| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Proglumide perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Proglumide_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.293329 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.121028 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0784206 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0566249 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0548066 |
| MKI67 | marker of proliferation Ki-67 | 0.049028 |
| OGA | O-GlcNAcase | 0.0487621 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0427658 |
| TXNRD1 | thioredoxin reductase 1 | 0.04273 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0426166 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0422957 |
| SET | SET nuclear proto-oncogene | 0.0400956 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0378938 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0375704 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0375342 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0370952 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0366262 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0358239 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.035714 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0353951 |
| STC1 | stanniocalcin 1 | 0.0353745 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0338785 |
| PTMA | prothymosin, alpha | 0.033314 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0330181 |
| CENPF | centromere protein F, 350/400kDa | 0.0297374 |
| EHBP1 | EH domain binding protein 1 | 0.029172 |
| CCND2 | cyclin D2 | 0.0291132 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.028834 |
| AHNAK | AHNAK nucleoprotein | 0.0287542 |
| RPS12 | ribosomal protein S12 | 0.0286775 |
| SRPK1 | SRSF protein kinase 1 | 0.028502 |
| VIM | vimentin | 0.028044 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0275793 |
| KIF5B | kinesin family member 5B | 0.0274183 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0272385 |
| TPR | translocated promoter region, nuclear basket protein | 0.0271864 |
| TPI1 | triosephosphate isomerase 1 | 0.0269835 |
| NSD2 | nuclear receptor binding SET domain protein 2 | 0.026872 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0259793 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.025975 |
| RPS2 | ribosomal protein S2 | 0.0258675 |
| MIS18BP1 | MIS18 binding protein 1 | 0.0258158 |
| PHIP | pleckstrin homology domain interacting protein | 0.0258057 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0252531 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0250382 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0249556 |
| PGK1 | phosphoglycerate kinase 1 | 0.0248173 |
| ZFR | zinc finger RNA binding protein | 0.0247987 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | 0.0247354 |
| SSB | Sjogren syndrome antigen B (autoantigen La) | 0.0235587 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0234446 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0233721 |
| ACTG1 | actin gamma 1 | 0.0233277 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0231222 |
| XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | 0.0228659 |
| NUP153 | nucleoporin 153kDa | 0.02277 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0227446 |
| TPM4 | tropomyosin 4 | 0.0226291 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0226184 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0225862 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0225766 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | 0.0224633 |
| BBX | bobby sox homolog (Drosophila) | 0.0223719 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0223431 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0221379 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0218629 |
| BMP5 | bone morphogenetic protein 5 | 0.0214467 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0214354 |
| ANXA5 | annexin A5 | 0.0214005 |
| SEPTIN2 | septin 2 | 0.0213872 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.021184 |
| VMP1 | vacuole membrane protein 1 | 0.0211447 |
| ADAR | adenosine deaminase, RNA-specific | 0.0207868 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0207787 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0204538 |
| RPS27A | ribosomal protein S27a | 0.0204376 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0203435 |
| KLF6 | Kruppel-like factor 6 | 0.020312 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0203012 |
| CIP2A | cellular inhibitor of PP2A | 0.0202503 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0202296 |
| RPS7 | ribosomal protein S7 | 0.0200494 |
| GLO1 | glyoxalase I | 0.0199861 |
| RNF145 | ring finger protein 145 | 0.0199747 |
| STK4 | serine/threonine kinase 4 | 0.0197808 |
| USP37 | ubiquitin specific peptidase 37 | 0.019733 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | 0.0197066 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0196116 |
| MYSM1 | Myb-like, SWIRM and MPN domains 1 | 0.0195831 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0191041 |
| POU2F1 | POU class 2 homeobox 1 | 0.018977 |
| RPS24 | ribosomal protein S24 | 0.018952 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0188341 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0187435 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0187309 |
| RPL26 | ribosomal protein L26 | 0.0186867 |
| DTNB | dystrobrevin, beta | 0.0185756 |
| XPO1 | exportin 1 | 0.0184808 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0184679 |
