Proglumide_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Proglumide perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Proglumide_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.135355
PM20D1 peptidase M20 domain containing 1 0.0846973
MCL1 myeloid cell leukemia 1 0.079735
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0778464
STC1 stanniocalcin 1 0.0700866
DST dystonin 0.0641812
FN1 fibronectin 1 0.0625576
FNDC3A fibronectin type III domain containing 3A 0.0621811
ELL2 elongation factor, RNA polymerase II, 2 0.0613504
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0577989
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0535538
VMP1 vacuole membrane protein 1 0.0488642
KYNU kynureninase 0.0478869
ITPRID2 ITPR interacting domain containing 2 0.0477089
DOCK5 dedicator of cytokinesis 5 0.0420281
MFF mitochondrial fission factor 0.0408968
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0404273
SDK1 sidekick cell adhesion molecule 1 0.0401267
NBEAL1 neurobeachin-like 1 0.0398419
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0396268
PDGFA platelet-derived growth factor alpha polypeptide 0.0387381
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0387346
PDLIM5 PDZ and LIM domain 5 0.038378
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0364156
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0357975
MSN moesin 0.034452
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0337215
ERRFI1 ERBB receptor feedback inhibitor 1 0.0335595
VCL vinculin 0.0331041
ESYT2 extended synaptotagmin-like protein 2 0.0323478
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0322935
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0321819
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0311537
NPAS2 neuronal PAS domain protein 2 0.0307791
AKAP13 A kinase (PRKA) anchor protein 13 0.0301485
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0300911
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0289535
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0285404
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0284919
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0281217
CHL1 cell adhesion molecule L1-like 0.0272433
TXNIP thioredoxin interacting protein 0.0269659
SMOC1 SPARC related modular calcium binding 1 0.0267155
LAMB1 laminin, beta 1 0.0252993
CLU clusterin 0.0244469
PYGL phosphorylase, glycogen, liver 0.0243465
BASP1 brain abundant, membrane attached signal protein 1 0.0240747
MAP7 microtubule-associated protein 7 0.0239394
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.023655
TMF1 TATA element modulatory factor 1 0.0232463
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0229399
FLNB filamin B, beta 0.0228106
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0227222
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0220339
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0217877
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0216961
IL6 interleukin 6 0.0210926
EGR1 early growth response 1 0.021021
EPHA4 EPH receptor A4 0.0208007
BTG1 B-cell translocation gene 1, anti-proliferative 0.020596
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.020175
SEC31A SEC31 homolog A (S. cerevisiae) 0.0199306
TMX4 thioredoxin-related transmembrane protein 4 0.0198772
MT2A metallothionein 2A 0.0192034
ZEB2 zinc finger E-box binding homeobox 2 0.0191014
PHF21A PHD finger protein 21A 0.0190429
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0190183
FNIP1 folliculin interacting protein 1 0.0188514
DGKD diacylglycerol kinase, delta 130kDa 0.0188025
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0187671
FNDC3B fibronectin type III domain containing 3B 0.0185753
HILPDA hypoxia inducible lipid droplet-associated 0.0181582
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0179418
COPA coatomer protein complex, subunit alpha 0.0178924
N4BP2L2 NEDD4 binding protein 2-like 2 0.0177194
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.01761
ARFGEF3 ARFGEF family member 3 0.0175444
GOLGB1 golgin B1 0.0175352
CDK19 cyclin-dependent kinase 19 0.0175307
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0174711
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0172202
ESM1 endothelial cell-specific molecule 1 0.0171138
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0170277
PGM2L1 phosphoglucomutase 2-like 1 0.0169994
BMERB1 bMERB domain containing 1 0.0169651
NEFL neurofilament, light polypeptide 0.0168989
SETD5 SET domain containing 5 0.016681
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.0166717
AKAP9 A kinase (PRKA) anchor protein 9 0.0166518
KMT2E lysine (K)-specific methyltransferase 2E 0.0163815
CFAP96 cilia and flagella associated protein 96 0.0162624
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0160424
ITGA6 integrin, alpha 6 0.0159864
CCDC88A coiled-coil domain containing 88A 0.0158668
MYPN myopalladin 0.0157841
NFX1 nuclear transcription factor, X-box binding 1 0.0155836
