Prolactinoma Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description OMIM mapping confirmed by DO. [SN]. (Human Disease Ontology, DOID_5394)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D015175
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Genes

197 genes/proteins associated with the disease Prolactinoma from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
BMP4 bone morphogenetic protein 4 2.88009
AIP aryl hydrocarbon receptor interacting protein 2.88009
PRL prolactin 2.88009
FSHB follicle stimulating hormone, beta polypeptide 1.83414
LHB luteinizing hormone beta polypeptide 1.55747
BMP7 bone morphogenetic protein 7 1.52865
IGF1 insulin-like growth factor 1 (somatomedin C) 1.43347
GREB1 growth regulation by estrogen in breast cancer 1 1.43184
GH1 growth hormone 1 1.40429
IGF2 insulin-like growth factor 2 1.3998
PGR progesterone receptor 1.38412
EGR3 early growth response 3 1.38384
TP53 tumor protein p53 1.36706
NR1I2 nuclear receptor subfamily 1, group I, member 2 1.36476
COMT catechol-O-methyltransferase 1.33553
TGFB1 transforming growth factor, beta 1 1.32428
PCNA proliferating cell nuclear antigen 1.32339
AR androgen receptor 1.32221
MKI67 marker of proliferation Ki-67 1.32192
ESR2 estrogen receptor 2 (ER beta) 1.31927
FAS Fas cell surface death receptor 1.31506
BAD BCL2-associated agonist of cell death 1.31208
TFRC transferrin receptor 1.30177
SREBF1 sterol regulatory element binding transcription factor 1 1.29966
VEGFA vascular endothelial growth factor A 1.29936
ADIPOQ adiponectin, C1Q and collagen domain containing 1.29348
TSC22D1 TSC22 domain family, member 1 1.29287
STAR steroidogenic acute regulatory protein 1.29133
TH tyrosine hydroxylase 1.28456
ESR1 estrogen receptor 1 1.27595
DRD2 dopamine receptor D2 1.26144
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.2599
CAMK4 calcium/calmodulin-dependent protein kinase IV 1.25588
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.25432
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.24905
INS insulin 1.2415
MMD2 monocyte to macrophage differentiation-associated 2 1.2393
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.2336
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.23169
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.22948
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.22758
TFF1 trefoil factor 1 1.22016
IGF1R insulin-like growth factor 1 receptor 1.20558
SDC2 syndecan 2 1.20526
FABP4 fatty acid binding protein 4, adipocyte 1.2046
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.20427
MMP3 matrix metallopeptidase 3 1.20295
CSHL1 chorionic somatomammotropin hormone-like 1 1.19868
SFN stratifin 1.19802
NRIP1 nuclear receptor interacting protein 1 1.19607
LHCGR luteinizing hormone/choriogonadotropin receptor 1.19574
DHRS3 dehydrogenase/reductase (SDR family) member 3 1.19345
HOXA10 homeobox A10 1.19146
ACP5 acid phosphatase 5, tartrate resistant 1.1908
KLK2 kallikrein-related peptidase 2 1.18587
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.18391
BAX BCL2-associated X protein 1.18326
GAL galanin/GMAP prepropeptide 1.18159
IGFBP3 insulin-like growth factor binding protein 3 1.18026
GINS3 GINS complex subunit 3 (Psf3 homolog) 1.17993
ASS1 argininosuccinate synthase 1 1.17926
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 1.17728
CCK cholecystokinin 1.17333
GDNF glial cell derived neurotrophic factor 1.16733
NGF nerve growth factor (beta polypeptide) 1.165
MAP2K1 mitogen-activated protein kinase kinase 1 1.16467
SOCS2 suppressor of cytokine signaling 2 1.16434
CCND1 cyclin D1 1.1607
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 1.16001
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 1.15831
CD36 CD36 molecule (thrombospondin receptor) 1.15729
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 1.15627
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 1.14438
ANXA3 annexin A3 1.14404
HSF1 heat shock transcription factor 1 1.14234
KLF9 Kruppel-like factor 9 1.14234
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.14166
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 1.1403
RBM24 RNA binding motif protein 24 1.13929
PCP4 Purkinje cell protein 4 1.13895
EGFR epidermal growth factor receptor 1.13724
NCOA1 nuclear receptor coactivator 1 1.13552
HMGB2 high mobility group box 2 1.13484
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.13041
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 1.12771
B2M beta-2-microglobulin 1.12771
LPL lipoprotein lipase 1.12634
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.12357
CXCL10 chemokine (C-X-C motif) ligand 10 1.12151
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 1.12151
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 1.11877
INHBA inhibin, beta A 1.11707
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 1.11639
