Programmed Cell Death Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
Description A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell. (Gene Ontology, GO_0012501)
External Link https://reactome.org/PathwayBrowser/#/R-HSA-5357801
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Genes

200 proteins participating in the Programmed Cell Death pathway from the Reactome Pathways 2024 dataset.

Symbol Name
ACIN1 apoptotic chromatin condensation inducer 1
ADD1 adducin 1 (alpha)
ADRM1 adhesion regulating molecule 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
APAF1 apoptotic peptidase activating factor 1
APC adenomatous polyposis coli
APIP APAF1 interacting protein
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
ARHGAP10 Rho GTPase activating protein 10
AVEN apoptosis, caspase activation inhibitor
BAD BCL2-associated agonist of cell death
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCAP31 B-cell receptor-associated protein 31
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BID BH3 interacting domain death agonist
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BMF Bcl2 modifying factor
BMX BMX non-receptor tyrosine kinase
C1QBP complement component 1, q subcomponent binding protein
CARD8 caspase recruitment domain family, member 8
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP4 caspase 4, apoptosis-related cysteine peptidase
CASP5 caspase 5, apoptosis-related cysteine peptidase
CASP6 caspase 6, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CD14 CD14 molecule
CDC37 cell division cycle 37
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN2A cyclin-dependent kinase inhibitor 2A
CFLAR CASP8 and FADD-like apoptosis regulator
CHMP2A charged multivesicular body protein 2A
CHMP2B charged multivesicular body protein 2B
CHMP3 charged multivesicular body protein 3
CHMP4A charged multivesicular body protein 4A
CHMP4B charged multivesicular body protein 4B
CHMP4C charged multivesicular body protein 4C
CHMP6 charged multivesicular body protein 6
CHMP7 charged multivesicular body protein 7
CLSPN claspin
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYCS cytochrome c, somatic
DAPK1 death-associated protein kinase 1
DAPK2 death-associated protein kinase 2
DAPK3 death-associated protein kinase 3
DBNL drebrin-like
DCC DCC netrin 1 receptor
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DIABLO diablo, IAP-binding mitochondrial protein
DNM1L dynamin 1-like
DSG1 desmoglein 1
DSG2 desmoglein 2
DSG3 desmoglein 3
DSP desmoplakin
DYNLL1 dynein, light chain, LC8-type 1
DYNLL2 dynein, light chain, LC8-type 2
E2F1 E2F transcription factor 1
ELANE elastase, neutrophil expressed
FADD Fas (TNFRSF6)-associated via death domain
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FLOT1 flotillin 1
FLOT2 flotillin 2
FNTA farnesyltransferase, CAAX box, alpha
GAS2 growth arrest-specific 2
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GSDMD gasdermin D
GSDME gasdermin E
GSN gelsolin
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
H1-0 H1.0 linker histone
H1-1 H1.1 linker histone, cluster member
H1-2 H1.2 linker histone, cluster member
H1-3 H1.3 linker histone, cluster member
H1-4 H1.4 linker histone, cluster member
H1-5 H1.5 linker histone, cluster member
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
IL18 interleukin 18
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IRF1 interferon regulatory factor 1
IRF2 interferon regulatory factor 2
ITCH itchy E3 ubiquitin protein ligase
KPNA1 karyopherin alpha 1 (importin alpha 5)
KPNB1 karyopherin (importin) beta 1
LMNA lamin A/C
LMNB1 lamin B1
LY96 lymphocyte antigen 96
MAGED1 melanoma antigen family D1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPT microtubule-associated protein tau
MLKL mixed lineage kinase domain-like
NMT1 N-myristoyltransferase 1
OCLN occludin
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
OMA1 OMA1 zinc metallopeptidase
OPA1 optic atrophy 1 (autosomal dominant)
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PDCD6IP programmed cell death 6 interacting protein
PELI1 pellino E3 ubiquitin protein ligase 1
PKP1 plakophilin 1
PLEC plectin
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRKCD protein kinase C, delta
PRKCQ protein kinase C, theta
PRKN parkin RBR E3 ubiquitin protein ligase
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PTK2 protein tyrosine kinase 2
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK3 receptor-interacting serine-threonine kinase 3
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPS27A ribosomal protein S27a
RRM1 ribonucleotide reductase M1
SATB1 SATB homeobox 1
SDCBP syndecan binding protein (syntenin)
SEM1 SEM1 26S proteasome subunit
SEPTIN4 septin 4
SFN stratifin
SPTAN1 spectrin, alpha, non-erythrocytic 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK24 serine/threonine kinase 24
STK26 serine/threonine protein kinase 26
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TFDP1 transcription factor Dp-1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TICAM1 toll-like receptor adaptor molecule 1
TICAM2 toll-like receptor adaptor molecule 2
TJP1 tight junction protein 1
TJP2 tight junction protein 2
TLR4 toll-like receptor 4
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TP63 tumor protein p63
TP73 tumor protein p73
TRADD TNFRSF1A-associated via death domain
TRAF2 TNF receptor-associated factor 2
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UNC5A unc-5 homolog A (C. elegans)
UNC5B unc-5 homolog B (C. elegans)
VIM vimentin
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta