Proglumide_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Proglumide perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

61 genes differentially expressed following the Proglumide_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NCOA3 nuclear receptor coactivator 3 0.169697
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.142551
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.132523
UBE2H ubiquitin-conjugating enzyme E2H 0.118853
ZMYND8 zinc finger, MYND-type containing 8 0.105299
DSCAM Down syndrome cell adhesion molecule 0.101812
UGCG UDP-glucose ceramide glucosyltransferase 0.101427
MYO1E myosin IE 0.0993693
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0938838
NKD1 naked cuticle homolog 1 (Drosophila) 0.0902126
PRKCA protein kinase C, alpha 0.0841322
SBF2 SET binding factor 2 0.0832673
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0805975
RUNX1 runt-related transcription factor 1 0.0710605
PGK1 phosphoglycerate kinase 1 0.0653721
PTMA prothymosin, alpha 0.0638483
RPS6 ribosomal protein S6 0.0629162
SMAD3 SMAD family member 3 0.0612266
DST dystonin 0.0587188
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.057634
RICTOR RPTOR independent companion of MTOR, complex 2 0.054337
NAMPT nicotinamide phosphoribosyltransferase 0.0495539
ENAH enabled homolog (Drosophila) 0.0482638
RTN4 reticulon 4 0.0478242
NUMB numb homolog (Drosophila) 0.0475208
ZBTB20 zinc finger and BTB domain containing 20 0.0439748
BIRC6 baculoviral IAP repeat containing 6 0.0420008
FAF1 Fas (TNFRSF6) associated factor 1 0.0270733
RPS3 ribosomal protein S3 0.0263384
NAP1L1 nucleosome assembly protein 1-like 1 0.0247548
NDRG1 N-myc downstream regulated 1 0.0233668
ANXA2 annexin A2 0.0207844
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0193085
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0186805
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0158013
CANX calnexin 0.0103124
UBC ubiquitin C 0.00743549
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.00709285

decreased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A -0.265291
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.241282
EFNA5 ephrin-A5 -0.194757
ASPH aspartate beta-hydroxylase -0.127406
EXT1 exostosin glycosyltransferase 1 -0.122714
PDE4D phosphodiesterase 4D, cAMP-specific -0.100166
FN1 fibronectin 1 -0.070837
TMSB10 thymosin beta 10 -0.0668632
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0653865
FTL ferritin, light polypeptide -0.0535788
ACTN4 actinin, alpha 4 -0.0470333
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0462629
FNDC3B fibronectin type III domain containing 3B -0.0451995
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0424653
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0269509
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0195852
RPL23 ribosomal protein L23 -0.018107
TRIO trio Rho guanine nucleotide exchange factor -0.0156881
NUP58 nucleoporin 58 -0.0138754
VIM vimentin -0.00835473
LDHA lactate dehydrogenase A -0.00816856
ELL2 elongation factor, RNA polymerase II, 2 -0.00127104
RBPJ recombination signal binding protein for immunoglobulin kappa J region -1.86801E-4