PRLR prolactin receptor 1.11571
BGLAP bone gamma-carboxyglutamate (gla) protein 1.11571
FOS FBJ murine osteosarcoma viral oncogene homolog 1.11466
KLK3 kallikrein-related peptidase 3 1.11255
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.10942
NR1I3 nuclear receptor subfamily 1, group I, member 3 1.10734
MAPK3 mitogen-activated protein kinase 3 1.10665
GADD45G growth arrest and DNA-damage-inducible, gamma 1.10246
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.10069
CREBBP CREB binding protein 1.09963
MAPK1 mitogen-activated protein kinase 1 1.09927
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.09786
ELOVL2 ELOVL fatty acid elongase 2 1.09471
SIAH2 siah E3 ubiquitin protein ligase 2 1.09471
BLNK B-cell linker 1.09471
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.0919
NFE2L1 nuclear factor, erythroid 2-like 1 1.09119
OLFM1 olfactomedin 1 1.09119
CALR calreticulin 1.09119
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 1.09119
INMT indolethylamine N-methyltransferase 1.09083
BDNF brain-derived neurotrophic factor 1.0894
S100A8 S100 calcium binding protein A8 1.08513
CA2 carbonic anhydrase II 1.08513
GPX2 glutathione peroxidase 2 1.08231
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 1.08126
RARA retinoic acid receptor, alpha 1.08091
RHOA ras homolog family member A 1.08091
DSC2 desmocollin 2 1.08019
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.07768
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 1.07768
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 1.07768
CCL8 chemokine (C-C motif) ligand 8 1.07696
MKNK2 MAP kinase interacting serine/threonine kinase 2 1.07696
PCSK6 proprotein convertase subtilisin/kexin type 6 1.07696
LPO lactoperoxidase 1.07589
TNF tumor necrosis factor 1.07518
CCNG1 cyclin G1 1.0734
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.07163
INHA inhibin, alpha 1.07128
GSK3B glycogen synthase kinase 3 beta 1.07128
UBB ubiquitin B 1.07093
AGR2 anterior gradient 2 1.07057
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.07057
LEP leptin 1.06917
DNMT1 DNA (cytosine-5-)-methyltransferase 1 1.06771
WFDC2 WAP four-disulfide core domain 2 1.06406
BSG basigin (Ok blood group) 1.06406
LOXL1 lysyl oxidase-like 1 1.06116
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1 1.0608
HOXA1 homeobox A1 1.05793
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.05573
SOCS3 suppressor of cytokine signaling 3 1.05423
SMC2 structural maintenance of chromosomes 2 1.052
PPARG peroxisome proliferator-activated receptor gamma 1.05163
NOS2 nitric oxide synthase 2, inducible 1.05089
ESRRA estrogen-related receptor alpha 1.04978
ACSL5 acyl-CoA synthetase long-chain family member 5 1.04314
IGFBP1 insulin-like growth factor binding protein 1 1.04239
PDZK1 PDZ domain containing 1 1.04126
LEPR leptin receptor 1.04126
EEF1G eukaryotic translation elongation factor 1 gamma 1.04088
ATF4 activating transcription factor 4 1.03976
WARS tryptophanyl-tRNA synthetase 1.03827
PRIM1 primase, DNA, polypeptide 1 (49kDa) 1.03715
CAV1 caveolin 1, caveolae protein, 22kDa 1.03604
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.03493
CD14 CD14 molecule 1.03456
HNF1A HNF1 homeobox A 1.03456
DDIT4 DNA-damage-inducible transcript 4 1.03235
CDT1 chromatin licensing and DNA replication factor 1 1.03235
PTCH1 patched 1 1.03159
CKS1B CDC28 protein kinase regulatory subunit 1B 1.02933
GSTM1 glutathione S-transferase mu 1 1.02858
CTSD cathepsin D 1.02858
INHBB inhibin, beta B 1.02746
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 1.02671
COL1A2 collagen, type I, alpha 2 1.02522
S100G S100 calcium binding protein G 1.02522
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.02522
BMP6 bone morphogenetic protein 6 1.02225
PRKCD protein kinase C, delta 1.02188
HOMER1 homer scaffolding protein 1 1.02188
BCL3 B-cell CLL/lymphoma 3 1.02188
NR2F2 nuclear receptor subfamily 2, group F, member 2 1.02151
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 1.02151
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 1.02114
CPXM2 carboxypeptidase X (M14 family), member 2 1.02077
NR5A2 nuclear receptor subfamily 5, group A, member 2 1.01966
GFAP glial fibrillary acidic protein 1.01814
SOCS1 suppressor of cytokine signaling 1 1.01701
EGR1 early growth response 1 1.01663
COL6A3 collagen, type VI, alpha 3 1.01625
RASD1 RAS, dexamethasone-induced 1 1.01625
RPL6 ribosomal protein L6 1.01625
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.01587
SOD2 superoxide dismutase 2, mitochondrial 1.01437
CSF1R colony stimulating factor 1 receptor 1.01399
NPVF neuropeptide VF precursor 1.01361
WNT7B wingless-type MMTV integration site family, member 7B 1.01249
IL1A interleukin 1, alpha 1.01249
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) 1.01137
SPC25 SPC25, NDC80 kinetochore complex component 1.01137
KRT10 keratin 10, type I 1.01137