OXSR1 oxidative stress responsive 1 0.0154231
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0154064
RPL21 ribosomal protein L21 0.0153808
INHBA inhibin, beta A 0.0153704

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.194952
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.175491
TXNRD1 thioredoxin reductase 1 -0.144729
PDE4D phosphodiesterase 4D, cAMP-specific -0.141878
PDE10A phosphodiesterase 10A -0.120886
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.117683
ASPH aspartate beta-hydroxylase -0.107326
NALF1 NALCN channel auxiliary factor 1 -0.106229
NAMPT nicotinamide phosphoribosyltransferase -0.10582
SMYD3 SET and MYND domain containing 3 -0.0953965
TMSB10 thymosin beta 10 -0.0937245
CDH13 cadherin 13 -0.0898819
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0886626
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0794059
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0787126
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0766246
TRIO trio Rho guanine nucleotide exchange factor -0.0713997
RPLP1 ribosomal protein, large, P1 -0.0685394
RPS24 ribosomal protein S24 -0.0680322
COL5A2 collagen, type V, alpha 2 -0.0666479
EFNA5 ephrin-A5 -0.0649663
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0637221
PTMA prothymosin, alpha -0.0582631
PSD3 pleckstrin and Sec7 domain containing 3 -0.0547613
GDA guanine deaminase -0.051866
TNPO1 transportin 1 -0.051626
AKR1C1 aldo-keto reductase family 1, member C1 -0.0507086
RPL35A ribosomal protein L35a -0.0492157
NAP1L1 nucleosome assembly protein 1-like 1 -0.0480609
EEF2 eukaryotic translation elongation factor 2 -0.047475
TPT1 tumor protein, translationally-controlled 1 -0.0464454
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0457706
RPL26 ribosomal protein L26 -0.0454348
LOC112694756 uncharaterized LOC112694756 -0.0450766
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0448805
RPL23 ribosomal protein L23 -0.0436115
PTPRM protein tyrosine phosphatase, receptor type, M -0.0434915
NRCAM neuronal cell adhesion molecule -0.042724
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0419192
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0416939
RPL4 ribosomal protein L4 -0.0408212
GRAMD1B GRAM domain containing 1B -0.0398655
FTL ferritin, light polypeptide -0.0381885
RPS4X ribosomal protein S4, X-linked -0.0381461
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0380794
ANTXR1 anthrax toxin receptor 1 -0.0379219
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0374423
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0370432
PRKN parkin RBR E3 ubiquitin protein ligase -0.0356629
PKM pyruvate kinase, muscle -0.0351957
RPLP0 ribosomal protein, large, P0 -0.0348465
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0344737
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0339541
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0332868
SERBP1 SERPINE1 mRNA binding protein 1 -0.0315485
RPS21 ribosomal protein S21 -0.031523
RPL13A ribosomal protein L13a -0.0313417
MAP1B microtubule-associated protein 1B -0.0310698
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0307815
ANXA2 annexin A2 -0.0307594
ACTG1 actin gamma 1 -0.0306858
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0306719
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0300072
PRDX1 peroxiredoxin 1 -0.0298372
RPL34 ribosomal protein L34 -0.0297874
SOD2 superoxide dismutase 2, mitochondrial -0.0296563
IARS1 isoleucyl-tRNA synthetase 1 -0.0295057
RPS8 ribosomal protein S8 -0.0294999
OLA1 Obg-like ATPase 1 -0.0291779
RTN4 reticulon 4 -0.0290825
APP amyloid beta (A4) precursor protein -0.0288066
PRRC2B proline-rich coiled-coil 2B -0.0286657
SPAG9 sperm associated antigen 9 -0.028502
ALPK2 alpha-kinase 2 -0.0284564
RPL31 ribosomal protein L31 -0.0281172
DNAH14 dynein, axonemal, heavy chain 14 -0.0280863
AOPEP aminopeptidase O (putative) -0.0279954
ARF1 ADP-ribosylation factor 1 -0.0279638
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -0.027886
FTH1 ferritin, heavy polypeptide 1 -0.0277612
MATR3 matrin 3 -0.0277276
LAMA1 laminin, alpha 1 -0.0277272
RPL37A ribosomal protein L37a -0.0277223
RPL12 ribosomal protein L12 -0.0276821
PGK1 phosphoglycerate kinase 1 -0.0276812
KDM3A lysine (K)-specific demethylase 3A -0.0275993
RBM39 RNA binding motif protein 39 -0.0275949
FLNA filamin A, alpha -0.0275143
FUS FUS RNA binding protein -0.0275089
ADGRD1 adhesion G protein-coupled receptor D1 -0.0271228
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0269698
MORF4L2 mortality factor 4 like 2 -0.0264977
IGF1R insulin-like growth factor 1 receptor -0.0264795
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0263704
RPH3AL rabphilin 3A-like (without C2 domains) -0.0263127
RPS6 ribosomal protein S6 -0.0260751
HLA-B major histocompatibility complex, class I, B -0.0258769
ANXA1 annexin A1 -0.0258076
RPL11 ribosomal protein L11 -0.0257961
PBX1 pre-B-cell leukemia homeobox 1 -0.0257064