| KRT18 | keratin 18, type I | 0.0184353 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0732659 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0674644 |
| EGR1 | early growth response 1 | -0.0641939 |
| COPA | coatomer protein complex, subunit alpha | -0.0547747 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0532534 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0528282 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0501364 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0454269 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.041885 |
| EGFR | epidermal growth factor receptor | -0.0407602 |
| AEBP2 | AE binding protein 2 | -0.0405883 |
| ATXN1 | ataxin 1 | -0.0405392 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0401831 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0371346 |
| DST | dystonin | -0.0365316 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0363648 |
| POTEF | POTE ankyrin domain family, member F | -0.0356566 |
| TMSB10 | thymosin beta 10 | -0.0346202 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0340162 |
| SLC38A2 | solute carrier family 38, member 2 | -0.032625 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.032547 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0322469 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0310589 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0309531 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0307072 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0302646 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0300785 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | -0.0297527 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0293763 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0290609 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0288474 |
| INTS6 | integrator complex subunit 6 | -0.0288365 |
| SCFD2 | sec1 family domain containing 2 | -0.0286461 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0284821 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0284427 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.027897 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0277472 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0272744 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0270466 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0268401 |
| FMNL2 | formin-like 2 | -0.0266362 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0264904 |
| PRKCE | protein kinase C, epsilon | -0.0262776 |
| PKP4 | plakophilin 4 | -0.0262015 |
| USP34 | ubiquitin specific peptidase 34 | -0.0261451 |
| NLGN1 | neuroligin 1 | -0.0260749 |
| CCNL1 | cyclin L1 | -0.0260007 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0256347 |
| BRD2 | bromodomain containing 2 | -0.0253672 |
| FARS2 | phenylalanyl-tRNA synthetase 2, mitochondrial | -0.0252885 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0251084 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.025106 |
| KMT2D | lysine (K)-specific methyltransferase 2D | -0.0248556 |
| MSN | moesin | -0.0248366 |
| PFN1 | profilin 1 | -0.0245387 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0244485 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0242163 |
| ALG13 | ALG13, UDP-N-acetylglucosaminyltransferase subunit | -0.0236724 |
| NOTCH2 | notch 2 | -0.0234768 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0233476 |
| EP400 | E1A binding protein p400 | -0.0232725 |
| RPLP1 | ribosomal protein, large, P1 | -0.0232004 |
| NF1 | neurofibromin 1 | -0.0231244 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0230541 |
| ATF6 | activating transcription factor 6 | -0.0229442 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0224903 |
| LOXL2 | lysyl oxidase-like 2 | -0.0224254 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0223826 |
| COMMD1 | copper metabolism (Murr1) domain containing 1 | -0.0223073 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0221973 |
| ARF4 | ADP-ribosylation factor 4 | -0.0219903 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0217295 |
| RAD51B | RAD51 paralog B | -0.0217076 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | -0.0215611 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0214748 |
| GOLGB1 | golgin B1 | -0.0214678 |
| MEF2D | myocyte enhancer factor 2D | -0.0213061 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0212742 |
| TAPBP | TAP binding protein (tapasin) | -0.0208294 |
| TPM2 | tropomyosin 2 (beta) | -0.0207153 |
| MT2A | metallothionein 2A | -0.0204952 |
| PTK2 | protein tyrosine kinase 2 | -0.0202628 |
| BRD4 | bromodomain containing 4 | -0.020163 |
| SEC16A | SEC16 homolog A (S. cerevisiae) | -0.0199359 |
| GRAMD1B | GRAM domain containing 1B | -0.0198594 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0198439 |
| PKM | pyruvate kinase, muscle | -0.0197595 |
| SRSF3 | serine/arginine-rich splicing factor 3 | -0.0195742 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0193607 |
| PCMTD2 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 | -0.0193605 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.019328 |
| FTL | ferritin, light polypeptide | -0.0191666 |
| AGRN | agrin | -0.0191547 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0191451 |
| CTIF | CBP80/20-dependent translation initiation factor | -0.0189115 |
| DOCK7 | dedicator of cytokinesis 7 | -0.0187425 |
| HYOU1 | hypoxia up-regulated 1 | -0.0185107 |
| CUL3 | cullin 3 | -0.0180306 |
| NBAS | neuroblastoma amplified sequence | -0.0180299 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0180055 |
