Prolactinoma Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description OMIM mapping confirmed by DO. [SN]. (Human Disease Ontology, DOID_5394)
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Genes

288 genes co-occuring with the disease Prolactinoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
PRL prolactin 3.994
POMC proopiomelanocortin 3.354
MEN1 multiple endocrine neoplasia I 3.195
AIP aryl hydrocarbon receptor interacting protein 3.011
SST somatostatin 2.985
DRD2 dopamine receptor D2 2.888
TRH thyrotropin-releasing hormone 2.87
IGF1 insulin-like growth factor 1 (somatomedin C) 2.76
PRLR prolactin receptor 2.691
TBX19 T-box 19 2.671
SSTR5 somatostatin receptor 5 2.646
SSTR2 somatostatin receptor 2 2.486
GPR101 G protein-coupled receptor 101 2.472
GH1 growth hormone 1 2.467
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 2.442
GHRH growth hormone releasing hormone 2.413
POU1F1 POU class 1 homeobox 1 2.409
GH2 growth hormone 2 2.407
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen) 2.382
CSH2 chorionic somatomammotropin hormone 2 2.373
USP8 ubiquitin specific peptidase 8 2.347
SSTR1 somatostatin receptor 1 2.303
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.289
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 2.274
GHR growth hormone receptor 2.247
FSHB follicle stimulating hormone, beta polypeptide 2.212
ESR1 estrogen receptor 1 2.187
INS insulin 2.174
TSHB thyroid stimulating hormone, beta 2.141
PTTG1 pituitary tumor-transforming 1 2.118
GHRHR growth hormone releasing hormone receptor 2.115
GNAS GNAS complex locus 2.102
GAST gastrin 2.089
VIP vasoactive intestinal peptide 2.058
CRH corticotropin releasing hormone 1.995
TP53 tumor protein p53 1.979
SSTR3 somatostatin receptor 3 1.974
CHGA chromogranin A 1.966
MGMT O-6-methylguanine-DNA methyltransferase 1.949
SSTR4 somatostatin receptor 4 1.931
SHBG sex hormone-binding globulin 1.927
HMGA2 high mobility group AT-hook 2 1.926
NR5A1 nuclear receptor subfamily 5, group A, member 1 1.922
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 1.919
PROP1 PROP paired-like homeobox 1 1.918
USP48 ubiquitin specific peptidase 48 1.911
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) 1.892
PTH parathyroid hormone 1.882
KISS1 KiSS-1 metastasis-suppressor 1.87
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 1.814
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.811
GAL galanin/GMAP prepropeptide 1.793
PPY pancreatic polypeptide 1.784
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.757
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.754
CDC73 cell division cycle 73 1.749
AVP arginine vasopressin 1.737
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 1.709
GCG glucagon 1.702
SYP synaptophysin 1.701
FGF2 fibroblast growth factor 2 (basic) 1.7
CCND1 cyclin D1 1.694
PRB3 proline-rich protein BstNI subfamily 3 1.685
GHSR growth hormone secretagogue receptor 1.685
TGFB1 transforming growth factor, beta 1 1.675
ESR2 estrogen receptor 2 (ER beta) 1.665
CHGB chromogranin B 1.663
BMP4 bone morphogenetic protein 4 1.637
GNRHR gonadotropin-releasing hormone receptor 1.63
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.63
EGF epidermal growth factor 1.625
RET ret proto-oncogene 1.625
SNED1 sushi, nidogen and EGF-like domains 1 1.622
LEP leptin 1.619
CLRN1 clarin 1 1.619
CORT cortistatin 1.618
EGFR epidermal growth factor receptor 1.617
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.615
PRLH prolactin releasing hormone 1.609
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.606
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.597
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.594
OXT oxytocin/neurophysin I prepropeptide 1.573
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.571
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.567
OR5M1 olfactory receptor, family 5, subfamily M, member 1 1.554
PITX1 paired-like homeodomain 1 1.549
CABLES1 Cdk5 and Abl enzyme substrate 1 1.547
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.546
SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa 1.531
GHRL ghrelin/obestatin prepropeptide 1.529
HIGD1B HIG1 hypoxia inducible domain family, member 1B 1.525
