| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Proglumide perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Proglumide_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| B2M | beta-2-microglobulin | 0.0730458 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0706597 |
| RPS12 | ribosomal protein S12 | 0.0596307 |
| PTMA | prothymosin, alpha | 0.0583146 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0577266 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0553923 |
| SETD5 | SET domain containing 5 | 0.0502161 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0501026 |
| RPS2 | ribosomal protein S2 | 0.0467843 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0466415 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0455962 |
| THOC2 | THO complex 2 | 0.0448334 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0434604 |
| NTM | neurotrimin | 0.0433791 |
| PRTG | protogenin | 0.0417744 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0411321 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0407722 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0374532 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0363228 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0360916 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0336022 |
| RPS6 | ribosomal protein S6 | 0.0321134 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0321062 |
| PLPP1 | phospholipid phosphatase 1 | 0.0317949 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0315974 |
| SERF2 | small EDRK-rich factor 2 | 0.0312593 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0300913 |
| CRY1 | cryptochrome circadian clock 1 | 0.0296315 |
| PGK1 | phosphoglycerate kinase 1 | 0.0295888 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0286218 |
| CLU | clusterin | 0.0283059 |
| TGFB2 | transforming growth factor, beta 2 | 0.027803 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0277123 |
| RPL23 | ribosomal protein L23 | 0.0276892 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0275081 |
| VEGFA | vascular endothelial growth factor A | 0.0270988 |
| SNX6 | sorting nexin 6 | 0.0270772 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0260831 |
| TMEM165 | transmembrane protein 165 | 0.0258278 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0257464 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0256128 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0254361 |
| PLS3 | plastin 3 | 0.0251217 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0249182 |
| RCOR1 | REST corepressor 1 | 0.0246155 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0243946 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0243346 |
| TBC1D12 | TBC1 domain family, member 12 | 0.0241847 |
| TLK1 | tousled-like kinase 1 | 0.0241333 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0238647 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.023803 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0233667 |
| RPS7 | ribosomal protein S7 | 0.0230936 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0228505 |
| ZFP36 | ZFP36 ring finger protein | 0.0228047 |
| ANXA5 | annexin A5 | 0.0225847 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | 0.0225414 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0224786 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0223873 |
| RIGI | RNA sensor RIG-I | 0.022217 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0221704 |
| SRPK2 | SRSF protein kinase 2 | 0.0221665 |
| SOX2 | SRY (sex determining region Y)-box 2 | 0.0220815 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.02207 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0219916 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0219865 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0217972 |
| RPL21 | ribosomal protein L21 | 0.0215407 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.021365 |
| TMED4 | transmembrane emp24 protein transport domain containing 4 | 0.0211419 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | 0.0211367 |
| H1-4 | H1.4 linker histone, cluster member | 0.0210516 |
| HECTD4 | HECT domain containing E3 ubiquitin protein ligase 4 | 0.0210175 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0209582 |
| RPS8 | ribosomal protein S8 | 0.0208263 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.020612 |
| NUCB2 | nucleobindin 2 | 0.0205935 |
| NCKAP1 | NCK-associated protein 1 | 0.0204002 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0203949 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0202444 |
| SEC24A | SEC24 family member A | 0.0200572 |
| RAB6A | RAB6A, member RAS oncogene family | 0.020003 |
| RYK | receptor-like tyrosine kinase | 0.0199303 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0198836 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0198796 |
| SLK | STE20-like kinase | 0.0196394 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.019569 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0195647 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0190959 |
| MSN | moesin | 0.0190453 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0188756 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0186991 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.0186398 |
| DENR | density-regulated protein | 0.0185982 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 0.0185111 |
| RACK1 | receptor for activated C kinase 1 | 0.0182623 |
| FOXG1 | forkhead box G1 | 0.0182361 |
| SEC24D | SEC24 family member D | 0.0182228 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0181142 |
