domain containing 3 -0.0266156
PRKN parkin RBR E3 ubiquitin protein ligase -0.0262773
RAD21 RAD21 homolog (S. pombe) -0.0261662
RPS19 ribosomal protein S19 -0.0260704
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0257323
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0256931
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0255786
EXOC4 exocyst complex component 4 -0.0255509
LRMDA leucine rich melanocyte differentiation associated -0.025497
FGB fibrinogen beta chain -0.025062
IGF1R insulin-like growth factor 1 receptor -0.0250393
RPL12 ribosomal protein L12 -0.0250352
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0249471