FGFR4 fibroblast growth factor receptor 4 1.515
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.514
JUND jun D proto-oncogene 1.51
WIF1 WNT inhibitory factor 1 1.499
BCL2 B-cell CLL/lymphoma 2 1.486
FGF4 fibroblast growth factor 4 1.485
POU6F2 POU class 6 homeobox 2 1.483
MMP9 matrix metallopeptidase 9 1.483
MAPK3 mitogen-activated protein kinase 3 1.482
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.479
SMAD3 SMAD family member 3 1.478
IGSF1 immunoglobulin superfamily, member 1 1.445
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.435
ESM1 endothelial cell-specific molecule 1 1.435
PRDM2 PR domain containing 2, with ZNF domain 1.426
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.425
SDHAF2 succinate dehydrogenase complex assembly factor 2 1.423
PXDN peroxidasin 1.416
AVPR1B arginine vasopressin receptor 1B 1.413
PXDNL peroxidasin-like 1.413
CASR calcium-sensing receptor 1.403
ERBB2 erb-b2 receptor tyrosine kinase 2 1.4
PGR progesterone receptor 1.391
JAK2 Janus kinase 2 1.386
PCNA proliferating cell nuclear antigen 1.384
STAT5B signal transducer and activator of transcription 5B 1.382
STAT5A signal transducer and activator of transcription 5A 1.381
KRTAP10-3 keratin associated protein 10-3 1.378
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.376
PRSS55 protease, serine, 55 1.376
ADIPOQ adiponectin, C1Q and collagen domain containing 1.374
E2F1 E2F transcription factor 1 1.373
RWDD3 RWD domain containing 3 1.367
PTEN phosphatase and tensin homolog 1.364
NPY neuropeptide Y 1.358
KISS1R KISS1 receptor 1.355
TGFA transforming growth factor, alpha 1.355
IL6 interleukin 6 1.353
BRAF B-Raf proto-oncogene, serine/threonine kinase 1.352
FLNA filamin A, alpha 1.351
TRHR thyrotropin-releasing hormone receptor 1.35
PTTG2 pituitary tumor-transforming 2 1.348
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.348
DLK1 delta-like 1 homolog (Drosophila) 1.345
HNF1A HNF1 homeobox A 1.34
CDKN2A cyclin-dependent kinase inhibitor 2A 1.329
MSH6 mutS homolog 6 1.328
AMH anti-Mullerian hormone 1.326
ESRRG estrogen-related receptor gamma 1.323
MAX MYC associated factor X 1.321
KLK1 kallikrein 1 1.317
CCK cholecystokinin 1.317
FGF8 fibroblast growth factor 8 (androgen-induced) 1.306
ANKRD23 ankyrin repeat domain 23 1.293
CCNL2 cyclin L2 1.29
SF3B1 splicing factor 3b, subunit 1, 155kDa 1.289
TG thyroglobulin 1.287
CDK2 cyclin-dependent kinase 2 1.286
FGF13 fibroblast growth factor 13 1.286
BGLAP bone gamma-carboxyglutamate (gla) protein 1.286
TMEM127 transmembrane protein 127 1.284
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.267
NF1 neurofibromin 1 1.262
ALB albumin 1.261
CGB5 chorionic gonadotropin, beta polypeptide 5 1.26
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 1.259
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 1.256
FGFR1 fibroblast growth factor receptor 1 1.254
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 1.254
ANOS1 anosmin 1 1.252
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.25
NTS neurotensin 1.248
SCT secretin 1.247
FSHR follicle stimulating hormone receptor 1.243
FAM90A1 family with sequence similarity 90, member A1 1.242
TAC3 tachykinin 3 1.241
FGF10 fibroblast growth factor 10 1.239
FGF17 fibroblast growth factor 17 1.236
BAX BCL2-associated X protein 1.232
FOS FBJ murine osteosarcoma viral oncogene homolog 1.23
CDK4 cyclin-dependent kinase 4 1.225
HESX1 HESX homeobox 1 1.218
LHX3 LIM homeobox 3 1.217
MMP2 matrix metallopeptidase 2 1.217
FGF18 fibroblast growth factor 18 1.212
SOX2 SRY (sex determining region Y)-box 2 1.211
CGA glycoprotein hormones, alpha polypeptide 1.209
GADD45G growth arrest and DNA-damage-inducible, gamma 1.202
EGR1 early growth response 1 1.2
FGF16 fibroblast growth factor 16 1.198
IGFBP3 insulin-like growth factor binding protein 3 1.196
FGF20 fibroblast growth factor 20 1.195
PAQR7 progestin and adipoQ receptor family member VII 1.195
DICER1 dicer 1, ribonuclease type III 1.193
KDR kinase insert domain receptor 1.192
FGF5 fibroblast growth factor 5 1.19
FGF22 fibroblast growth factor 22 1.189
LHB luteinizing hormone beta polypeptide 1.189
PECAM1 platelet/endothelial cell adhesion molecule 1 1.189