| RPS29 | ribosomal protein S29 | 0.018051 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.166933 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.153509 |
| CADM2 | cell adhesion molecule 2 | -0.117696 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.11612 |
| THBS1 | thrombospondin 1 | -0.114085 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.110542 |
| PEG10 | paternally expressed 10 | -0.104159 |
| GPC3 | glypican 3 | -0.10226 |
| TMSB4X | thymosin beta 4, X-linked | -0.101118 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0880658 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0840597 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.079063 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0743868 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0716859 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0688407 |
| ACTG1 | actin gamma 1 | -0.0685921 |
| HDAC9 | histone deacetylase 9 | -0.0659248 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0629762 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0628864 |
| VIM | vimentin | -0.0620514 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.061804 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0592139 |
| AHNAK | AHNAK nucleoprotein | -0.0566848 |
| TENM3 | teneurin transmembrane protein 3 | -0.0566294 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0565018 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.0560206 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0555692 |
| SYT1 | synaptotagmin I | -0.0543767 |
| HNRNPL | heterogeneous nuclear ribonucleoprotein L | -0.0531098 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0524645 |
| ACTN4 | actinin, alpha 4 | -0.05124 |
| APP | amyloid beta (A4) precursor protein | -0.0510555 |
| EMP1 | epithelial membrane protein 1 | -0.0502173 |
| RAD51B | RAD51 paralog B | -0.0499322 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0497444 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0491146 |
| JMJD1C | jumonji domain containing 1C | -0.0485808 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0472355 |
| COL5A2 | collagen, type V, alpha 2 | -0.0471701 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0466944 |
| MKI67 | marker of proliferation Ki-67 | -0.0466132 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0465221 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0465154 |
| SHROOM3 | shroom family member 3 | -0.0458885 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0449614 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0445809 |
| ZNF292 | zinc finger protein 292 | -0.0429768 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0427985 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0419949 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0419672 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0419107 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0417443 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0412004 |
| ENAH | enabled homolog (Drosophila) | -0.0407794 |
| MATR3 | matrin 3 | -0.0403335 |
| NFIA | nuclear factor I/A | -0.0393561 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0384209 |
| CDC50A | cell division cycle 50 P4-ATPase accessory subunit A | -0.0382236 |
| CLTC | clathrin, heavy chain (Hc) | -0.0377349 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0375017 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0373142 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0370932 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0369063 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0359746 |
| ABI2 | abl-interactor 2 | -0.0358173 |
| NF1 | neurofibromin 1 | -0.0356616 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0353935 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0351864 |
| DST | dystonin | -0.0350743 |
| METAP2 | methionyl aminopeptidase 2 | -0.0349664 |
| ZFR | zinc finger RNA binding protein | -0.0348014 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0345053 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | -0.0338922 |
| CENPF | centromere protein F, 350/400kDa | -0.0334577 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0331596 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0327956 |
| SMYD3 | SET and MYND domain containing 3 | -0.0327035 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.032533 |
| CDK6 | cyclin-dependent kinase 6 | -0.0325087 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0321851 |
| CDC73 | cell division cycle 73 | -0.0321411 |
| FAM171B | family with sequence similarity 171, member B | -0.032097 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.031672 |
| CBX3 | chromobox homolog 3 | -0.0313446 |
| FOXP2 | forkhead box P2 | -0.0311835 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0309366 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0305348 |
| RPL19 | ribosomal protein L19 | -0.0304987 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0303609 |
| BRMS1L | breast cancer metastasis-suppressor 1-like | -0.0303369 |
| FBL | fibrillarin | -0.0300292 |
| RPS16 | ribosomal protein S16 | -0.0300161 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0298721 |
| WDR70 | WD repeat domain 70 | -0.0298563 |
| KIAA1328 | KIAA1328 | -0.0297587 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0296846 |
| PCDH7 | protocadherin 7 | -0.0296594 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0295343 |
| CPLANE1 | ciliogenesis and planar polarity effector complex subunit 1 | -0.0294718 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0292387 |