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 1.188
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 1.187
FGF6 fibroblast growth factor 6 1.187
ACTB actin, beta 1.183
CDKN3 cyclin-dependent kinase inhibitor 3 1.182
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.181
JUN jun proto-oncogene 1.181
FGF9 fibroblast growth factor 9 1.18
PTHLH parathyroid hormone-like hormone 1.18
LHCGR luteinizing hormone/choriogonadotropin receptor 1.176
GATA2 GATA binding protein 2 1.175
KLK2 kallikrein-related peptidase 2 1.174
FGF3 fibroblast growth factor 3 1.174
SHH sonic hedgehog 1.173
DRD5 dopamine receptor D5 1.168
CDH23 cadherin-related 23 1.16
LGALS3 lectin, galactoside-binding, soluble, 3 1.156
AHR aryl hydrocarbon receptor 1.153
RAB3B RAB3B, member RAS oncogene family 1.153
NGF nerve growth factor (beta polypeptide) 1.152
ATRX alpha thalassemia/mental retardation syndrome X-linked 1.149
FGF7 fibroblast growth factor 7 1.146
CREB1 cAMP responsive element binding protein 1 1.142
CRMP1 collapsin response mediator protein 1 1.14
RP1L1 retinitis pigmentosa 1-like 1 1.14
TPT1 tumor protein, translationally-controlled 1 1.138
LHX4 LIM homeobox 4 1.136
CCNB1 cyclin B1 1.135
SNAP25 synaptosomal-associated protein, 25kDa 1.133
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 1.127
TH tyrosine hydroxylase 1.125
ERBB4 erb-b2 receptor tyrosine kinase 4 1.118
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 1.117
NNAT neuronatin 1.116
C6ORF141 chromosome 6 open reading frame 141 1.115
PITX2 paired-like homeodomain 2 1.107
NES nestin 1.102
IGF2 insulin-like growth factor 2 1.102
TPO thyroid peroxidase 1.1
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 1.095
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.094
ESX1 ESX homeobox 1 1.094
AP2S1 adaptor-related protein complex 2, sigma 1 subunit 1.094
REN renin 1.092
KBTBD6 kelch repeat and BTB (POZ) domain containing 6 1.089
ZNF676 zinc finger protein 676 1.086
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.084
CRP C-reactive protein, pentraxin-related 1.083
GRP gastrin-releasing peptide 1.082
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.079
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.078
ENO2 enolase 2 (gamma, neuronal) 1.077
CD274 CD274 molecule 1.077
TIMP2 TIMP metallopeptidase inhibitor 2 1.076
PAQR8 progestin and adipoQ receptor family member VIII 1.072
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.072
IGFBP1 insulin-like growth factor binding protein 1 1.072
BIRC5 baculoviral IAP repeat containing 5 1.072
PPARG peroxisome proliferator-activated receptor gamma 1.069
FOXP1 forkhead box P1 1.069
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 1.066
THBS1 thrombospondin 1 1.066
TNF tumor necrosis factor 1.065
GFAP glial fibrillary acidic protein 1.064
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.064
NEK3 NIMA-related kinase 3 1.06
RXRG retinoid X receptor, gamma 1.06
NOTCH3 notch 3 1.057
ARRB2 arrestin, beta 2 1.056
TMEM141 transmembrane protein 141 1.053
PREB prolactin regulatory element binding 1.051
NME1 NME/NM23 nucleoside diphosphate kinase 1 1.049
RRAD Ras-related associated with diabetes 1.045
OR6T1 olfactory receptor, family 6, subfamily T, member 1 1.044
KRT8 keratin 8, type II 1.042
TIMP1 TIMP metallopeptidase inhibitor 1 1.037
ANXA5 annexin A5 1.036
CCNA2 cyclin A2 1.035
JAG1 jagged 1 1.035
CD34 CD34 molecule 1.035
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.031
PRRX2 paired related homeobox 2 1.031
CRHR1 corticotropin releasing hormone receptor 1 1.03
CCNB2 cyclin B2 1.029
CENPI centromere protein I 1.019
ATG7 autophagy related 7 1.019
DAPK1 death-associated protein kinase 1 1.019
SLC2A11 solute carrier family 2 (facilitated glucose transporter), member 11 1.019
TIMP3 TIMP metallopeptidase inhibitor 3 1.019
NCAM1 neural cell adhesion molecule 1 1.015
MAPK12 mitogen-activated protein kinase 12 1.014
HEPN1 hepatocellular carcinoma, down-regulated 1 1.011
IGF1R insulin-like growth factor 1 receptor 1.011
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.01
CABS1 calcium-binding protein, spermatid-specific 1 1.007
PROM1 prominin 1 1.005
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 1.0